CURRICULUM VITAE

M. Allen Northrup, Ph.D., FRSC

POB 2197 Orinda, CA

94563

925-***-**** ad018g@r.postjobfree.com

ad018g@r.postjobfree.com

Member, National Academy of Engineering (NAE.edu)

Fellow, Chairman, American Institute of Medical and Biological Engineers (AIMBE.org).

Fellow, Royal Society of Chemistry (RSC.org )

Personal: Born November 23, 1954. Syracuse, New York

Career Objectives: My goals are to consult companies in the biomedical industry.

ACADEMIC TRAINING:

University of California at Davis. College of Engineering, Ph.D. Biomedical Engineering (1991). Dissertation: Application of Fluorescence Spectroscopy to In Situ Physical and

Chemical Analyses. Course work emphasis: Analytical Toxicology, Biochemical Engineering.

California State University-Humboldt. M.A. Biology Thesis research: Analytical Marine Toxicology. (1981)

University of Vermont. Burlington, VT. B.A. Zoology (1976).

INDUSTRIAL EXPERIENCE:

Spiritus Bio, 6 Oriole Rd, Orinda, CA 94563. Co-Founder, CEO, (2021 -Present) Developed and patented a new and safe face mask. Current face masks are inefficient in not allowing for the wearer to breath good air. Built the team and am seeking funding. U.S. Application Serial No. 17/545,877. Entitled: Face Mask With Improved Air Flow

PREVIOUS

MIODx, Inc. 5941 Optical Ct, San Jose, CA. 95138. Co-Founder, CEO (2014 – 2021,

(Currently BOD Member). Commercialized genetic marker-based cancer diagnostic arrays and TCell-based immuno-sequencing assays. Several patents have been issued and licensed. Completed seed funding. Built the MIODx Team.

MicroFluidic Systems. 47790 Westinghouse Dr. Fremont, CA 94539. Founder, President, CEO and CTO. (2001-2011), www.microfluidicsystems.com. Initiated all company activities; secured over $45M in contract funding; licensed 3 patents; manages executive team, corporate development, contracts, and projects; leads private funding activities; develops company strategy; interfaces with public and strategic partners. Company is focused on airborne and fluidics-based PCR and immunoassay-based pathogen detection instrumentation development. Filed over 30 patents, 13 issued.

Cepheid. 904 Caribbean Dr. Sunnyvale, CA 94089. Co-founder, VP and CTO (1997-2001). Development and management of the Research Department, made key company decisions, and participated in Executive Team and Board of Directors meetings with the other 3 officers of the company, provided foresight into advanced areas of R and D, and product development. Principal Investigator of extramurally and competitively funded grants totaling over $12M. Part of the IPO team and successfully brought the company public in June, 2000. Company is focused on PCR fluidics-based pathogen detection instrumentation development. Cepheid was purchased by Danaher Corporation in 2006. https://www.danaher.com/

Finnigan Corp., San Jose, CA. 6 years. System Test Technician (1981-82). Final testing of gas chromatograph/mass spectrometers and associated systems. Evaluation of instrument chemical sensitivity, vacuum and electrical components, and troubleshooting of entire system. Responsible for final quality of instrument to customer. Reliability /Chemist (1982-83). Instrument design reviews, standards generation, failure analysis, margin testing, component design and testing, and package design. Worked with research and engineering to incorporate reliability as a major factor in instrument design. Marketing Support Writer/Editor (1984- 86). Managing Editor of technical mass spectrometry journal, SPECTRA, and other technical marketing publications. Co-organizer of technical seminar series.

AWARDS AND FELLOWSHIPS:

•NSF-NATO Advanced Study Institute 1988, 1990). Biological Spectroscopy, Loutraki, Greece and Convective Heat and Mass Transfer in Porous Media, Izmir, Turkey.

•Graduate Fellowship (1988, 1990-91). Associated Western Universities/U.S.D.O.E.

•National Research Council Postdoctoral Fellowship (1991, not accepted).

•R and D 100 Award, (1998), for the Cepheid Smart Cycler Instrument.

•INC. Magazine Award (2009-2010). One of fastest growing 5000 small companies in US.

•Entrepreneur’s Hall of Fame (2012), Lawrence Livermore National Laboratory (LLNL). www.llnl.gov News News Center News Releases

•Innovator Award - Engineering In Medicine (2012), University of California, Davis. College of Engineering (http://engineering.ucdavis.edu/go/50years/innovators.html)

•Fellow, American Institute of Medical and Biological Engineers (AIMBE.org) 2013

•Member, National Academy of Engineering (NAE.edu), 2013 – present

•Fellow, Royal Society of Chemistry (RSC.com), 2013 - present

ACADEMIC AND RESEARCH POSITIONS:

Graduate Fellow (1986 -1991). Biomedical and Environmental Research Program, Lawrence

Livermore National Laboratory (LLNL). Development of analytical spectroscopic and fiber

optic sensor instrumentation. Concurrently, Managing Editor of SPECTRA, a semi-annual mass spectrometry journal published by Finnigan Corp.

Postdoctoral Fellow (1991-92). Microtechnology Center, LLNL.

Visiting Scholar (1991- 93) Berkeley Sensor and Actuator Center (BSAC), Department of Electrical Engineering and Computer Science, University of California at Berkeley.

Principal Engineer (1992-1997). Microtechnology Center, LLNL. Research and development of microinstrumentation for analytical biotechnology and actuator-based medical devices.

Adjunct Assistant Professor (1993-1996). Dept. of Radiology, University of California at San Francisco Medical School.

Consulting Assistant Professor (1996-2002). Center for Integrated Systems (CIS), Dept. of Electrical Engineering, Stanford University.

TEACHING AND MENTORING EXPERIENCE:

•As a graduate student, laboratory instructor for: Introductory Biology, Vertebrate Anatomy, and Human Anatomy.

•UCLA Extension, Department of Engineering, Information Sciences and Technical Management (3-day course, 1995, 96, 97). MEMS for Medical and Biotechnological Applications. Course coordinator and co-instructor.

•SPIE Short Course, 1997, MEMS for Medical and Biotechnological Applications. Course coordinator and co-instructor.

•Thiel Foundation adviser and Mentor “20 under 20” Fellowship Program and Breakout Labs, April 2012-Present.

•Recent (Fall, 2020) invited lectures on entrepreneurism Cal. State U. Monterey Bay (BUS 310-02) Entrepreneurship, and Biotechnology for Agriculture (BIO 306)

PAST AND PRESENT MEMBERSHIPS:

American Optical Society (OSA), International Society for Optical Engineering (SPIE).

American Association for the Advancement of Science (AAAS), Institute of Electrical and

Electronic Engineers (IEEE, Engineering in Medicine and Biology), the Society For Minimally

Invasive Therapy (SMIT), and the International Society for Endovascular Surgery (ISES),

American Academy of Asthma, Allergies, and Immunology (AAAAI), National Defense Industry Association (NDIA). National Academy of Engineering (NAE), Fellow of the American Institute of Medical and Biological Engineers (AIMBE). Fellow of the Royal Society of Chemistry (RSC), UK.

JOURNAL ARTICLES, PUBLISHED PROCEEDINGS, AND REPORTS.

1.Schmidt, M. and Northrup, M. A., A Cost-Effective Instrument for Accurate Trace Element Analysis, Amer. Lab., Feb., 1986, 125-134.

2.Northrup, A., Computer-Aided Chemistry: Effective Management of Chemical Information, Bio/technology, 5 (5), 1987, 455-459.

3.Northrup, M. A., Stanker, L., Vanderlaan, M., and Watkins, B., Development and

Characterization of a Fiber Optic Immuno-Biosensor, In Spectroscopy of Inorganic Bioactivators, T. Theophanides (Ed.), Kluwer Academic, Norwell, 1989, 229-241.

4.Northrup, M. A., Langry, K., and Angel, S. M., Stability Studies of a pH-Sensitive Polymer Matrix: Applications to Fiber Optic pH Sensors, Proceedings of SPIE Conference on Optical Fibers in Medicine V, vol. 1201, 1990, 368-374.

5.Northrup, M. A., Kulp, T.J., and Angel, S.M., Fluorescent Particle Imaging Velocimetry: Applications to Porous Media Flow, Applied Optics, vol. 30, 1991, 3034-3040.

6.Northrup, M. A., Kulp, T.J., Angel, S.M., and Pinder, G.F., Determination of Velocity Vectors in Porous Media WithFluorescent Particle Image Velocimetry (FPIV), In Convective Heat and Mass Transfer in Porous Media. S. Kakac, B. Kilkis, F. Kulacki, and F. Arinc (Eds.), Kluwer Academic Pub., Dordrecht, The Netherlands, 1991, 867-881.

7.Northrup, M.A., Kulp, T.J., and Angel, S.M., Application of Fluorescent Particle Imaging to Measuring Flow in Complex Media, Analytica Chimica Acta, vol. 255, no. 2, 1991, 275-282.

8.Northrup, M.A., Kulp, T.J., Angel, S.M. and G.F. Pinder, Direct Measurement of Interstitial Velocity Field Variations in a Porous Medium using Fluorescent-Particle Image Velocimetry, Chemical Engineering Science, vol. 48, no. 1, 1993, 13-21.

9.Angel, S.M. and Northrup, M.A., Stability of a Fiber Optic pH Sensor at 100 F. Electric Power Research Institute (EPRI), Report TR-101972, 1993.

10.Northrup, M.A., Ching, M.T., White, R.M., and Watson, R.T., DNA Amplification in a Microfabricated Reaction Chamber, In Transducers ‘93, Seventh International Conference on Solid State Sensors and Actuators, IEEE Proceedings, Yokohama, Japan, 1993, 924-927.

11.Lee A.P., Hong K., Trevino, J., Northrup, M.A. Thin Film Conductive Polymer for Microactuator and Micromuscle Applications., Annual Meeting of the American Society of Mechanical Engineers (ASME), Chicago, Nov. 1994.

12.Krulevitch, P., Ramsey, P.B., Makoweicki, D.M., Lee, A.P., Johnson, G.C., and Northrup,

M.A., Mixed Sputter Deposition of Ni-TI-Cu Shape Memory Films, in Proceedings of

SMST-94, First International Conference on Shape Memory and Superelasticity, A.R. Pelton, D. Hodgson, and T. Duerig (Eds.), Nitinol Development Corp., Fremont, CA. 1995.

13.Krulevitch, P., Ramsey, P.B., Makoweicki, D.M., Lee, A.P., Johnson, G.C., and Northrup, M.A., Mixed Sputter Deposition of Ni-TI-Cu Shape Memory Films, Thin Solid Films, vol. 274, 1996, 101-105.

14.Northrup, M.A., Hills, R.F., Landre, P., Lehew, Hadley, D., Watson, R. A MEMS-based DNA Analysis System., Transducers ‘95, Eighth International Conference on Solid State Sensors and Actuators, IEEE Proceedings, Stockholm, Sweden, June, 1995, 764-767.

15.Hsueh, Y-T., Smith, R.L., and Northrup, M.A., A Microfabricated Electrochemiluminescence Cell for the Detection of Amplified DNA, Transducers ‘95, Eighth International Conference on Solid State Sensors and Actuators, IEEE Proceedings, Stockholm, Sweden, June 1995, 768-771.

16.Lee, A.P., Ciarlo, D.R., Krulevitch, P.A., Lehew, S., Trevino, J., and Northrup, M.A., A

Practical Microgripper by Fine Alignment, Eutectic Bonding, and SMA Actuation, Transducers ‘95, Eighth International Conference on Solid State Sensors and Actuators, IEEE, Stockholm, Sweden, June, 1995, 368-371.

17.Lee, A.P., Ciarlo, D.R., Krulevitch, P.A., Lehew, S., Trevino, J., and Northrup, M.A., A Practical Microgripper by Fine Alignment, Eutectic Bonding, and SMA Actuation, Sensors and Actuators A.SNA 054/1-3, 1996), 755-759.

18.Lee A.P., Lehew, S., Yu, C., Ciarlo, D.R., and Northrup, M.A. Selective Au-Si Eutectic

Bonding for Si-Based MEMS Applications, Third International Symposium on

Semiconductor Wafer Bonding, Meeting of Electrochemical Society, Reno, NV, May, 1995, 518-527.

19.P. Krulevitch, A.P. Lee, P.B. Ramsey, J. Trevino, J. Hamilton, and M.A. Northrup, Thin Film Shape Memory Alloy Microactuators, Journal of Micro Electro-Mechanical Systems, vol. 5 (4), 1996.

20.Hsueh, Y-T., Smith, R.L., and Northrup, M.A., A Microfabricated Electrochemiluminescence Cell for the Detection of Amplified DNA, Sensors and Actuators, B33, 1996, 110-114

21.Woolley, A.T., Hadley, D., Landre, P., deMello, A.J., Mathies, R.A. and Northrup, M.A., Functional Integration of PCR Amplification and Capillary Electrophoresis in a Microfabricated DNA Analysis Device. Anal. Chem., 68, 1996, 4081-86.

22.Northrup, M.A., Beeman, B., R.F., Hadley, D., Landre, P., Lehew, S. Integrated Miniature DNA-based Analytical Instrument . In Anal. Methods and Instrumentation, Special Issue on MicroTAS, H. M. Widmer (ed) c/o Ciba Geigy, Basel, Nov. 1996, 153-157.

23.M. A. Northrup, B. Beeman, D. Hadley, P. Landre, S. Lehew, Development of a

Micromachined Chemical Reaction Chamber: Application to the Polymerase Chain Reaction,” in Automation Technologies for Genome Characterization, edited by T. J. Beugelsdijk, J Wiley & Sons, New York, NY, 1997. Chapter 9.

24.Belgrader, P., Smith, J.K., Weedn, V.W., and Northrup, M.A., The Application of a Portable, Miniature Thermal Cycler for Human Identification., Journal of Forensic Science,43(3), 1998, 315-119.

25.Ibrahim, M.S., Lofts, R.S., Henchal, E.A., Jahrling, P., Weedn, V.W., Northrup, M.A., and Belgrader, P. Real-time Microchip PCR for Detecting Single-Base Differences in Viral and Human DNA, Anal. Chem., 70(9), 1998, 2013-2017.

26.M. A. Northrup, D. Hadley, P. Landre, S. Lehew, J. Richards, and P. Stratton., A Miniature

DNA-based Analytical Instrument Based on Micromachined Silicon Reaction Chambers, Analytical Chemistry, 70, (5) 1998, 918-922

27.Petersen, K.E., McMillan, W.A., G.T.A. Kovacs, M.A. Northrup, L.A. Christal, and F. Pourahmadi, “Toward the Next Generation Clinical Diagnostic Instruments: Scaling and New Processing Paradigms” Biomedical Microdevices, (Kluwar Academic) Vol. 1 no. 1, 1998, 71-80.

28.Christel, L.A., Petersen, K., McMillan, W., Northrup, M.A. Rapid, Automated Nucleic Acid Probe Assays Using Silicon Microstructures for Nucleic Acid Concentration, Journal of Biomechanical Engineering, Vol. 211, 1998 22-27.

29.Petersen, K., McMillan, W.A., Kovacs, G.A., Northrup, M.A., Christel, L., and Pourahmadi, The Promise of Miniaturized Clinical Diagnostic Systems”, IVD Technology, 4(4), 43-49, 1998.

30.Northrup, M.A., Christel, L., McMillan, W.A., Petersen, K., Pourahmadi, F., Western. L., and Young, S. “A New Generation of PCR Instruments and Nucleic Acid Concentration Systems” in PCR Applications, Protocols for Functional Genomics, Innis, M.A.,. et al (Eds), Academic, San Diego, Chapter 8. 1998.

31.Belgrader, P., Hansford, D., Kovacs, G.T.A., Kudomidi, V., Mariella, R. P., Milanovich, F., Nasarabadi, S., Okuzumi, M., and Northrup, M.A., A Minisonicator to Rapidly Disrupt Bacterial Spores for DNA Analysis, Analytical Chemistry, Vol. 17, (19) 4232-4236. 1999.

32.Belgrader, P. Okuzumi, M., Pourahmadi, F., Borkholder, D.A., and Northrup, M.A., A Microfluidic Cartridge to Prepare Spores for PCR Analysis, Biosensors and Bioelectronics, Vol. 14, 849-852, 2000.

33.Belgrader, P., Benett, W., Hadley, D., Mariella, R.P., Northrup, M.A., Richards, J., Stratton, P., and Milanovich., F. Development of Battery-powered, Portable Instrumentation for Rapid DNA Analysis,. in Integrated Microfabricated Device Technologies, Heller and Guttman (Eds.), Marcel Dekker, in Press.

34.Pourahmadi F, Taylor M, Kovacs G, Lloyd K, Sakai S, Schafer T, Helton B, Western L, Zaner S, Ching J, McMillan B, Belgrader P, Northrup MA. Toward a rapid, integrated, and fully automated DNA diagnostic assay for Chlamydia trachomatis and Neisseria gonorrhoeae. Clin Chem. 46(9):1511-3. 2000.

35.Taylor, M.T., Belgrader, P. Furman, B.J., Pourahmadi, F., Kovacs, G.T.A., and M Northrup, M.A. Lysing Bacterial Spores by Sonication Through a Flexible Interface in a Microfluidic System, Analytical Chemistry, vol. 73, ( 3), 492-496, 2001.

36.Belgrader, P., Young, S., Yuan, B., Primeau, M., Christel, L.A., Pourahmadi, F., and Northrup, M.A., A Battery-Powered Notebook Thermal Cycler for Rapid Multiplex RealTime PCR Analysis. Analytical Chemistry, vol. 73, (2), 286-289, 2001.

37.Raisi, F., Belgrader, P., Borkholder, D.A., Herr, A.E., Kintz, G.J., Pourhamadi, F., Taylor, M.T., and Northrup, M..A. (2001) Microchip Isoelectric Focusing Using a Miniature Scanning Detection System. Electrophoresis, 22:2291-2295.

38.Taylor, M.T., Belgrader, P. Joshi, R., Kintz, G.A. and Northrup, MA. (2001) Fully

Automated Sample Preparation for Pathogen Detection Performed in a Microfluidic Cassette. In Micro Total Analysis Systems 2001 (eds. A. Van den Berg et. al), Kluwer Academic Publishers. Netherlands, 2001.

39.Taylor, M.T., Raisi, F., Belgrader, P., Pourahmadi, F., Herr, A.E., Kintz, G.A., and Northrup, M.A. (2001) Microfluidic Bioanalysis Cartridge with Interchangeable Microchannel Separation Components. Transducers ‘01 Eurosensors XV, Munich, 1214-1217.

40.Northrup, M.A., Pourahmadi, F., Brounstein, K., Velasco, J., Yuan, B., and Belgrader, P. Autonomous, Continuously Operating Pathogen Detection System, In Micro Total Analysis Systems 2003 (eds. A. Van den Berg et. al), Kluwer Academic Publishers. Netherlands (2003)

41.M. Sanchez, L. Probst, E. Blazevic, B. Nakao, M. A. Northrup. The microfluidic bioagent autonomous networked detector (M-BAND): an update. Fully integrated, automated, and networked field identification of airborne pathogens. SPIE Proceedings Volume 81, October 2011

ISSUED PATENTS

1.Northrup, M. A. and Langry, K., pH Optrode, #5,273,716, (1994).

2.Mariella, R.P., van den Engh, G., and Northrup, M.A., Aqueous Carrier Waveguide in a Flow Cytometer, # 5,475,487, (1995).

3.Northrup, M.A., Mariella, R.P., Balch, J., and Carrano, A. Silicon-based Sleeve Devices for Chemical Reactions, # 5,589,136, (1996).

4.Benett, W.J., Krulevitch, P.A., Lee, A.P., Northrup, M.A., Folta, J.A. Miniature Plastic Gripper and Fabrication, #5,609,601, (1997).

5.Northrup, M.A., and White, R.M. Microfabricated Reactor, #5,639,423, (1997).

6.Northrup, M.A., Ciarlo, D., Lee, A.P., Krulevitch, P.A. Microfabricated Therapeutic Actuator Mechanisms, # 5,645,564 (1997)

7.Northrup, M.A., and White, R.M. Microfabricated Reactor, (divisional) #5,646,039, (1997).

8.Lee; A.P., Northrup; M. A.,, Ahre; P. E., Dupuy; P.C., Polymer Micromold and Fabrication Process, #5,658,515(1997).

9.Northrup, M.A., and White, R.M. Microfabricated Reactor, (divisional) #5,674,742, (1997).

10.Benett; W. J., Krulevitch; P. A., Lee; A.P., Northrup; M. A., and Folta; J. A., Fabrication Method for Miniature Plastic Gripper, # 5,783,130 (1998):

11.Lee; A. P., Krulevitch; P. A., Northrup; M. A., Trevino; J.C., Micromachined Actuators/ sensors for Intratubular Positioning/steering,, #5,771,902 (1998)

12.Lee; A. P., Krulevitch; P. A., Northrup; M. A., Trevino; J.C. Microvalve. #5,819,749 (1998)

13.Northrup, M.A., Yu, C., and Raley, N. Porous Silicon Structure with High Surface Area/ Specific Pore Size, # 5,882,496, (1999).

14.Lee, A.P., Northrup, M.A., Ciarlo, D, Benett, W., Krulevitch, P.A. Microfabricated Therapeutic Actuators, # 5,911,937 (1999).

15.Lee; A. P., Krulevitch; P.A., Northrup; M. A. Benett, W.J., Microbiopsy/precision cutting devices,# 5,928,161, (1999).

16.Lee; A. P., Krulevitch; P.A., Northrup; M. A. Micromachined electrical cauterizer. #5,944,717 (1999).

17.Krulevitch; P.A., Lee; A. P., Northrup; M. A. Benett, W.J., Microfabricated Instrument for Tissue Biopsy and Analysis #5,985,217 (1999)

18.Northrup, M.A., Yu, C., and Raley, N. Process for Forming A Porous Silicon Member in a Crystalline Silicon Member, # 6,004,450, (1999).

19.Lee; A. P., Northrup; M. A., Ciarlo; D. R., Krulevitch; P.A., Benett; W. J.. Release Mechanism Utilizing Shape Memory Polymer Material, # 6,102,933 (2000)

20.Krulevitch; P. A., Lee, A.P., Northrup; M. A., Benett, W., Microfabricated instrument for tissue biopsy and analysis,# 6,319,474, ( 2001)

21.Christal, L.A., Kovacs, G.T.A., ., McMillan, W.A Northrup, M.A., Petersen, K.E.,Pourahmadi, F., Non-planar microstructures for manipulation of fluid samples, #6,368,871 (2002).

22.Christal, L.A., Northrup, M.A., Petersen, K.E., McMillan, W.A., Kovacs, G.T.A., Dority,

D.B., Hebert, R.T., Kintz, G.J., Multi-channel Optical Detection System, #6,369,893 (2002).

23.Petersen, K.E.,, Taylor, M.T Pourahmadi, F., McMillan, W.A., Chang, R., Sakai, S.H., Ching, J., Dority, D.B., Belgrader, P., Northrup, M.A.,. Apparatus for analyzing a fluid sample,# 6,391,54, (2002).

24.Pourahmadi, F, McMillan, W.A., Ching, J., Chang, R., Christal, L.A., Kovacs, G.T.A., ., Northrup, M.A., Petersen, K.E. Integrated fluid manipulation cartridge, #6,440,725 (2002).

25.Northrup, M.A., Hseuh, Y.T., Smith, R. Microfabricated Electrochemiluminescence Cell for Chemical Reactions, #6,521,181 (2003)

26.Northrup, M.A., Microfabricated sleeve devices for chemical reactions, #6,524,532 (2003). 27. Chang, R., Christal, L.A., Kovacs, G.T.A.,, McMillan, W.A Northrup, M.A., Petersen, K.E.,Pourahmadi, F.Yuan, R., Dority, D., Heat exchanging, optically interrogated chemical reaction assembly,, # 6,565,815 (2003).

28.Northrup, M. A. Temperature Control Apparatus, #6,602.473, (2003)

29.Pourahmadi, F, McMillan, W.A., Ching, J., Chang, R., Christel, L.A., Kovacs, G.T.A., .,

Northrup, M.A., Petersen, K.E. Device Incorporating a Microfluidic Chip for Separating Analyte from Sample #6,664,104 (2003)

30.Pourahmadi, F, McMillan, W.A., Ching, J., Chang, R., Christel, L.A., Kovacs, G.T.A., ., Northrup, M.A., Petersen, K.E. Device for Lysing Cells, Spores, or Microorganisms, #6,678,540, (2005)

31.Petersen, K.E.,, Taylor, M.T Pourahmadi, F., McMillan, W.A., Chang, R., Sakai, S.H., Ching, J., Dority, D.B., Belgrader, P., Northrup, M.A.,. Apparatus for analyzing a fluid sample,# 6,881,541 (2005).

32.McMillan, W.A., Petersen, K.E., Christel, L.A, Chang, R., Pourahmadi, F.,Ching., J.,

Kovacs, G.T.A J Northrup, M.A.,. Device and Method for Lysing Cells, Spores, or Microorgansims (2005)

33.Petersen, K.E., McMillan, W.A., Christel, L.A, Chang, R., Pourahmadi, F.,Ching., J., Kovacs, G.T.A J Northrup, M.A, Method for Separating analyte from a Sample. #6,893,879 (2005).

34.Christel, L.A ., Northrup, M.A., Petersen, K.E., McMillan, W.A, Kovacs, G.T.A., Young, S..j., Chang, R., Dority, D.B., Hebert, R.T., and Kintz., G.J. Multichannel Optical Detection System. #6,940,598 (2005)

35.Northrup, M.A., Petersen, K.E., McMillan, W.A, Kovacs, G.T.A., Integrated Sample Analysis Device. #6,979,424. (2005)

36.Christel, L.A ., Kovacs, G.T.A., McMillan, W.A Northrup, M.A., Petersen, K.E.,, Method for Manipulation of a Fluid Sample #7,135,144 ((2006)

37.Northrup, M.A., White, R.A., Microfabricated Reactor, #7,169,601 (2007)

38.Young, S.J., Kovacs, G.T.A., ., Northrup, M.A., Petersen, K.E., McMillan, W.A, Othmer, K., Christel, L.A. System and Method for Temperature Control, #7,188,001 (2007)

39.Chang, R., ., Christel, L.A . Kovacs, G.T.A., McMillan, W.A, Northrup, M.A, Petersen, K.E., Pourahmadi, F., Young, S.J., Yuan, R. Apparatus and Reaction Vessel for Controlling the Temperature of a Sample., #7,255,833 (2007)

40.Northrup, M.A., White, R.A. Microfabricated Reactor, Process for Manufacturing the Reactor, and Method of Amplification, #7,297,313 (2007)

41.Petersen, K.E., McMillan, W.A., Christel, L.A.. Chang, R., Pourahmadi, F, Ching, J., Kovacs, G.T.A., Northrup, M.A. Method for Separating Analyte from a Sample, # 7,569,346 (2009).

42.Northrup., M.A., Beeman, B.V., Benett, W.J., Hadley, D.R., Landre, P., Lehew, S.L., Krulevitch, P.A., Sleeve Reaction Chamber System., #7,578,976 (2009)

43.Northrup, M.A., Pourahmadi, F., Yuan, B., Devitt, A.J., Integrated Airborne Substance Collection and Detection System, # 7,633,606 (2009)

44.Northrup, M.A., Pourahmadi, F., Yuan, B., Devitt, A.J., Integrated Airborne Substance Collection and Detection System, # 7,705,739 (2010) (2009)

45.Yuan, B., Northrup, M.A., Pourahmadi, F., Apparatus to Automatically Lyse A Sample, # 7,785,868 (2010)

46.Northrup, M.A., Pourahmadi, F., Yuan, B., Devitt, A.J., Integrated Airborne Substance Collection and Detection System, #&7,858,366 (2010))

47.Petersen, K.E., McMillan, W.A., Christel, L.A.,. Chang, R., Pourahmadi, F, Ching, J., Kovacs, G.T.A., Northrup, M.A. Method for Separating Analyte from a Sample, # 7,914,994 (2010)

48.Northrup, M.A., White, R.A. Microfabricated Reactor, Process for Manufacturing the Reactor, and Method of Amplification, #7,935,312 (2011)

49.Chang, R, Christel, L.A., ., Kovacs, G.T.A.., McMillan, W.A., P Northrup, M.A. Petersen,

K.E., Pourahmadi, F,Young, S.J., Yuan, R. Dority, D. B. .,Thermal Cycler with Optical Detector #8,029,733 (2011)

50.Northrup, M.A., Apparatus and Method of Extracting and Optically Analyzing an Analyte from a Fluid-based Sample. #8,053,214 (2011)

51.Petersen, K. E. McMillan, W. A. Christel, L. A., Chang, R., Pourahmadi, F. Ching, J, Kovacs, G. T. A., Northrup; M. A. Method for Separating an Analyte from a Sample. # 8,247,176, (2012)

52.Dahiya, Rajvir; Northrup, M. A. Method of Multivariate Molecules Analysis, #10,822,661 (Nov., 2020).

53.Dahiya, Rajvir; Northrup, M. A. Method of Analysis allowing Avoidance of Surgery #10,801,072. (Oct., 2020

54.U.S. Application Serial No. 17/545,877. Entitled: Face Mask With Improved Air Flow (2022)

REVIEW COMMITTEES AND PANELS

1.Study Section Committee (Ad Hoc), National Institutes of Health (NIH), National Center for Human Genome Research, Washington, D.C., June 17-18, 1996.

2.Panelist, Future of DNA Technology in The Criminal Justice System, National Institutes of Justice, U.S. Department of Justice, Washington, D.C., June, 14-15, 1996.

3.Co-Chairman, Chem/Bio Panel, DoD Advanced Research and Experimental Sensing (ARES) Burton Richter (Nobel Laureate, Chairman). 1997.

4.Editorial Board, Biomedical Microdevices, Kluwar Academic, 1997-present.

5.Invitee, Workshop on MicroChemical Systems and Their Applications, Sponsored by ARO and DARPA. June 16-18, 1999 Wash. D.C.

6.Appointed to National Academy of Sciences (NAS)/Research Council (NRC). Committee on the Future of Biotechnology for the Army. 1999.

7.Expert Witness, National Academy of Sciences (NAS) National Research Council (NRC) Committee on Biothreats for Agriculture (2004)

8.Policy Board Member of the Center for Biochemical Optoelectronic Microsystems (CBOM), Harvard and Cornell Universities, 2001-2004

9.Panelist, National Academy of Sciences (NAS)/Research Council (NRC). 2001. Committee on the Biological Threats to Animals and Agriculture.

10.Program Reviewer, National Science Foundation of Ireland, 2003

11.Proposal Reviewer, National Science and Engineering Research Center (NSERC), 2004

12.Founding Member, Steering Committee Member, Conference Chairman, uTAS (microTotal Analysis Systems), Chemical and Biological Microsystem Society (CBMS). (1996 - present).

13.Department of Defense, Defense Threat Reduction Agency (DTRA), Scientific and Technical Evaluation Council (SciTEC) (2011-2013).

14.Committee Member, National Academy of Sciences, Board on Life Sciences, BioWatch PCR

Assays: Building Confidence, Ensuring Reliability. National Academy Press.(2017) Paperback: 978-0-309-13971-7 Ebook: 978-0-309-18763-3, doi.org/10.17226/12668

15.National Academy of Science Review Panel of NIST Physical Measurements Laboratory. May 2018- January 2019.

JOURNAL REVIEWER:

J. Applied Fluids, Bio/techniques, Nucleic Acids Res., Science, American Chemical Society, Analytical Chemistry, Biosensors and Bioelectronics, Nature/Biotechnology.

NATIONAL ACADEMY OF SCIENCES REPORT REVIEWER:

•Confronting Commercial Sexual Exploitation and Sex Trafficking of Minors in the United

States Paperback: 978-0-309-28655-8, Ebook: 978-0-309-28658-9 doi.org/

10.17226/18358 (2013)

•Environmental Chemicals, the Human Microbiome, and Health Risk: A Research Strategy, ISBN 978-0-309-46869-5 doi.org 10.17226/24960 (2018)

•Advancing Understanding of the Implications of Environmental-Chemical Interactions with the Human Microbiomes doi.org/10.17226/24960 (2018).

•The Science of Effective Mentorship in STEMM. Doi.org/10.17226/25568 Library of Congress Control Number: 201-***-****. (2019)

FUNDING RECEIVED AS PRINCIPAL INVESTIGATOR (PI), 2001-2014

Various Industry: $4.5 MM;

Dept. of Defense, DoD: $17.6 MM;

Dept. of Homeland Security, DHS: $42.0 MM;

Dept. of Justice, DOJ: $2.8 MM;

Dept. of Energy, DOE: $3.3 MM

Business Experience

M. Allen Northrup, Ph.D., FRSC

POB 2197 Orinda, CA

94563

925-***-**** ad018g@r.postjobfree.com

ad018g@r.postjobfree.com

Vision

Candidly, it’s hard to “self-aggrandize”, but I’ll reflect on what others have said, and what I think probably represents vision on my part. Back in early 1990s, in learning from a colleague about PCR methodology, it was apparent to me on me that the state-of-the art PCR machines were horribly designed: large, power intensive, expensive, and basic. The heater block was machined aluminum, and it was heating/cooling only about 25-50 microliters of reagent liquids. At the same time, I was talking to UC Berkeley Sensor and Actuator Center (BSAC) for a possible post-doctoral position. At this point, it dawned on me that some basic micromachining of silicon with an integrated heater could replace the big PCR machine with much greater efficiency, portability, and very low power. I subsequently approached a colleague at local Cetus Corporation (later bought by Roche) where PCR was invented.

From there, I was given access td Roche to implement Roche PCR technology onto a BSAC fabricated PCR Silicon chip. This was in 1990/91 and I was the first the implement PCR on a silicon chip. The collaboration continued and I was the first to implement real-time, optically interrogated PCR chip with the very early Nichia Blue LED and the pre-product Roche Taqman Chemistry in 1993. I filed several patents at Lawrence Livermore National Laboratory (LLNL) (my employer at the time) and UC Berkeley (I was named a Visiting Scholar) which ultimately lead to me co-founding Cepheid in 1996, with those patents as a basis for the technology.

This was the first “visionary” effort for me, and it became a theme of my career, as I did similar activities across multiple technologies, intellectual property, collaborations, and product concepts. Examples include: micro-actuators from LLNL for interventional surgery with surgeons from UC San Francisco medical school, LLNL PCR chip

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