AIDA S. ANGELES
Phoenixville, PA 19460
Cell phone #: 609-***-****
SUMMARY OF QUALIFICATIONS
Highly motivated professional with a strong background in LC/MS/MS, HPLC and GC method development and validation. Flexible worker with significant experience in the operation and troubleshooting of analytical instruments. Experienced analyst of various pharmaceutical formulations. Methodical, meticulous and recognized for providing quality output. Ability to manage multiple projects at the same time. Works well both independently and as part of a team.
Vast experience and knowledge on operation of various analytical instruments such as mass spectrometry, high performance liquid chromatography, gas chromatography, thin-layer chromatography, atomic absorption spectro- photometer, FTIR spectrophotometer, UV spectrophotometer, differential scanning calorimeter, liquid handlers(MP II,Tomtec, Janus), automated dissolution tester. Computer knowledge on Totalchrom, Turbochrom, Analyst, Watson, Microsoft Word and Excel.
Pharmaceutical Product Development (BMS site)
Research Scientist April2015 to Feb 24, 2017
Assoc Research Scientist June 2014 to March 2015
Collaborate in the development and validation of procedure for protein/peptide analysis using UPLC/ESI- MS/MS. Skillfully perform GLP and non-GLP study sample analysis using established assay validation method. Comply with applicable client and PPD SOPs, safety regulations and other guidelines. Keep current with required client and PPD trainings. Prepare or contribute to study report following the departmental policies, procedures and report templates. Assist in communication with project teams and/or external clients. Contribute to the development of LC-MS/MS assays for analysis of clinical and nonclinical pharmacokinetic or toxicokinetic samples. Contribute to trouble-shooting. Help in different project study support.
Aerotek (BMS Site)
Assoc Research Scientist Nov 2010 - June 2014
Collaborate in the development and validation of LC-MS/MS assays and perform study sample
analysis of clinical and non-clinical pharmacokinetic or toxicokinetic samples in a GLP-like or GLP environment. Performed bioanalytical analysis of study samples of different species and matrices with no QA findings. Proficient in using liquid handlers such as Janus mini and Tecan for sample preparation and extractions. Expert in the analysis of Human Dried Blood Spots and Saliva Spots and have improved extraction procedure resulting higher recovery. Troubleshoot with supervision and fixes ordinary assay problems. Keep an accurate and timely documentation of notebooks and study records per departmental guidelines.
Wyeth Research Arcola Road Collegeville, PA 19426
Scientist II Feb.2005 to March 2010
Develop and validate analytical methods to support nonclinical and clinical studies using LC/MS/MS. Develop methods to analyze compounds and metabolites for IND submission. Work independently on GLP and Non-GLP studies. Calibrate and troubleshoot LC/MS/MS, and Tomtec.
Lavipharm Corp. 69 Princeton-Hightstown Rd, Hightstown, NJ 08520 Analytical Chemist Sept. 2004 – Jan. 2005
Established dissolution test for drug release of transdermal drug delivery systems and analyzed by HPLC- Waters PDA. Improved the development of analytical procedure for the assay of sublingual formulation.
Kelly Scientific 2525 Route 130 Bldg. B, Cranbury, NJ 08512
Bioanalytical Chemist Oct 1996- Oct. 1999
Assisted senior research scientist in method development and validation of analytical methods for various biological samples of different matrices (e.g., blood, plasma) using HPLC. Prepared samples for analysis utilizing variety of extraction techniques including solid phase cartridges with the Zymark Rapid Trace System. Trained newly-hired chemist in the operation of analytical instruments.
Evaluated and conducted tests on raw materials based on USP. Established dissolution testing of finished tablets and stability samples.
Science Temps 02 North Ave. East, Cranford, NJ 07016
Bioanalytical Chemist May 1993 - May 1996
Developed and validated GC and HPLC methods. Conducted HPLC analyses on biological samples of different matrices. Improved the extraction by liquid-liquid phase of blood and plasma samples for LC/MS analyses.
Conducted and provided tests on raw materials. Performed dissolution of finished products. Conducted chemical analyses of finished and stability samples using multiple techniques and laboratory procedures.
United Laboratories Pharmaceutical Research, Inc. Manila, Philippines
Researcher 1980 - 1992
Developed analytical procedures and perform analyses on different pharmaceutical dosage forms. Conducted preformulation studies on bulk drugs. Prepared and designed stability protocols and conducted stability tests on finished products. Performed bioanalytical assay on human blood samples. Evaluated and approved raw materials from new suppliers. Conducted dissolution testing and performed chemical analyses on finished products.
1.Detergent-Assisted Elution: Method Optimization to Improve Analyte Elution and Assay Performance for Dried Matrix Spots (DMS) by uHPLC-MS/MS Naiyu Zheng; Jianing Zeng; Qin C. Ji; Aida Angeles; Shenita Basdeo; Anne-Francoise Aubry; Ishani Savant; Navin Jariwala; Mark E. Arnold
2.Liquid-Liquid Extraction with Inter-Well Volume Replacement Dilution Workflow and its Application to Quantify BMS- 927711 in Rat Dried Blood Spots by UHPLC-MS/MS" Naiyu Zheng, Jianing Zeng, Qin C. Ji, Aida Angeles, Adela Buzescu, Shenita Basdeo, Anne-Françoise Aubry, Kevin Trouba, Laura M. Patrone, Qianping Peng, Mark E. Arnold.
3.Novel and Cost Effective Method of Removing Excess Albumin from Plasma/Serum Samples and Its Impacts on LC-MS/MS Bioanalysis of Therapeutic Proteins: Liu, Guowen; Zhao, Yue; Angeles, Aida; Hamuro, Lora; Arnold, Mark; Shen, Jim
4.Quantitative Analysis of Creatinine Using LC-MS/MS in Support of Renal Toxicity Investigation for First-In-Human Study of BMS-962212 Yue Zhao, Guowen Liu, Aida Angeles, Shen Hong, Tongtong Liu, Bridget Morse, Yurong Lai, Lisa Christopher, Jim X. Shen and Mark E. Arnold. BMSIARC, Nov. 2014, Edison,NJ
5. Pre-digestion Sample Treatment for LC-MS/MS Bioanalysis of BiotherapeuticsGuowen Liu, Yue Zhao, Aida Angeles, Mark E. Arnold, Jim X. Shen. AAPS-NBC, May 2014, San Diego, CA
6.Method Validation and Sample Analysis of a Protein Drug Candidate in Monkey Serum Using LC-MS/MS Yue Zhao, Guowen Liu, Aida Angeles, Lora Hamuro, Mark Arnold, Jim Shen. ASMS Conference, June 2014, Baltimore, MD
7.4. Bioanalysis of dried saliva spot (DSS) samples using detergent-assisted sample extraction with UHPLC-MS/MS detection: Dr. Naiyu Zheng;Jianing Zeng, Ph.D.; Qin C Ji, Ph.D.; Aida Angeles; Anne-Francoise Aubry, Ph.D.; Shenita Basdeo; Adela Buzescu; Ishani Savant Landry, Ph.D.; Navin Jariwala; Wesley Turley; Richard Burrell, Ph.D.; Mark E Arnold, Ph.D.
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