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Post doctoral Fellow

Location:
Bethesda, Maryland, United States
Posted:
April 21, 2017
Email:
aczw2s@r.postjobfree.com

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Sri Kumar Veleti

Tel: (419) ***-**** E-mail: aczw2s@r.postjobfree.com P a g e 1

SUMMARY OF QUALIFICATIONS

Over 6 years of research experience in molecular modelling, medicinal/organic synthesis, and inhibition studies.

Well versed in analyzing and interpreting complex scientific problems and provide step-wise approach to solve them.

Self-motivated in generating new ideas and strategizing hypothesis driven research.

Experience in initiating collaborations with cross functional academic and industrial research teams.

Efficient communication skills with good record of scientific publications and presentations. WORK EXPERIENCE

Post-doctoral Fellow, National Institute of Health/ National Institute of Allergy and Infectious Diseases, Bethesda, Maryland. Jun 2016 – Present

Synthesized chemical probes to investigate the target enzyme using activity based protein identification.

Synthesized quinazoline analogs to inhibit dihydrofolate reductase.

Synthesized trehalose-based lipid radical sensor molecules. Graduate Research Assistant, University of Toledo, Toledo, Ohio. Aug 2011 – May 2016

Synthesized arabino-furanosides for inhibiting Ag85C that were crystallized to identify the binding interactions.

Synthesized first lead inhibitor and transition state inhibitors for Mycobacterium tuberculosis enzyme GlgE.

Conducted inhibition studies of enzymes by inhibitors Research Assistant, Indian Institute of Chemical Technology, Hyderabad, India. Feb 2011 - June 2011

Synthesized anthracene derivatives and studied their fluorescence properties. Research Chemist, Vasanth Chemicals, Hyderabad, India. Aug 2010- Jan 2011

Optimized the process of synthesis of active pharmaceutical ingredients and catalysts to make a cost-efficient scale up process.

Research Assistant, University of Hyderabad, Hyderabad, India. April 2009 - July 2009

Developed synthetic methodology for synthesis of pyrimidines using palladium as catalyst. Internship, Hetero labs, Hyderabad, India. May 2005- Aug 2005

Worked on large scale synthesis of Nevirapine, a non-nucleoside inhibitor of HIV-1 reverse transcriptase. EDUCATION

Ph.D. Organic Chemistry, University of Toledo, Ohio. 2011 – 2016 Advisor: Prof. Steven J. Sucheck

Dissertation title: Synthesis and evaluation of glycosyl Hydrolase- like Inhibitors

M. Sc. Organic Chemistry, Osmania University, Hyderabad, India. 2008 - 2010

B. Sc. Chemical Technology, Osmania University, Hyderabad, India. 2004 -2007 LEADERSHIP

Organized the one day event “CHEMZONE” a state level paper and poster presentation. 2007 Loyola Academy, India.

Organized the two-day work shop on Modern aspects of organic spectroscopy and drug design. 2009 Loyola Academy, India.

Sri Kumar Veleti

Tel: (419) ***-**** E-mail: aczw2s@r.postjobfree.com P a g e 2 SKILLS

Organic Synthesis: Experience in synthesizing complex molecules, small molecule probe development, medici- nal chemistry using structure-active relationship studies and their purification by chromatography.

Spectroscopic Characterization: 1H and 13C NMR, gradient NMR, UV-Vis, IR, Fluorescence spectroscopy, ESI-MS, EPR Spectroscopy, MALDI-TOF mass spectrometry.

Biochemistry: Hands-on experience in developing assays and inhibition studies of enzymes with synthesized molecules.

Computational Chemistry: Excellent knowledge of drug design by using molecular docking studies.

Communication Skills: Published research articles in various scientific journals and presented posters and oral presentations both in university and national meetings. PUBLICATIONS

Veleti, S. K.; Petit C.; Ronning, D. R.; Sucheck S. J. “Zwitterionic pyrrolidine-phosphonates: Transition state mimics of the glycoside hydrolase-like phosphorylase Streptomyces coelicolor GlgEI-V279S” Org. Biomol. Chem., 2017 (In press)

Veleti S. K. and Sucheck, S. J. “Glycoconjugate-based inhibitors of Mycobacterium tuberculosis GlgE” Witczak, Z. J., Bielski, R., Eds.; Wiley: New Jersey, 2017. (In press)

Lindenberger, J. J.; Veleti, S. K.; Wilson, B.; Sucheck, S. J.; Ronning, D. R. “Crystal structures of Mycobacterium tuberculosis GlgE and complexes with non-covalent inhibitors” Sci. Rep. 2015, 5, 12830.

Veleti, S. K.; Lindenberger, J. J.; Thanna, S.; Ronning, D. R.; Sucheck, S. J. “Synthesis of a poly-hydroxypyrolidine- based inhibitor of Mycobacterium tuberculosis GlgE” J. Org. Chem. 2014, 79 (20), 9444. (Featured Article)

Veleti, S. K.; Lindenberger, J. J.; Ronning, D. R.; Sucheck S. J. “Synthesis of a C-phosphonate mimic of maltose-1- phosphate and inhibition studies on Mycobacterium tuberculosis GlgE” Bioorg. Med. Chem. 2014, 22, 1404.

Ibrahim, D. A.; Boucau, J.; Lajiness, D. H.; Veleti, S. K.; Trabbic, K. R.; Adams, S. S. Ronning, D. R.; Sucheck S. J.

“Design, synthesis and X-ray analysis of a glycoconjugate bound to Mycobacterium tuberculosis Antigen 85C” Biocon- jugate Chem. 2012, 23, 2403.

SELECTED PRESENTATIONS

Veleti, S. K.; Lindenberger J. J.; Thanna S.; Ronning D. R.; Sucheck, S. J. “Synthesis and inhibition studies transition- state inhibitor for Mycobacterium tuberculosis GlgE” 249th ACS National Meeting & Exposition, March 2014, Denver, Colorado. (Oral presentation)

Veleti, S. K.; Lindenberger J. J.; Thanna S.; Ronning D. R.; Sucheck, S. J. “Synthesis and inhibition studies of substrate analog and transition-state inhibitor for Mycobacterium tuberculosis GlgE” 10th MCGS Symposium on carbo- hydrate and glycobiology, September 2014, University of Michigan, Ann Arbor, Michigan. (Oral presentation)

Veleti, S. K.; Lindenberger J. J.; Ronning D. R.; Sucheck, S. J. “Synthesis and inhibition studies of substrate analog for Mycobacterium tuberculosis GlgE” 247th ACS National Meeting & Exposition, August 2013, Texas, Dallas. (Poster)

Veleti, S. K.; Sucheck, S. J. “Synthesis of a non-hydrolysable C-phosphonate mimic of maltose-1-phosphate” 244th ACS National Meeting & Exposition, August 2012, Philadelphia, PA. (Poster) AWARDS

Won Dr. A.P.J. Abdul kalam award 2016 awarded by International student association and Indian student cultural organization, University of Toledo, Toledo, OH.

Won best poster for presenting “Synthesis and inhibition studies of substrate analog for Mycobacterium tuberculosis GlgE,” 9th MCGS Symposium on Carbohydrate and Glycobiology, September 2014, University of Toledo, Toledo, OH.

ACS Travel grant award, spring, 2014, Dallas, TX.

1st place for presenting paper on “Catalysis and green chemistry”, Loyola Academy, Hyderabad, India.



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