JAKKALA VENKATESHWARLU

Synthetic/Medicinal Chemist

Email: aczsy6@r.postjobfree.com

Phone: +91-988*******

HNO: 515,

V.H Road,

Sholinganallur,

Chennai- 600119.

PROFESSIONAL PROFILE

As an R&D professional, have 11+ years of industrial experience in the field of synthetic organic and medicinal chemistry.

Experienced in synthesizing wide range of bioactive molecules from mg to 100g scale.

Involved in identification of hit to lead development and finding out literatures, trouble shooting the reaction with feasible synthetic schemes and a true team oriented contributor.

Training the team of researchers and technicians, and guiding them day- to-day activity.

Contribute a routine flow of quality ideas for synthesizing target compounds. This will be evident by the level of productivity in the group.

Discuss routinely with supervisor the status of assigned projects and potential problems.

Excellent analytical skills in characterization of compound by NMR, Mass, IR and Reaction Monitoring by TLC and HPLC.

Orchid chemicals & pharmaceutical limited. Chennai, Tamilnadu (July 2005 to present)

Drug Discovery Research Dept

Research Associate

In Anti-bacterial Therapeutic Area, synthesized a novel beta-lactam, cephalosporin and carbapenem based molecules in multi-step approach for the anti-bacterial drug candidate and studied the activity of the molecules with other biologically active cores such as oxazolidinones, Fluoroquinolones etc.

Designed, planned and executed multi-step organic synthesis and purification for the production of libraries of drug-like compounds based on the lead β-Lactum to target Cell wall synthesis inhibitor or ribosome synthesis inhibitor depletion/disintegration related conditions

Synthesize compounds, design novel synthetic routes to target molecules, and modify reactants and/or equipment as required. Solve the more complex chemical problems which arise in the group.

Experience in handling and decision making for the project.

Successfully completed lead optimization within one year that resulted in the selection of a group of compounds that went on to an advanced stage of in vivo studies.

Actively participated in the drafting of patents, project drafts & planning/reporting.

KEY RESULT AREA

Designing the synthetic route for complex organic molecules using various reaction schemes.

Analysing the viability of the scheme before scale up.

Planning the reaction schemes to identify the source of the starting materials, if required.

Using the state-of-the-art Laboratories and its facility in synthesising the organic molecules and

Identify the prepared compounds and also elucidate the structure of synthesised molecules in order to ascertain their purity.

SKILLS & EXPERTISE

As a part of medicinal chemistry team, actively involved in total synthesis and characterization of novel alicyclic and aromatic heterocyclic with different scaffolds

Handling various kinds of instruments such as Autoclave (for Hydrogenation and various other kinds of other reactions), par shaker.

Handling air & moisture sensitive reagents, reactions under inert conditions, metal catalyst reactions for synthesising

Experienced in making library of New Chemical Entities (NCE?s), and also worked on the chemistry of lead molecules for further development.

Hands on experience in performing oxidation, reduction & Cyanations, halogenations, hydrogenation, nitration reaction

Problem solving of flaws in synthetic schemes and process.

Gained exposure in performing alkylation?s (N and O), acylation.

Organo metallic reagents (n-Buli, LiHMDS, LDA) mediated reactions

Electrophilic fluorinations, Enolate addition reactions

Experience in handling chemicals like sodium metal, sodium hydride, Protection/deprotections (Boc, Cbz, TMS, TBDMS, PNz, Cbz etc.)

Synthesis of 1-ethyl carbapenems using chiral auxiliary (Evans Oxazolidinones).

Synthesis of enol Triflate carbapenem

Asymmetric alkylation?s involving Evan?s oxazolidinones. Evans Oxazolidinones Auxiliaries in Asymmetric Synthesis

Sand Meyer?s reaction for the diazotization of amine to Chloro, bromo, iodo, etc, using cuprous chloride, cuprous bromide, and potassium iodide. Both Aqueous & Non- Aqueous method.

Handled several naming reactions such as Grignard reactions, Bedoukian halogenations, Suzuki, Buchwald-Hartwig, Ullmann cross coupling reactions, Finkelstein, Kolbe-nit rile synthesis, Gould-Jacob quinolones synthesis, Newman Kwart rearrangement, Masamune reaction

Apple reaction, Click chemist, Buchald coupling, Dess martin oxidation, still coupling etc?

Transition metal catalyzed CH-insertion using Du Bios Rh-catalysis, (Rh2 (OAc) 2 or Rh2 (Oct) 2

Synthesis of Active 1-methyl carbapenems using Rhodium octonate (Mechanism of intermolecular carbene insertion reaction & reductive cyclization using triisopropyl phosphite, tri ethyl phosphite.

Cycloaddition triazoles (1, 3-dipolar), tetrazoles (3+2).

Synthesis of heterocyclic (thiazoles, Amino thiazoles, substituted tetrazoles)

Hands on experience in performing microwave assisted reactions.

Skilled in the purification of compounds by chromatographic techniques and Recrystallisation methods

Acquainted with structure elucidation using NMR, IR, Mass and UV spectroscopy for synthesized compounds.

Exposed to scientific websites like prous integrity, scifinder, patents search online.

ORGANIC REAGENTS

Handled bulk scale of pyrophoric chemicals N- Butyl lithium, Sec-BuLi, tert-BuLi, Rany nickel, LiHMDS, KHMDS, Isobutylene, Borane in THF, Triethylsilane and DIBAL-H

Palladium catalysts such as palladium hydroxide, platinum oxide, Palladium acetate, palladium chloride.

Handle deadliest chemicals such as cuprous cyanide, sodium cyanide, potassium cyanide

EDUCATIONAL CREDENTIALS

M.SC (Chemistry) from the C.K.M College (Kakatiya University) Warangal 2005

B.SC chemistry from Ng college (Osmania University) nalgonda 2002

PATENTS

(PCT Provisional patent filed in India) Carbapenem compounds, Gopalan Balasubramanian, Maneesh Paul-Satyaseela, Chidambaram Venkateswaran Srinivasan, Sridhar Ramanathan Iyer, Hariharan Periaswamy, Venkatesan Parameswaran, Bharani Thirunavukkarasu, Prabhakar Rao Gunturu, Manjuladevi Deshkumar, Venkateswarlu Jakkala, Sheo Singh, Ravi Nargund, Michael Wayne Miller

WO patent filled by the title of Novel cephalosporin?s W02007096740

RAMACHANDRAN, Uma; REDDY, Gaddam, Om; TADIPARTHI, Ravi Kumar; THERATIPALLY, Prabhakar; VENKATESHWARLU, Jakkala; SUBRAMANIAN, Santhosh;

Cephalosporins are beta-lactams in which the beta-lactam ring is fused to a 6- membered dihydrothiazine ring, thus forming the cephem nucleus. A side chain modification to the cephem nucleus confers in addition to pharmacokinetic advantages an improved spectrum of antibacterial activity.

CONFERENCE ATTENDED

Attended National Symposium on chemistry at IISC Bangalore, in February 2008

Indo-US Symposium on Frontiers in Medicinal Chemistry, JSS medical college December 13 to 16th 2010

COMPUTER SKILLS

Basic fundamentals of MS-Office, MS-power point/Excel and Chem. Draw, ISIS draw, Chemsketch and Internal reagent database.

PERSONAL DETAILS:

NAME : Venkateshwarlu Jakkala

Date of birth : 08/06/1979

Father name : Ramulu

Marital status: Married

Nationality : Indian

REFERENCES

Dr. CV Srinivasan

Senior Vice President

Medicinal Chemistry, Drug Discovery

Orchid Chemicals & Pharmaceuticals Ltd

Chennai 600119

Email: aczsy6@r.postjobfree.com

aczsy6@r.postjobfree.com

Mobile: 91-956*******

Dr.Ravikumar T

Drug Discovery, medicinal Chemistry,

Wockhardt Research Laboratories Limited,

Aurangabad, India.

E-mail: aczsy6@r.postjobfree.com; aczsy6@r.postjobfree.com

Mobile: +910**********

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