Clinical Research Development
Resume:
CURRICULUM VITAE
Oonagh Dowling PhD
Sr. Clinical Research Analyst
Email: **************@*****.***
Current Address
Woodside, NY 11377, USA
Telephone: 917-***-****
Citizenship: USA
OPENING STATEMENT
Highly motivated clinical research professional with 10 years postdoctoral scientific research experience in human disease genetics and the role of inflammation in disease. Working in clinical research for 6 years. Experience in medical writing, editing, clinical study design, protocol development and statistical analysis. Current role involves collaboration with diverse clinical and scientific teams involved in interventional and non-interventional clinical research studies. Proven track record in clinical research, publishing and teaching. Excellent interpersonal, verbal and written communication skills with the ability to develop relationships with stakeholders across diverse clinical and scientific disciplines. Clinical research disciplines: Human genetics, immunology, oncology, anesthesiology, biomarkers, urology, orthopedics.
EDUCATION
• London School of Hygiene and Tropical Medicine: MSc. Epidemiology, graduation 2018
(Distance program)
• Texas A&M University: Graduate Certificate in Applied Statistics 2015
• Dublin City University: PhD. Biotechnology, 1998
• Dublin City University: BSc (Hons) in Analytical Science, 1994 Intra: Department of Receptor Pharmacology, Glaxo, Verona, Italy 1993 EMPLOYMENT EXPERIENCE
March 2011-Present Assistant Professor/Sr. Clinical Research Analyst Health Services Research
2
Departments of Medicine and Anesthesiology, Northwell Health, New Hyde Park, New York
Responsibilities include:
• Collaborates in the design and development of interventional and non- interventional clinical research studies.
• Study protocol development and writing.
• Statistical planning, data analysis, statistical report generation.
• Medical and scientific writing, abstract and paper preparation.
• Document quality review and editing of study protocols, manuscripts and regulatory applications.
• Regulatory submissions and ensuring GCP-ICH.
• Adverse event monitoring.
• Grant proposal writing and editing, budget development.
• Curriculum development for new medical school and Masters in public health program, Hofstra Northwell Health School of Medicine.
• Supervision of medical students, residents, coordinators and research nurse.
2004-Feb 2011: Research Scientist
Laboratory of Medicinal Biochemistry,
Feinstein Research Institute, Manhasset, New York. Projects:
• The role of inflammatory cytokines in preterm labor and pregnancy-induced hypertension (PIH).
• Cholinergic regulation of inflammatory cytokines at the maternal/fetal interface.
• The effect of magnesium sulfate tocolysis on TNF and inflammatory gene expression at the maternal/fetal interface and uterus during infection-induced preterm labor. Skills: Quantitative RT-PCR, microarrays, flow cytometry, immunoassays, primary cell culture. Conclusion: Research lead to a better understanding of the role of inflammatory cytokines in preterm labor and preeclampsia, how magnesium sulfate and other test compounds work to delay preterm labor and improve outcomes in women with preeclampsia. Research also demonstrated potential mechanism for magnesium sulfate and improved fetal outcomes during maternal infection-induced preterm labor. 2000-2004: Postdoctoral Research Fellow
Department of Human Genetics,
Mount Sinai Hospital, New York.
Projects:
3
• Gene discovery and function studies in inherited pediatric skeletal development disorders
• Human hereditary MMP-2 deficiency and the multicentric osteolysis.
• Discovered CMG-2 mutations resulting in loss of gene function result in allelic disorders, Juvenile Hyaline Fibromatosis and Infantile Systemic Hyalinosis.
• Evaluation of an MMP-2 deficient animal model and the effect of MMP-2 deficiency on the osteogenic potential of bone marrow stem cells.
Skills: DNA Sequencing, genotyping, quantitative RT-PCR, site-directed mutagenesis, animal model characterization, diagnostic assay development, stem cell culture. Conclusion: Research lead to discovery of novel disease causing mutations in MMP-2 and CMG-2 and their role in skeletal development.
1994-1999: Graduate Student
School of Biotechnology,
Dublin City University.
PhD Thesis: The characterization of a prolyl specific endopetidase isolated from brain.
Skills: Techniques in protein biochemistry, enzymology/enzyme kinetics and assay development, protein purification methods, HPLC, fluorimetry, mass spectrometry. GRANTS/PATENTS
1998: HRB graduate student fellowship,
School of Biotechnology,
Dublin City University.
Project: A study of a novel serum prolyl-specific peptidase and its role in clinical depression.
2005: Patent
Department of Human Genetics, Mount Sinai Hospital, New York. Title: Mutations in capillary morphogenesis gene-2 (CMG-2) and use thereof. TEACHING EXPERIENCE
March 2011-Jan 2015 Assistant Professor
Hofstra-Northwell Health School of Medicine,
MPH: Quantitative Research Methods.
2004-Feb 2011 Laboratory Mentor
Feinstein Institute for Medical Research,
4
Maternal Fetal Medicine Fellowship Program,
Laboratory Techniques in Genetics and Immunology.
1997-1999 Assistant Lecturer, Undergraduate Biochemistry School of Biotechnology,
Dublin City University.
1994-1997 Biochemistry Laboratory Instructor
School of Biotechnology,
Dublin City University.
1998 Center for Talented Youth Instructor
School of Biotechnology,
Dublin City University.
Established Genetics Curriculum.
PUBLICATIONS
Peer Reviewed Publications:
Marino J, Dowling O, Overdyk F, Scuderi G. Analgesic Efficacy of Knee Infiltration with Liposomal Bupivacaine versus Femoral Nerve Block in Total Knee Arthroplasty Postoperative Pain Management. A Randomized Controlled Trial. Submitted to Journal of Arthroplasty January 2016 V. Arya1, S. Singh, S. Agarwal, A. Valluri, O. Dowling, C. Sison, K. A. Gupta. Position Change During Colonoscopy Improves Cecal Intubation Rate, Mucosal Visibility and Adenoma Detection In Patients With Suboptimal Cecal Preparation. Gastroenterology Review. Accepted for Publication Nov. 30th 2016 Dowling O, Overdyk FJ. Response to: 'Statistical analysis of differences in turnover times among operating theatres' by Dexter. BMJ Qual Saf. 2016 Mar 10. pii: bmjqs-201*-******. doi: 10.1136/bmjqs-2016- 005271
Overdyk FJ, Dowling O, Marino J, Qiu J, Chien HL, Erslon M, Morrison N, Harrison B, Dahan A, Gan TJ. Association of Opioids and Sedatives with Increased Risk of In-Hospital Cardiopulmonary Arrest from an Administrative Database. PLoS One. 2016 Feb 25;11(2). Overdyk FJ, Dowling O, Newman S, Glatt D, Chester M, Armellino D, Cole B, Landis GS, Schoenfeld D, DiCapua JF. Remote Video Auditing with Real Time Feedback in an Academic Surgical Suite Improves Safety and Efficiency Metrics. BMJ Qual Saf. 2015 Dec 11. pii: bmjqs-201*-******. doi: 10.1136/bmjqs- 201*-******.
Marino J, Curtin J, Carol P, Theal K, Sison C, Koutsouras G, Alpert S, Healy S, Dowling O, Pekmezaris R, Chelly JE. Continuous Lumbar Plexus Catheter Removal in Postoperative Total Hip Replacement 5
Patients Receiving Warfarin Thrombophrophylaxis: A Retrospective Analysis. Open Journal of Anesthesiology 2013; 3 (6): 293-297.
Chatterjee PK, Yeboah MM, Dowling O, Xue X, Powell SR, Al-Abed Y, Metz CN. Nicotinic acetylcholine receptor agonists attenuate septic acute kidney injury in mice by suppressing inflammation and proteasome activity. PLoS One. 2012; 7(5).
Dowling O, Chatterjee PK, Gupta M, Tam Tam HB, Xue X, Lewis D, Rochelson B, Metz CN. Magnesium sulfate reduces bacterial LPS-induced inflammation at the maternal-fetal interface. Placenta. 2012 May; 33(5):392-8.
Tam Tam HB, Dowling O, Xue X, Lewis D, Rochelson B, Metz CN. Magnesium sulfate ameliorates maternal and fetal inflammation in a rat model of maternal infection. Am J Obstet Gynecol. 2011 Apr; 204(4):364-8.
Cummins PM, Dowling O, O'Connor BF. Ion-exchange chromatography: basic principles and application to the partial purification of soluble mammalian prolyl oligopeptidase. Methods Mol Biol. 2011; 681:215. Schwartz N, Xue X, Elovitz MA, Dowling O, Metz CN Progesterone suppresses the fetal inflammatory response ex vivo. Am J Obstet Gynecol. 2009 Aug; 201(2):211. Huston JM, Rosas-Ballina M, Xue X, Dowling O, Ochani K, Ochani M, Yeboah MM, Chatterjee PK, Tracey KJ, Metz CN Cholinergic neural signals to the spleen down-regulate leukocyte trafficking via CD11b. J Immunol. 2009 Jul 1; 183(1):552-9.
Dowling O, Rochelson B, Way K, Al-Abed Y, Metz CN. Nicotine inhibits cytokine production by placenta cells via NFkappaB: potential role in pregnancy-induced hypertension. Mol Med. 2007 NovDec;13(11- 12):576-83.
Mosig RA, Dowling O, DiFeo A, Ramirez MC, Parker IC, Abe E, Diouri J, Aqeel AA, Wylie JD, Oblander SA, Madri J, Bianco P, Apte SS, Zaidi M, Doty SB, Majeska RJ, Schaffler MB, Martignetti JA. Loss of MMP-2 disrupts skeletal and craniofacial development and results in decreased bone mineralization, joint erosion and defects in osteoblast and osteoclast growth.Hum Mol Genet. 2007 May 1;16(9):1113-23. Rochelson B, Dowling O, Schwartz N, Metz CN. Magnesium sulfate suppresses inflammatory responses by human umbilical vein endothelial cells (HuVECs) through the NFkappaB pathway. J Reprod Immunol. 2007 Apr;73(2):101-7.
Dowling O, Difeo A, Ramirez MC, Tukel T, Narla G, Bonafe L, Kayserili H, Yuksel-Apak M, Paller AS, Norton K, Teebi AS, Grum-Tokars V, Martin GS, Davis GE, Glucksman MJ, Martignetti JA. Mutations in capillary morphogenesis gene-2 result in the allelic disorders juvenile hyaline fibromatosis and infantile systemic hyalinosis. Am J Hum Genet. 2003 Oct; 73(4):957-66. 6
Sweedler JV, Li L, Rubakhin SS, Alexeeva V, Dembrow NC, Dowling O, Jing J, Weiss KR, Vilim FS. Identification and characterization of the feeding circuit-activating peptides, a novel neuropeptide family of aplysia. J Neurosci. 2002 Sep 1; 22 (17):7797-808. Martignetti JA, Aqeel AA, Sewairi WA, Boumah CE, Kambouris M, Mayouf SA, Sheth KV, Eid WA,Dowling O, Harris J, Glucksman MJ, Bahabri S, Meyer BF, Desnick RJ. Mutation of the matrix metalloproteinase 2 gene (MMP2) causes a multicentric osteolysis and arthritis syndrome. Nat Genet. 2001 Jul; 28 (3):261-5.
Book Chapters:
Anesthetic Management during Laparoscopic /Robotic Surgery. Smith's Textbook of Endourology - 4th Edition. Aronsohn J, Dowling O, Palleschi G. Edited by Louis Kavoussi. In Press 2nd Edition: MMP2 and the Multicentric Osteolysis,Nodulosis, and Arthropathy (MONA) and Winchester Syndromes. Inborn Errors of Development, the Molecular Basis of Clinical Disorders of Morphogenesis. Mosig RA, Dowling O, Martignetti JA. Edited by Charles J. Epstein, M.D. UCSF, Robert P. Erickson, M. D., University of Arizona and Anthony Wynshaw-Boris, University of California Pediatrics, April 2008.
Human MMP-2 Deficiency and MONA syndrome. Inborn Errors of Development, the Molecular Basis of Clinical Disorders of Morphogenesis. Dowling O, Martignetti JA Edited by Charles J. Epstein, M.D. UCSF, Robert P. Erickson, M. D., University of Arizona and Anthony Wynshaw-Boris, University of California Pediatrics, Dec 2003.
Abstracts:
2016 American Heart Association
Risk factors and Complications of Perioperative Transfusions during Cardiac Surgery: A Review of STS National Database.
Gorgy A, Hart D, O .Dowling, L. Shore-Lesserson
2016 International Anesthesia Research Society
Perioperative glucose management during cardiac surgery reduces incidence of sternal wound infections. M. Ji, O . Dowling, L. Shore-Lesserson
2015 American Society of Anesthesiologists
ASA Physical Status Inversely Correlates to Adverse Events during Procedural Sedation by Non- Anesthesiologists. W. Lee, O. Dowling, L.K. Hahn, F. J. Overdyk. Capnography Use during Procedural Sedation by Non-Anesthesiologists Reduces Incidents of Adverse Events. L. K. Hahn, O. Dowling, W. Lee, F. J. Overdyk. 7
2015 International Anesthesia Research Society
Chlorhexidine versus Povidone-Iodine in Preventing Colonization of Femoral Nerve Catheters for total knee arthroplasty. J. Marino, D. Blitz, O. Dowling, D. Bosshart, F. Overdyk. 2014 American Society of Anesthesiologists
Somatosensory Deficits From Steep Trendelenburg Positioning During Gynecologic Robotic Surgery. F J. Overdyk, O. Dowling, Joseph Danto, David M. Glatt, D.O., E Gillman, M.D. 2014 International Anesthesia Research Society
Remote Video Audits of Operating Room Practices Sustainable Improve Operating Room Throughput. F.J. Overdyk, O. Dowling, J. F. DiCapua, D. Armellino, J. Iammatteo, R. Mercieca. Effect of Single Dose IV Acetaminophen on PONV/PDNV, Pain and Patient Satisfaction in Outpatients Undergoing Laparoscopic Cholescystectomy . O. Dowling, F.J. Overdyk, D. Bosshart, J. Aronsohn, F. Macchio, J. F. DiCapua.
REFERENCES AVAILABLE UPON REQUEST
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