Hojin Kang (Ph.D.)

Instructor

Department of Pharmacology,

University of Illinois at Chicago College of Medicine Accomplished researcher with a quality track record of publications, presentations and awards in the life sciences, seeking a scientist position

Professional Experience

Instructor- Department of Pharmacology, University of Illinois-Chicago, College of Medicine 2015 - Present Discovered the novel therapeutic effect of using a Piezo1 and S1P receptor inhibitor to regulate the phosphorylation-induced gating function in a mouse model of angiogenesis model (in submission to Nature Communication). This discovery led to collaborations with physicians at the UIC hospital and industry scientists, in pursuit of designing novel therapeutic inhibitors against Piezo1 and S1P receptor.

Validated the efficacy of matrix metalloproteinase inhibitor as modulators of inflammation in a lung injury mouse model Contributed to other projects by promoting endothelial differentiation and angiogenesis using human embryonic stem cells and fibroblasts (Cell Report 2016).

Collaborated with other scientist to discover the novel molecular mechanism of angiogenesis by biochemical factors (VEGF and S1P) in vitro 2D and 3D model. The kinesin family (KIF13B), GTP-binding proteins (Septin-2), MicroRNAs (miRNA-23/27/24) Postdoctoral Fellow- Baylor college of medicine 2014 - 2014 Performed bladder cancer cell invasion and metastasis in 3D collagen matrices. Experience working with various tumor cell lines and developing a tumor microenvironment. Postdoctoral Fellow- Molecular and Cellular Medicine, Texas A&M University Health Science Center 2011 - 2014 Demonstrated that fluid shear stress promotes proprotein convertase-dependent activation of MMP14 (BBRC 2015). Demonstrated that mechanical force and biochemical factors promote matrix metaolloproteinases membrane translocation and sprouting angiogenesis in 3D collagen matrices (J Biol Chem. 2011). Provided technical and analytical expertise in collaboration with other colleagues (J Biol Chem. 2013; Angiogenesis 2012; Cell Mol Bioeng 2011).

Contributed to other projects by promoting tumor cell (U87, BT116, T24, 647V, 639V) invasion in 3D collagen matrices Researcher- Biomedical Engineering, Texas A&M University University (College Station, United States) 2005 - 2011 Demonstrated that mechanical forces modulate angiogenesis in vitro 3D model (Am J Physiol Heart Circ Physiol. 2008) Demonstrated the synergic effects of biomechanical and biochemical factors in angiogenesis Designed and established a parallel plate flow chamber, cell-culture incubator, 3D in vitro model and fluid flow system Researcher- Korea Institute of Science and Technology and Korea University (Korea) 2000 - 2003 Participated in establishment of Nano-specific Fab center Developed induction motor and brushless DC motor drive simulator using MATLAB simulink Digital signal processing based speed control of induction motor Honors and Awards

Selected oral presentation in North American Vascular Biology Organization Annual Meeting, Boston, MA 2015

First Place Poster Presentation, Texas A&M University Health Science Center College of Medicine, CS, TX 2013

Honorable Mention in the Tissue and Cellular Biomechanics and Engineering of ASME, Naples, FL 2010

Selected oral presentation in Summer Bioengineering Conference of ASME, Keystone, CO 2007

Research Fellow, Biomedical Engineering of Korea University, Korea 2005 - 2011

Research Fellow, Mechatronics Engineering of Korea University, Korea 2000 - 2002

Deputy Chief Scholarship, Control Engineering of Korea University, Korea 1995 Education

Ph.D. Texas A&M University Biomedical Engineering 2005 - 2011 To understand the molecular mechanisms of regulation of angiogenesis in developing therapeutic angiogenesis

(Am J Physiol. Heart Circ. Physiol. 2008).

Masters Korea University (Korea) Mechatronics Engineering 2000 - 2002 I have developed induction motor drive simulator using MATLAB Simulink and performed Digital Signal Processing (DSP) based speed control of induction motor.

Bachelors Korea University (Korea) Control and Instrumentation Engineering 1995 – 2000 I have performed Linear Matrix Inequality-based solutions for associative memories and fuzzy control. 1255 S State St. 1402 Chicago, IL, 60605

Email: aczk7a@r.postjobfree.com

Tel: 1-630-***-****

Volunteer and Leadership Experience

Member, North American Vascular Biology Organization 2006 - Present Member, American Society of Mechanical Engineering 2007 - Present Vice-President at Texas A&M University, Korean-American Scientists and Engineers Association 2007 – 2009 Selected Peer-reviewed Publications

1. Yamada KH, Kang H, Malik AB (2016) ‘The anti-angiogenic therapeutic potential of peptides derived from the kinesin motor KIF13B transporting VEGFR2.’ Am J Pathol. 2017 Jan; 187(1):214-224. 2. Marsboom G, Zhang GF, Pohl-Avila N, Zhang Y, Yuan Y, Kang H, Hao B, Brunengraber H, Malik AB, Rehman J. ‘Glutamine metabolism regulates the pluripotency transcription factor OCT4.’ Cell Report. 2016 July 12; 16(2) 323-32 3. Kang H, Duran CL, Abbey CA, Kaunas R, Bayless KJ. ‘Fluid shear stress promotes proprotein convertase-dependent activation of MT1-MMP.’ BBRC. 2015 May; 460(3):596-602.

4. Dave JM, Kang H, Abbey CA, Maxwell SA, Bayless KJ. ‘Proteomic profiling of endothelial invasion revealed RACK1 Complexed with Vimentin to Regulate FAK.’ J Biol Chem. 2013 Oct 18; 288(42):30720-33. 5. Kwak HI, Kang H, Dave JM, Mendoza EA, Su SC, Maxwell SA, Bayless KJ, ‘Calpain-mediated vimentin cleavage occurs upstream of MT1-MMP membrane translocation to facilitate endothelial sprout initiation.’ Angiogenesis. 2012 Jun; 15(2):287-303. 6. Kaunas R, Kang H, Bayless KJ. ‘Synergistic Regulation of Angiogenic Sprouting by Biochemical Factors and Wall Shear Stress.’ Cell Mol Bioeng. 2011 Dec; 4(4):547-559.

7. Kang H, Kwak HI, Kaunas R, Bayless KJ. ‘Fluid shear stress and S1P activate calpain to promote MT1-MMP membrane translocation and endothelial invasion into 3D model.’ J Biol Chem. 2011 8. Kang H, Bayless KJ, Kaunas R. ‘Fluid shear stress modulates endothelial cell invasion into 3D collagen matrices.’ Am J Physiol Heart Circ Physiol. 2008 Nov; 295(5):H2087-97.

9. Oh W, Kang H, Kim JS, Shin EC, Yoo JY, Kim SH, Park TS, ‘A development on induction motor drive simulator using MATLAB simulink.’ The Korean Institute of Power Electronics. 2002 10. Kang H, Abbey CA, Kaunas R, Bayless KJ. (2017) ‘Filamin A stabilizes a mechanosensitive complex at the endothelial surface to promote angiogenesis.’ (in preparation)

11. Kang H, Kaunas R, Bayless KJ. (2017) ‘Fluid shear stress and S1P promote enhance sustained MT1-MMP surface localization complexing with EC junctions during EC invasion.’ (in preparation) 12. Tsang KM, Cheng TC, Hyun JS, Vargas M, Kang H, Komarova YA, Mehta D, Ushio-Fukai M, Rehman J, Malik AB (2017) ‘HIF1α activated Etv2 and Notch1 signaling biphasically mediates ESC differentiation to arterial endothelial cells with enhanced sequestration in ischemic tissue.’ (in submission to Stem Cell Reports) 13. Kang H, Mittal M, Karginov AV, Komarova YA, Mehta D, Malik AB (2017) ‘Piezo1 sensing of endothelial wall shear stress synergizes with S1P signaling to mediate angiogenesis.’ (under revision The Journal of Circulation Research) Total publication list: https://scholar.google.com/citations?user=e2EshroAAAAJ&hl=en Research Support

T32 NIH Lung Biology and Pathology Training Program Role: Investigator 01/16/2015-01/15/2017 Technical Skills

Exceptional molecular and cell biology skills and expertise in tissue and cell culture (primary human endothelial cells, pericytes, smooth muscle cells, 293FTs, fibroblasts, U87, BT116, T24, 647V, 639V, HT1197), DNA and shRNA or siRNA based eukaryotic cell transfection, generating recombinant lentiviruses, molecular cloning, ELISA, FACS, transgenic mice handling and genotyping, mouse dermal fibroblasts isolation, PCR and analyzing in vitro angiogenic assays, matrigel plug in vivo angiogenic assay, 3D invasion assays (endothelial cell, immune cells, tumor cells), 2D cell attachment and migration assays, molecular cloning, protein purification, subcellular fraction, cell-surface labelling, immunofluorescence, immunohistochemistry, tissue sectioning using microtome, epifluorescence and confocal microscopy, immunoprecipitation, western blotting Scientific Writing Skills

Over 10 years of composing effective, descriptive, and concise scientific and technical compositions including objective, processes and procedures, techniques, methodology, data gathering and interpretation, graphic composition, executive summary developments organize and present scientific research in multiple posters and talks Knowledge of Kits and Reagents

Over 10 years of experience utilizing kits and reagents from various manufacturers for molecular biology research Computer and Other Skills

Windows, Microsoft Office, C/C++, Matlab, image Z, Labview, SAS, ANSYS, Auto CAD, Mathematica, GraphPad Prism, Language (English, Korean); organize and present scientific research in multiple posters and talks

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