Curriculum vitae

Weigang Tang, Ph.D

Slowit, Inc.

**** ****** ******

Department of Animal Biology

University of Pennsylvania

Philadelphia, PA 19104

Email: aczdv4@r.postjobfree.com, aczdv4@r.postjobfree.com,

aczdv4@r.postjobfree.com

Phone:

U.S.A. 215-***-**** (office) 215-***-**** (home)

China Shanghai; 021-********, cell phone : 136******** .

Male. Permanent resident in U.S.A.

Resident in Shanghai, China.

Education and work experience:

1.Bachelor: 1987-1991, major in physical chemistry, Jiangxi University,

Nanchang, P.R.China.

2. Ph.D: 1994-1999, studied phage display library, major in molecular biology and biochemistry, Shanghai Institute of Biochemistry, Chinese Academy of Sciences, Shanghai, P.R.China.

3. Postdoctor

1999-2000, postdoctor, studied neuroscience in gustducin transgenic/knochout mouse in Howard Hughes Medical Institute, Mount Sinai School of Medicine, New York, U.S.A.

2000-2003, postdoctor, studied NF KB and beta TrCP signaling pathways in cancer at the University of Pennsylvania, Philadelphia, U.S.A.

4. 2003--2005, research associate, affiliated with both the DNA and proteomics facility and Department of Animal Biology, utilized the two key proteomics tools (2-D SDS PAGE and nano-HPLC MS/MS ) to study IKB beta signaling in cancer, established mouse model of cancer by lentivirus-mediated transduction of inducible siRNA to address the role of IKB beta in mitochondrial stress signaling in cancer development, at the University of Pennsylvania, Philadelphia, U.S.A.

5. 2005- 2011, senior investigator, cancer biology and therapy,

at the University of Pennsylvania, Philadelphia, U.S.A.

Publications in selected peer-reviewed journals:

(1). Tang W, Gan R, Wang K: Construction and screening of a peptide phage display library. Progress Biochemistry Biophysics, 1997, 24 (3): 203- 06

(2). Tang W. Selection of cytokine mimics from peptide phage display libraries. Symposium of the 3rd Meeting of the Chinese Doctors' Forum on New Medicine 1997; 196 - 8

(3). Tang W, Gao X, Che F, Wang K. Potential GM-CSF antagonists selected from a pVIII-based phage display library. Acta Biochim Biophys,1999, 31(4): 463-65

(4). Tang W, Li j, Li C, Wang K. Selecting EGF-binding clones from a pVIII-based phage display library. Progress Biochemistry Biophysics,1999, 27 (4): 432-34

(5). Spiegelman VS, Tang W, Chan AM, Igarashi M, Aaronson SA, Sassoon DA, Katoh M, Slaga TJ, Fuchs SY. Induction of homologue of Slimb ubiquitin ligase receptor by mitogen signaling. J Biol Chem. 2002 Sep 27; 277(39): 36624-30.

(6). Spiegelman VS, Tang W, Katoh M, Slaga TJ, Fuchs SY. Inhibition of HOS expression and activities by Wnt pathway. Oncogene. 2002 Jan 24; 21(5): 856-60.

(7). Tang W, Pavlish OA, Spiegelman VS, Parkhitko AA, Fuchs SY. Interaction of Epstein-Barr virus latent membrane protein 1 with SCFHOS/beta-TrCP E3 ubiquitin ligase regulates extent of NF-kappaB activation. J Biol Chem. 2003 Dec 5; 278(49): 48942-9.

(8). Kumar KG, Tang W, Ravindranath AK, Clark WA, Croze E, Fuchs SY. SCF(HOS) ubiquitin ligase mediates the ligand-induced down-regulation of the interferon-alpha receptor. EMBO J. 2003 Oct 15; 22(20): 5480-90.

(9). Li Y, Suresh Kumar KG, Tang W, et al. Negative Regulation of Prolactin Receptor Stability and Signaling Mediated by SCF(beta-TrCP) E3 Ubiquitin Ligase. Mol Cell Biol. 2004 May;24(9):4038-48.

(10). Tang W, Li Y, Yu D, Thomas-Tikhonenko A, Spiegelman VS, Fuchs SY. Targeting beta-transducin repeat-containing protein E3 ubiquitin ligase augments the effects of antitumor drugs on breast cancer cells. Cancer Res. 2005, 65(5):1904-8.

(11). Biswas G, Tang W, Sondheimer N, Guha M, Bansal S, Avadhani NG. A distinctive physiological role for Ikappa Bbeta in the propagation of mitochondrial respiratory stress signaling. J Biol Chem. 2008 May 2; 283(18):12586-94.

(12). Plotnikov A, Li Y, Tran TH, Tang W, Palazzo JP, Rui H, Fuchs SY. Oncogene-mediated inhibition of glycogen synthase kinase 3 beta impairs degradation of prolactin receptor. Cancer Res. 2008 Mar 1;68(5):1354-61.

(13). Sangar MC, Anandatheerthavarada HK, Tang W, Prabu SK, Martin MV, Dostalek Muengerich FP, Avadhani NG. Human liver mitochondrial cytochrome P450 2D6--individual variations and implications in drug metabolism. FEBS J. 2009; 276(13):3440-53.

(14). Guha M, Tang W, Sondheimer N, Avadhani NG. Role of calcineurin, hnRNPA2 and Akt in mitochondrial respiratory stress-mediated transcription activation of nuclear gene targets. Biochim Biophys Acta. 2010 Jun-Jul;1797(6-7):1055-65.

(15).Tang W, Anindya Roy Choudhury, Manti Guha, Li Huang, Thomas Van Winkle, Anil K. Rustgi, and Narayan G. Avadhani .Silencing of IkBβ mRNA Causes Disruption of Mitochondrial Retrograde Signaling and Suppression of Tumor Growth In Vivo. Carcinogenesis . 2012 Sep;33(9):1762-8

(16). Bajpai P, Sangar MC, Singh S, Tang W, Bansal S, Chowdhury G, Cheng Q, Fang JK, Martin MV, Guengerich FP, Avadhani NG.

Metabolism of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine by mitochondrion-targeted cytochrome P450 2D6: implications in Parkinson disease.J Biol Chem. 2013 Feb 8;288(6):4436-51.

6. 2011-present, chief scientific officer and senior manager (business development, clinical trial design and management) of Slowit, Inc. which is dedicated to applying its unique and revolutionary liver-targeting drug delivery system HDL on industrial scale in human medicine.

Patent of the unique liver-targeting HDL drug delivery system: patent number: 201210321702.0 (China ) .

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