Zunqiu Chen, E-mail: acz58p@r.postjobfree.com, Tel: 503-***-****

1

Zunqiu (Eric) Chen

Division of Biostatistics

Department of Public Health & Preventive Medicine

Oregon Clinical and Translational Research Institute Oregon Health & Science University

E-mail: acz58p@r.postjobfree.com

Phone: 503-***-****

SUMMARY:

As a Statistician, I have actively collaborated with researchers in many areas, including pediatric cardiology, advanced imaging, diagnostic radiology, urology, breast cancer, hematology oncology, epidemiology, infectious disease, family medicine, Obstetrics and gynecology, etc. So far, I have provided statistical consulting for more than 120 studies, and have helped with study designs, analytics, and conference presentations in 54 studies. I have co-authored about 23 peer-reviewed publications and book chapter publications which I contributed heavily as a statistician, providing data management, analysis and writings for statistical method and result sections. As an enthusiast of statistical programming, I am proficient in data management and statistical analysis using SAS and R in the context of various medial works. In particular, I extensively write SAS Macros and R functions to improve the efficiency of analysis works procedures and advance the OCTRI BERD team and BDP team capacity for reproducible research. I also have extensive experience in conducting research on simulations for novel statistical methods or designs, and have developed online interactive applications using R Shiny and JavaScript for proposed methodologies which has been presented at local and international meetings. I have been a leader among my peers at OHSU, promoting professional development of OCTRI BERD practitioners. I am also familiar with Python, Revolution Enterprise for big data analytics.

With all achievements above, I have been acknowledged by American Statistic Association (ASA) as an ACCREDITED PROFESSIONAL STATISTICIANTM with peer recognition of having advanced statistical training and knowledge; having experience in applying statistical expertise competently; maintaining appropriate professional development; being able to communicate effectively. My current interests: Statistic modeling, Survival analysis, Machine learning, Data mining, Big Data, Business analytics, Financial analysis, Geo-spatial analysis, Classification analysis, Clustering analysis, Factor analysis, Marketing research.

EDUCATION/TRAINING:

Year Program Major/Interest Institution

2006 –2008 MS Biostatistics Dept. of Biostatistics, University of Iowa, U.S.

2005 – 2008 PhD program Geo-spatial Analysis

in Public Health area

Dept. of Geography, University of

Iowa, U.S.

2000 –2004 Research Trainee Geographic Information Science

Dept. of Geography, University of

London, U.K.

1999 –2000 MS Geographical

Information

Dept. of Geography, University of

Durham, U.K.

Zunqiu Chen, E-mail: acz58p@r.postjobfree.com, Tel: 503-***-**** 2

for Development

1998 – 1999 MS International Marketing Dundee Business School, University of Abertay Dundee, U.K.

1994 – 1998 BS Management and

Planning of

Environment and

Resource

Dept. of Geography, University of

Zhejiang, P.R.China

EXPERIENCE:

2008- Present: Research Associate, Department of Public Health & Preventive Medicine, Oregon Clinical and Translational Research Institute (OCTRI), Oregon Health and Science University

Collaborating as primary statistician in multiple NIH funded studies.

Providing medical study designs and grants applications with power analysis, design considerations, questionnaire designs, analysis plan, and randomization.

Writing statistical methods and result sections for manuscripts and conference presentations.

Conducting data management (all kinds of data extraction, transformation, manipulation, etc.) and data analysis for medical studies, some are from huge database such as SEER, Medicare, NSQIP.

Providing professional talks in regular Biostatistician staff meeting.

Holding regular drop-in consultation sessions for prompt statistical solutions to investigators throughout campus.

Projects management and triage for Biostatistics Design Group 2007-2008 Research Assistant, UIHC Dept. of Child and Adolescent Psychiatry, University of Iowa

Working as Biostatistician for multiple projects 2007- 2008 Research Assistant, UIHC Dept. of Internal Medicine, University of Iowa

Working as Biostatistician for multiple projects 2005- 2007 Research Assistant and Teaching Assistant, Dept. of Geography, University of Iowa

Conducting geo-spatial analysis and disease mapping analysis

Data management for spatial data

Assisting undergraduate in their GIS related lab exercises 2001 – 2004 Part-time Marketing Assistant in Overseas Radio and Television Inc. U.K. Branch

Conducting marketing survey questionnaire design

Conducting marketing segment analysis and plan

Conducting advertisement design and publication

Conducting products sale promotion plan

2000 – 2004 Demonstrator, Dept. of Geography, University of London

Demonstrating different applications of GIS software to graduates, undergraduates and other professionals (like UK home office people, etc.) CERTIFICATIONS:

ACCREDITED PROFESSIONAL STATISTICIANTM by American Statistical Association http://www.amstat.org/accreditation/MemberList.cfm Zunqiu Chen, E-mail: acz58p@r.postjobfree.com, Tel: 503-***-**** 3

Certified Data Scientist by Data Science Central Community group http://www.datasciencecentral.com/group/data-science-certification/user/list?page=4 COMPUTATIONAL SKILLS HIGHLIGHTS:

Proficient in SAS/BASE, SAS/STAT, SAS/SQL, SAS/MACRO, SAS/GRAPH, SAS GTL, SAS/ODS, SQL in windows environment (part of my SAS codes online: http://www.yiyichenbiostatistics.com/program.html)

Proficient in R, R Shiny, ArcGIS, ACCESS, EXCEL, Micro Office, Photoshop, Dreamweaver

Experienced in Python, HTML5/CSS, Bootstrap, JQuery, D3.js, NVD3.js, RCharts.js, JavaScript, WinBUGS

PEER-REVIEWED PUBLICATIONS:

1. MacDonald K, Vesco K, Funk K, Donovan J, Nguyen T, Chen Z, Lapidus J, Stevens V, McEvoy C, (2016) Maternal body mass index before pregnancy is associated with increased bronchodilator dispensing in early childhood: A cross-sectional study, Pediatric Pulmonology 2. Los E, Quezada E, Chen Z, Lapidus J, Silberbach M, (2016), A Pilot Study of Blood Pressure in Girls with Turner Syndrome: An “awareness gap,” clinical associations, and new hypotheses, journal Hypertension

3. Hammarlund E, Thomas A, Poore E, Rynko A, Mori T, Chen Z and Slifka M, (2016), Cross- sectional Analysis of Vaccine-Mediated Immunity Against Tetanus and Diphtheria Toxins, in Clinical Infectious Diseases

4. King LA, Jennifer W, Chen Y, Ron B, John N; Chen Z, Andrea S, Fay B (2015), Effects of Group, Individual, and Home Exercise in Persons With Parkinson Disease: A Randomized Clinical Trial, Journal of Neurologic Physical Therapy (the Golden Synapse Award for 2015) 5. Quezada E, Lapidus J, Shaughnessy R, Chen Z, Silberbach M, (2015), Aortic dimensions in Turner syndrome, American Journal of Medical Genetics Part A 6. Sun B, Chi DL, Schwarz E, Milgrom P, Yagapen A, Malveau S, Chen Z, Chan B, Danner S, Owen E, Morton V, Lowe RA (2015). Emergency department visits for non-traumatic dental problems: a mixed methods study. American Journal of Public Health. In Press. 7. Simpson EL, Chalmers JR, Hanifin JM, Thomas KS, Cork MJ, McLean WH, Brown SJ, Chen Z, Chen Y, Williams HC (2014). Emollient enhancement of the skin barrier from birth offers effective atopic dermatitis prevention, J Allergy Clin Immunol, 134(4):818-23. 8. Findholt NE, Izumi BT, Nguyen T, Pickus H, Chen Z (2014). Availability of Healthy Snack Foods and Beverages in Stores Near High-Income Urban, Low-Income Urban, and Rural Elementary and Middle Schools in Oregon. Childhood obesity, 10(4):342-8. Zunqiu Chen, E-mail: acz58p@r.postjobfree.com, Tel: 503-***-**** 4

9. King LA, Priest KC, Nutt J, Chen Y, Chen Z, Melnick M, Horak F(2014). Comorbidity and Functional Mobility in Persons with Parkinson’s Disease, Archives of Physical Medicine and Rehabilitation, 95(11):2152-7.

10. Le TD, Carney P, Lee F, Mori M., Chen Z, Leung H, Lau C, Lieberman D (2013). Differences in Knowledge, Attitudes, Beliefs, and Perceived Risks Regarding Colorectal Cancer Screening Among Chinese, Korean, and Vietnamese Sub-Groups. Journal of Community Health. 13:2

11. Hassouneh D, Nguyen T, Chen Z, McNeff E (2013). Healing pathways: a program for women with physical disabilities and depression. Rehabilitation research and practice. 649875.

12. Solomon AJ, Hills W, Chen Z, Rosenbaum J, Bourdette D, Whitham R (2013). Autoantibodies and Sjogren's Syndrome in Multiple Sclerosis, a Reappraisal. PLoS ONE; 8(6):e65385.

13. Ganzini L, Chen Z, Peters D, Misra S, Macht M, Osborne M, Keepers G (2012). Medical student views on interactions with pharmaceutical representatives. Academic Psychiatry 36(3):183-7.

14. Chen Y, Chen Z, Mori M (2012). A new statistical decision rule for single-arm phase II oncology trials. Statistical Methods in Medical Research, http://smm.sagepub.com/content/early/2012/03/28/0962280212442584.full.pdf+html 15. Allen RC, Suhler EB, Flaxel CJ, Chen Z, Choi D (2012). Long-term follow-up of patients with multiple fluocinolone implants for the treatment of non-infectious uveitis. Journal of Ophthalmic Inflammation and Infection, 2(4):177-82. 16. Spurgeon SE, Pindyck T, Okada C, Chen Y, Chen Z, Mater E, Abbi K, Epner EM (2011). Cladribine plus rituximab is an effective therapy for newly diagnosed mantle cell lymphoma. Leukemia & lymphoma 52(8):1488-94.

17. Humphrey L, Shannon J, Partin M, O’Malley J, Chen Z and Helfand M (2011). Improving the follow-up of positive hemoccult screening tests: An electronic intervention, Journal of General Internal Medicine. 26(7):691-7.

18. Le TD, Carney PA, Lee F, Leung H, Lau C, Mori M, Chen Z, Lieberman D (2011). Differences in Knowledge, Attitudes, Beliefs, and Perceived Risks Regarding Colorectal Cancer Screening Among Chinese, Korean, and Vietnamese Sub-Groups Gastroenterology, 140(5) 19. Tanyi JA, Kato C, Chen Y, Chen Z, and Fuss M (2011). Impact of the high-definition multileaf collimator (HD-MLC) on linear-accelerator-based intracranial stereotactic radiosurgery (SRS), British Journal of Radiology. 84(1003):629-638. Zunqiu Chen, E-mail: acz58p@r.postjobfree.com, Tel: 503-***-**** 5

20. Ryan CW, Vuky J, Chan JS, Chen Z, Beer TM and Nauman D (2009). A phase II study of everolimus in combination with imatinib for previously treated advanced renal carcinoma, Investigational New Drugs, 29(2):374-9.

21. Polgreen PM, Chen Z, Segre A, Harris ML, Pentella M, and Rushton G (2009). Optimizing Influenza sentinel surveillance at the State Level, American Journal of Epidemiology, 15:170(10):1300-6.

22. Harris R, Chen Z (2005). Giving dimension to point locations: urban density profiling using population surface models, Computers, Environment and Urban Systems, 29:22, 115-132, Elsevier Science.

BOOK CHAPTER PUBLICATIONS:

1. Chen Z, Rushton, G., and Smith, G. (2007). Preserving Privacy: De-identifying data by applying a random perturbation spatial mask, in Book Geocoding Health Data: The Use of Geographic Codes in Cancer Prevention and Control, Research and Practice, CRC Press. 2. Rushton G, Cai Q, and Chen Z (2007). Geocode and Kernel Density Selections for Producing Smoothed Cancer Maps, in Book Geocoding Health Data: The Use of Geographic Codes in Cancer Prevention and Control, Research and Practice, CRC Press. MANUSCRIPTS SUBMITTED:

1. Marriott L. Coppola L, Mitchell S, Bouwma J, Chen Z, Shaoon J, Impulsivity and mindset as behavioral correlates of science self-efficacy and STEM interest in adolescents MANUSCRIPT IN PREPARATION:

1. Chen Y, Chen Z, Mori M, Park B, Tyner JW, Loriaux MM, Kovacsovics T, Druker BJ. A Bayesian Response-Based Adaptive Randomization Design for Phase II Trials of Targeted Therapy.

ONLINE PUBLICATIONS:

1. Chen Z, Chen Y (2015). A Review of Medical Big Data. Capital of Statistics, http://cos.name/2015/03/the-big-data-of-medicine1/ 2. Chen Z, Chen Y (2015). Rethinking the Wearable Device and Data Utilization. Newspaper of Medical Economics, http://www.yyjjb.com/html/2015-04/13/content_222557.htm. 3. Chen Z, Chen Y(2015). Precision Medicine and Genetic and Genomic Testing. Vcbeat, http://www.vcbeat.net/12607.html

JOURNAL REVIEWS:

Zunqiu Chen, E-mail: acz58p@r.postjobfree.com, Tel: 503-***-**** 6

Preventing Chronic Disease

Heliyon

PRESENTATIONS:

1. Chen Z, Gao L, Chen Y (2016). R shiny Application for An Adaptive Bayesian Sequential Design Implemented. ICSA. Shanghai, China. December 19-22 2. Chen Z, Gao L, Halsey M, Chen Y (2016). An Adaptive Bayesian Sequential Design Implemented through a Interactive Software for Onsite Treatment Assignment. Society of Clinical Trials Annual Conference. Montreal, Canada. May 14-18. 3. Chen Z, Chen Y, Ramsey K, Los E, Lapidus J (2015). Sample Size Determination for Medical Studies of Clustered Diagnostic Tests, OHSU Research Week, Oregon Health and Science University, Oregon, U.S.

4. Los E, Lapidus J, Chen Z, Silberbach M (2015). Hypertension is common among girls with Turner Syndrome and repaired coarctation of the aorta, Pediatric Academic Societies Annual Meeting, San Diego, U.S.

5. Chen Z (2015). Reproducible research work using SAS ODS, SQL and SAS Macro, Biostatistics staff meeting, Oregion Health and Sicience University,Oregon, U.S. 6. Quezada E, Nguyen T, Chen Z, and Silberbach M (2014). What is the normal aortic size in turner syndrome, American Heart Association Session 2014, Dallas, Texas, U. S. 7. Tudorica A, Oh KY, Chui S Y-C, Roy N, Troxell ML, Chen Y, Naik A, Lopez-Chavez A, Holtorf ML, Afzal A, Jayatilake M, Chen Z, Springer CS, Li X, and Huang W(2013). Early Prediction of Breast Cancer Therapeutic Response and Evaluation of Residual Disease Using Quantitative DCE-MRI. Twenty First Annual Meeting of the International Society for Magnetic Resonance in Medicine; Salt Lake City, U.S. 8. Chen Y, Chen Z, Mori M (2012). A Bayesian Response-Based Adaptive Randomization Rule for a Phase II Clinical Trial of Targeted Therapy. 2012 DAE, Athens, GA. poster presentation, U.S.

9. Chen Y, Chen Z, Mori M, Park B, Tyner JW, Loriaux MM, Kovacsovics T, Druker BJ

(2012). A Bayesian Response-Based Adaptive Randomization Design for Phase II Trials of Targeted Therapy. The 2012 JSM. San Diego, CA., U.S. 10. Simpson EL, Chalmers JR, Hanifin JM, Berry T, Samrao A, Chen Y, Chen Z, Williams HC (2012). Barrier Enhancement for Eczema Prevention- the BEEP Feasibility Study. Society for investigative dermatology, 2012 Annual Meeting. Raleigh, NC. Selected for an oral presentation, U.S.

11. Barnett A, Thomas C, Daya M, Chen Y, Chen Z, Herzig D (2012). Curative Versus Palliative Therapy for Patients with Colorectal Cancer Presenting to the Emergency Zunqiu Chen, E-mail: acz58p@r.postjobfree.com, Tel: 503-***-**** 7

Department. The American Society of Clinical Oncology, 2012 GI Cancers Symposium, San Francisco, CA. Poster presentation, U.S.

12. Barnett A, Thomas C, Daya M, Chen Y, Chen Z, Herzig D (2012). Curative Versus Palliative Therapy for Patients with Colorectal Cancer presented to the Emergency Department. The Society for Academic Emergency Medicine, 2012 SAEM Annual Meeting, Chicago, IL. Poster presentation, U.S.

13. Chen Y, Fu R, and Chen Z (2010). Randomized or Single-arm Trial? The selection of Designs for Phase II Oncology Trials. Joint Statistical Meeting, Vancouver B. C. Canada. 14. Pindyck T, Spurgeon SE, Loriaux MM, Okada C, Chen Y, Chen Z, Mater E, Epner EM

(2010). Cladribine plus rituximab for the initial treatment of mantle cell lymphoma. American Society of Clinical Oncology, Chicago, IL. U.S.

15. Chen Y, Chen Z, and Mori M (2009). Using Historical Data for a Transitional Decision of Single-arm Phase II Clinical Trials. Joint Statistical Meeting, Washington D.C. U.S. 16. Chen Y, Chen Z and Mori M (2009). The Use of Testing Confidence Value for “Go / No Go” Decisions for Phase II Oncology Trials. The Western North American Region of the International Biometric Society Meeting, Portland OR.U.S. 17. Chen Z (2008). A spatial analysis of the Iowa child passenger safety survey based on generalized linear mixed models, Biostatistics preceptorship presentation, Department of Biostatistics, University of Iowa, U.S.

18. Chen Z (2007). The problem of mapping mortality rate: geocoding complexity, Geography Colloquium Department of Geography, University of Iowa, U.S. 19. Chen Z (2006). Urban density profiling using population surface modeling, Westlake conference, U.S.

20. Chen Z (2003). The application of point-based space filling method in human characteristics point, Royal Geographical Society-Institute of British Geographers Annual Conference, London, U.K.

21. Chen Z (2003). Urban density profiling using population surface models, GISRUK conference, U.K.

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