State University Project

Nalini Sathyanarayan

Phone: 270-***-****

Email: ***********@*****.***

SUMMARY

A self-motivated and dedicated individual with over 6 years of pharmaceutical experience in laboratory, biochemistry and cGMP areas with excellent communication skills and ability to work with diversified people with a leverage of Master of Science in Chemistry

Synthetic Organic Chemist possessing a good fundamental understanding and proficiency in Organic synthetic methodologies, reactions, mechanisms, performing and interpreting spectroscopic and chromatographic data.

Extensive experience in Biopharmaceutical Company, having a diversified skill set in drug conjugation and cGMP manufacturing of small molecule drug synthesis targeted towards Cancer therapy.

WORK EXPERIENCE:

Scientist – September 2010 to October 2016

Immunomedics, Inc. Morris Plains, NJ

Executed an important role in the cGMP manufacturing of activated SN-38 with active roles in performance, verification, and project logistics.

Participated in drafting batch record revisions, SOPs, DCos and NCRs.

Involved in the process development of Doxorubicin-linker involving multi-step synthesis.

Proficient in carrying out various reactions like PEGylations, di-acetoxylation, reductive amination, oxidation, Click reaction.

Prepared and analyzed antibody-drug conjugates.

Analyzed various tissue samples of mouse origin like liver, small intestine, large intestine, skin tissue for the determination of drug-release kinetics of antibody-drug conjugates.

Performed experiments involved in the determination of drug-release kinetics of antibody-drug conjugates in biological media.

Heavily involved in the method development for determining the residual small molecule drug remaining after the conjugation.

Hands on experience with HPLC (Empower software), LC-MS, SDS-PAGE, Silica gel column chromatography, Nanodrop, homogenization of tissues.

EDUCATION:

Master of Science in Chemistry, Thesis Option, Murray State University, Murray, KY – 2009

Project: Synthetic organic chemistry and material science

Diploma in Medical Laboratory Technology, India – 1998

Bachelor of Science, India – 1996

TECHNICAL SKILLS:

Proficient in Microsoft Word, Excel, Power point presentation, ISIS draw/ ChemDraw & MestReNova software, Prism.

RESEARCH EXPERIENCE

Master’s Thesis research work includes:

“Synthesis of Unsymmetrical Aryl-alkyl Disulfides as Potent Inhibitors of Staphylococcus aureus and Bacillus anthracis.”

Synthesized a series of nitrobenzyl and nitrophenethyl disulfides for the inhibition of virulent, drug-resistant strains of bacteria, particularly methicillin resistant Staphyloccoccus aureus. The synthesized compounds gave desirable results against the target organisms.

“Synthesis of Aryl-Alkynyl Monomers for the Application in Organic Photovoltaic Devices”

As an alternative approach to the high cost of the inorganic solar cells, the synthesis of diaryl-alkynyl monomers was attempted for the application in organic solar cell devices. This research project gave me the opportunity for hands-on experience in performing various reactions, including coupling reactions, Sonogashira coupling, Suzuki coupling, Miyaura coupling, Sandmeyer reaction, Fries rearrangement and various reduction reactions. Worked on various instrumentation techniques, this included Thin Layer Chromatography (TLC), Gas Chromatography (GC), 1H NMR, for the determination of the products.

SEMINARS:

November 2008 – ACS (American Chemical Society) meeting, Nashville, TN

January 2008 - Presented a literature seminar as an integral part of MS Chemistry program at Murray State: “One Pot Glycosylation Reactions for the Synthesis of Branched Oligosaccharides.”

2007 - Achieved 2nd place on a talk presented at the Kentucky Academy of Sciences (KAS): “Synthesis of Aryl-Alkynyl Monomers for the Application in Organic Photovoltaic Devices.”

2007 - Presented a talk at ACCM (Area Collegiate Chemistry Meeting): “Synthesis of Unsymmetrical Aryl-Alkyl Disulfides as Potent Inhibitors of Staphylococcus aureus and Bacillus anthracis.”

Published an article on the research topic as “Unsymmetric aryl-alkyl disulfide growth inhibitors of methicillin resistant Staphylococcus aureus and Bacillus anthracis”

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