Jagath Kadurugamuwa. PhD
North Richland Hills
TX 76182
************@*****.***
EDUCATION
Ph.D. in Microbiology, University of Aston, Birmingham, England
B.Sc. Honors degree in Microbiology University of Surrey, Guildford, England
Diagnostic Medical Microbiologist, St. Luke’s Hospital, Guildford, England
O.N.D. in Physical Sciences, NESCOT, Epsom, England.
PROFESSIONAL EXPERIENCE
ALCON RESEARCH, Ltd, (a Novartis company) Fort Worth, TX, USA (2011-2016)
Project Lead, Safety Microbiology
Provide technical leadership for pipeline development and product support activities including Pharmaceutical Formulation development to drive ideation and contribute to the objectives across all three business franchises (Pharmaceutical, Surgical, and Vision Care). Execute microbial testing related to FDA/EU/JP regulations and guidelines for assigned projects, monitor quality and project timelines, assist in preparation and implementation of company policies, quality systems and training programs. Recommendations resulted in initiation of an innovative approach for treatment of Dry Eye.
CLOROX CORPORATION, Pleasanton, CA, USA (2005-2011)
Research Fellow (R &D) Core Capabilities and Expertise
Provided scientific direction, technical solutions and guidance to Corporate R&D programs from technology evaluation to product launch through commercialization.
Extensive experience with EPA/FDA test methods for product approval of consumer and hospital disinfectants for robust antimicrobial activity to meet FDA/EPA regulatory requirements.
Developed rapid high-throughput in vitro screening assay for predicting EPA test method and shelf-life of food products. This resulted in reducing internal microbiological testing cost by 25% and improved laboratory efficiency.
Served as a member for Corporate Research Council.
Earned company award for Technology Advancement.
XENOGEN CORPORATION, Alameda, CA USA (2001-2005)
Directed and executed Infectious Disease Research group to support in vivo optical imaging technology for pre-clinical evaluation of therapeutic agents and host response to infections.
Initiated and managed contract research service to monitor therapeutics for medical device related infections using pre-clinical animal models. This generated additional revenue, and promoted in vivo imaging technology.
Pioneered and introduced real-time non-invasive, in vivo optical imaging strategies to concurrently monitor pathogen distribution, neuronal injury, medical device-associated infections and treatment outcomes in experimental infectious models.
Collaborated with engineers to develop novel biophotonic imaging methodologies, resolve technical problems, and support sales teams to drive $ 20-40 million annual sales.
AWARDS
Awarded research scholarship by UK Committee of vice-chancellors for outstanding Overseas Students (ORS award). England.
Awarded Alexander von Humboldt Stiftung research scholarship by the Federal Republic of Germany.
Clorox Corporation R &D Award for Technology advancement.
INVITED SPEAKER
Biophotonic Monitoring of Infections Associated with Medical Implants and treatment in Experimental Animal Models. J. Kadurugamuwa Strategic Research Institute on Medical Device R&D & Manufacturing Summit, Redwood City, CA.
Tracking Infectious Agents and Imaging Host Response. J. Kadurugamuwa. 3rd Annual Meeting of the Society for Molecular Imaging. St. Louis, MO.
Biofilms V: Molecular Biology and Reporters. Bioluminescent monitoring of biofilms and whole body imaging. Faculty Member at ASM General meeting Workshop.. Washington, DC
Bioluminescent Monitoring of Biofilms and Activities of Antibiotics In vivo. ASM Conference on Biofilms,, Victoria, British Columbia, Canada. J. Kadurugamuwa, L. V. Sin, J. Yu, K. P. Francis, A. F. Purchio, P. R. Contag.
Liposomes as delivery vehicles for antigens, antiviral and antibacterial agents. Annual Canadian Society of Microbiologists. 46th University of Prince Edward Island, Charlottetown, P.E.I., Canada. J.L Kadurugamuwa. The multi-functional role of bacterial membrane vesicles and the commercial applications
The Envelope in Bacterial Physiology and Antibiotic Action. . Garada, Italy. T.J. Beveridge and J.L. Kadurugamuwa. Periplasm, periplasmic spaces and their relation to bacterial wall structure: novel secretion of selected periplasmic proteins from Pseudomonas aeruginosa.
Pathophysiology of bacterial meningitis – implication for new management strategies. La Costa, Carlsbad, California, U.S.A.. J.L. Kadurugamuwa, B. Hengstler, and O. Zak. Effects of anti-inflammatory drugs on arachidonic acid metabolites and cerebrospinal fluid proteins during infectious pneumococcal meningitis in rabbits.
INVITED REVIEW
Natural release of virulence factors in membrane vesicles by Pseudomonas aeruginosa and the effect of aminoglycoside antibiotics on their release. (1997) J.L. Kadurugamuwa and T.J. Beveridge. Journal of Antimicrobial Chemotherapy. 1997;40: 615-621.
BOOK CHAPTER
Methods in Molecular Biology series entitled Bacterial Pathogenesis Methods and Protocols. (2007) J. L. Kadurugamuwa and Kevin P. Francis. Humana Press Inc.
ACHIEVEMENTS
Principal Inventor US patent 6,916,478. Membrane vesicle technology and its related applications. Commercial development of technology licensed to Roche Vitamins, Inc, NJ, USA.
Principal Inventor US patent 435 27. Method and Kit for Detecting Microorganisms on a Household Surface.
Media highlights. Several presentations at Annual General Meeting were selected by ASM Communications and Program Committee to highlight to the press
PUBLICATIONS.
35 + in peer reviewed journal articles