Laura O. Copp

**** ********* **. *******, ** ****4

919-***-****

acyts6@r.postjobfree.com

senior research scientist targeting positions in

research and development

Areas of Knowledge: Extensive knowledge in molecular biology, immunology, microbiology, virology, vaccines, drug development, nano-technologies, assay development.

Molecular and Immunological Techniques: (not inclusive) cloning, pcr, strain construction, mutagenesis, sequencing. isolation, purification and quantification of sirna, rna and dna, real time pcr, multiplex assays. in vitro and in vivo sirna and mrna purification, quantification and gene expression assays, elisa, elispot, icc, facs, phenotyping, virus titration sds-page and staining assays/analysis, Western, Northern, Southern Blot & hybridization (certified to work with radioactive isotopes), ChIP, ß-Galactosidase Assay and in vivo transcription rate analysis.

Cellular Assays: cell culture (numerous cell lines including transgenic human and mouse). primary cell culture, hemagglluttination, hemaggllutination inhibition, neuraminidase enzyme detection assays, red blood cell aggregation, antigen specific tolerance induction, t-reg cell/peptide re-stimulation, binding assays Antigen specific tolerance induction, T-regulatory cell/peptide re-stimulation, binding assays, neutralization assays, mtt, mts and confocal microscopy.

Professional Experience

percorso life sciences, llc. plymouth mtg, pa 2010 – 2011 (contract)

business development - Hired to develop database and create product portfolio to identify existing and prospective clients to expand market base in North America. Primary product portfolio is specific to innate immunity.

epivax vaccines, inc. providence, ri 2009 – 2010 (contract)

senior research and development scientist- Hired to direct vaccine team and implement new techniques to

elevate productivity, reduce variability, efficacy and ensure ongoing project deadlines were met/

completed.

designed protocols for all biological assays; developed protocol for processing nasal aspirates and blood from local hospital to test for novel influenza positives.

headed colaborations to develop novel vaccine therapeutics and prove efficacy. ensured stringent timelines were met to achieve critical milestones.

generated and ensured budget adherance alongside cfo.

liquidia technologies, inc., durham, nc 2007 – 2009

senior research and development scientist – Hired to assist director of biology

to build start-up biology/vaccine department to focus on innovative ways to

deliver nucleic acids, inhaled therapeutics, and vaccines.

designed protocols for all biological assays to implement novel delivery of nucleic acids, inhaled therapeutics and vaccines using nanoparticles.

developed/optimized novel delivery of nucleic acids, drugs, vaccines, and therapeutics (including inhaled) using viral vectors (vrp), nanoparticles, vlp’s, and electroporation.

collaborated with senior management at large pharma companies to develop sirna therapeutics, and implement by nanoparticles.

charged with new hires and lab design and build-out.

developed budgets for the biology department and worked with cfo, purchasing and accounting departments to ensure budget adherence.

alphavax vaccines, inc., durham, nc 2003 – 2006

research and development scientist (2005–2006)

research associate (2003-2005) - Hired to develop new vaccine products for infectious diseases, biodefense

and cancer. generated alphavirus replicon particles for use as platform vaccine technology.

generated methods of enhancing immune responses (authored on patents referenced below).

guided the design of multiple animal studies (non-human primate – mice) and assembled, analyzed and presented data.

formulated vaccines used in clinical trials. (influenza, hcmv, hiv, cea, her2neu, psma). demonstrated protection in over half a dozen species ranging from mice to non-human primates.

designed the first her2neu elisa that demonstrated consistent results and now standardized for use in clinical trials.

monitored new reagents to advance projects efficiently and improve techniques and ensure deadlines were met.

bsl-3 certified

emory university (aftab a. ansari lab), atlanta ga 2002-2003

research specialist - Hired to conduct research involving analysis of immunological mechanisms of disease

resistance vs. disease susceptibility in nonhuman primate model of human HIV-1 infection.

Instituted new technology to remove lipids from human blood.

processed and analyzed non-human primate wbc's using immunological assays to measure and compare immune responses in siv positive and negative animals.

reported on peer data and brainstormed with director to generate key questions to guide design of follow-on studies.

managed study budgets; wrote animal study protocols and assisted with grant writing.

Resume addendum

scientific patents and publications

PATENTS

"Alpha virus Replicon Particles Matched to Protein Antigens as Immunological Adjuvants"

"Alpha virus Replicon Particles as Immunological Adjuvants"

“ Immunomodulator Particles and Methods of Treating”

PUBLICATIONS

Analysis of Venezuelan Equine Encephalitis Replicon Particles Packaged in Different Coats.

plos one. 2008 Jul 16; 3(7):e2709. Kamrud, Kurt I., Alterson, Kim D., Andrews, Chasity, Copp, Laura O., Lewis,

Whitney C., Hubby, Bolyn, Patel, Deepa, Rayner Jonathan O; Talarico, Todd, Smith Jonathan F.

Prostate Stem Cell Antigen Vaccination Induces A Long-Term Protective Immune Response Against Prostate

Cancer In The Absence Of Autoimmunity. kamrud Kurt I; Alterson Kim D; Andrews Chasity; Copp Laura O; Lewis Whitney C; Hubby Bolyn; Patel Deepa; Rayner Jonathan O; Talarico Todd; Smith Jonathan F

VRP Immunotherapy Targeting HER2 Neu: Treatment Efficacy And Evidence For Immunoediting In A Stringent

Rat Mammary Tumor Model. Breast cancer research and treatment 2007; 106(3):371-82.

2007: Hubby Bolyn; Talarico Todd; Maughan Maureen; Reap Elizabeth A; Berglund Peter; Kamrud Kurt I; Copp

Laura; Lewis Whitney; Cecil Chad; Norberg Pamela; Wagner Jordan; Watson Aubrey; Negri Sarah; Burnett Bruce K; Graham Andrew; Smith Jonathan F; Chulay Jeffrey D

Vaccine. 2007 Oct 5; : 17961878 Bolyn Hubby, Todd Talarico, Maureen Maughan, Elizabeth A Reap, Peter Berglund, Kurt I Kamrud, Laura Copp, Whitney Lewis, Chad Cecil, Pamela Norberg, Jordan Wagner, Aubrey Watson, Sarah Negri, Bruce K Burnett, Andrew, Graham, Jonathan F Smith, Jeffrey D Chulay

Education

Georgia State University, Atlanta, GA; 2002

M.S. in Molecular Genetics and Biochemistry

Activities: Research Technician, Teaching Assistant

North Carolina State University, Raleigh, NC; 1997

B.S. in Zoology

professional development

Certification in Blood Borne Pathogen

(CITI) GMP-GLP training and certification

Certified to work in BSL3

ELISPOT training & collaboration with Sylvia Janetzki, M.D., Ph.D (Zellnet Consulting)

computer / equipment skills

Vector NTI, ABI Sequencer/analytical software, FACSCalibur Flow Cytometer, FlowJo, Guava Cell Counter, Tissue Disrupter, Molecular Devices Plate Reader, Zeiss Confocal Microscope, SoftMax Pro, Fuji Image Reader, Jmp Statistical Software, Graph Pad Prism, Primer Express, UV Probe, Microsoft Office

references

available upon request

Contact this candidate