Quality Control State University

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Xi Liang

*** ****** ***** ****, ****, North Carolina 27513

Cell Phone: 919-***-**** E mail: *******@*******.*** BACKGROUND SUMMARY

Research Chemist with a successful 19 year career in pharmaceutical industry with broad experience in analytical and medicinal chemistry

PROFESSIONAL EXPERIENCE

MDDX Research and Informatics, Research Triangle Park, North Carolina Testing and Validation Specialist (2015 – present)

Perform validation for in house clinical trial data platform to compliance with 21 CFR Part 11 and other FDA regulations

Design and implement in house clinical trial quality control system by analyzing client business requirements

Perform regular security analysis in infrastructure, document systems, processes, and procedures to identify gap not meeting the compliance rules (GCP, HIPAA, FDA). GlaxoSmithKline, Research Triangle Park, North Carolina Research Chemist (2001 2015)

Medicinal and Analytical Chemistry Department, Molecular Discovery Research

Synthesis, purification, and characterization of novel drug like molecules across different therapeutic areas, such as obesity / diabetes, anti virus, anti bacterial, immune disease, and cardiovascular.

Parallel synthesis, high throughput purification and final QC analysis of compound library for the discovery of biologically active lead molecules in the nuclear receptor area

Stability study and pharmacokinetic properties characterization of large non absorbable drug molecules for the type 2 diabetes program

Scios Inc. (later acquired by Johnson & Johnson), Sunnyvale, California Research Chemist (1996 2001)

Kinase Research, Medicinal / Analytical Chemistry

Applied complex organic syntheses in the p38 kinase candidate seeking program for inflammatory disorders. Synthesized and developed a p38 kinase clinical candidate (SCIO 469), which progressed to Phase II clinical trial within Johnson & Johnson

TECHNICAL SKILLS

Highly experienced in complex small molecule synthesis, analysis, and characterization

Highly proficient with multiple analytical technologies: Biotage / ISCO flash and reversed phase chromatography systems, Agilent/Gilson analytical and preparation HPLC/UPLC systems, LC MS, GC /GC MS, UV spectroscopy, and IR spectroscopy

Highly proficient at obtaining and interpreting analytical data: 1H NMR, 13C NMR, HPLC, LC MS, GC MS, IR

Thorough understanding of GMP, USP, and FDA guidelines; OSHA and EPA regulations, and their application to Active Pharmaceutical Ingredient (API) process

Standard Operation Procedure (SOP) writing, organizing and lift cycle management

Proficient with chemistry database and software: Chemdraw, ACD SpecManager, Mass Lynx, MOE, SciFinder, Beilstein, and e Notebook

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Skills that I take the most pride in are my ability to effective planning of my chemistry, time management of my lab work, and creativity in solving problem

EDUCATION

Master’s of Science. 1996, Medicinal chemistry, College of Pharmacy, Oregon State University, Corvallis, Oregon HONORS AND AWARDS

Two GlaxoSmithKline Exceptional Science Awards (2006 and 2007) For outstanding significant scientific contributions to the discovery of two lead molecules for the progesterone receptor program (2006) and a pre candidate for the estrogen beta receptor program (2007) PATENTS AND PUBLICATIONS

1. Sparks, Steve M.; Aquino, Christopher J.; Banker, Peri; Collins, Jon. L; Cowan, David J; Diaz, Caroline; Dock, Steve T.; Hertzog, Don; Liang, Xi; Yuen, Josephine; Chen, Grace; Jayawickreme, Chana; Rash, Vincent; Rimele, Thomas; Roller, Shane.; Ross, Sean. Exploration of Phenylpropanoic Acids as Agonists of the Free Fatty Acid Receptor 4 (FFAR4/GPR120): Identification of In Vivo Tool Compounds. Manuscript in preparation for submission to Journal of Medicinal Chemistry 2. Sparks, Steven M.; Chen, Grace; Collins, Jon L.; Danger, Dana; Dock, Steven T.; Jayawickreme, Channa; Jenkinson, Stephen; Laudeman, Christopher; Leesnitzer, M. Anthony; Liang, Xi; Maloney, Patrick; McCoy, David C.; Moncol, David; Rash, Vincent; Rimele, Thomas; Vulimiri, Padmaja; Way, James M.; Ross, Sean. Identification of diarylsulfonamides as agonists of the free fatty acid receptor 4 (FFA4/GPR120). Bioorganic & Medicinal Chemistry Letters 2014, 24(14), 3100 3103 3. Wu, Yulin; Aquino, Christopher J.; Cowan, David J.; Anderson, Don L.; Ambroso, Jeff L.; Bishop, Michael J.; Boros, Eric E.; Chen, Lihong; Cunningham, Alan; Dobbins, Robert L.; Feldman, Paul L.; Harston, Lindsey T.; Kaldor, Istvan W.; Klein, Ryan; Liang, Xi; McIntyre, Maggie S.; Merrill, Christine L.; Patterson, Kristin M.; Prescott, Judith S.; Ray, John S.; Roller, Shane G.; Yao, Xiaozhou; Young, Andrew; Yuen, Josephine; Collins, Jon L. Discovery of a Highly Potent, Nonabsorbable Apical Sodium Dependent Bile Acid Transporter Inhibitor (GSK2330672) for Treatment of Type 2 Diabetes. Journal of Medicinal Chemistry, 2013, 56(12), 5094 5114

4. Johnson, Christopher N.; Jones, David G.; Liang, Xi; Macpherson, David T.; Miller, Aaron B.; Stanway, Steven J.; Takle, Andrew K.; Trani, Giancarlo. Indazoles used to treat estrogen receptor beta mediated. disordersGlaxoSmithKline, 2011, US patent 7,960,563 5. Johnson, Christopher N.; Jones, David G.; Liang, Xi; Macpherson, David T.; Miller, Aaron B.; Naylor, Antoinette; Stanway, Steven James; Takle, Andrew K.; Trani, Giancarlo. Substituted 4 hydroxy n (4 hydroxyphenyl) indoles as estrogenic agents. GlaxoSmithKline, 2011 US patent 7,956,083 6. Allen, Scott; Blackwell, William C., III; Boros, Eric; Collins, Jon L.; Hertzog, Don; Liang, Xi; Ray, John; Reister, Steven Michael; Samano, Vicente; Sherrill, Ron. Preparation of bis pyridylpyridones as melanin concentrating hormone receptor 1 antagonists. GlaxoSmithKline, 2011 US 201******** Page 3

7. Jones, David G.; Brown, Peter J.; Clackers, Margaret; Gray, David; Gomez, Melissa; Hoekstra, William J.; Kaldor, Istvan W.; Kallander, Lara; Lambert, Millard H.; Li, Hu; Liang, Xi; Madauss, Kevin; Miller, Aaron B.; Noe, Robert A.; Sasse, Rosemary; Stewart, Eugene L.; Stuart, L. William; Thompson, Scott K.; Turnbull, Philip; Villeneuve, Manon; Washburn, David; Williams, Shawn; Willson, Timothy M. Multiple parallel approaches to steroid hormone receptor lead identification. Abstracts of Papers, 235th ACS National Meeting, New Orleans, LA, United States, 2008

8. Mavunkel, Babu J.; Chakravarty, Sarvajit; Perumattam, John J.; Dugar, Sundeep; Lu, Qing; Liang, Xi. Indole type derivatives as inhibitors of p38 kinase. Scois Inc. 2007, US patent 7,304,048 9. Mavunkel, Babu J.; Chakravarty, Sarvajit; Perumattam, John J.; Dugar, Sundeep; Lu, Qing; Liang, Xi. Indole type derivatives as inhibitors of p38 kinase. Scois Inc. 2007, US patent 7,238,712 10. Mavunkel, Babu J.; Chakravarty, Sarvajit; Perumattam, John J.; Dugar, Sundeep; Lu, Qing; Liang, Xi. Benzofuran derivatives as inhibitors of p38 alpha kinase. Scois Inc. 2007, US patent 7,189,726 11. Jones, David G.; Kaldor, Istvan; Liang, Xi; Turnbull, Philip Stewart; Hammond, Marlys; Kallander, Lara S.; Thompson, Scott Kevin; Washburn, David. Preparation of N cyanoaryl amino acid amides for treating endometriosis or uterine fibroids. GlaxoSmithKline, PCT Int. Appl. 2006 WO 200-***-**** A2 12. Jones, David G.; Liang, Xi; Stewart, Eugene L.; Noe, Robert A.; Kallander, Lara S.; Madauss, Kevin P.; Williams, Shawn P.; Thompson, Scott K.; Gray, David W.; Hoekstra, William J. Discovery of non steroidal mifepristone mimetics: Pyrazoline based PR antagonists. Bioorganic & Medicinal Chemistry Letters 2005, 15(13), 3203 3206

13. Mavunkel, Babu J.; Chakravarty, Sarvajit; Perumattam, John J.; Dugar, Sundeep; Lu, Qing; Liang, Xi. Indole type derivatives as inhibitors of p38 kinase. Scois Inc. 2005, US patent 6,867,209 14. Mavunkel, Babu J.; Chakravarty, Sarvajit; Perumattam, John J.; Dugar, Sundeep; Lu, Qing; Liang, Xi. Indole type derivatives as inhibitors of p38 kinase. Scois Inc. 2005, US patent 6,864,260 15. Hoekstra, William J.; Patel, Hari S.; Liang, Xi; Blanc, Jean Baptiste E.; Heyer, Dennis O.; Willson, Timothy M.; Iannone, Marie A.; Kadwell, Sue H.; Miller, Lisa A.; Pearce, Kenneth H.; Simmons, Catherine A.; Shearin, Jean. Discovery of novel quinoline based estrogen receptor ligands using peptide interaction profiling. Journal of Medicinal Chemistry, 2005, 48(6), 224*-****-**. Liang, Xi; Jones, David G.; Schoenen, Frank; Stewart, Eugene; Brown, Peter. Pauson Khand synthesis of an array of tricyclic cyclopentenones. Abstracts of Papers, 228th ACS National Meeting, Philadelphia, PA, United States, 2004

17. Mavunkel, Babu J.; Perumattam, John J.; Luedtke, Gregory R.; Liang, Xi; Lim, Don; Xu, Yong jin; Laney, Maureen; Liu, David Y.; Schreiner, George F.; Lewicki, John A.; Dugar, Sundeep. Indole based heterocyclic inhibitors of p38a MAP kinase: designing a conformationally restricted analogue. Bioorganic & Medicinal Chemistry Letters, 2003, 13(18), 308*-****-**. Zabriskie, T. Mark; Kelly, Wendy L.; Liang, Xi. Stereochemical course of the oxidation of L pipecolic acid by the flavoenzyme L pipecolate oxidase. Journal of the American Chemical Society 1997, 119(27), 6446 6447

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19. Zabriskie T. Mark; Liang, Xi. Mechanism based inactivity of L pipecolate oxidase by a sulfur containing substrate analog, 5 thia L pipecolic acid. Bioorganic & Medicinal Chemistry Letters 1997, 7(4), 457 462 20. Zabriskie, T. Mark; Liang, Xi. Studies on the mechanism and inhibition of L pipecolate oxidase. Abstracts of Paper, 211th ACS National Meeting, New Orleans, LA, 1996

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