Aaron A. Ruch. Ph.D.

Department of Chemistry

Baylor University

**** *. *** **. *** 307

Waco, TX 76706

405-***-****

acxv57@r.postjobfree.com

Objective

Challenging and rewarding position that I can utilize my experiences gained in my different fields of research.

Qualifications

Organic chemist with strong synthetic organic and organometallic chemistry background

Experience with protein biophysics, protein purification, fibrillation assays, and designing therapies for protein aggregation diseases

Production of multi-gram and milligram quantities of target compounds

Characterization of intermediates using various instrumentation such as NMR, ICP-MS, IR, HPLC, X-ray crystallography, LC-MS, and HRMS

Resolution of enantiomers using chiral HPLC

Education

Post-doctoral fellow, Protein Biophysics, Baylor University, Waco, TX 2016-present

Mentor: Dr. Bryan Shaw

Research Focus: The design, synthesis, and evaluation of molecules that bind and modify the net electrostatic charge of amyloid fibrils through lysine acylation

Ph.D.; Organic Chemistry, University of North Texas, Denton, TX 2016

Advisor: Dr. LeGrande M. Slaughter

Dissertation: Ligand effects in enantioselective homogeneous gold catalysis: rationally designing ligands to achieve higher levels of asymmetric induction

B.S., Chemistry. Oklahoma State University, Stillwater, OK 2011

Advisor: Dr. Richard Bunce

Senior Project: Design and synthesis of bulky acyclic diaminocarbene ligands for homogeneous gold catalysis

Experience

Post-doctoral research, Baylor University, Waco, TX 2016-present

Designed and synthesized analogs of positron emission tomography agents as compounds that selectively bind amyloid fibrils and modify their net electrostatic charge as a potential therapy for protein aggregation diseases such as amyotrophic lateral sclerosis

Purification and characterization of mutant Cu/Zn superoxide dismutase (SOD1) protein

Graduate research, University of North Texas, Denton, TX 2011-2016

Designed novel synthetic routes to chiral acyclic diaminocarbenes utilizing gold templated isocyanides

Evaluation of chiral acyclic diaminocarbene ligands in enantioselective intramolecular hydroamination of allenes: identification of key structural features in ligand to achieve high levels of asymmetric induction. Resolution of enantiomers using chiral HPLC to determine observed selectivity in catalytic reactions

Undergraduate research, Oklahoma State University 2009-2011

Design and synthesis of extremely bulky acyclic diaminocarbene ligands: Understanding steric effects on regioselectivity in homogeneous gold catalysis

Computational chemistry utilizing Extended-Transition-State method combined with the Natural Orbitals of Chemical Valence (ETS-NOCV) to probe potential unusual π-acidity of acyclic diaminocarbene ligands

Laboratory technician, Accurate Laboratory Services, Stillwater, OK 2008-2009

The extraction of various pesticides, diesel-range organics, and herbicides from wastewater and solid waste samples using various EPA methods such as EPA 608/8081A for pesticides

Concentration and preparation of the samples for further analysis

Honors and Certifications

Chemistry Student of the Year, American Chemical Society Southwest Regional Division, 2016

Ed and Julia Hodges Memorial Scholarship, University of North Texas, 2015

Graduate Assistantship Tuition Scholarship for best third year talk, UNT, 2014

Travel Grant, College of Arts & Sciences, UNT 2013 &2014

Affiliations

Member of American Chemical Society, Organic Division 2011-present

Golden Key Honor Society, Oklahoma State University Chapter 2010-present

Keywords

Organic and inorganic synthesis, synthesis of isotopically labeled compounds, asymmetric synthesis, chiral resolution, HPLC, multidimensional NMR, heteronuclear NMR, Gaussian 09 and ADF modeling software, protein purification, EPR, HRMS, LC-MS, GC-MS, kinetic studies, mechanistic studies, IR, X-ray crystallography, UV-Vis

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