Xingpei Hao M.D.,Ph.D.

Rockville, MD *****

acxp0m@r.postjobfree.com 301-***-****

Executive Summary:

Accomplished, self-motivated, research professional with over twenty years of experience conducting

high level research in the fields HIV, cancer, and animal studies within government, university, and

corporate settings. Driven to solve challenges in the R&D and clinical industry with sustainable solutions.

Dedicated scholar with over fifty published papers in peer-reviewed journals with experience in grant

writing. Leader. Teammate. Critical Thinker. Fluent in English and Chinese.

Education:

ECFMG Certified M.D. by passing STEP 1,2,3 of USMLE - 2014

University of Westminster United Kingdom: 1998 Ph.D. in Cancer Biology and Pathology

Guangdong Medical University China: 1989 MSc. in Pathology

Binzhou Medical University China: 1986 M.D./B.S. in Medicine

Professional Experience:

Leidos Biomedical Research Inc. - Research Associate II 2009-Present Frederick MD:

Contracted as a research associate consultant for National Cancer Institute focusing on

designing and implementing experiments for cancer related HIV studies

Focused on the mechanism of lymphoma pathogenesis through immunohistochemistry

Authored multiple SOPs for immunohistochemistry and in situ hybridization

Rutgers University - Research Assistant Professor 2005-2008 Piscataway NJ:

Designed and conducted research on carcinogenesis in different animal models.

Collaborated with multiple PIs to execute cross functional goals

Mentored high achieving graduate students in the field of cancer research.

National Institute of Allergy and Infectious Disease, NIH Fellowship Intramural Research

Training 2002-2005 Bethesda MD:

First to establish and characterize megakaryocytic leukemia in mouse models

Performed cell cultures with regards to implementing leukemia research

Applied molecular level DNA and RNA analysis to various strands of leukemia and

lymphoma

Biogenix Laboratories Scientist 2001-2002, San Ramon CA:

Collaborated with high level company leaders to discuss direction of the company by

informing them of technical studies.

Developed strategy to analyze and organize over 5,000 surgical specimen tissues

Tested and validated different diagnostic antibodies

Designed and validated tissue array for pharmaceutical application

Case Western Reserve University Research Associate 1998-2000:

Executed immunohistochemistry and molecular techniques to study colorectal

carcinogenesis.

Technical skills:

Cell Culturing, Immunohistochemistry, Animal Testing and Studies (Rodents, Primates), In Situ

Hybridization, Tissue Processing, Tissue Array Design, PCR, QRT-PCR, Northern and Western Blotting,

DNA/RNA Extraction, Genomic DNA sequencing, Digital Pathology Analysis, Clinical Research,

Clinician

Professional Affiliations:

Member of American Association of Cancer Research

Member of National Society of Histotechnology

Awards:

Second place in 4th International Scientific Symposium on Tea and Human Health USDA in 2007

Intramural Research Training Award from NIH in 2002-2005

Sino-British Friendship Scholarship Award in 1995-1998

Christine King Memorial Trust Fellowship Award in 1996-1998

Second place for Excellence in Research Paper in Pathology Society Meeting of Great Britain and Ireland

in 1998

Publications

1. Hao XP, Xiao H, Ju J, Hewitt SM, Morse HC. Decreased expression of retinoid X receptors

during human and azoxymethane induced colorectal carcinogenesis in the rat. Anticancer

Research 2016;36: 2659-2664. I am the first and corresponding author. This paper was selected as

Exceptional Quality Paper by the Journal and highly praised by other journals.

2. Hao XP, Xiao H, Jihyeung Ju J, Lee MJ, Joshua D Lambert JD, Yang CS. Green tea polyphenols

inhibit colon tumorigenesis. in azoxymethane-treated F344 rats. Nutrition and Cancer 2016, in

print

3. Hao XP, Qi CF, Han W, Zhou JX, Fredrickson TN, Hartley JW, and Morse HC. Gene Expression

Profiling of MiceHistiocytic Sarcoma through cDNA and Tissue Microrray. Plus ONE 2016 in

revision

4. Deleage C, Wietgrefe SW, Del Prete G, Morcock DR, Hao XP, Michael Piatak M, Bess J,

Anderson JL, Reilly C, McCune JM, Haase AT, Lifson JD, Schacker TW, Estes JD. Defining

HIV and SIV in reservoirs in lymphoid tissues. Pathogen and Immunity. 2016;1:68-106.

5. Marshall V, Hao XP, Cornejo Castro E, Labo N, Miley W, Holdridge B, Coalter V, Smedle J,

Jaffe E, Lifson J, Estes J, Whitby D. The role of gammaherpesviruses in malignancies occurring in

immuno-suppressed rhesus macaques. Blood 2016 in preparation

6. Li H, Wang S, Kong R, Ding W, Lee FH, Parker Z, Kim E, Learn GH, Hahn P, Policicchio B,

Brocca-Cofano E, Deleage C, Hao XP, Chuang GY, Gorman J, Gardner M, Lewis MG,

Hatziioannou T, Santra S, Apetrei C, Pandrea I, Alam SM, Liao HX, Shen X, Tomaras GD,

Farzan M, Chertova E, Keele BF, Estes JD, Lifson JD, Doms RW, Montefiori DC, Haynes BF,

Sodroski JG, Kwong PD, Hahn BH, Shaw GM. Envelope residue 375 substitutions in simian-

human immunodeficiency viruses enhance CD4 binding and replication in rhesus macaques. Proc

Natl Acad Sci U S A. 2016;113(24):E3413-22. doi: 10.1073/pnas.160*******

7. Qi CF, Xiang S, Ouyang G, Hao XP, Shin MS, Kovalchuk AL, Liang P, Xiong H, Morse HC,

Zhuang Z, Zhou JX and Pierce SK. TMEM4 is Highly Expressed in Plasma Cell Neoplasms and

Associated with B Lymphocyte Differentiation. Immunol Disord Immunother 2016;1:102.

doi:10.4172/IDIT.1000102

8. Evans TI, Li H, Schafer JL, Klatt NR, Hao XP, Traslavina RP, Estes JD, Brenchley JM, Reeves

RK. SIV-induced translocation of bacterial products in the liver mobilizes myeloid dendritic and

natural killer cells associated with liver damage. J Infec. Dis. 2016; 213(3):361-9

9. Hao XP, Lucero C, Turkbey B, Bernardo M, Choyke P, Jeffrey Lifson J, Brenchley J, Apetrei C,

Pandrea I. Estes J Experimental colitis in SIV-uninfected rhesus macaques recapitulates the key

features of pathogenic SIV infection. Nature Communication. 2015 Aug 18;6:8020. doi:

10.1038/ncomms9020

10. Tabb B, Morcock DR, Trubey CM, Quiones OA, Hao XP, Smedley J, Macallister R, Piatak M

Jr, Harris LD, Paiardini M, Silvestri G, Brenchley JM, Alvord WG, Lifson JD, Estes JD. Reduced

inflammation and lymphoid tissue immunopathology in rhesus macaques receiving anti-tumor

necrosis factor treatment during primary simian immunodeficiency virus infection. J Infect Dis.

2013 Mar 15;207(6):880-92

11. Brenchley JM, Vinton C, Tabb B, Hao XP, Connick E, Paiardini M, Lifson JD, Silvestri G, Estes

JD. Differential infection patterns of CD4+ T cells and lymphoid tissue viral burden distinguish

progressive and nonprogressive lentiviral infections. Blood. 2012;120:4172-81

12. Del Prete GQ, Kearney MF, Spindler J, Wiegand A, Chertova E, Roser JD, Estes JD, Hao XP,

Trubey CM, Lara A, Lee K, Chaipan C, Bess JW Jr, Nagashima K, Keele BF, Macallister R,

Smedley J, Pathak VK, Kewalramani VN, Coffin JM, Lifson JD. Restricted replication of

xenotropic murine leukemia virus-related virus in pigtailed macaques. J Virol. 2012;86:3152-66

13. Ju J, Kwak Y, Hao XP, Yang CS. Inhibitory effects of calcium against intestinal cancer in human

colon cancer cells and Apc(Min/+) mice. Nutr Res Pract. 2012;6:396-404

14. Ortiz AM, Klatt NR, Li B, Yi Y, Tabb B, Hao XP, Sternberg L, Lawson B, Carnathan PM,

Cramer EM, Engram JC, Little DM, Ryzhova E, Gonzalez-Scarano F, Paiardini M, Ansari AA,

Ratcliffe S, Else JG, Brenchley JM, Collman RG, Estes JD, Derdeyn CA, Silvestri G. Depletion

of CD4 T cells abrogates post-peak decline of viremia in SIV-infected rhesus macaques. J Clin

Invest. 2011;121:4433-45

15. Hao X, Fredrickson TN, Chattopadhyay SK, Han W, Qi CF, Wang Z, Ward JM, Hartley JW,

Morse HC 3rd. The histopathologic and molecular basis for the diagnosis of histiocytic sarcoma

and histiocyte-associated lymphoma of mice. Vet Pathol. 2010 May;47(3):434-45

16. Warren M, Chung YJ, Howat WJ, Harrison H, McGinnis R, Hao X, McCafferty J, Fredrickson

TN, Bradley A, Morse HC 3rd. Irradiated Blm-deficient mice are a highly tumor prone model for

analysis of a broad spectrum of hematologic malignancies. Leuk Res. 2010 Feb;34(2):210-20.

17. Khor TO, Yu S, Barve A, Hao X, Hong JL, Lin W, Foster B, Huang MT, Newmark HL, Kong

AN. Dietary feeding of dibenzoylmethane inhibits prostate cancer in transgenic adenocarcinoma

of the mouse prostate model. Cancer Res. 2009;69:7096-102

18. Hao J, Zhang B, Liu B, Lee M, Hao X, Reuhl KR, Chen X, Yang CS Effect of alpha-

tocopherol, N-acetylcysteine and omeprazole on esophageal adenocarcinoma formation in a

rat surgical model. International J Cancer 2009;124:1270-5

19. Ju J, Hao X, Lee MJ, Lambert JD, Lu G, Xiao H, Newmark HL,Yang CS. A g-tocopherol-rich

mixture of tocopherols inhibit colon inflammation and carcinogenesis in azoxymethane and

dextran sulfate sodium-treated mice. Cancer Prevention Research 2009;2(2):143-52

20. Liu Y, Xiao H, Tian Y, Nekrasova T, Hao X, Lee HJ, Suh N, Yang CS, Minden A. The pak4

protein kinase plays a key role in cell survival and tumorigenesis in athymic mice. Mol Cancer

Res. 2008;6(7):1215-24

21. Barve A, Khor TO, Hao X, Keum YS, Yang CS, Reddy B, Kong AN. Murine Prostate Cancer

Inhibition by Dietary Phytochemicals-Curcumin and Phenyethylisothiocyanate. Pharm Res.

2008;25(9):2181-9

22. Khor TO, Huang MT, Prawan A, Liu Y, Hao X, Yu S, Cheung WK, Chan JY, Reddy BS, Yang

CS, Kong AN. Increased susceptibility of Nrf2 knockout mice to colitis-associated colorectal

cancer. Cancer Prev Res (Phila Pa). 2008 Aug;1(3):187-91

23. Yang CS, Ju J, Lu G, Xiao H, Hao X, Sang S, Lambert JD. Cancer prevention by tea and tea

polyphenols. Asia Pac J Clin Nutr. 2008;17 Suppl 1:245-8

24. Liu Y, Ju J, Xiao H, Simi B, Hao X, Reddy BS, Huang MT, Newmark H, Yang CS. Effects of

combination of calcium and aspirin on azoxymethane-induced aberrant crypt foci formation in

the colons of mice and rats. Nutr Cancer. 2008;60(5):660-5

25. Lambert JD, Kwon SJ, Ju J, Bose M, Lee MJ, Hong J, Hao X, Yang CS. Effect of genistein on

the bioavailability and intestinal cancer chemopreventive activity of -epigallocatechin-3-

gallate. Carcinogenesis. 2008; 29:2019-24

26. Xiao H, Hao XP, Simi B, Ju J, Jiang H, Reddy BS, Yang CS. Green tea polyphenols inhibit

colorectal aberrant crypt foci (ACF) formation and prevent oncogenic changes in dysplastic ACF

in azoxymethane-treated F344 rats. Carcinogenesis 2008; 29:113119. Contributed equally.

27. Suh NJ, Paul S, Hao XP, Simi B, Xiao H, Rimando AM, Reddy BS. Pterostilbene, an active

constituent of blueberries, suppresses aberrant crypt foci formation in the azoxymethane-induced

colon carcinogenesis model in rats. Clin Cancer Res 2007;13:350-355

28. Hao XP, Mousumi Bose M, Lambert JD, Ju J, Lu G, Lee MJ, Park S, Husain A, Wang S, and

Chung S. Yang CS. Inhibition of Tumorigenesis in ApcMin/+ Mice by Green Tea Polyphenols

(Polyphenon E) and Individual Catechins. Nutrition and Cancer 2007 2007; 59:62-9.

29. Bose M, Hao XP, JU J, Husain A, Park S, Lambert JD, Yang CS. Inhibition Of Tumorigenesis in

Apc(Min/+) Mice by a Combination of -Epigallocatechin-3-gallate and Fish Oil. J. Agric.

Food Chem. 2007, 55, 76957700

30. Hao XP, Shin MS, Zhou JX, Qi CF, Hartley JW, Fredrickson TN, Lee C, Naghashfar Z, Morse

HC. Histologic and molecular characterizations of megakaryocytic leukemia in mice. Leukemia

Research 2006;30:397-406

31. Qi CF, Xiang S, Shin MS, Hao XP, Lee CH, Zhou JX, Torrey TA, Hartley JW, Fredrickson TN,

Morse HC. Expression of the cyclin-dependent kinase inhibitor p27 and its deregulation in mouse

B cell lymphomas. Leukemia Research 2006;30:153-163

32. Yang CS, Lambert JD, Hou Z, Ju J, Lu G, Hao XP. Molecular targets for the cancer preventive

activity of tea polyphenols. Molecular Carcinogenesis 2006;45:431-435

33. Shen RR, Ferguson DO, Renard M, Hoyer KK, Kim U, Hao XP, Alt FW, Roeder RG, Morse HC,

Teitell MA. Dysregulated TCL1 Requires the germinal center and genome instability for mature

B cell transformation. Blood 2006;108:1991-8.

34. Lu G, Liao J, Yang GY, Reuhl KR, Hao XP, Yang CS. Inhibition of Adenoma Progression to

Adenocarcinoma in a 4-(Methylnitrosamino)-1-(3-Pyridyl)-1-ButanoneInduced Lung

Tumorigenesis Model in A/J Mice by Tea Polyphenols and Caffeine. Cancer Res 2006;66:11494-

501

35. Hao, X.P., Frayling, I.M., Du, M.Q., Willcocks, T.C., Talbot, I.C., Tomlinson, I. The spectrum of

p53 mutations in colorectal adenomas differs from that in colorectal carcinomas. Gut

2002;50:834-839

36. Hao, X.P., Frayling, I.M., Willcocks, T.C., Tomlinson, I.P., Pignatelli, M.N., Pretlow, T.P., Talbot,

I.C. b-catenin expression and allelic Loss at APC in sporadic colorectal carcinogenesis. Virchows

Archiv 2002; 440:362-6

37. Hao, X.P., Pretlow, T.G., Rao, J.S., Pretlow, T.P. Beta- catenin expression is altered in human

colonic aberrant crypt foci. Cancer Res.,2001;61: 8085-8

38. Hao, X.P., Pretlow, T.G., Yao, S., Pretlow, T.P. Inducible nitric oxide synthase (iNOS) is

expressed similarly in multiple aberrant crypt foci and colorectal tumors from the same patients.

Cancer Res.2001;61:419-422

39. Hao, X.P., Willis, J., Pretlow, T.G., Yao, S., Pretlow, T.P. Loss of Fhit protein expression in

colorectal cancer and premalignant lesions. Cancer Res.,2000;60:18-21

40. Hao, X.P., Bishop, A.E., Wallace, M., Wang, H., Willcocks, T.C., Maclouf, J., Polak, I.M.,

Knight, S., Talbot, I.C. Early expression of Cox-2 during sporadic colorectal carcinogenesis. J.

of Pathol. 1999;187:295-301

41. Day, R.M., Hao, X.P., Ilyas, M., Daszak, P., Talbot, I..C., Forbes, A. Changes in the expression

of syndecan-1 in the colorectal adenoma-carcinoma sequence. Virchows Arch,1999;434:121-5

42. Hao, X.P., Du, M.Q., Bishop, A.E., Talbot, I.C. Imbalance between cell proliferation and

apoptosis in the development of colorectal cancer. Virchows Arch. 1998;433:523-527

43. Hao, X.P., Gunther, T., Roessner, A., Price, A.B., Talbot, I.C. Expression of MDM2 and p53 in

the epithelial neoplasms of the colorectum. Clinical Mol. Pathol., 1998;51:26-29

44. Ilyas, M., Hao, X.P., Wilkinson, K., Tomlinson, I.P.M., Abbasi, A.M., Forbes, A., Bodmer, W.F.,

Talbot, I.C. Loss of Bcl-2 expression correlates with recurrence in colorectal cancer. Gut

1998;43:383-387

45. Hao, X.P., Tomlinson, I., Ilyas, M., Palazzo, J.P., Talbot, I.C. Reciprocity between membranous

and nuclear expression of b-catenin in colorectal tumours. Virchows Arch., 1997;431: 167-172

46. Hao, X.P., Palazzo, J.P., Ilyas, M., Tomlinson, I., Talbot, I.C. Reduced expression of molecules

of the cadherin/catenin complex in the transition from colorectal adenoma to carcinoma.

Anticancer Res.,.1997;17:2241-2248

47. Hao, X.P., Ilyas, M., Talbot, I.C. Expression of Bcl-2 and p53 in the colorectal adenoma-

carcinoma sequence. Pathobiol.,1997;65:140-145

48. Hao, X.P.. Pathology of breast tumor. Evaluation of prognosis with breast carcinomas. in Xu Z,

Zuo W, Lui Q (eds.) "Advanced Breast Oncology". Shandong Scientific and Technical Publisher

199*-***-***. 218-252.

49. Hao, X.P., Zong, Y.S.. Comparison of nuclear DNA content between primary nasopharyngeal

carcinoma and its metastatic deposit. Chinese Journal of Current Oncology 1994;1:156-161.

50. Hao, X.P. Study of the relationship between C-erbB-2 oncoprotein overexpression and the

prognosis in ANN breast carcinoma. Chinese Journal of Current Oncology,1994;1:74-78

51. Hao, X.P. Pathology of Ano-Colorectal Tumour, Evaluation of prognosis of colorectal carcinoma.

In Xu Z Zou W (eds) "Advanced Ano-Colorectal Oncology, Shandong Scientific and Technical

Publisher 1993;62-85, 96-102.

52. Hao, X.P., Wang, L. Malignant lymphoma in colorectum. Chinese Journal of Colo-

Proctology,1993;11:308-312.

53. Hao, X.P., Zong, Y.S. The characteristics of nuclear DNA content and morphometry with atypia

of nasopharyngeal carcinoma. Chinese Journal of Pathology, 1992;21:106-109

54. Hao, X.P., Zong, Y.S. Analysis of nuclear DNA content with paracancerous lesions in

nasopharyngeal carcinoma. Chinese Journal of Clinical and Experimental Pathology 1992;8:169-

173.

55. Hao, X.P., Zong, Y.S. Analysis of nuclear DNA content with early nasopharyngeal squamous

carcinoma. Chinese Journal of Clinical and Experimental Pathology 1992;8:174-179.

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