Research Chemist

Joseph Kelly

*** ********* ****, ******, *.J. *8859

Phone : Home 732-***-****,

e-Mail: acxnw8@r.postjobfree.com

Education National University of Ireland, University College, Cork (1973 - 1977 )

BSc (Honours ) in Chemistry, June 1977

Experience:

Company Beecham Pharmaceuticals, Surrey, UK.

Research Chemist (July 1977 - Feb. 1979)

Syntex (Ireland) Ltd, County Clare, Ireland

Development Chemist (Feb. 1979 - April 1982)

Ayerst Labs, Montreal, Canada.

Research Chemist ( May 1982 - July 1983 )

Burrough's Wellcome, N.C. USA

Research Chemist ( July 1983 - Dec 1983 )

Ayerst Labs, Princeton, N.J. USA

Research Chemist (Dec 1983 - April 1987)

Schering Plough/Merck, RahwayN.J. USA

Research Chemist (April 1987 – Nov 2016)

Publications

1. Tolrestat analogs as Aldose Reductase Inhibitors

J. Med. Chem. 1989, 32, 2493 -2500.

2. Tolrestat analogs as Aldose Reductase Inhibitors

J . Med. Chem. 1991, 34, 2504 - 2520.

Benzoquinazoline Inhibitors of Thymidylate 3. Synthase

J. Med. Chem. 1993, 36, 2279 -2291.

4. Synthesis and evaluation of Pyrazoloquinoline Ribofuranosides and their derivatives as inhibitors of oncogenic ras (Bioorganic and Medicinal Chemistry Letters Vol 6,No 2, 195- 200, 1996.

5. "Sch 51344 inhibits ras Transformation by a novel mechanism"

Cancer Research 55, 5106 - 5117, 1995

6. In - Vitro and In - vivo efficacy of Sch 43478 and analogs as antiherpesvirus agents (Antiviral Research 35 (1997) 139-146 ) 7. . Synthesis of Isomeric 3-Piperidinyl and 3- Pyrrolidinyl Benzocycloheptapyridines : Sulfonamido derivatives as Inhibitors of Ras Prenylation. ( Bioorganic&Medicinal Chemistry Vol 6 (1998) 1-14)

8. Acid Catalyzed Rearrangement of 5-Bromo-3-[1- allyl-2(3,5-dimethoxyphenyl)ethyl]-2- cyanopyridine(J.Org.Chem.1998, 63, 6039-6042)

9. Synthesis of a C11 Spirocyclopropyl derivative of 8- Chloro-6,11-dihydro-5H-Benzo[5,6]cyclohepta[1,2- b]pyridine.(Td Letters 39-199*-****-****)

10. Synthesis of a C11 Spiropiperidino derivative of 8- Chloro-6,11-dihydro-5H-Benzo[5,6]cyclohepta[1,2- b]pyridine.(Td Letters 39-199*-****-****)

11. Inhibitors of Farnesyl Protein Transferase. Synthesis and biological activity of amide and cyanoguanidine derivatives containing a 5,11- dihydro[1]benzthiepin,benzoxepin,and benzazepin[4,3-b]pyridine ring system (Bioorganic & Medicinal Chemistry Letters (199*-****-****.

12. -4-[2-[4-(8-Chloro-3,10-dibromo-6,11-dihydro- 5H-Benzo[5,6]cyclohepta[1,2-b]pyridin-11(R)-yl)- 1-piperidinyl]-2-oxo-ethyl]-1- piperidinecarboxamide.(Sch 66336).A very potent Farnesyl Protein Transferase Inhibitor as a novel antitumor agent.(J.Med.Chem.(1998), 41, 4890- 4902.

13. Analogs of 1-(3,10-Dibromo-8-Chloro-6,11- dihydro-5H-Benzo[5,6]-cyclohepta[1,2-b]pyridin- 11-yl)piperidine as inhibitors of Farnesyl Protein Transferase(Bioorganic& Medicinal Chemistry Letters (1999).

14. Analogs of 4-(3-Bromo-8-Methyl-6,11- dihydro-5H-Benzo[5,6]-cyclohepta[1,2-b]pyridin- 11-yl)-1-(4-pyridinylacetyl)piperidine N-Oxide as inhibitors of Farnesyl Protein Transferase(Bioorganic& Medicinal Chemistry Letters 9(13) (199*-****-****.

15 Synthesis of substituted bipiperidine amide

compounds as CCR-3 antagonists

Bioorganic & Med.Chem.Letters 2005 15(5) 1375-8

16 Non-Aromatic A-ring replacement in the triaryl bis-

sulfone CB2 receptor inhibitors.

Bioorganic & Med.Chem.Letters 2010 (20) 608-611

Patents N-Acyl-N-Napthoyl Glycines as Aldose Reductase Inhibitors.

U.S. Patent 4,843,062

4-Substituted Pyrazoloquinoline derivatives as antiherpesvirus and antitumor agents.

U.S. Patents 5,459,146: 5,506,236: 5,608,067: 5,786,480

Pyrazoloquinoline-Ribofuranosides as inhibitors of Ras P21.

U.S. Patent 5,595,998.

Tricyclic Inhibitors of ras Farnesyl Protein Transferase

U.S. Patents: 5,684,013: 5,703,090: 5,874,442: 6,130,229: 6,143,758: 6,214,828: 6,218,401: 6,372,747: 6,440,989: 6,576,639; 6,740,661;6,800,636;PCT/US20007001123.

Substituted urea neuropeptide Y Y5 Receptor

antagonists.

U.S. Patent 6,894063.

US Patent 200-***-****

A preparation of piperidine derivatives useful

as CCR-3 antagonists

U.S. Pat.Appl. Publ (2005) US2005182095

Pyrrolidine derivatives as Erk Inhibitors PCT/ US20007003665

WO 2008/153858 A

WO 2007/070398 A

Polycyclic indazole derivatives that are Erk inhibitors WO2009105500 (International)

PCT/US2008006979

Heterocyclic compounds and their use as Erk Inhibitors PCT/US2008007509

Awards A.C.S. National Meeting @ Chicago, August,1995.

Seminar presented on Pyrazoloquinolines as antitumor and antiherpesvirus agents.

Schering Plough President's Award (1995)

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