Organic and Inorganic Chemistry laboratory and lecture instructor
Resume:
DR. GARY B. FISHER
Boulder Creek, CA 95006
acxlc2@r.postjobfree.com
RESEARCH OBJECTIVES
To further advance the laboratory skills and theoretical insights developed while working as a Graduate Student and Post-Doctoral Researcher under the supervision of Professor Bakthan Singaram; to organize and direct or be an actively contributing member of a vigorous and creative research program in medicinal or synthetic chemistry; to interact in a creative and collaborative manner with members of a research group to fulfill the objectives of the research group and the research institution as well as my own professional goals; to continue to explore and develop new synthetic methodologies for more effectively achieving basic functional group transformations; to explore structure- activity relationships in non-toxic biochemically active compounds to develop new therapeutic agents.
ACADEMIC OBJECTIVES
To further develop the innovative teaching methods and comprehensive library of chemistry teaching publications that I have created over the last twenty years, including the authorship of two university-level organic chemistry laboratory manuals, three volumes of introductory chemistry lecture notes, three volumes of organic chemistry lecture notes, and extensive editorial work with numerous text book publishers on university-level chemistry texts.
AREAS of RESEARCH
Development of novel synthetic methodologies for the synthesis of optically active compounds of biological, medicinal, and synthetic significance; development and utilization of modified metal hydride reagents; synthesis and development of terpene- based reagents for the asymmetric transformation of functional groups; the synthesis of modified cysteine derivatives and their interactions with the “cysteine switch” in matrix metalloproteinases.
RESEARCH and WORK EXPERIENCE
Jan 2014-Present: Adjunct Professor of Chemistry, San Jose City College, San Jose, CA Jan 2015-April 2015: Adjunct Professor of Chemistry, UC Santa Cruz, Santa Cruz, CA Jan 2013-Present: Adjunct Professor of Chemistry, West Valley College, Saratoga, CA Aug 2013-Jan 2014: Oligonucleotide synthetic chemist, DNA 2.0, Menlo Park, CA Feb 2013-Dec 2013:Adjunct Professor of Chemistry, West Valley College, Saratoga, CA May 2011-Aug 2013: AP/Honors Chemistry tutor/teacher for private teaching companies 1996-2012: Tenured Professor of Chemistry at De Anza College (Retired) 2003: Visiting researcher, Theravance, Inc., South San Francisco, CA 1988-1996: Doctoral and Post-Doctoral research under the supervision of Professor Bakthan Singaram, Dept. of Chemistry, UC Santa Cruz. My doctoral and post-doctoral research included the development of new synthetic methodology for the racemic and asymmetric synthesis of β-amino alcohols from enamines, β-amino ketones, and epoxides utilizing a variety of hydroboration, amination, and reducing agents, including
(Dr. Gary B. Fisher-2)
terpene-based asymmetric hydroboration and reducing agents. I discovered and developed the chemistry of lithium aminoborohydrides, a new class of powerful, safe, air-stable reducing agents. My current research interests include the chemistry of asymmetric lithium aminoboro-hydrides, the development of new syntheses of aldehyde and ketone enamines, and the development of asymmetric epoxidation reagents. RESEARCH and WORK EXPERIENCE
1987-1988: Senior research project under Professor Joseph Konopelski, University of California, Santa Cruz: “(1) Synthesis of 3-Iodo-2,4-dimethylbutyrolacone; (2) Synthesis of Bicyclofarnesylic Acids”.
1987: Summer Immunology Research Internship, DNAX Research Institute, Palo Alto, CA.
1985-1988: Fulfillment of undergraduate requirements for the Bachelors Degree in Chemistry
EDUCATION
Doctor of Philosophy (June, 1993: Chemistry)
University of California, Santa Cruz, Santa Cruz, CA Research Advisor: Professor Bakthan Singaram
Thesis Research: “The Hydroboration and Subsequent Elaboration of Aldehyde Enamines: Extraordinary New Chemistry of Aldehyde Enamines” Bachelor of Arts (June, 1988: Chemistry)
University of California, Santa Cruz, Santa Cruz, CA
(Dr. Gary B. Fisher-3)
TEACHING ABILITIES
Organic Chemistry, General Chemistry, Mathematics, Expository and Creative Writing TEACHING EXPERIENCE
Jan 2015-April 2015: Adjunct Professor of Chemistry, UC Santa Cruz, Santa Cruz, CA Jan 2014-Present:Adjunct Professor of Chemistry, San Jose City College, San Jose, CA Jan 2013-Present: Adjunct Professor of Chemistry, West Valley College, Saratoga, CA 2013-2014: Oligonucleotide chemist, DNA 2.0, Menlo Park, CA 2013-2014: Adjunct Professor of Chemistry, West Valley College, Saratoga, CA Fall 1996-Jan. 2012:Tenured Professor of Chemistry, De Anza College, Cupertino, CA (Retired) 2011-2013: AP/Honors Chemistry tutor/teacher for various private teaching companies: FLEX College Prep (Los Altos, CA), Insight Education (Cupertino, CA), WyzAnt Education
(Chicago, IL), Zenith College Prep (Mountain View, CA) 2007: General Chemistry Lab Instructor, Summer Session, West Valley College, Saratoga, CA 2006: Organic Chemistry Instructor, Summer Session, Santa Clara University, Santa Clara, CA 2005: General Chemistry Lab Instructor, Summer Session, West Valley College, Saratoga, CA 2002: Organic Chemistry Instructor, Summer Session, Santa Clara University, Santa Clara, CA 1996: General Chemistry Instructor, Winter Semester, Cabrillo College, Aptos, CA 1996: General Chemistry Instructor, Winter Quarter, De Anza College, Cupertino, CA 1995: Organic Chemistry Instructor, Summer Session, Santa Clara University, Santa Clara, CA 1995: General Chemistry Instructor, Spring Quarter, U.C. Santa Cruz, Santa Cruz, CA 1995: Honors General Chemistry Instructor, Winter Quarter, UC Santa Cruz, Santa Cruz, CA 1994-1995: Organic Chemistry Lab Instructor, CSU San Jose, San Jose, CA (3 semesters) 1994: Organic Chemistry Instructor, Summer Session, CSU San Jose, San Jose, CA 1994: Preparatory Chemistry Instructor, Summer Session, Cabrillo College, Aptos, CA 1994: Health Sciences Chemistry Instructor, Spring Semester, Cabrillo College, Aptos, CA 1994: Organic Chemistry Instructor, Winter Quarter, UC Santa Cruz, Santa Cruz, CA 1993: Organic Chemistry Instructor, Summer Session, UC Santa Cruz, Santa Cruz, CA 1993: Coordinator/Instructor, Summer Bridge Chemistry Program, UC Santa Cruz, Santa Cruz, CA 1988-1993: Graduate teaching assistant, general/organic chemistry lab/lecture discussion sections, UC Santa Cruz, Santa Cruz, CA
1970-Present: Mathematics (algebra I, II, and geometry) and chemistry (general and organic) tutor
(Dr. Gary B. Fisher-4)
REFERENCES
Professor Bakthan Singaram Professor David Gray
Department of Chemistry and Biochemistry Department of Chemistry University of California, Santa Cruz De Anza College 1156 High Street 21250 Stevens Creek Blvd.
Santa Cruz, CA 95064 Cupertino, CA 95014
acxlc2@r.postjobfree.com
Professor Eugene Switkes Professor Cinzia Muzzi
Department of Chemistry and Biochemistry Department of Chemistry University of California, Santa Cruz De Anza College 1156 High Street 21250 Stevens Creek Blvd.
Santa Cruz, CA 95064 Cupertino, CA 95014
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Dr. Sara Singaram Dr. Eric Stangland
Department of Chemistry and Biochemistry 809 Corona Drive University of California, Santa Cruz Pacifica, CA 94044 1156 High Street 650-***-****
Santa Cruz, CA 95064 acxlc2@r.postjobfree.com
Dr. Mark Pacheco, DDS Dr. Nicole Pacheco, DVM
21941 Schillingsburg 21941 Schillingsburg
San Jose, CA San Jose, CA
Howard Simon, CFO
DNA 2.0
1140 O’Brien Drive
Suite A
Menlo Park, CA 94025
acxlc2@r.postjobfree.com
(Dr. Gary B. Fisher-5)
PROFESSIONAL MEMBERSHIPS
American Chemical Society
Chemical Heritage Foundation
CONTRIBUTED PAPERS
1.) Asymmetric Synthesis of β-Amino Alcohols. A Facile Conversion of Enamines to the Corresponding B-Amino Alcohols in High Enantiomeric Purity Gary B. Fisher, Christian T. Goralski, Lawrence W. Nicholson, and Bakthan Singaram Paper ORGN-251 presented at the American Chemical Society 203rd National Meeting, San Francisco, CA, April 5-10, 1992
2.) Asymmetric Synthesis of β-Amino Alcohols. A Facile Conversion of Enamines to the Corresponding β-Amino Alcohols in High Enantiomeric Purity Gary B. Fisher, Christian T. Goralski, Lawrence W. Nicholson, and Bakthan Singaram Paper BUSA 33, presented at the Third Annual Boron USA Meeting (BUSA III) Washington State University, Pullman, Pullman, WA, July 8-11, 1992 3.) Lithium Aminoborohydrides: A New Class of Powerful, Safe, and Highly Selective Reducing Agents
Gary B. Fisher, Joseph C. Fuller, John Harrison, Christian T. Goralski, and Bakthan Singaram
Poster A-75, presented at the American Chemical Society 33rd National Organic Chemistry Meeting, Montana State University, Bozeman, Bozeman, MT, June l3-17, 1993
PUBLICATIONS
Dr. Gary B. Fisher
1.) Unusual Directive Effects in the Hydroboration of β,β-Disubstituted Enamines. Conversion of β-Substituted Aldehydes to the Corresponding Alkenes and β-Amino Alcohols
Bakthan Singaram, Christian T. Goralski, and Gary B. Fisher J. Org. Chem. 1991, 56, 5691
2.) Synthesis and Characterization of Lithium Aminoborohydrides: A New Class of Powerful Reducing Agents
Gary B. Fisher, John Harrison, Joseph C. Fuller, Christian T. Goralski, and Bakthan Singaram
Tetrahedron Lett. 1992, 33, 4533
3.) A Novel Conversion of Aldehydes to Boronic Esters. Simultaneous IGOR2 Computer Generation and Experimental Observation of An Unusual Rearrangement of β-Aminoboranes
Gary B. Fisher, Jesus J. Juarez-Brambila, Christian T. Goralski, W. Todd Wipke, and Bakthan Singaram
J. Am. Chem. Soc. 1993, 115, 440
(Dr. Gary B. Fisher-6)
4.) Aminoborohydrides. 3. A Facile Reduction of Tertiary Amides to the Corresponding Amines and Alcohols in High Purity Using Lithium Aminoborohydrides. Sterically Controlled Selective C-N or C-O Bond Cleavage
Gary B. Fisher, John Harrison, Joseph C. Fuller, Christian T. Goralski, and Bakthan Singaram
Tetrahedron Lett. 1993, 34, 1091
5.) Boranes in Synthesis. 1. Asymmetric Synthesis of β-Amino Alcohols. A Facile Conversion of Enamines to the Corresponding β-Amino Alcohols in High Enantiomeric Purity
Gary B. Fisher, Christian T. Goralski, Lawrence W. Nicholson, and Bakthan Singaram Tetrahedron Lett. 1993, 34, 7693
6.) The Discovery, Synthesis and Characterization of Lithium Aminoborohydrides: A New Class of Powerful Yet Selective Reducing Agents Gary B. Fisher, John Harrison, Joseph C. Fuller, Christian T. Goralski, and Bakthan Singaram
Ventron Alembic 1994, Issue #50 (July)
7.) A Facile New Synthesis of Aldehyde Enamines in High Yield and Purity Gary B. Fisher, Frederick W. Klettke, and Lawrence Lee Synth. Commun. 1994, 24, 1541
8.) Boranes in Synthesis. 2. Asymmetric Synthesis of β-Amino Alcohols. A Facile Conversion of 2-Amino Acetophenones to the Corresponding β-Amino Alcohols in High Enantiomeric Purity
David Beardsley, Gary B. Fisher, Christian T. Goralski, Lawrence W. Nicholson, and Bakthan Singaram
Tetrahedron Lett. 1994, 35, 1511
9.) Boranes in Synthesis. 3. Conversion of the Morpholine and Pyrrolidine Enamines of Symmetrical Dialkeylketones to the Corresponding β-Amino Alcohols via Hydroboration/ Oxidation
Christian T. Goralski, Dennis L. Hasha, Lawrence W. Nicholson, Donald Zakett, Gary B. Fisher, and Bakthan Singaram
Tetrahedron Lett. 1994, 35, 3521
10.) Aminoborohydrides. 4. The Synthesis and Characterization of Lithium Aminoboro- hydrides: A New Class of Powerful, Selective, Air-Stable Reducing Agents Gary B. Fisher, John Harrison, Joseph C. Fuller, Salvador G. Alvarez, Elizabeth Burklhardt, Christian T. Goralski, and Bakthan Singaram J. Org. Chem. 1994, 59, 6378
11.) Boranes in Synthesis. 6. A New Synthesis of β-Amino Alcohols From Epoxides. Use of Lithium Amides and a Novel Aminoborane Catalyst to Synthesize β-Amino Alcohols From Terminal and Internal Epoxides in High Yield and Purity Clifford E. Harris, Gary B. Fisher, Lawrence Lee, David Beardsley, Christian T. Goralski, and Bakthan Singaram
J. Org. Chem. 1994, 59, 7746
(Dr. Gary B. Fisher-7)
12.) HPLC Separation of β-Amino Alcohols. 1. Separation of (R,S)-1-(Dialkylamino)-2- alkanols On An Amylose-Based Chiral Stationary Phase. Lawrence W. Nicholson, C.D. Pfeiffer, Christian T. Goralski, Gary B. Fisher, and Bakthan Singaram
J. Chromatogr. 1994, 687, 241
13.) Asymmetric Synthesis of β,β-Disubstituted Amino Alcohols From Enamines and Reactions Thereof
Bakthan Singaram, Gary B. Fisher, Christian T. Goralski, and Lawrence W. Nicholson U.S. Patent. 847 171, 1994
14.) Aminoborohydrides. 8. A Facile Reduction of Aliphatic and Benzylic Azides to the Corresponding Amines in High Yield and Purity Using Lithium Aminoborohydrides Salvador G. Alvarez, Gary B. Fisher, and Bakthan Singaram Tetrahedron Lett. 1995, 36, 2567
15.) Boranes in Synthesis. 5. The Hydroboration of Enamines with Mono- and Dialkylboranes. Asymmetric Synthesis of β-Amino Alcohols of Moderate Enantiomeric Purity Aldehyde Enamines
Gary B. Fisher, Christian T. Goralski, Lawrence W. Nicholson, Dennis L. Hasha, and Bakthan Singaram
J. Org. Chem. 1995, 60, 2026
16.) Synthesis of Lithium Aminoborohydrides and Reactions Thereof Bakthan Singaram, Gary B. Fisher, Joseph C. Fuller, John Harrison, and Christian T. Goralski
U.S. Patent. 5 466 798, November 14, 1995
17.) The Synthesis, Characterization, and Synthetic Utility of Lithium Aminoborohydrides: A New Class of Powerful, Selective, Air-Stable Reducing Agents Gayane, Godjoian, Gary B. Fisher, Christian T. Goralski, and Bakthan Singaram ACS Symposium Series. #641, Reductions In Organic Chemistry Ed. Ahmed F. Abdel- Magid, American Chemical Society Books: Washington, D.C., 1996; Chapter 10, p. 153- 166
18.) Aminoborohydrides. 9. Selective Reductions of Aldehydes, Ketones, Esters, and Epoxides in the Presence of a Nitrile Using Lithium N,N-Dialkylaminoborohydrides Christopher C. Collins, Gary B. Fisher, Adeena Reem, and Bakthan Singaram Tetrahedron Lett. 1997, 38, 529
19.) Chlorinated Hydrocarbons: The Good, The Bad, and The Ugly Gary B. Fisher
The Carson: Journal of Environmental Studies 2004, 1, 127 20 . ) Lithium Aminoborohydrides 16. Synthesis and Reactions of Monomeric and Dimeric Aminoboranes. Luba Pasumansky, D . Haddenham, J.W. Clary, Gary B. Fisher, Christian T. Goralski, and Bakthan Singaram
J. Org. Chem. 2008, 73, 1898
(Dr. Gary B. Fisher-8)
EDUCATIONAL PUBLICATIONS
1.) Guide to the Bruker 250-MHz NMR: 1H-, 13C-, and : 11B-NMR, Fall Quarter 1992 Gary B. Fisher and Gayane Godjoian
2.) Chemistry 112N Laboratory Manual, Spring Quarter 1993 Gary B. Fisher, John Harrison, and Bakthan Singaram 3.) Chemistry 112N Special Projects Laboratory Manual, Spring Quarter 1993 Gary B. Fisher, John Harrison, and Bakthan Singaram 4.) Organic Chemistry Lecture Notes and Study Guide, Summer Quarter 1993 Gary B. Fisher
5.) Comprehensive IR and NMR Spectroscopy Correlation Tables, Summer Quarter 1993 (25th Revision, Fall Quarter, 2010)
Gary B. Fisher
6.) Summer Bridge Program General Chemistry Laboratory Manual, Summer Quarter 1993
Gary B. Fisher
7.) Chemistry 112M Laboratory Manual, Winter Quarter 1994 Gary B. Fisher
8.) First-Quarter Organic Chemistry Lecture Notes and Laboratory Guide, Fall Quarter 1996 (12th Edition, Spring 2016)
Gary B. Fisher
9.) Second-Quarter Organic Chemistry Lecture Notes and Laboratory Guide, Winter Quarter 1997 (12th Edition, Spring 2016)
Gary B. Fisher
10.) Third-Quarter Organic Chemistry Lecture Notes and Laboaratory Guide, With An Introduction to Biochemistry, Spring Quarter 1997 (10th Edition, Spring 2015) Gary B. Fisher
11.) First-Quarter General Chemistry Lecture Notes and Laboratory Guide, Winter Semester 1996 (12th Edition, Spring 2016)
Gary B. Fisher
12.) Second-Quarter General Chemistry Lecture Notes and Laboratory Guide, Winter Quarter 1998 (12th Edition, Fall 2016)
Gary B. Fisher
13.) Third-Quarter General Chemistry Lecture Notes and Laboratory Guide, Spring Quarter 1998 (12th Edition, Fall 2016)
Gary B. Fisher
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