BIODATA

Dr. P. SENTHIL MURUGAN

acxblg@r.postjobfree.com

Education Credentials

Ph.D. in Biology

Department of Biochemistry

Madurai Kamaraj University, Madurai, India.

****-****

Master of Science in Biochemical Technology

Department of Biochemistry

Madurai Kamaraj University, Madurai, India.

2003-2005 68%

Bachelor of Science in Biochemistry

Department of Biochemistry

Madras University, Madurai, India.

2000-2003 59%

Research Experience

Research Trainee

Department of Biochemistry and Molecular Biology

Hebrew University of Jerusalem, Israel.

Dec 2013-May 2014

Research topic: Mechanistic aspects of Diastolic Heart Failure (DHF) related to dysregulation of iron homeostasis using diabetic heart model of DHF in rat. Doctoral Research at Madurai Kamaraj University Apr 2009- Nov 2013 Dissertation topic: Cardioprotective effect of Acalypha indica against myocardial infarction and left ventricular proteomic analysis of furosemide and potassium chloride treated rats. Senior Research Fellow (UGC-UPE sponsored project) Junior Research Fellow (UGC-UPE sponsored project) Madurai Kamaraj University, India.

Apr, 2008-Mar, 2012

Apr, 2007-Mar, 2008

Research topic: “ Identification of Novel Biomarker for Oral Cancer using saliva” under the category of ‘Anti-cancer therapeutics and drug delivery’ – 5 years funded project Teaching Assistant at Department of Biochemistry,

Madurai Kamaraj University

Jun, 2005- Apr, 2007

Master Graduate Research project

Madurai Kamaraj University

Nov, 2002- May, 2003

Research topic: Non-invasive drug delivery using cardiac isoform of α2-macrogloblin into myocardium in rat.

Teaching Experience

June 2016 - till date - NEET biology faculty in CBSE School, Kovilpatti. One year and two months – 7Arrows (Madurai, India) training for AIPMT examination – April, 2015 – June 2016. No. of NEET QUALIFIED students = 6 (CRASH COURSE)

Knowledge Transfer

Grants

Involved in writing research proposals to various Indian funding agencies. Funded project

– ICMR (Indian Council for Medical Research, India)- Major project –Rs. 21 lakhs. I am currently assisting the doctoral students for smooth running the project – (2011-2015). Master graduate projects guided-

1. Screening for polymorphism in cardiac arrhythmia patients in South Indian population, 2009.

2. Cloning of HERG gene in pcDNA3.1-GFP and its role in development of cardiac arrhythmia, 2009.

3. Screening for HERG gene polymorphism in cardiac arhythmic patients using SSCP analysis, 2009

4. Screening of HERG polymorphism in Indian population and sub-cloning of HERG1a in pcDNA3-GFP, 2010.

5. Cardioprotective effect of medicinal plants in Isoproterenol induced myocardial infarcted rats, 2010.

6. Screening of Protein Biomarker for Cardiac Arrhythmia in Hypokalemia and Hyperkalemia induced Rats and H9c2 cell lines, 2011. 7. Screening of protein biomarker for cardiac arrhythmia in hypokalemia and hyperkalemia induced rats, 2012.

Publications

1. Panneerselvam Gomathi, Anandi Chandramouli Iyer, Sundaresan Sasikumar, Ponniah Senthil Murugan, Sivagnanam Nallaperumal, Govindan Sadasivam Selvam (2016) Association between paraoxonase 1 (PON1) polymorphisms and its risk on Type 2 Diabetes in South Indian population. PlosOne, Under review. 2. Murugan PS, Selvam GS (2015). Identification and quantification of phytocompounds in Acalypha indica leaves. International Journal of Pharma and Biosciences, 6(2), 11 – 21.

3. Murugan PS, Selvam GS (2014). Furosemide and potassium chloride induced alteration in protein profile of left ventricle and its associated risk for sudden cardiac death. Toxicology International, 21(1), 1-7.

4. Murugan PS, Ramprasath T and Selvam GS (2011). Cardioprotective role of Acalypha indica extract on Isoproterenol induced myocardial infarction in rats. Journal of Pharmacy Research, 4(7), 2129-2132.

5. Ramprasath T, Murugan PS, Prabhakaran AD, Gomathi P, Rathinavel A, Selvam GS

(2011). Potential risk modifications of GSTT1, GSTM1 and GSTP1 (glutathione-S- transferases) variants and their association to CAD in patients with type-2 diabetes. Biochemical and Biophysical Research Communications, 407, 49-53. 6. Ramprasath T, Murugan PS, Kalaiarasan E, Gomathi P, Rathinavel A, Selvam GS

(2012). Genetic association of Glutathione peroxidase-1 (GPx-1) and NAD(P)H:Quinone Oxidoreductase 1(NQO1) variants and their association of CAD in patients with type-2 diabetes. Molecular and Cellular Biochemistry. 361, 143–150. 7. Ramprasath T, Kumar PH, Puhari SSM, Murugan PS, Vasudevan V, Selvam GS (2012). L-Arginine ameliorates cardiac left ventricular oxidative stress by up regulating eNOS and Nrf2 target genes in alloxan-induced hyperglycemic rats. Biochemical and Biophysical Research Communications, 428, 389–394. National and International Scientific Presentation 1. Senthil Murugan P and Selvam GS. Oral Presentation on Cardioprotective effect of Acalypha indica against myocardial infarction and left ventricular proteomic analysis of furosemide and potassium chloride treated rats. 43rd National Aqua-terr annual conference, Madurai Kamaraj University, India, 2012. 2. Senthil Murugan P and Selvam GS. Conference on Bioinorganic chemistry and its applications. School of Chemistry, Madurai Kamaraj University, India, 2012. 3. Senthil Murugan P and Selvam GS. Participated in Two day seminar on Heart Failure and Arrhythmia Summit 2011 organized by Fortis Malar Hospital, held at Biotechnology department, IIT-Madras, India, 2011. 4. Senthil Murugan P and Selvam GS. Participated in two days seminar on “Proteomics- principles, methods and application PSI Madurai 2011” at Aravind Medical Research Foundation, India, 2011.

5. Senthil Murugan P and Selvam GS. “Role of Essential ions on Rhythmic regularity of Rat cardiomyocytes” at National Science day and 42nd Aqua-terr annual conference on Genomic sciences at School of Biological Sciences, Madurai Kamaraj University, Madurai, India, 2011.

6. Senthil Murugan P and Selvam GS. Posters presentations on “Cardioprotective effect of medicinal plants on isoproterenol induced myocardial infracted rats and Screening of polymorphism in HERG gene of cardiac arrhythmia in South Indian Population” at Science day and Aqua-terr, 41st annual conference on Organism and Functional genomics, Madurai Kamaraj University, India, 2010. 7. Senthil Murugan P, Ramprasath T, Gomathi P and Selvam GS. Screening of polymorphism in HERG gene of cardiac arrhythmia in South Indian population. International conference on Genomic sciences-Recent trends (ICGS-2010), School of Biological Sciences, Madurai Kamaraj University, Madurai, India. 2010. 8. Senthil Murugan P and Selvam GS. Resource person for UGC-NRCBS Summer School program conducted by Department of Biochemistry on ‘Advanced Biochemistry and Molecular Diagnostic Techniques’, 2010.

9. Senthil Murugan P, Ramprasath T and Selvam GS. Identification and Nanoscale Detection of Oral Cancer markers in saliva. University of Hyderabad, India, International Workshop on Cell Cycle Regulation. 2009. 10. Senthil Murugan P, Ramprasath T and Selvam GS. Screening and detection of oral cancer protein marker in saliva. Institute of Chemical Biology, Indo-US workshop on nanotechnology: Applications and implications held in Indian Institute of Chemical Technology. 2009.

11. Senthil Murugan P and Selvam GS. Poster presentation on “Screening and detection of oral cancer protein marker in saliva” at Indo US workshop on Nanotechnology: Applications and Implications at Indian institute of Chemical Technology, India. 2009. 12. Ramprasath T, Senthil Murugan P, Sasi Kumar P and Selvam GS. Studying the effect of dietary bioflavanoid in ROS scavenging and modulating eNOS through Nrf2-ARE mediated gene expression in cultured cardiomyoblasts. University of Hyderabad, India, International Workshop on Cell Cycle Regulation. 2009. 13. Senthil Murugan P and Selvam GS. Workshop on “Bioinformatics in genomics and proteomics” organized by IIT Karagpur, India, 2009. 14. Senthil Murugan P and Selvam GS. Poster presentation on “Identification and nanoscale detection of oral cancer markers in saliva” at XXXIII All India Cell Biology Conference & International workshop on Cell cycle Regulation at University of Hyderabad, India, 2009.

Awards and Honours

Qualified State Eligibility Test (Tamil Nadu SET-2016)- Qualifying exam for Assistant Professor in Tamil Nadu, India.

I am an awardee of UGC (JRF & SRF), which is prestigious fellowship for outstanding research students in India.

Being a research guide, I involved in designing research projects for Master graduate students (Biochemical Technology) at Department of Biochemistry, MKU, India.

Cleared All India entrance examination for the course of Masters of Science in Biochemical Technology.

Cleared All-India entrance examination for Research position in Madurai Kamaraj University under the scheme of UGC-UPE (University Grants Commission-University with potential for excellence)

Best project presentation award in under graduation and won Gold medal for two consecutive years (II and III year)

Best attendance (100%) award in under graduation and won Gold medal in the final year of under graduation.

Technical Expertise

Preparative and Analytical

In vivo and ex vivo models of ischemia/reperfusion.

Ex vivo Langendorff model of the isolated rat heart.

RNA isolation, real-time PCR, western blot analysis, ELISA.

Analytical and preparative techniques using HPLC and UV-spectrophotometer.

Preparative and analytical gel electrophoresis of DNA, RNA and proteins.

Qualitative and quantitative PCR analysis.

Western, Northern and Southern techniques.

Experience in rat model in induction of myocardial infarction, analysis enzymatic and biochemical parameters.

Experience in recording and analysing ECG for rat and human models.

Performing 2D-gel electrophoresis and analysing the MALDI-TOF/MS results. Personal Information

Name : P. Senthil Murugan

Date of Birth : 19th September, 1981

Sex : Male

Marital status : Married

Languages Known : English, Hindi and Tamil

Nationality : Indian

Permanent Address : 3/1023, Vaigai street, Agasthiyarpatti, Ambasamudrum, Tirunelveli, Tamil Nadu, India- 627416.

Communication Address : 3/5C, MGR Nagar, First street, Aalampatti, Theni Main road, Madurai -625 019

Mobile No. : +91-960*******.

REFERENCE:

Prof. G.S.Selvam,

Head, Department of

Biochemistry,

UGC-CEGS, CAS, NRCBS, DBT-IPLS,

School of Biological Sciences,

Madurai Kamaraj University,

University with Potential for Excellence

Madurai, India – 625 021

E-mail: acxblg@r.postjobfree.com

Phone -++91-452-*******, 223

Fax - ++91-452-*******

Dr. U Ramesh

Assistant Professor,

Department of Molecular Biology

UGC-CEGS, CAS, NRCBS, DBT-IPLS,

University with Potential for Excellence

School of Biological Sciences

Madurai Kamaraj University

University with Potential for Excellence

Madurai, Tamil Nadu – 625 021

Email: acxblg@r.postjobfree.com

Phone: ++91-452- 2458210

Prof. Hussain Munavar

Head, Department of Molecular Biology

UGC-CEGS, CAS, NRCBS, DBT-IPLS,

School of Biological Sciences

Madurai Kamaraj University

University with Potential for Excellence

Madurai, Tamil Nadu – 625 021

Email: acxblg@r.postjobfree.com

Phone: ++91-452-*******

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