Research biomedical

IVAN GOUSSAKOV Ph.D.

**** *. ******** ***, **** *N, Chicago IL, 60615

Email: *************@*****.***

Phone: 847-***-****

Email: *************@*****.***

Phone: 847-***-****

Expertise

Neuroscience.

Stereotaxic surgery.

Histological preparation of brain tissue.

Excitotoxic lesions.

Behavioral testing of rodents.

Patch clamp electrophysiology.

In vivo and in vitro electrophysiology.

Brain slicing.

Designing, developing and testing new equipment, instruments, reagents, and experimental protocols for research (including hardware, software and statistical methods).

Microscopic imaging.

Optogenetics.

Synaptic transmission and plasticity.

Supervising research staff.

Participating in the preparation and writing of grant applications and reports, and (co-)authors scientific research manuscripts.

Conducting analytic investigations and reviews from professional publications.

Highlights

Strong administrative and scientific skills.

Excellent interpersonal, verbal and written communication skills.

Successful in working in a team environment.

Presentation and Consultative skills.

Ability to take initiative and work independently.

Employment History

The University of Chicago Department of Pediatrics 2010-2013

Research Associate (Assistant Professor)

Investigated cellular mechanisms for treatment of neurological diseases.

Worked with patch clamp electrophysiology using brain slices and cell culture.

Investigated synaptic plasticity using a combination of whole cell patch clamp, glutamate photorelease, and channelrhodopsin photostimulation techniques.

Conducted analytical research for identifying the methods and technologies for their application in area of treatment neurological diseases.

Rosalind Franklin University of Medicine and Science 2006-2010

Department of Neuroscience

Research Associate.

Investigated cellular mechanisms of memory and memory disorders in Alzheimer’s disease.

Worked with a combination of patch clamp electrophysiology and two photon calcium imaging techniques on brain slices.

Published seven articles in professional journals and presented posters at international and local meetings.

Developed an equipment complex for combinational multi-photon imaging and patch clamp electrophysiology.

Contract Research Organization CorDynamics 2005-2006

Contractor Scientist

Examined pharmacological effects of emerging drug candidates for human safety.

Conducted analytical research for identifying technologies, equipment and software for application in drug safety and drug discovery.

Reported results to the company’s CEO and customers.

Schering-Plough Research Institute 2003-2005

Department of Safety Pharmacology

Consultant

Conducted whole cell patch clamp experiments to study drugs effects.

Advised department of safety pharmacology in the field of patch clamp electrophysiology.

Organized industrial laboratory for patch clamp electrophysiology.

Presented analytical research and reviews for identification of technology, equipment and software for application of electrophysiology in the area of safety pharmacology and drug discovery.

Gained experience in consultation and business communications with departments and services in industrial environment.

Harvard Medical School 2000-2003

McLean Hospital

Cellular Neurobiology Laboratory

Postdoctoral Research Fellow

Researched mechanisms of memory and CNS diseases.

Worked with visualized patch clamp electrophysiology technique using brain slices for investigation of synaptic transmission and plasticity.

Taught methods of experimental neuroscience such as electrophysiology, microscopy, pharmacology and experimental surgery to Harvard Medical School students and employees in the laboratory.

Published the results in high-wire press scientific journals and reported them at international and local meetings.

Education

Institute of Experimental Medicine, St. Petersburg, Russia

Ph.D., Biology

St. Petersburg State University, Russia

B.S., Biology

Postdoctoral Research and Education

Harvard Medical School, McLean Hospital

Belmont, MA, USA

Postdoctoral Research Fellow

Accomplished postdoctoral training in Neurobiology and Pharmacology.

Bonn University

Bonn, Germany

Postdoctoral Research Fellow

Received training in the fields of Physiology, Neurobiology, Pharmacology and CNS pathogenesis.

Accomplished postdoctoral training in Bonn University from lectures titled “Pathogenesis of CNS diseases”.

SELECTED PUBLICATIONS

1.Goussakov I, Chakroborty S, Stutzmann GE. Generation of dendritic Ca2+ oscillations as a consequence of altered ryanodine receptor function in AD neurons. Channels (Austin). 2011 Jan-Feb;5(1):9-13. Epub 2011 Jan 1.

2.Perez MF, Ford KA, Goussakov I, Stutzmann GE, Hu XT. Repeated cocaine exposure decreases dopamine D-like receptor modulation of Ca(2+) homeostasis in rat nucleus accumbens neurons. Synapse. 2011 Feb;65(2):168-80.

3.Goussakov I, Miller MB, Stutzmann GE. NMDA-mediated Ca(2+) influx drives aberrant ryanodine receptor activation in dendrites of young Alzheimer's disease mice. J Neurosci. 2010 Sep 8;30(36):12128-37.

4.Goussakov I. G Stutzmann G. Linking ER calcium signaling disruptions to synaptic alterations in Alzheimer disease Alzheimer & Dementia. The Journal of the Alzheimer’s Association. 2008 July Volume 4, Issue 4, Supplement, P. T750-T750 (Published presentation at The Alzheimer's Association 2008 International Conference on Alzheimer's Disease).

5.Goussakov, I., Chartoff, E. H., Tsvetkov, E., Gerety, L. P., Meloni, E. G., Carlezon, W. A., Jr. and Bolshakov, V. Y. LTP in the lateral amygdala during cocaine withdrawal. Eur J Neurosci. 2006 Jan;23(1):239-50.

6.Feinmark, S. J., Begum, R., Tsvetkov, E., Goussakov, I., Funk, C. D., Siegelbaum, S. A. and Bolshakov, V. Y. 12-lipoxygenase metabolites of arachidonic acid mediate metabotropic glutamate receptor-dependent long-term depression at hippocampal CA3-CA1 synapses. J Neurosci. 2003 Dec 10;23(36):11427-35.

7.Hinds, H. L., Goussakov, I., Nakazawa, K., Tonegawa, S. and Bolshakov, V. Y. Essential function of alpha-calcium/calmodulin-dependent protein kinase II in neurotransmitter release at a glutamatergic central synapse. Proc Natl Acad Sci. U S A. 2003 Apr 1; 100(7):4275-80. (Goussakov I and Hinds H. L. equally contributed to this work).

8.Goussakov, I. V., Fink, K., Elger, C. E. and Beck, H. Metaplasticity of mossy fiber synaptic transmission involves altered release probability.

J Neurosci. 2000 May 1;20(9):3434-41.

9.Beck, H., Goussakov, I. V., Lie, A., Helmstaedter, C. and Elger, C. E. Synaptic plasticity in the human dentate gyrus. J Neurosci. 2000 Sep 15;20(18):7080-6.

10. Gusakov IV, Sharonov BP, Oparina TI, Kambarova DK.

The effect of superoxide dismutase on seizure in an experimental rat model of

epilepsy. Biull Eksp Biol Med. 1995 Jul;120(7):20-2.

11. Gusakov IV, Ivanenko AI, Grantyn' VA, Laur OIu.

Neurophysiologic and histopathologic correlates of the effect of deferoxamine on

the formation of an epileptic focus during blood injection into the rat cerebral

cortex. Patol Fiziol Eksp Ter. 1993 Jul-Dec;(4):4-6.

12. Golubev AG, Gusakov IV, Kambarova DK.

Prevention and control of hypoxic, circulatory and paroxysmal brain disorders:

where is boundary? Fiziol Cheloveka. 1993 Mar-Apr;19(2):156-70.

PATENTS

1.Goussakov IV. Patent of Russian Fed. No 2004264 from 12.03.92. The Method of electro-diagnostic and electro-therapy and electrodes for this method.

2.Goussakov IV, Finogenov VV. Patent of Russian Fed. No 94004926/14(004480) from 08.02.96. The Method of production biomedical electrodes.

3.Goussakov IV, Shenderov AD. Provisional patent for method providing automated “cumulative” patch clamp technique. Submitted to US PTO.

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