Prajakta Kokate

Maiden name: Prajakta Berde

A-*, Rajlaxmi CHS, Andheri (W) n Mumbai 400 058 n 91-961******* n acwosq@r.postjobfree.com

Scientist

Delivering accurate diagnosis in the field of cancer and otherwise

Contributed in the field of Cytogenetics for over 16 years.

Initiated, established, validated and conducted the Fluorescence in situ hybridization test in two organizations in India, for neoplastic and non-neoplastic disorders.

Improvisation in the technical front for cost-effective, quality assured diagnosis.

Education

Mumbai University, India

MSc by Research in Applied Biology, 2001

Mumbai University, India

BSc in Microbiology, 1998

Experience

SRL Diagnostics (Leading Diagnostic Lab in Asia) Mumbai

Section Technical Supervisor, 2004 till present

Job Description

Standardized, validated and established molecular cytogenetic testing for around 20 cancer types/subtypes.

Led the molecular cytogenetic division to deliver rapid, accurate diagnosis.

Provided technical support for various research projects.

Interpreted atypical/ tricky results accurately to pin-point the most appropriate diagnosis.

Actively participated in National and International Audits.

Established methods with significant cost reduction without compromising on quality.

Reliance Life Sciences Pvt Ltd.

Job Description

Standardized, validated and established molecular cytogenetic testing for microdeletion syndromes.

Standardized molecular cytogenetic testing on sperm and follicular fluid cells.

Gained Experience in Pre-Implantation Genetic Diagnosis.

Assisted in establishing Conventional cytogenetics.

Provided technical support for various research projects.

Bai Jerbai Wadia Hospital for Children

Job Description

Standardized the molecular cytogenetic testing for Prader-Willi and Angelman Syndromes.

Standardized the Methylation- specific PCR for Prader-Willi and Angelman Syndromes.

Gained training for High resolution banding for the detection of microdeletion syndromes.

The above was the MSc project titled ‘Molecular investigations of mental retardation cases associated with defects in chromosome 15.

Publications

1.A complex three-way translocation with deletion of the TP53 gene in a blast crisis chronic myeloid leukemia patient.

Kokate P, Dalvi R, Mandava S.

J Cancer Res Ther. 2015 Oct-Dec;11(4):1037.

doi: 10.4103/0973-1482.144372.

2.Cytogenetic Profile of De Novo B lineage Acute Lymphoblastic Leukemia: Determination of Frequency, Distribution Pattern and Identification of Rare and Novel Chromosomal Aberrations in Indian Patients.

Bhandari P, Ahmad F, Dalvi R, Koppaka N, Kokate P, Das BR, Mandava S.

Asian Pac J Cancer Prev. 2015;16(16):7219-29.

3.Evaluation of genetic status of HER-2/neu and aneusomy 17 by fluorescence in situ hybridization and comparison with immunohistochemistry assay from Indian breast cancer patients.

Kokate P, Sawaimoon S, Bhatia S, Mandava S.

Genet Test Mol Biomarkers. 2012 Apr;16(4):239-45.

doi: 10.1089/gtmb.2011.0125. Epub 2011 Oct 24.

4.Molecular cytogenetic investigations in a novel complex variant of t(8;21)(q22;q22) with ins(15;21)(q15;q22.2q22.3) in a patient with AML-M2 subtype.

Kokate P, Ahmad F, Dalvi R, Das BR, Mandava S.

Cancer Genet Cytogenet. 2008 Jul;184(1):52-6.

doi: 10.1016/j.cancergencyto.2008.03.008.

5.Molecular cytogenetic findings in a three-way novel variant of t(1;8;21)(p35;q22;q22): a unique relocation of the AML1/ETO fusion gene 1p35 in AML-M2.

Ahmad F, Kokate P, Chheda P, Dalvi R, Das BR, Mandava S.

Cancer Genet Cytogenet. 2008 Jan 15;180(2):153-7.

doi: 10.1016/j.cancergencyto.2007.10.005.

6.Down syndrome: a study of chromosomal mosaicism.

Modi D, Berde P, Bhartiya D.

Reprod Biomed Online. 2003 Jun;6(4):499-503.

Poster presentations /book chapters

1Madon P.F, Berde P.P, Shewale L.H, Koppaka N.T, Sarangdhar V., Sharma V., Parikh F.R., The increasing use of FISH in oncology. 27th Annual Conference of Mumbai Hematology Group, February 2003.

2Prochi Madon, Neeraja Koppaka, Prajakta Berde, Usha Shriyan, Vishwas Sarangdhar and Firuza Parikh - 45,X,t(Y;13)(q11.2;q11),-der(13) with Y microdeletions in an Azoospermic male - Abstract, 4th European Cytogenetics Conference, Bologna, Italy.September 6-9,2003.

3P. Berde, N. Koppaka, M. Banerjee, D. Bhartiya, F. Parikh - “Fluorescent in situ Hybridisation and Detection of Microdeletion Syndromes” - Expanding Horizons in Human Genetics, Ed. Bhasin and Kalla; 2002

4Neeraja Koppaka, Prajakta Berde, Deepa Bhartiya, Firuza Parikh - “Significance of Conventional Cytogenetic Procedures in a Modern Genetic Laboratory – A Case Report” - Expanding Horizons in Human Genetics, Ed. Bhasin and Kalla; 2002.

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