Ramasamy P. Pandian, Ph.D
Upper Arlington, OH, 43221
Indian Institute of Technology (IIT) Kanpur, India
Ph.D. Synthetic Chemistry
Madurai Kamaraj University Madurai, India
Organic Chemistry and Research and Development
Motivated and result-oriented Synthetic Chemist with hands-on research and development experience
Demonstrated ability and extensive hands-on experience in designing and executing multi-step synthesis, optimizing chemical processes and scale-up of synthetic methods
Extensive working experience in design and multi-step organic synthesis of π-conjugated hetero(macro)cycles such as porphyrins and phthalocyanines.
An ability to deliver difficult target molecules. Specifically, a proven ability to be successful in compound synthesis, troubleshooting problematic routes and delivering required compounds in a timely manner, in suitable yield and purity.
Experience in various purification and separation techniques: Good knowledge and understanding with different chromatographic principles and hand-on experience with modern chromatographic techniques such as flash column chromatography, HPLC, TLC, preparative liquid chromatography (scaling up), Ion exchange chromatography and crystallization techniques.
Worked in the toxic chemical environment
Experience in GMP and ISO
Experience in various analytical techniques operation and interpretation of results from spectroscopic techniques such as NMR, IR, UV-Vis, fluorescence, and mass (LC and GC)
Experienced in inert double manifold handling techniques (Schlenk).
Familiar with analysis nanoparticle using light scattering method (particle size analyzer)
Extensive working experience in macromolecules such as porphyrins, phthalocyanines (absorbs in the visible and near IR regions) and their fluorescent and magnetic properties.
Expertise in experimental design for structure – activity relationship determination, data analysis and analytical problem solving.
Highly motivated, excellent organizational and communication skills, and able to work independently and as part of a multi-disciplinary team.
Maintain laboratory notebook according to company policy and analyze experimental data and prepare reports for the high level managers
Experience in writing grant proposal to federal agencies (Worked as Co-investigator (R01 and R21 NIH grants)
Experience in training students, junior level chemists and technicians
Ricerca Biosciences Concord, OH
Scientist, Chemical and process development April 2015 to Present
Experience in synthesis of complex organic compounds by multi step organic synthesis. (Pigments, metabolites, active pharmaceutical ingredients (API).
Experience in the purification of organic compounds by flash column chromatography
Experience in HPLC
Experience in handling of ISCO systems for the purification and isolation of organic compounds with liquid and solid loading
Extensive experience in characterization of organic compounds by NMR and mass (LC and GC), UV-Visible and IR spectroscopies.
Experience in making stable labels compounds
The Ohio State University Columbus, OH
Research Scientist (PI), Center for Emergent Materials (CEM) Jan. 2013- April, 2015
Development of oxygen sensing organic magnetic materials by multi-step organic synthesis: purification by chromatographic techniques, characterization by various spectroscopic techniques.
The Ohio State University Columbus, OH
Research Scientist (Chemist) (PI), Wexner Medical Center Oct. 2002- Dec-2013
Synthesized various complicated π-conjugated porphyrins and phthalocyanines macrocycles (Pigments) and studied their spectroscopic properties
Synthesized and characterized the phthalocyanine based crystalline organic paramagnetic materials by multi-step organic synthesis.
Synthesized perchlorotriarylmethane radicals as detection and quantification agent for superoxide in cells
Synthesized fluorescent chromophores (porphyrins, BODIFY) attached to trityl spin- probes for simultaneous measurement of the reactive oxygen species (superoxide)
Developed oxy chip based on using polymeric materials and organic sensor materials, and their characterization and applications
Developed novel implantable biosensors (organic films) using organic spin probe and FDA approved polymers
The Johns Hopkins University Baltimore, MD
Research fellow, School of Medicine Oct. 2001-Sept. 2002
Synthesized lithium phthalocyanine and napthalocyanine radicals as oxygen sensors
University of California Davis, CA
Postdoctoral fellow, Department of Chemistry Dec. 1999-Sept. 2001
Synthesized various fluorescent metal-free and metallo protoporphyrins and hemato-porphyrins, with different lengths of hydrophobic alkyl carboxyl groups
Established structure activity relationships and optimized lead structures to produce active compounds for photodynamic therapy
Pierre et Marie Curie University Paris, France
Research Associate, Lab de organique et organometallique Nov. 1998-Nov. 1999
Synthesized symmetric chiral metallo-porphyrins bearing binaphthyl handles to mimic the catalytic property of heme-containing enzymes
Synthesized the chiral porphyrins as efficient catalysts for olefin epoxidation, and high turnover numbers
Synthesized and characterized the “Double Picket Fence” porphyrins as biomimic heme precursors
and substituted diporphyrin systems in a distinct comparison to normal diporphyrin units
Good working knowledge of several packages:- MS Word, PowerPoint, Excel, Chem.Draw, SciFinder and graphic software sigma plot, peak fit programs, Photoshop, familiar with programs with optical, florescent Cary spectrometers, NMR and EPR programs and fully conversant with the Internet.
Research fellowship award from Johns Hopkins University, Baltimore, USA, September, 2001
CNRS fellowship award from CNRS, Paris, France, November, 1998
Japan Society for Promotion of Science (JSPS) competitive fellowship for young international scientists, Tokyo, Japan
A Short Term Israel Government Fellowship for Higher Education, Israel, November, 1995
Research Associate Award with Research Grant from Council of Scientific and Industrial Research (CSIR), New Delhi, India, 1995
Junior and Senior Research Fellowship from Indian Institute of Technology (IIT), Kanpur, India, December, 1988-1993
Published more than fifty research papers and patents on on organic, material chemistry and their applications.