Chemist
Resume:
BRENDA PIPIK
Edison, NJ *****
******@*****.***
CHEMIST
Analytical chemist with experience in QC analysis of pharmaceuticals and cosmetics. Expertise in analytical techniques and instrumentation for HPLC, GC, SEC, NMR, ICP, KF, pH, and mass spectrometry used daily in laboratory procedures. Experienced in working on cross-functional teams, actively participating in project meetings with presentations. Skilled at keeping thorough research notebooks and documentation of research results, technical writing and editing ability.
LAB/RESEARCH SKILLS
Uses HPLC, GC, ICP, NMR, TLC and mass spec extensively for determination of API purity, detection and identification of impurities
Maintains and relies on HPLC (Agilent 1100, Shimadzu) in the laboratory and develops methods for projects
Crystallization and salt formation expertise
Chromatography: ISCO, silica column, reverse phase, size exclusion, UPLC, TLC for purification of compounds
Supported small and large scale preparations (<1 mg to multikilograms and factory prep)
Large molecule expertise, modification and bioconjugation of RNA, insulin, vaccine
Multistep purification of large molecules
Other instrumentation: pH meter, KF, viscosity apparatus, hydrogenation, centrifuge, Lyophilizer, multichannel pipettors
Familiar with OSHA, GMP and GLP, FDA, QC standards and regulations
Software: Chemdraw, Chemstation, Microsoft Office, Scifinder, EZChrome Elite, Totalchrom
Independently synthesized novel small molecule organic compounds
PROFESSIONAL EXPERIENCE
IMPAX (Corepharma), (Analytical chemist, QC) June 2016-present
Determination of Active Pharmaceutical Ingredient content and impurities by HPLC
Daily verification of gram and micro balances
Daily standardization of pH meters
Document results in laboratory notebooks, QCMs/SOPs, usage logbooks, prepares laboratory testing working folders for finished goods and raw materials, updating regularly
L’OREAL, (Analytical chemist, QC) April 2015-June 2016
Validation of products for market release by HPLC, GC, ICP, pH, density and viscosity
Became certified in color and odor test to validate products for color, odor and appearance
Efficient communication with all departments for timely submission of documents
Document results in laboratory notebooks, QCMs/SOPs, usage logbooks, prepares laboratory testing working folders for finished goods and raw materials, updating regularly
CONSULTING, (Technical Editor, Writer) May 2014
Successfully edited 100 page procurement documents
Demonstrated efficient use of Microsoft Word, Excel, Power Point
Maintained close communication with clients for timely submission of documents
MERCK & CO., INC (Staff Chemist) June 1991-November 2013
Developed a cost-effective, high-yielding (90%) one-pot synthesis of 1,2,4-oxadiazoles for a specific intermediate on a PDE4 inhibitor project and expanded the use of the reaction to include other substrates, resulting in primary authorship of a publication in Synthetic Communications and giving a talk at an ACS meeting. The synthesis of the intermediate was successfully implemented on a 30 kg scale.
Improved small molecule synthetic routes to produce drug intermediates and final drug substances in kilogram quantities for over 15 years
Developed 3 synthetic steps for the chemical synthesis of carbapenem antibiotic Invanz and transferred the technology to the factory for marketing of the drug
Thoroughly investigated stability and degradation of Invanz intermediates for the entire process and final product. Isolated and identified 12 major in-process impurities for Invanz, providing pure samples to analytical dept to use as standards for future assays and demonstrating how they were generated. A memo was provided and procedures were included in the final process memo.
Developed and implemented analytical methods (HPLC, GC, mass spec) for following the progress of chemical reactions, determination of final purity, detection and identification of impurities in small molecule and large molecule projects on a daily basis.
Acquired 2 years experience in automation RNA synthesis involving instrumentation (Mermade) use and troubleshooting, purification methods and associated analytical techniques when Merck acquired siRNA, assisting in the transfer of technology
Researched bioconjugation chemistry associated with novel chemical modification of RNA and insulin, 2 cutting edge projects resulting in authorship on publications and patents (patent pending)
THEATRICAL EMPLOYMENT 1981-1989
Dancer/Singer/Actress in the Broadway company and first national tour of “42nd Street”
EDUCATION
Bachelor of Arts- chemistry- Rutgers
Graduated Metuchen High School
Drew University Medicinal Chemistry course
ACS Short Course Synthetic Organic Chemistry: Modern Methods and Strategies
Merck Recent Advances in Organic Synthesis Methodology
Merck Crystallization
Merck Organometallic Chemistry and its Application to Organic Synthesis
Hewlett Packard GC Troubleshooting and Maintenance
Merck Design and Strategy in Organic Synthesis: The Chiron Approach
Merck Basic Principles of HPLC and System Troubleshooting
Merck Heterocyclic Chemistry
Rutgers Advanced Organic Synthesis
Merck The Directed Ortho Metalation Reaction in Org. Synth. and Methods and Strategies in Heteroaromatic directed Metalation
PRESENTATION EXPERIENCE
2007: “Polysaccharide Activation and Conjugation Chemistry for Pneumoconjugate Vaccine” poster at the Merck world wide meeting and departmental meeting
2006: Speaker at the American Chemical Society Mid-Atlantic Regional Meeting “Scale-up of PDE4 Inhibitor for use in treatment of asthma and COPD”
2000: Annual Process Research Retreat (Merck), Poster of synthetic process for Invanz
1999: Speaker at the National American Chemical Society meeting “New Broad-Spectrum Carbapenem Antibiotic Ertapenem (“Invanz”)”
1999: Speaker at the American Chemical Society Mid-Atlantic Regional Meeting “Oral Fibrinogen Receptor Antagonist”
1991: Speaker at the American Chemical Society Mid-Atlantic Regional Meeting
PUBLICATIONS
Erin Guidry, Julie Farand, Arash Soheili, Craig A. Parish, Nancy J. Kevin, Brenda Pipik, Kathleen B. Calati, Nori Ikemoto, Jacob H. Waldman, Andrew H. Latham, Bonnie J. Howell, Anthony Leone, Robert M. Garbaccio, Stephanie E. Barrett, Rubina Giare Parmar, Quang T. Truong, Bing Mao, Ian W. Davies, Steven Coletti and Laura Sepp-Lorenzino, “Improving the In Vivo Therapeutic Index of siRNA Polymer Conjugates through Increasing pH Responsiveness,” Bioconjugate Chemistry; 2014, DOI: 10.1021/bc400442p
Yong-Li Zhong, Brenda Pipik, Jaemoon Lee, Yoshinori Kohmura, Shigemitsu Okada, Kazunobu Igawa, Chie Kadowaki, Akihiro Takezawa, Shinji Kato, David A. Conlon, Hua Zhou, Anthony O. King, Robert A. Reamer, Donald R. Gauthier, Jr. and David Askin, “Practical Synthesis of a HIV Integrase Inhibitor,” Org. Process Res. Dev.; 2008, 12 (6); 1245–1252
Conlon, D. A.; Drahus-Paone, A.; Ho, G.-J.; Pipik, B.; Helmy, R.; McNamara, J. M.; Shi, Y.-J.; Williams, J. M.; Macdonald, D.; Deschenes, D.; Gallant, M.; Mastracchio, A.; Roy, B.; Scheigetz, J., “Process Development and Large-Scale Synthesis of a PDE4 Inhibitor,” Org. Process Res. Dev.; 2006; 10(1); 36-45
Engelhardt, F. C.; Shi, Y.-J.; Cowden, C. J.; Conlon, D. A.; Pipik, B.; Zhou, G.; McNamara, J. M.; Dolling, U.-H., “Synthesis of a NO-Releasing Prodrug of Rofecoxib,”
J. Org. Chem.; 2006; 71(2); 480-491.
Brenda Pipik, Guo-Jie Ho, J. Michael Williams, David A. Conlon, “A Preferred Synthesis of 1,2,4-Oxadiazoles,” Synthetic Communications, 2004, 34, No. 10, 1863-1870
Conlon, David A.; Pipik, Brenda; Ferdinand, Simone; LeBlond, Carl R.; Sowa, John R., Jr.; Izzo, Bill; Collins, Paul; Ho, Guo-Jie; Williams, J. Michael; Shi, Yao-Jun; and Sun Yongkui, “Suzuki-Miyaura cross-coupling with quasi-heterogeneous palladium,” Advanced Synthesis & Catalysis, 2003, 345 (8), 931-935
Raymond J. Cvetovich, Brenda Pipik, Frederick W. Hartner and Edward J. J. Grabowski, “Rapid Synthesis of tetrahydro-4H-pyrazolo[1,5-a]diazepine-2-carboxylate,” Tetrahedron Letters, 2003, 44, 5867-5870
Karel M.J. Brands, Ronald B. Jobson, Karen M. Conrad, J. Michael Williams, Brenda Pipik, Mark Cameron, Anthony J. Davies, Peter G. Houghton, Michael S. Ashwood, Ian F. Cottrell, Robert A. Reamer, Derek J. Kennedy, Ulf-H. Dolling and Paul J. Reider, “Efficient One-Pot Synthesis of the 2-Aminocarbonylpyrrolidin-4-ylthio Containing Sidechain of the New Broad-Spectrum Carbapenem Antibiotic Ertapenem (MK-0826),” Journal of Organic Chemistry, 2002, 67 (14), 4771-4776
Sajonz, P.; Natishan, T.K.;Wu, Y.; Williams, J.M.; Pipik, B.; DiMichele, L.; Novak, T.; Pitzenberger, S.; Dubost, D.; Almarsson, O. J. Liq. Chrom. & Rel. Technol, 2001, 24, 2999-3015
F.W. Hartner, R.J. Cvetovich, F.R. Tsay, J.S. Amato, B. Pipik, E.J.J. Grabowski, P.J. Reider, “A Highly Convergent Synthesis of a Fibrinogen Receptor Antagonist”, Journal of Organic Chemistry, 1999, 64(21), 7751-7755.
S.A. King, B. Pipik, D.A. Conlon, M. Bhupathy, “Preparation of Cyclic Sulfites by Transesterification of Diols and Diisopropyl Sulfite”, Synthetic Communications, 1997, 27(4), 701-707.
S.A. King, B. Pipik, A.S. Andrews, A. DeCamp, T.R. Verhoeven, “Efficient Synthesis of Carbapenems via the Oxalimide Cyclization. Manipulation of Protecting Groups at the Oxalimide Stage”, Tetrahedron Lett., 1995, 36(26), 4563-6.
D.M. Tschaen, R. Desmond, A.O. King, M.C. Fortin, B. Pipik, S. King, T.R. Verhoeven, “An Improved Procedure for Aromatic Cyanation”, Synthetic Communications, 1994, 24(6), 887-890.
S.Knapp, A.B.J. Naughton, C. Jaramillo, B. Pipik, “Reactions of some Pyranoside Diol Monotriflates with Nucleophiles and Bases”, J. Org. Chem., 1992, 57(26), 7328-34.
PATENTS
Askin, David; Conlon, David; Lee, Jaemoon; Pipik, Brenda; Zhong, Yong-Li; Kohmura, Yoshinori, “Preparation of hexahydropyrimido[1,2-a]azepine-2-carboxylates for treatment of HIV and AIDS.,” PCT Int. Appl. (2005), 100 pp. WO 200-***-****
S.A. King, B. Pipik, D.A. Conlon, “Process for the Preparation of 1,1-Cyclopropane Dimethanol Cyclic Sulfite as well as 1-(thiomethyl)Cyclopropaneacetic Acid and 1-(hydroxymethly)Cyclopropaneacetonitrile”, US 95-37671
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