Medical Management

Dr. SANJEEV KUMAR MATHUR (M.D.)

**** ******* ***** ********* ** 49053

Phone US Cell 609-***-**** *********@*****.*** Summary

MD degree holder with expertise in preclinical orthotopic and xenograft rodent t umor model development, preclinical Imaging micro pet/ct, Spect/ct mri, Ultrasound (Visualsonic 770) including echocardiography and optical Imaging. Novel radiotracer and drug evaluation with extensive hands on animal anaesthesia, microsurgery, multi modality imaging co registration, region of interest(ROI) 3D segmentation and post processing. Technical Skills

Preclinical Imaging

● Extensive hands on experience Siemens Inveon micro pet spect/ct, and ultrasound Imaging (visual sonic 770) Bioscan nano spect/ct mosaic pet with ge ct and vivoquant multi modality image post processing for spect, ct, pet,ct,and mri including optical imaging. Independent image assessment and analysis. Visualsonic ultrasound tumor implantation and assessment of tumor progression (prostate, lung, and liver) Doppler ultrasound measurements and preclinical cardiac echocardiography.

● Advanced protocol analysis to assess whole body, organ, and sub organ radiopharmaceutical uptake and distribution. Multimodality imaging, advanced imaging image fusion, data analysis, 3D image segmentation and manipulation.

● Studies on cardiac and respiratory gating in mouse and rats, cardiac Sesta MIBI uptake, and MDP bone studies. Morphometric bone analysis by Siemens Inveon software. Individual tumor segmentation and brain mapping of fMRI brain data analysis.

● Longitudinal tumor imaging of innovative drug compounds by micro pet/spect/ct and f 18 fdg pet analysis, advanced quantification tools including 3d roi segmentation and analysis.

● Nano spect/ct studies on thallium and Indium (dota) including bio distribution, dynamic renal perfusion studies and dual isotope imaging.

● Optical imaging and hands on experience in xenogen ivis 50 for tumor imaging,bioluminescence and cri maestro multi spectral fluorescence imaging. Regular qc of imaging equipment maintenance and troubleshooting. Animal Surgery and Anesthesia

● Significant expertise in animal handling and test drug administration (iv,ip,sc, and oral) including intratracheal and pulmonary delivery in rodents by whole body or nose only

(Glascol/ Intox) and oral gavages. Anesthesia short term (IV and inhalation), long term anesthesia (summit anesthesia system) ventilator assisted intratracheal intubation in rodents.

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● Surgery in accordance with highest scientific, humane and ethical principles in accordance to Aaalac, Federal, State and University regulations.Extensive aseptic live surgery, including microsurgery in rodent major vascular identification, isolation, cannulation, ligation and anastomosis (cardiovascular shunts) and post surgical care.Stereotactic rodent brain surgery including brain tumor implantation brain trauma models. (cci and lfp) and post surgical angiography and imaging.

● Cell culture and implantations for orthotopic and xenograft tumor developments.Tumors of Lung, Liver, Prostate and Kidney. Tumor measurement by imaging and extent of spread including grading and staging of tumors. Developed Orthotopic model of lung tumor on rodents by intrabronchial implantation of malignant cells. Euthanasia, Necropsy, perfusions and histology for tissue staining and antibody staining. Radioactivity and Biohazard tissue handling

● Radioactivity handling (high energy gamma rays in terms of time activity and distance) and injections (iv, ip retro orbital) in rodents and disposal of radioactive animals.

● Radioactivity record maintenance including documenting radiation safety procedures radioactivity handling and administration to rodents high energy gamma radiation. Independent licensed radioactivity user at Uniformed Services University.Biohazard tissue collection and waste disposal, worked in animal BSL level 3, with infectious cultures and with personal protective equipment’s. Tissue dissection, histology and Cryosection, h&e staining, autoradiography, microscopy, and immunohistochemistry.Standardized tumor and tissue autoradiography procedure on phosphoimager plate by Imagequant software

Responsibilities as team leader

Management and Supervisory

● Managed a small sized imaging laboratory. Established performance standards of subordinates, assisted in selection of methodology and instrumentation. Conducted specialized research to adapt methods and techniques.

● Understanding and following various iacuc protocols. Writing sop and safety procedures in accordance to iacuc protocols and laid out directives to follow the protocols.

● Organizing workflow for multiple studies and overall management of projects to ensure timely and effective completion of project. Standardized technical and research operations related to activities in the laboratory.

● Coordination with different departments including business development, hr, finance, legal, regulatory etc. to ensure smooth and hassle free function in team and help them to meet stringent timelines.conducted training to demonstrate knowledge of technical principles, processes, and concepts.Provide scientific inputs for design and conduct of imaging studies.

● Demonstrated success in motivating staff and directing the productive outcome of complex research. Implemented new methods and processes to solve project related problems and collaborative teamwork.

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● Monitor biosafety and worked as a member of institutional biosafety Committee. Define and document data management plan and develop protocol specific workflow to design and implement database.

● Strategic planning for current and future needs including expansion of small animal imaging facilities. Overall responsibility for project management including Contract agreement, and budget Management.

Power point presentations to doctors and staff to address issues and questions pertaining to study design. presented studies at scientific meetings, national and international conferences. Liaison with clients in order to get business and by meeting quality and timelines in order to get repeat business. Execution & implementation of studies in the development stage. Disease understanding

● Excellent understanding of disease patho physiology and animal models of human diseases including oncology autoimmune, pulmonary and infectious disease mechanisms in animal models and its applied aspects for clinical / diagnostic purposes.

● Design, and develop methodological approaches to answer research questions, writing research proposals and implement studies in accordance to all applicable regulations, policies and procedures offer scientific and medical input for study sections of regulatory application submissions. Member of Harvard joint program in nuclear medicine and innovative molecular imaging techniques.Suggest imaging modality for different imaging projects. Teach and instruct students, post docs researcher and other nonprofessional staff in animal surgery, anesthesia, radioactive administration for imaging projects. Organized in computer documentation of clinical trial, backup database and apply recent innovative techniques in computer technologies, Electronic record keeping, and follow 21 CFR Part 11. Internet to collect drug literature, regulatory manuals and guidelines for industry Scientific evaluation and PK/PD of innovative drugs, and develop study reports, and protocols. Indications, pharmacokinetic/dynamic, mechanism of actions and adverse reactions of commonly used drugs.

Education

● M.S. (masters of surgery) s.p. medical college Bikaner (Raj) India aug 95 98.

● M.b.b.s (Bachelor of medicine and bachelor of surgery) s.p medical college bikaner

(Raj) India July 86 94.

Licensure & certifications

● Licensed to practice medicine and surgery by medical council of India vide Registration MCI/10754 India

● Clinical research certification by massachusetts biotechnology council Boston spring 2007.

● Certification for cancer clinical trials by National institute of health Baltimore Maryland.

● Gcp and ich certificate courses by University Of Washington Seattle WA January 23 2003.

● Health insurance portability and accountability act 1998 (HIPAA) Certification March 2003.

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Awards and fellowship

● 1999 2000: Awarded research scholar award department of surgery Harborview medical center University of Washington Seattle wa October 2000.

● 1998: Merit certificate and award for performing excellent work at department of Cardiovascular Surgery Batra Hospital and Regional Medical Center September 98.

● 1996: First prize for the paper presentation on 11 National symposium and workshop of surgical gastroenterology, October 26 27, 1996. Jaipur, Rajasthan, India Professional experience

● Jan 2015 to present

Licensed physician practising medicine and surgery in india.

● Sept 2010 to Nov 2014 Imaging Research Associate Organization Uniformed services university Bethesda Maryland Website https://www.usuhs.edu/

● Stereotactic rodent brain surgery simulating brain injury followed by pet/ct and mri imaging, anesthesia histology and behavioral studies Image post processing by vivoquant.

● Manage in vivo preclinical imaging studies in collaboration with investigators within Uniformed services University, and external organisations including project management from start to finish.

● Developed and perfected traumatic brain injury models in rodents and f18 fdg pet imaging of injured brain in live rodents.

Oct 09 to Aug 2010 UT southwestern medical center Dallas Texas

● Cell culture, cell assays and cell implantations in rodents, and measure tumor growth by visualsonic ultrasound (prostate and lung). Suggest right imaging modality for different imaging projects.

● Developed orthotopic model of lung cancer on rodents by intrabronchial implantation.

● Ultrasound Visualsonic (770) prostate tumor cell implantations and lung tumor cell culture implantation and imaging measure growing tumor by ultrasound and bioluminescence imaging.

● Disease (mainly cancer) nature, cause, progress, treatment and structural and functional changes induced in animal models (primarily Rats) and imaging by ultrasound. Review imaging projects from researchers for imaging projects and research funding tumor measurements, Ives imaging.

Reviews grant proposals, grant submissions and suggest changes. July 07 to Aug 08 Harvard University Boston Massachusetts

● Managed a small sized Imaging Lab with Inveon micro pet/ct,/spect/ct and, bioluminescence imaging.

April 03 To Dec 06 University of medicine and dentistry Newark New jersey Animal surgery and lymph node dissection in absl 3 necropsy. April 2000 To March 2003 University Of Washington Seattle Rodent surgery

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March 1999 to March 2000 Batra Hospital New Delhi

Senior resident cardiac surgery

Abstracts and Publications

1)M ild traumatic brain injury results in depressed cerebral glucose uptake: An (18)FDG PET study.S elwyn R, Hockenbury N, Jaiswal S, Mathur S, Armstrong RC, Byrnes KR.J Neurotrauma. 2013 Dec 1 30(23):1943 53. doi: 10.1089/neu.2013.2928. Epub 2013 Oct 2. 2) D evelopment of a locally advanced orthotopic prostate tumor model in rats for assessment of combined modality therapy.T umati V, Mathur S, Song K, Hsieh JT, Zhao D, Takahashi M, Dobin T, Gandee L, Solberg TD, Habib AA, Saha D.

Int J Oncol. 2013 May 42(5):1613 9. doi: 10.3892/ijo.2013.1858. Epub 2013 Mar 19. 3) D etection of breast cancer microcalcifications using a dual modality SPECT/NIR fluorescent probe.

Bhushan KR, Misra P, Liu F, Mathur S, Lenkinski RE, Frangioni JV. J Am Chem Soc. 2008 Dec 31 130(52):17648 9. doi: 10.1021/ja807099s. 4) B 7 costimulation is critical for host control of chronic Mycobacterium tuberculosis infection. Bhatt K, Uzelac A, Mathur S, McBride A, Potian J, Salgame P. J Immunol. 2009 Mar 15 182(6):3793 800. doi: 10.4049/jimmunol.0802996. 5) E quivalent functions for B7.1 and B7.2 costimulation in mediating host resistance to Mycobacterium tuberculosis.

Bhatt K, Kim A, Kim A, Mathur S, Salgame P.

Cell Immunol. 2013 Sep Oct 285(1 2):69 75. doi: 10.1016/j.cellimm.2013.09.004. Epub 2013 Sep 23.

6) M ycobacterium tuberculosis H37Rv: Delta RD1 is more virulent than M. bovis bacille Calmette Guérin in long term murine infection.

Sherman DR, Guinn KM, Hickey MJ, Mathur SK, Zakel KL, Smith S. J Infect Dis. 2004 Jul 1 190(1):123 6. Epub 2004 Jun 11. 7) I ndividual RD1 region genes are required for export of ESAT 6/CFP 10 and for virulence of Mycobacterium tuberculosis.

Guinn KM, Hickey MJ, Mathur SK, Zakel KL, Grotzke JE, Lewinsohn DM, Smith S, Sherman DR.

8) R einforced silicone elastomer sheeting, an improved method of temporary abdominal closure in damage control laparotomy.

Foy HM, Nathens AB, Maser B, Mathur S, Jurkovich GJ. Am J Surg. 2003 May 185(5):498 501.

9) R at model of pulmonary arteriovenous malformations after right superior cavopulmonary anastomosis.

Starnes SL, Duncan BW, Fraga CH, Desai SY, Jones TK, Mathur SK, Rosenthal GL, Lupinetti FM.

10) Angiogenic proteins in the lungs of children after cavopulmonary anastomosis. S tarnes SL1, Duncan BW, K neebone JM, R osenthal GL, P atterson K, F raga CH, K ilian KM, M athur SK, Lupinetti FM. J Thorac Cardiovasc Surg 2001 Sep 122 (3): 518 23Am J Physiol Heart Circ Physiol. 2002 Nov 283(5):H2151 6.

11)Characterization of the controlled cortical brain injury model based on longitudinal monitoring by fdg pet.

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colin M. Wilson Shalini Jaiswal Sanjeev Mathur Elizabeth Broussard Scott Jones Bernard J. Dardzinski Kimberly R. Byrnes Reed G. Selwyn

Translational Imaging Core, Center for Neuroscience and Regenerative Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 12) Serial FDG PET Imaging Reveals Functional Changes in the Amygdala of a Controlled Cortical Impact Small Animal Model of Traumatic Brain Injury Colin M. Wilson Shalini Jaiswal Sanjeev Mathur Elizabeth Broussard Bernard J. Dardzinski Scott Jones Reed G. Selwyn

13) Investigation of Glucose Metabolism after Mild Traumatic Brain Injury Using Positron Emission Tomography (PET)

Selwyn R Hockenbury N Jaiswal S Mathur S Byrnes KR PAPERS PRESENTED

“Mathur, S.K., and Bothra, A.C., Doda addicts Effects on GIT –11 National symposium and workshop of Surgical Gastroenterology, October 26 27, 1996. Jaipur, Rajasthan, India.

“Deletion of RD1 from Mycobacterium tuberculosis mimics bacilli Calmette Guerin attenuation” Lewis KN Mathur SK, Reiling Liao, Kristi M. Guinn, Mark J. Hickey, Sherilyn Smith, Marcel A. Behr, and David R.Sherman .US Japan Conference 2000

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