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Research Chemistry

Location:
Hyderabad, Telangana, India
Posted:
October 20, 2016

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Curriculum Vitae

Dr. GANGADASU BANDA Ph. D

Previous Present Address

Dr. Gangadasu Banda (Ph.D) Senior Scientist

Postdoctoral Research Associate, Medicinal Chemistry Laboratory (MCL) Department of Chemistry & Biochemistry, GVK Biosciences Private Ltd. University of California, San Diego, Hyderabad-INDIA-500 076 California - 92093-0358, USA E-mail: acw5ge@r.postjobfree.com Phone: Lab 858-***-**** Phone#: +91-929*******

Home: 858-***-****

Highlights

Expertise in design and executing multi-step synthesis of bioactive molecules.

Synthetic experience on the development of scaffolds and synthesis of New Chemical Entities towards Drug Discovery.

Highly conversant with chromatographic purification and spectroscopic techniques.

Skilled in handling air sensitive and micro scale reactions.

Experienced in working with international pharmaceutical R & D projects, highly professional in reaching goals within time limits and standards.

Capable to carry out both collaborative and independent research work.

Expertise in development of novel organic synthetic methodologies.

Working knowledge in most of the chemical databases and basics in computers.

Independent handling of NMR, HPLC, GC, GC-MS, LC-MS, UV-Visible and Fluorescence instruments.

Research Experience

Postdoctoral Research Associate (3 years)

Feb 2007-Dec 2009; University of California, San Diego, CA; Advisor: Prof. Trevor C. McMorris Design and synthesis of novel analogs of potent anticancer agents, i.e. Illudin, Acylfulvene and Irofulven.

Irofulven (MGI 114, NSC 683863), which is one of the analog of illudin-S is in phase III clinical trials for pancreatic cancer. Several analogs are in phase II clinical trials at NCI and MGI Pharma Inc., Minnesota. (http://www.mgipharma.com/wt/page/irofulven)

Prepared carbamate and hydroxycarbamate derivatives of irofulven and acylfulvenes.

Synthesized urea, hydroxyurea, and hydroxythiourea derivatives of irofulven and acylfulvenes.

An efficient one pot method to prepare amine derivative of irofulven.

Synthesized 90-120 Analogs.

Worked in MGST-1 enzyme catalysed conjugation of HCBD with Glutathione and its metabolites studies.

Worked in Thalidomide derivates to synthesis to study the RNA/DNA polymerize inhibition. Pharmaceutical Industry Experience (6.3 years)

Currently involved in the Discovery Research projects of a MNC based client)

January 2010-Present: Medicinal Chemistry Division GVK Biosciences Private Ltd.

Hyderabad, INDIA

GVK Bio (India’s No 1 Contract Research Organisation http://www.gvkbio.com/)

Position: Senior Scientist in Medicinal/Synthetic Organic Chemistry Responsibilities:

Solely responsible for the succeeding the projects including timely delivery of the target compound with required quantity and purity from multi gram to milligram amounts.

Designing, Estimation, planning and execution of complex organic molecules assigned by the client along with a group force of 15-16 chemists including M.Sc.’s and Ph.D’s.

Involving and working for the drug discovery programs for various international pharmaceutical companies. Particularly, design and synthesizing NCEs during hit identification, lead identification and lead optimization as per customers’ need for diverse therapeutic areas.

Designing schemes/route of synthesis, costing, planning, execution, data interpretation, problem solving, delivery and scientific documentation.

The delivery of the final products which includes from milligram to kilogram level.

Client communication by teleconference, email and sending weekly reports with detailed results and plans.

Designing viable and economic routes and preparing quotations/estimation for the short term services like PO based projects.

Responsible for the communication and coordination with the internal and external customers and with other business functions.

Graduate Research Fellow (Ph.D)

01/2001-01/2006; Indian Institute of Chemical Technology, Hyderabad, India; Advisor: Dr. V. Jayathirtha Rao.

Designed and synthesized biologically active compounds such as anti-malarial, anti-microbial and insecticidal.

Synthesized various substituted heterocyclic compounds (Nicotinaldehydes) through Vilsmeier cyclization reaction.

Several Baylis-Hillman adducts were synthesized from 2-chloro-3-pyridine carboxaldehyde derivatives exhibited substantial anti-malarial and antimicrobial activity.

Imidacloprid analogues were synthesized and evaluated for their insecticidal activity and these compounds showed potent insecticidal activity.

Phosphonates (HWE reagents) were prepared for the synthesis of olefin derivatives with specific configuration (trans and cis isomers).

2-Chloro-5-methyl pyridine-3-olefin derivatives were prepared and studied the photochemical E(trans)-Z(cis) isomerization.

Developed several novel environmentally benign synthetic methodologies using Lewis acids and reusable polyaniline catalysts.

Projects Handled

Imidacloprid is a world emerging insecticide. A process was developed for the preparation of 2-chloro-5methyl-pyridine, which is a very good intermediate in Imidacloprid manufacturing.

Gained experience by working in IICT-Overseas project for making chemical libraries. Education

Ph.D.: 01/2001 – 12/2006 In Organic Chemistry at Indian Institute of Chemical Technology (IICT)/ Osmania University, Hyderabad, India; Research Guide: Dr. V. Jayathirtha Rao; Thesis Title:

“Design and Synthesis of Novel Heterocyclic Compounds Through Vilsmeier Cyclization– Their Biological Activity, Photochemical Cis-Trans Isomerization of Heterocycles and Development of New Synthetic Methodologies”.

M.Sc.: 07/1997 – 08/1999; Organic Chemistry, Osmania University, Hyderabad, India B.Ed.: 07/1996 – 07/1997 Biological Science, Osmania University, Hyderabad, India B.Sc.: 06/1993 – 06/1996 (Chemistry, Botany, Zoology), Osmania University, Hyderabad, India Awards and Honors:

2007- 2009: Postdoctoral Fellowship, University of California San Diego, CA, USA

2003- 2006: Senior Research Fellowship, Council of Scientific Industrial Research (CSIR) India

2001-2003 : Junior Research Fellowship, Council of Scientific Industrial Research (CSIR) India

2000 – Junior Research Fellowship, (IICT-JRF 2000) Hyderabad, India Publications

1. Structural Activity Studies of Urea, Carbamate and Sulfonamide Derivatives of Acylfulvene. Journal of Medicinal Chemistry 2010, 53(3), 1109-1116. Trevor C McMorris, Ramesh Chimmani, Kashinatham Alisala, Michael D Staake, Gangadasu Banda, Michael J Kelner. 2. Synthesis, photochemical E (trans) Z (cis) isomerization and antimicrobial activity of 2-chloro-5- methylpyridine-3-olefin derivatives. European Journal of Medicinal Chemistry 2009, 44, 4661-4667. B. Gangadasu, M. Janaki Ram Reddy, M. Ravinder, S. Bharat Kumar, B. China Raju, K. Pranay Kumar, U.S.N. Murthy, and V. Jayathirtha Rao

3. Synthesis of Imidacloprid Analogues from Novel Chloronicotinaldehydes Journal of Heterocyclic Chemistry 2009, 46, 1213-1217. B. Gangadasu, B. China Raju, V. Jayathirtha Rao. 4. Larvicidal Efficacy of Neonicotinoid Class of Compounds on Culex quinquefaciatus. Journal of Entomology 2008, 5(1), 45-50. M. Srinivasa Rao, U.S.N. Murty, B. Gangadasu, B. China Raju, Ch. Ramesh, S. Bharat Kumar, V. Jayathirtha Rao

5. Facile and Selective Synthesis of Chloronicotinaldehydes by the Vilsmeier Reaction. Tetrahedron 2006, 62, 8398-8403. B. Gangadasu, P. Narender, S. Bharat Kumar, B. Anand Rao, M. Ravinder, B. China Raju, V. Jayathirtha Rao

6. Baylis-Hillman adducts between pyridine carboxaldehyde derivatives and cylic enones. Tetrahedron 2006, 62, 954-959. P. Narender, B. Gangadasu, M. Ravinder, U. Srinivas, G.Y.S.R. Swamy, K.Ravi kumar and V. Jayathirtha Rao

7. Synthesis of Multisubstituted Quinolines from Baylis-Hillman Adducts Obtained from Substituted 2- Chloronicotinaldehydes and Their Antimicrobial Activity. Bioorganic & Medicinal Chemistry, 2006, 14, 4600-4609. P. Narender, U. Srinivas, M. Ravinder, B. Ananda Rao, Ch. Ramesh, K.Harakishore, B. Gangadasu, U.S.N. Murthy and V. Jayathirtha Rao

8. Polyaniline Salts and Complexes: Efficient and Reusable Catalyst for the One-Pot Synthesis of 5-

(Methoxycarbonyl)-6-methyl-4-phenyl-3,4-dihydropyrimidin-2 (1H)-one. Journal of Applied Polymer Science 2006, 102(2), 1741-1745. B. Gangadasu, S. Palaniappan C. Amarnath and V. Jayathirtha Rao 9. Calcium chloride catalyzed three component, one-pot condensation reaction: An efficient synthesis of3,4-dihydropyrimidin-2(1H)-ones. Indian Journal of Chemistry Section B 2006, 45(5), 1259-1263. B. Gangadasu, P. Narender, B. China Raju` and V. Jayathirtha Rao 10. Anti-malarial activity of Baylis-Hillman adducts from substituted 2-chloro nicotinaldehydes. Bioorganic & Medicinal Chemistry Letters 2005, 15(24), 5378-5381. P. Narender, U. Srinivas, B. Gangadasu, Sukla Biswas, and V. Jayathirtha Rao

11. Base Induced Carbon-Nitrogen (C=N) Double Bond Migrations in Schiff Bases B. Gangadasu, P. Narender, B. China Raju and V. Jayathirtha Rao. Indian Journal of Chemistry Section B 2005, 44B, 2598-2600

12. One-Pot Synthesis of Dihydropyrimidinones Using Polyaniline-Bismoclite Complex. A Facile and Reusable Catalyst for the Biginelli Reaction. Synlett 2004, 7, 1285-1287. B. Gangadasu, S. Palaniappan and V. Jayathirtha Rao

13. ZrCl4 Catalyzed Solvent Free Synthesis of Coumarins. Journal of Chemical Research 2004, 7, 480-481. B. Gangadasu, P. Narender, B. China Raju and V. Jayathirtha Rao 14. Facile and Selective Synthesis of Chloromethylpyridine and Chloro pyridines by Using Diphosgene/Triphosgene. Synthetic Communication 2004, 34(6), 1097-1103. P. Narender, B. Gangadasu, Ch. Ramesh, B. China Raju and V. Jayathirtha Rao 15. A Simple and Convenient Preparation of 2-Chloro-5-Methyl-Pyridine-3-Carbaldehyde imines. Heterocyclic Communications 2002, 8(3), 242-248.B. Gangadasu, B. China Raju and V. Jayathirtha Rao 16. An Improved Process for the Preparation of 2-Chloro-5-methylpyridine-3-carbaldehyde using Diphosgene and Triphosgene. Banda Gangadasu, B. China Raju, V. Jayathirtha Rao. US. Patent No: 6,479,664, 2002

17. Substituted Dihydropyrimidinone Preparation Using Polyaniline Salt Catalyst. Palaniyappan Srinivasan, Vaidya Jayathirtha Rao, Banda Gangadasu, US Patent No: US2005/0215790 A1. 18. Novel Antimalarial Baylis-Hillman adducts and Methods of making them. Puli Narender, Banda Gangadasu, Uppalanchi Srinivas, Mettu Ravinder, Sriramoju Bharath Kumar, Chilukuri Ramesh, Vaidya Jayathirtha Rao, Janamadugu Madhusudan Rao US Patent No: US2010/766883 B2. Presentation in Symposiums/Seminars

1. Presented a poster entitled “Synthesis of 2-Chloro-5-Substituted Pyridine-3-Carbaldehyde”in 4th National Symposium in Chemistry. February 1-3, 2002, held at NCL PUNE. INDIA. B.Gangadasu, B.China Raju, Ch.Ramesh, V.Jayathirtha Rao.

2. Attended “6th National Symposium in Chemistry. February 6-8, 2004, held at Indian Institute of Technology (IIT), Kanpur, INDIA.

3. Presented a poster entitled “Synthesis and Photochemistry of Heterocyclic Compounds” in 2nd International Conference on “Organic Synthesis and Process Chemistry (OSPC)”, April 1-3, 2005, Indian Institute of Chemical Technology (IICT), Hyderabad, INDIA. B.Gangadasu, P. Narender, S. Bharath Kumar, B.China Raju, V.Jayathirtha Rao.

4. Attended “11 th Annual San Diego Medchem Symposium” July 11, 2008. Organized by San Diego American Chemical Society and Dept. of Chemistry and Biochemistry, University of California San Diego La Jolla, CA, USA.

References

Prof. Trevor C. McMorris

Dept of Chem & Biochem

Univ of California San Diego

La Jolla, CA-92093-0358

Tel: 1-858-***-****

Fax: 1-858-***-****

acw5ge@r.postjobfree.com

Dr. V. Jayathirtha Rao

Director

Organic Chem Div- II,

Indian Inst of Chem Tech,

Hyderabad – 500 007, India

Phone: +91-40-271*****

Fax: +91-40-271*****

Email: acw5ge@r.postjobfree.com

Dr. B. China Raju,

Principal Scientist,

Organic Chemistry Division-I

Natural Product Laboratory,

Indian Inst of Chem Tech,

Hyderabad 500 007, India

Phone: +91-40-271*****

Email:acw5ge@r.postjobfree.com



Contact this candidate