E-mail: acv3aa@r.postjobfree.com

Mobile: 981*******; 991*******

Permanent Address: BA/26-A, Ashok Vihar, Phase-I, Delhi: 110052

Highlights

Strong leadership, consultation, collaboration, training of personnel and team building skills proven in Pharmaceuticals and Contract Research Organization.

Broad working knowledge of pharmaceutical industry R&D processes, setting up drug discovery labs.

Significant contribution in conceptualizing, developing new bioassays and models in various therapeutic areas including dermatology, oncology, cardio-toxicity, tuberculosis research, neuropathy, diabetes and immunotherapy.

More than 16 years of experience in biotechnology, toxicology, pharmacology, pharmacokinetics, formulation, protein expression and purification, project management, scientific writing and quality assurance.

In-depth knowledge and experience in new drug discovery biology, worked in different new drug discovery labs associated with five different Pharmaceuticals and one contract research organization.

Lead biology group in five Investigational New Drug Applications (INDAs) submitted with Drugs Controller General of India (DCGI) and helped in IND for USFDA for Drug Discovery project in the past.

Business development, external project handling, target selection, research partnering, strategic planning, establishing critical paths for several integrated new drug discovery projects and recruitment practices. Critical evaluation and generation of reports.

Well versed with Good Laboratory Practices (GLP). Worked as Study Director for Safety, Efficacy and Toxicology. Delivering GLP and Non GLP certified studies for peptides/herbal/synthetic novel molecules/formulations to International and National clients as an integral part of Contract Research Organization.

Experienced in Non Clinical Risk Assessment (Efficacy, Safety and Toxicology Studies in oncology and other areas) – xenograft, orthotopic, acute, sub-acute, sub-chronic studies and development of toxicity models and new disease models in animals for drugs (including NCEs, herbal extracts, generic products and Coded Compounds), industrial chemicals, biotechnology products, herbal medicines for submission to WHO, USFDA and other national and international Regulatory Bodies.

Recruiting, training lab scientists as a part of Personnel management. Tracking the contribution of each of the team member towards each project and training and troubleshooting and providing technical inputs towards the project completion in close association with the management and the sponsor. Imparted training as supervisor for the dissertation to more than 50 biotechnology/ pharmacology /life science scientists in various areas of drug discovery /development in Oncology and allied therapeutic areas.

Individually handled writing manuscripts and patents for US/PCT and Indian market, writing Research articles for international journals.

“Proof of Concept” studies and in-vitro & in-vivo correlation of surrogate biomarkers of efficacy/toxicity for molecules in Discovery, Animal efficacy and Clinical development stages.

Planning, Designing, setting up and maintenance of animal facility/animals and further approval for experimentation and breeding from CPCSEA and IAEC. Overall setting up and maintenance of new tissue culture facility. Organizing SAC and IAEC meeting.

Significant contribution in developing website for Curadev Pharma and Dabur Pharma/Dabur research Foundation, designing the contents of CD’s and brochures for BIO 2006, 2007, 2008.

At AIIMS; November 2012-Present

Scientist –D

Strategizing/formalizing/ executing new concepts/proposals in translational research. Developing alliance with collaborators.

Guiding/ mentoring Ph.D students.

Imparting basic science lectures to MD students and Ph.D students.

Establishment and structuring new research labs.

Development and validation of cytogenetics and molecular screens for cancer patients

Organizing seminars/workshops

Esteemed member of doctoral committee

Generation of Proposals in field of cancer biology and blood stream infections.

At Curadev Pharma Pvt. Ltd. ; December 2010- August 2012

Lab head, Senior Scientist, Animal House In charge

Founded the Small Animal Vivarium, blueprint approval, CPCSEA approval for experimentation and breeding, construction, infrastructural details and further conceptualization and execution of experimentation.

Development of immnunodeficient animal facility.

Presently leading in vivo pharmacology and toxicology team and in-charge –Small Animal Vivarium.

Organizing JSC, IAEC meetings, consulting and interacting effectively with clients, business units, study scientist.

Laying down SOPs and protocols and releasing reports

Early ideation and assessment of toxicity biomarker/ signatures, translational research.

Retrospective and prospective biomarker program.

Target selection and setting up Pre-formulation lab for new projects/NCEs

LPS induced target specific models; Elucidating PK/PD correlation

Development, standardization and validation of immunotherapy model in Oncology, development of renal capsule tumor growth, xenograft development using trocarAt Department of biochemistry;

University of Delhi; February 2010- November 2010

Postdoctoral fellow, B.N. Bakshi fellowship

Tuberculosis Research; working in Biosafety level III facility for Virulant species

At Dabur Research Foundation; July 2001- November 2009

Senior Research Scientist

Lead the team for New Drug Research

Drugs evaluated for Clinical Development: for cancer

Drugs in Preclinical Development, licensed to Pharma unit for commercialization

Interacting effectively with the clients, business units, study scientists and performing life and post phase audits for related studies.

Lead the team for Development, standardization, validation and analysis of various bioassays for Oncology screens.

Lead the team for various phases of Development, standardization, validation and analysis for Dermatology, Cardiotoxicity, Neuropathic pain, Clinical toxicity evaluation and screens, diabetes/ inflammation screens and Toxicity studies

Studies submitted as part integral part of FDA document

Docetaxel: Liposomal formulation.

Nanoxel: Nanoparticle formulation

At Skin Institute And School of Dermatology; Jan 2000 to May 2001

Research Assistant

Designing, setting up and maintenance of research laboratory devoted to primary cell cultures with clinical relevance for vitiligo and acne.

Nominated and selected for undertaking research for collaborative projects with Shanghai Medical University, at shanghai, China.

At Willard India Ltd; 1996 to Oct 1999

Research Officer

Research and development for new patented varieties.

Patents and Publications

Patents

APPLICANT NAME

NAME OF THE INVENTOR

TITLE

PATENT APPLICATION PUBLICATION

DABUR RESEARCH FOUNDATION

Address of Applicant :22 SITE IV, SAHIBABAD,

GHAZIABAD-201 010, UTTAR PRADESH, INDIA

MUKHERJEE, RAMA, SINGH, ANU, T., DUTTA, KAKALI, MAIKAP, G,C.,SHUKLA, ANIL, KUMAR, KHATTAR, DHIRAJ, BURMAN, ANAND, C.

USE OF 5-METHOXYTRYPTAMINE AS A CARDIOPROTECTIVE AGENTS

INDIA, Application No.6123/DELNP/2005 A, Publication Date : 09/05/2008

MUKHERJEE, RAMA, SINGH, ANU, T., DUTTA, KAKALI, MAIKAP, G,C.,SHUKLA, ANIL, KUMAR, KHATTAR, DHIRAJ, BURMAN, ANAND, C.

CARDIOPROTECTIVE AGENTS

UNITED STATES, US 2007/0203248 A1, Publication date: August 30, 2007

MUKHERJEE, RAMA, SINGH, ANU, T., DUTTA, KAKALI, MAIKAP, G,C.,SHUKLA, ANIL, KUMAR, KHATTAR, DHIRAJ, BURMAN, ANAND, C.

USE OF 5-METHOXYTRYPTAMINE AS A CARDIOPROTECTIVE AGENTS

WIPO/PCT : Publication date May 10, 2006, PCT number PCT/IN2004/000216; WO2005009419A2)

MUKHERJEE, RAMA, SINGH, ANU, T., DUTTA, KAKALI, MAIKAP, G,C.,SHUKLA, ANIL, KUMAR, KHATTAR, DHIRAJ, BURMAN, ANAND, C.

USE OF 5-METHOXYTRYPTAMINE AS A CARDIOPROTECTIVE AGENTS

EUROPEAN PATENT OFFICE: EP 1653948 B1 20070926 (EN)

ANU T SINGH, SUDHANAND PRASAD, KAKALI DATTA, RINKU AHUJA, RAMA MUKHERJEE, ANAND C BURMAN

NOVEL PEPTIDES USEFUL FOR TREATMENT OF ALOPECIA

WIPO/PCT : Publication date Oct 12, 2006, PCT numberPCT/IN2005/000453, WO2006106528 A1

ANU T SINGH, SUDHANAND PRASAD, KAKALI DATTA, RINKU AHUJA, RAMA MUKHERJEE, ANAND C BURMAN

NOVEL PEPTIDES USEFUL FOR TREATMENT OF ALOPECIA

INDIA, Application No.898/DEL/2005 A, Publication date : 07/04/2005

SANJAY S, VIVEK KUMAR, KAKALI DATTA, RAMA MUKHERJEE, ANAND C BURMAN

NOVEL 1,8 NAPHTHAHYDRINE DERIVATIVES AS ANTICANCER AGENTS

INDIA, IN/3192/DEL/2005

SANJAY S, BEENA BHAT, VIVEK KUMAR, KAKALI DATTA, RAMA MUKHERJEE, ANAND C BURMAN

NOVEL DEHYDOCOSTUS LACTONE DERUIVATIVES AS ANTICANCER AGENTS

INDIA, IN/3395/DEL/2005

Publications

4 manuscripts ready for submission.

DRF7295: A novel peptide based signal transduction modulator for the treatment of gastrointestinal carcinomas. Singh, AT, Jaggi, M, Prasad, S, Singh, G, Dutta, K, Rajendran, P, Burman, AC, Mukherjee, R. Clin. Cancer Research (2005) 11: 9010S.

Synthesis and cytotoxic evaluation of 4/5-hydroxy-2,3-diaryl(substituted)-cyclopent-2-en-1-ones as cis-restricted analogues of combretastatin A-4. Mukund K. Gurjar, Radhika D. Wakharkar, Anu T. Singh, Manu Jaggi, Hanumant B. Borate, Ritu Verma, Praveen R., Sarjana Dutt, Gurvinder Singh, Vinod Sanna, Manoj K. Singh, Popat D. Shinde, Vishal A. Mahajan, Vinod H. Jadhav, Kakali Dutta, K Karthik, Shiv K. Agarwal and Rama Mukherjee. J Med Chem. 2007 Apr 19; 50 (8):1744-53. Epub 2007 Mar 21.

Modulation of Key Signal Transduction Molecules by Drf 7295: A Combination Of Four Synthetic Neuropeptide Analogs. Rama Mukherjee, Anand Burman, Anu T. Singh, Manu Jaggi, Sudhanand Prasad, Gurvinder Singh & Kakali Datta. Invest New Drugs. 2008 Dec;26(6):505-16. Epub 2008 Mar 6.

Bombesin analogs containing a-aminoisobutyric acid with potent anticancer activity Sudhanand Prasad, Archna Mathur, Neena Gupta, Manu Jaggi, Anu T Singh, Praveen Rajendran, Vinod Sanna, Kakali Dutta and Rama Mukherjee. J Pept Sci. 2007. Jan; 13(1) : 54-62.

Eclipta alba extract with potential for hair growth promoting activity.

Publication year: 2009.Source: Journal of Ethnopharmacology, Volume 124, Issue 3, 30 July 2009, Pages 450-456. Kakali Datta, Anu T. Singh, Ashok Mukherjee, Beena Bhat, B. Ramesh.

K Purkayastha, A Srivastava, Amitabh, S Sapra, Gautam P, T Thomas, B Singh, R Seth. Psychosocial Approach, A Necessity For Holistic Treatment For Childhood Cancers; A Step Ahead for Consideration in Developing Countries like India: communicated and manuscript number allotted.

K.Purkayastha, Amitabh, R. Seth, I. Xess, A. Kapil, V Sreenivas. To determine the role of procalcitonin as a diagnostic tool in febrile neutropenic episodes of children undergoing treatment for childhood cancers. Accepted in Journal of Clinical Case Reports.

K. Purkayastha, R. Seth. The issues and challenges with cancer biomarkers, communicated to Journal of Biomedical Science.

Qualifications

Doctorate in Biotechnology from Chaudhary Charan Singh University; sponsored scholar from Dabur Research Foundation - 2007.

Masters Degree in Zoology from Chaudhary charan Singh University Meerut-1996. Gold medalist, Ist class first.

Bachelors Degree with Zoology, Botany and Chemistry from Delhi University - 1993; Ist class.

Post Graduate Degree in Personnel management and Industrial relations from Institute of management studies and social research-1996; Ist class

Scientific Societies:

Society of biological chemists

Biological chemists of India

ABLE India.

Biotechnology research society of India

Laboratory Animal Scientist’s Association (LASA)

Awards

Gold Medal and certificates for Merit

Certificates of merits for extracurricular activities

BN Bakshi fellowship for post doctoral research work.

Memberships and honors

Appointed as CPSEA nominee by ministry of environment and forest

Invited Oral presentation at PHOCON 2014, Chennai on 12th October 2014

Invited lecture at NSAALSR in February 2014 at Banaras Hindu University

Invited oral lecture at the XXXIII Annual Conference of Society of Toxicology, (STOX) India for Synergy of Toxicology Research in SAARC Countries” October -2013.

Invited oral lecture at the national conference on “Use of animals and alternatives in biomedical research with special reference to drug discovery and development” Feb-2013

Member of International Psyco-oncology society

Life member of Society of biological chemists

Life member biological chemists of India

Life member of ABLE India.

Life member biotechnology research society of India

Life Membership of Laboratory Animal Scientist’s Association (LASA)

Invited external examiner for M.Sc. Pharmaceutical biotechnology at Amity University.

External reviewer for Ph.D. synopsis; Banasthali university 2013

Reviewer of 6 international scientific journals.

Assigned as a member doctoral committee for Ph.D. Students in the department.

Associate editor and reviewer of AshEse Journal of pharmacy, UK.

Esteemed member of Editorial board of

International Journal of Analytical and Applied Chemistry

International Journal of Photochemistry and Photomorphogenesis.

International Journal of Molecular Biotechnology

International Journal of Animal Biotechnology

International Journal of Cell Biology and Process.

Conferences/Workshop Attended

Organizer/ participant in Pedicon 2015-hematology and oncology workshop, January 2015.

Organizer/ participant in National training workshop 2014 on practical pediatric Oncology, December 2014.

Oral presentation at Phocon 2014, October 2014

Participant in Nulife /Abcam workshop on WB and IHC, December 2013, AIIMS

Organizer/ participant in Phocon workshop 2013-Psycho-social approach in pediatrics cancer patients, November 2013.

Participant in Ranbaxy roundtable conference in cancer, November 2013, AIIMS, Ramalingaswamy board room.

Participant in AIIMS capacity building workshop on pharmacovigilance in clinical trial. 16th July 2013 AIIMS, Delhi.

CII, NCD summit on strengthening policies on Diabetes Care. 7th-8th June 2013, Taj Palace Hotel. Delhi.

Skill enhancement workshop series ‘effective communication with patients and health team’. AIIMS; December 2012.

ABLE-OSHL-DUKE workshop on meeting the challenges of developing new anticancer therapies, India International Centre; September 2012.

Workshop/conference on animal welfare, IGIB;July2012

4 day AACR conference; December 2011.

From antibody inventions to start up companies and blockbuster therapeutics’ Biotech Idea to Innovation Seminar-February 2007.

Participated in conference on the occasion of international meeting on animal ethics committee; February 2003. “Alternatives for usage of animals in experiments”.

Participated in workshop on cancer and related therapies, November 2001.

Participated in workshop by Ad instruments Australia, October 2001.

Seminar on primary cultures and use in clinical dermatology, Shanghai Medical University, Shanghai, China November 2000.

Trainings and Certifications

5 day training on animal ethics, CPCSEA, Ministry of Environment and Climate change, May

2015.

3 day training course in biostatistics and epidemiology in biomedical research at ICPO

Noida, January 2010.

3 day GLP training workshop by WHO/TDR certified professionals. August 2008.

Program of advanced training in melanocyte and fibrocyte cell culture at Hua Shan Hospital,

Shanghai Medical University, China. October-November 2000.

Computer skills

MS word, Excel, Graph pad prism, computer based statistical analysis, Image analysis software, fluorescence imaging software, FACS software, Adobe Photoshop, PowerPoint, Gel Doc, KEGG software, Tbsgc software, NNPP and Sigma genosis software’s.

Personal details

Date of Birth: 29th January 1973

Marital Status: Married

Nationality: Indian

Languages Known: English, Hindi, Bangla and Marathi

Kakali Purkayastha

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