DR. CHRISTIAN R.J. CARTER

#****, **** ***** *********** *****

Edmonton, Alberta T6R 0M3

780-***-****

acufr2@r.postjobfree.com

Re: Medical Science Liaison

Dear Sir/Madam,

It is with great interest that I am forwarding my curriculum vitae for consideration as a Medical Science Liaison. Given my extensive and diverse background in all aspects of Pharmacology, Molecular Biology, Immunology, Oncology, Biochemistry, Physiology and my proven track record as an multiple award winning, astute educator of adult learners at the undergraduate and graduate level I feel that I am the candidate you are looking for. Throughout my tenure with the department of Pharmacology, the Alberta Diabetes Institute and the Faculty of Nursing I not only became an expert in multiple scientific ideologies but I excelled in clinical practice. Following graduation I was employed as a Registered Nurse in the emergency department of a the large tertiary care center, the University of Alberta Hospital where I became the first nurse to present at the National Emergency Nurses Association only months after graduation with distinction. In late 2015 I entered the field of clinical research as a research coordinator to learn the fundamentals of the clinical trial process and logistics involved in trial design/development regarding regulatory and administrative components. My ability to break down complex scientific/clinical concepts into easily understandable lay information has helped me to excel in the education of students, patients, and colleagues. I have years of experience initiating and maintaining relationships and collaborations with fellow researchers as well as filling the role of liaison between multiple stakeholders while managing various research projects in both scientific and clinical arenas. As a clinician scientist I possess an expert- level, in-depth understanding of Physiology and Pharmacology that allows me to quickly adapt to novel projects and concepts. I am a highly motivated and active team member/leader able to establish and maintain collaborative activities with various stakeholders, physicians, researchers and educators. I feel that my skillset and personality would enable me to excel as a Medical Science Liaison. I received my PhD in Pharmacology from the University of Alberta in 2010. Though my doctoral work focused on Neuropharmacology I played a very active role as a lecturer in the Department of Pharmacology teaching all aspects of Pharmacology (Neuro, cardiovascular, endocrine, oncology, antimicrobial, autonomic and molecular theory). After receiving my PhD in Pharmacology I pursued postdoctoral work at the Alberta Diabetes Institute where I moved to the field of Diabetes/Cardiovascular Pharmacology while continuing to excel in undergraduate education. My training resulted in the development of an incredibly diverse scientific background that lead me to explore various topics in-depth. I am well known by colleagues as an excellent writer, developer of educational material and communicator. I believe it is a combination of these skills that aided in my recognition as an educator. Currently I am filling the role of clinical research coordinator at the Northern Alberta Clinical Trials and Research Centre (NACTRC) in Edmonton Alberta Canada. I run early phase trials, mostly comprised of phase 1B or seamless phase 1B/2A studies. During my time with NACTRC I have been able to take part in all regulatory/administrative aspects of negotiating, implementing, carrying out and closing a clinical trial. I have acted as the point of contact for various stakeholders and successfully liaise between them. Currently I am expanding NACTRC’s role into trial design and protocol development with one area of particular interest being the use of biomarkers, not only in the assessment of clinical outcomes but to forecast possible adverse events, as individual diagnostics, to generate an epigenetic snapshot of health and disease and their use in precision medicine and adaptive trial design. To date I am acting well beyond the role of clinical research coordinator and feel that the position I am looking for is that of a Medical Science Liaison. By combining my expertise in the medical sciences, clinical science/practice, education and outstanding interpersonal skills I feel I am the person you are looking for. I look forward to hearing from you, in the interim, I thank you for reviewing this letter and the accompanying material.

DR. CHRISTIAN R.J. CARTER

#3105, 7347 South Terwillegar Drive

Edmonton, Alberta T6R 0M3

780-***-****

acufr2@r.postjobfree.com

Sincerely yours,

Christian R.J. Carter, Ph.D

DR. CHRISTIAN R.J. CARTER

#3105, 7347 South Terwillegar Drive

Edmonton, Alberta T6R 0M3

780-***-****

acufr2@r.postjobfree.com

EDUCATION

University of Alberta Edmonton, AB, Canada

B.Sc. Nursing 2013-Aug 2015

With distinction

Intensive clinical integration

Preceptorship at the University of Alberta Emergency Department University of Alberta/Alberta Diabetes Institute Edmonton, AB, Canada Postdoctoral Fellowship Aug 2010 – Mar 2015

Focus on ion channels in Diabetes and Cardiovascular Disease

Worked on novel additions to The Edmonton Protocol

University lecturer

University of Alberta Edmonton, AB, Canada

Ph.D. in Pharmacology 2004 - 2010

Successfully defended thesis April, 13, 2010

Candidacy exam completed December 2006

Thesis proposal completed November 2006

Course work completed April 2005

Award winning university lecturer

University of Alberta Edmonton, AB, Canada

B.Sc. with Specialization in Pharmacology 1999 - 2004 NURSING EXPERIENCE

Clinical Research Coordinator December 2015- Present Northern Alberta Clinical Trials and Research Centre

Review of assigned protocols and other protocol documentation (ICF, IB, etc.) for accuracy, feasibility, timing, and resources

Active role in overall coordination of all required start-up activities ensuring compliance with all aspects of approved protocol

Preparation and presentation of Research Ethics Board applications

Project management involving ARO activity such as early phase clinical trial design, protocol development, selection of biomarkers for epigenetic profile and their application towards the development of precision medicine

Liaise between academic basic scientists, clinical principal investigators and al staff involved in trail design/development.

Clinic logistics planning, schedule of clinic activities and team training

Preparation, review, and/or finalization of clinic source documents, time and events tables, and other required study materials; review of Case Report Forms (CRFs), laboratory workbooks, staff requirements, and schedules.

In collaboration with the responsible teams, establishes and/or maintains safety assessment requirements, Quality Control (QC) and monitoring plans, pharmacy/dispensing requirements, study supplies/equipment, meal plans, and other elements as applicable to the study

Confirms all required regulatory and contractual documentation is present prior to study start. DR. CHRISTIAN R.J. CARTER

#3105, 7347 South Terwillegar Drive

Edmonton, Alberta T6R 0M3

780-***-****

acufr2@r.postjobfree.com

Recruitment of patients for research studies and preparation of educational materials to endorse patient recruitment into research studies.

Electronic data entry, electronic medical records and data capture/entry.

Phlebotomy, and general clinical practice required for research study.

Ability to maintain a high standard of operation, high level of accuracy and attention to detail.

Exceptional written and verbal communication skills.

Ability to understand protocol/IB at extremely in-depth level, execute and act on detailed instructions while understanding their scientific and clinical relevance.

High level of organization, time management, critical thinking and multi-tasking to manage various upcoming, active and closing clinical studies.

Decision-making, analytical and problem solving

Emergency Department June 2015- Jan 2016

University of Alberta Hospital

Final nursing preceptor placement

Hired at 1.0 FTE

Large tertiary trauma unit

Presented on” Remote Ischemic Conditioning” at national emergency nursing meeting

Provided assessment, planning, implementation and evaluation of care for emergency patients

Utilization of strong interpersonal and problem solving skills

Demonstrated ability to adapt quickly to changing/fluctuating priorities and workloads Undergraduate Nurse Employee 2015

Forensics unit 3-5

Alberta Hospital Edmonton

Performed nursing care and assessment in complex situations

Gained experience in the practice of mental health nursing

Delivered nursing care in a dynamic team environment

Received training in non-violent crisis intervention General Medicine

Royal Alexandra Hospital Unit 41 384 Hours

Nursing 308, Acute Care Nursing Practice I

Achieved grade of A+

General Surgery

Misericordia Hospital Unit 5 West 384 Hours

Nursing 408, Acute Care Nursing Practice II

Achieved grade of A+

Community Mental Health

108 St Building, Edmonton Community Mental Health Clinic 384 Hours

Mental Health Nursing Practice

Focus on adult with developmental delay

Education of family and support workers regarding physiology, reasoning behind pharmacotherapeutic program, and provision of optimal patient care

Achieved grade of A+

Community Health 384 Hours

West jasper Place Community Health Center

Achieved a grade of B+

DR. CHRISTIAN R.J. CARTER

#3105, 7347 South Terwillegar Drive

Edmonton, Alberta T6R 0M3

780-***-****

acufr2@r.postjobfree.com

RESEARCH EXPERIENCE

Post-doctoral Fellow Aug 2010 – Mar 2015

Department of Pharmacology/Alberta Diabetes Institute University of Alberta, Edmonton, Alberta

Principle Investigator: Dr. Peter Light

Designed and conducted complex scientific research specifically as it relates to the development of novel therapeutics for type 1 and 2 diabetes mellitus including: o Genetic engineering of porcine and human islets to establish novel local immunosuppression and prolonged survival of transplanted islets in the Edmonton Protocol

o Alteration of the sodium-calcium exchanger activity and its effects on insulin and GLP-1 release

o Novel mechanism of ion channel regulation in the inhibition of glucagon release o Evaluated the effects of novel small molecules on ion channels involved in atrial fibrillation

o Elucidated the effect of long chain acyl-CoAs on ion channels involved in inflammation and autoimmune disease

Collection, analysis and interpretation of data relating to research, clinical translation and precision medicine

Set research activity objectives in consultation with director Alberta diabetes institute and members of the Edmonton Protocol.

Troubleshooting of experimental protocols

Independent development of research documents, methods and protocols

Writing of research papers published in peer-reviewed journals and assisted with the preparation of research grant applications.

Presented research results at laboratory meetings, departmental seminars, scientific conferences, and related settings

Evaluated project proposals for clinical translatability, feasibility and impact

Managed lab personnel including technicians, graduate, undergraduate and summer students

Created and delivered lecture and exam material in undergraduate and graduate level Pharmacology courses

Undergraduate educator in medicine, molecular biology, biochemistry, physiology and neuroscience

Performed peer review of manuscripts for medical science journal publication PhD Candidate Sept 2004 - Apr 2010

Department of Pharmacology

University of Alberta, Edmonton, Alberta

Research supervisor: Drs. Susan Dunn and Peter Smith

Focus on neuropharmacology and Cys-loop receptors structure to function relationship which was adapted to diseased states, their pathology and treatments including: o Depression

o Anxiety

DR. CHRISTIAN R.J. CARTER

#3105, 7347 South Terwillegar Drive

Edmonton, Alberta T6R 0M3

780-***-****

acufr2@r.postjobfree.com

o Psychosis

o Cognitive function

o Epilepsy

o Huntington’s

o Parkinson’s

o Headache/Migraine

o Smoking cessation

o Addiction/Drugs of abuse

Multiple award winning lecturer in undergraduate Pharmacology

Undergraduate educator in medicine, molecular biology, biochemistry, physiology and neuroscience

Developed an in-depth understanding of electrophysiology, molecular biological techniques including mutagenesis, microarray analysis, complex experimental design, data analysis and assessment of project feasibility

Managed multiple concurrent projects, course load, teaching and an intense research program

Writing of research papers published in peer-reviewed journals

Acted as a peer reviewer for medical science publications Summer Studentship May 2004 - Sept 2004

Department of Pharmacology

University of Alberta, Edmonton, Alberta

Research supervisor: Dr. Peter Smith

Research focused on neuropathic pain, it’s pathophysiology at the ion channel/intracellular signalling level and potential for novel therapeutics

Utilization of bullfrog sympathetic ganglia and whole cell patch clamp for experimental system

Performed general laboratory duties

Assisted in writing/editing manuscripts for peer-reviewed publication Undergraduate Research Project (Pharmacology 498) Sept 2003 - May 2004 Department of Pharmacology

University of Alberta, Edmonton, Alberta,

Research supervisor: Drs. Amy and Fred Tse

Research focused on the effect of pituitary adenylate cyclase-activating polypeptide (PACAP) on epinephrine release from cultured rat adrenal chromaffin cells

Acquired skills in carbon fiber amperometry, whole cell patch clamp, animal handling and micosurgical techniques

Developed an in-depth understanding of G-protein/7TMD receptor signal transduction and intracellular signalling

Developed research proposal and summary of findings for publication TEACHING EXPERIENCE

Pharmacology 300, Oral Biology Pharmacology (2007 to 2014)

Two 110 minute lectures for class of approximately 100 Dental Hygiene undergraduate students.

Topics covered: Routes of Administration, Drug Distribution, Receptor Concept, Anti-Convulsant Drugs, Anti-Anxiety Drugs and Sedative/Hypnotic Drugs.

Helped write and administer examinations.

DR. CHRISTIAN R.J. CARTER

#3105, 7347 South Terwillegar Drive

Edmonton, Alberta T6R 0M3

780-***-****

acufr2@r.postjobfree.com

Student ratings

2014: Overall rating 4.7 out of 5, 41 students responded. 2013: Overall rating 4.8 out of 5, 46 students responded. 2012: Overall rating 4.7 out of 5, 34 students responded. 2011: Overall rating 4.7 out of 5, 45 students responded. 2010: Overall rating 4.8 out of 5, 45 students responded. 2009: Overall rating 4.7 out of 5, 41 students responded. 2008: Overall rating 4.7 out of 5, 39 students responded. 2007: Overall rating 4.2 out of 5, 40 students responded. Pharmacology 498, Pharmacology Research Program (2010 to 2014)

One on one mentorship of an undergraduate research student

Develop and educate student regarding project

Teach to use evidence-based scientific principals

Aid in research and development of research papers and presentations. Pharmacology 343, Scientific Basis of Pharmacology: Part I (2010-2011)

Three 50 minute lectures to approximately 55 undergraduate Science students discussing the pathophysiology of type 1 and 2 diabetes mellitus, the molecular/genetic disease components and current and future treatments.

Topics covered: Genetic polymorphisms, autoimmune disease, molecular pathophysiology, gene therapy and pharmacotherapeutics.

Student ratings

2011: Due to last minute addition to the syllabus I was not included in student evaluation sheets

2010: Overall rating 4.0 out of 5, 51 students responded. MED 526 Patient Centered Care Part II, Section II Human Sexuality (2010-2011)

Facilitate four 120 minute small group sessions.

Instructed students in taking a sexual history as well as provided insight into possible pharmacotherapies.

Student ratings

2011: Overall rating 4.3 out of 5, 7 students in group. 2010: Overall rating 4.2 out of 5, 6 students in group. Pharmacology 412, Central Nervous System Pharmacology (2006-20010)

Eleven 50 minute lectures for a class of approximately 50 pharmacology undergraduate students

Topics covered: Excitatory Amino Acids, Inhibitory Amino Acids, Noradrenaline, Dopamine, The Autonomic Nervous System, Anxiety, Depression, Mood, Memory, Dementia, Higher Cognitive Function and Psychosis. Helped write and administer examinations.

Student ratings

2009: Overall rating 4.4 out of 5, 34 students responded. 2008: Overall rating 4.1 out of 5, 39 students responded. 2007: Overall rating of 3.8 out of 5, 57 students responded. Pharmacology 344, Scientific Basis of Pharmacology (2008)

Two 50 minute lectures for class of approximately 100 Pharmacology undergraduate students.

Topics covered: Anti-Mycobacterials, Anti-Mycotics and Anti-Protozoal Agents.

Student ratings

2008: Overall rating 4.4 out of 5, 100 students responded. DR. CHRISTIAN R.J. CARTER

#3105, 7347 South Terwillegar Drive

Edmonton, Alberta T6R 0M3

780-***-****

acufr2@r.postjobfree.com

Pharmacology 508, Molecular Pharmacology (2007-2008)

Two 50 minute lectures for class of approximately 15 graduate students.

Topics covered: Ligand Gated Ion Channels: Nicotinic Receptor and Ligand Gated Ion Channels: GABAA Receptors. Helped write and administer examinations.

Student ratings

2008: Overall rating 4.4 out of 5, 5 students responded. 2007: Overall rating of 3.8 out of 5, 13 students responded. Pharmacology 337, Experimental Procedures in Pharmacology (2006-2008)

Teaching assistant for two weekly 6 hour laboratories for class of approximately 12 Pharmacology undergraduate students.

Assisted students with serial Dilutions, drug preparation, solution preparation, animal surgeries and explanation of theory

TEACHING AWARDS

2010 FGSR Graduate Student Teaching Award

Faculty of Medicine and Dentistry

Awarded for excellence in undergraduate teaching 2009 Honorary Class President

Voted favourite instructor by the 2009 graduating class of from the Pharmacology program. First time ever awarded to a graduate student.

PUBLICATIONS

Fatehi M, Carter CR, Youssef N, Hunter BE, Holt A, Light PE. Molecular determinants of ATP-sensitive potassium channel MgATPase activity: diabetes risk variants and diazoxide sensitivity (2015) Biosci Rep. Jul 7;35(4)

Yu Y, Carter CR, Youssef N, Dyck JR, Light PE. Intracellular Long-Chain Acyl CoAs Activate TRPV1 Channels (2014) PLoS One. May 5;9(5)

Samokhvalov V, Alsaleh N, El-Sikhry HE, Jamieson KL, Chen CB, Lopaschuk DG, Carter C, Light PE, Manne R, Falck JR, Seubert JM. Epoxyeicosatrienoic acids protect cardiac cells during starvation by modulating an autophagic response (2013) Cell Death Dis. Oct 24;4 Thomas J. Wang, Debby Ngo, Nikolaos Psychogios, Andre Dejam, Martin G. Larson, Ramachandran S. Vasan, Anahita Ghorbani, John O’Sullivan, Susan Cheng, Eugene P. Rhee, Sumita Sinha, Elizabeth McCabe, Caroline S. Fox, Christopher J. O’Donnell, Jennifer E. Ho, Jose C. Florez, Martin Magnusson, Kerry A. Pierce, Amanda L. Souza, Yi Yu, Christian Carter, Peter E. Light, Olle Melander, Clary B. Clish and Robert E. Gerszten. 2-Aminoadipic acid is a biomarker for diabetes risk (2013) J Clin Invest. Epub ahead of print doi: 10.1172/JCI64801

DR. CHRISTIAN R.J. CARTER

#3105, 7347 South Terwillegar Drive

Edmonton, Alberta T6R 0M3

780-***-****

acufr2@r.postjobfree.com

Soliman D, Wang L, Hamming KS, Yang W, Fatehi M, Carter C, Clanachan AS and Light PE. Late INa inhibition alone with ranolazine is sufficient to reduce ischemia- and cardiac glycoside-induced calcium overload and contractile dysfunction mediated by reverse-mode sodium/calcium exchange (2012) J Pharmacol Exp Ther. Nov;343(2):325-32

Fatehi M, Raja, M. Carter C. Soliman D. Holt A and Light PE. The ATP-sensitive potassium channel ABCC8 S1369A type 2 diabetes risk varient increases MgATPase activity. (2012) Diabetes. 61(1): 241-9 Chris R.J. Carter, Janna Kozuska And Susna M.J. Dunn. Insights into the Structure and Pharmacology of GABAA Receptors. (2011) Future Medicinal Chemistry. Vol. 3(2). 177-182 Chris R.J. Carter, Cao L., Kawai H., Smith P.A. Dryden W.F. Raftery M.A. And Dunn S.M.J. Chain Length Dependence of the Interactions of Bisquaternary Ligands with the Torpedo Nicotinic Acetylcholine Receptor. (2007) Biochem. Pharmacol. 1:73(3). 417-426 C.R. Carter, P.A. Smith, W.F. Dryden and S.M.J Dunn. Interaction of bis-quaternary compounds with the Torpedo nicotinic acetylcholine receptor. Soc Neurosci Abstract 523.1(2006) M.A. Kula, C.R.J. Carter, P.A. Smith, S.M.J. Dunn and W.F. Dryden. Novel nicotinic ligands reveal new activated state of the nicotinic acetylcholine receptor. Soc Neurosci Abstract 951.2(2005) C.R. Carter, P.A. Smith, S.M.J. Dunn and W.F. Dryden. Interaction of nicotine and bis-quaternary agonists with ganglionic nicotinic acetylcholine receptors. Soc Neurosci Abstract 951.8(2005) MANUSCRIPTS IN PREPARATION

C.R.J. Carter, I.L. Martin, P.A Smith, W.F. Dryden and S.M.J. Dunn. α1Arg94/α4Arg100 and its Role in Agonist Binding and Efficacy at synaptic and extrasynaptic GABA(A) Receptors. C.R.J. Carter, Kevin SC Hamming, Daniel Soliman, Jelena Kolic, Shaheen Rahman, Xiao-Qing Dai, Patrick E MacDonald and Peter E Light. The b-cell sodium-calcium exchanger as a putative target for the antidiabetic effects of Ranolazine.

Fatehi M, Carter C. Soliman D. Holt A and Light PE. The role of the Mg-ATPase properties of the ATP- sensitive potassium channel on channel function and ischemic preconditioning. PRESENTATIONS

National Emergency Nurses Association (NENA) Alberta 2015

RIP with RIC: Remote Ischemic Conditioning

COMMUNITY ACTIVITIES

Member of the Alberta Graduate Council 2008 - 2010 DR. CHRISTIAN R.J. CARTER

#3105, 7347 South Terwillegar Drive

Edmonton, Alberta T6R 0M3

780-***-****

acufr2@r.postjobfree.com

Member of the General Faculty Council 2008 - 2010

University of Alberta

Graduate Students Association 2008 - 2010

University of Alberta

Active member of scholarship review committees

Post-doctoral Representative 2010 - 2015

Department of Pharmacology

Member of the Board of Directors 2010 - Present

Pulse Generator University of Alberta Hospital Fitness Facility Expert Reviewer of Peer Reviewed Scientific Manuscripts 2008 – Present Ambassador of postsecondary education in rural Alberta 2012– 2015

Meet with community leaders and educators

Student Representative 2013 – 2015

BsCN After Degree Class of 2015

Founder of the Susan Dunn Memorial Golf Tournament 2010 – Present CERTIFICATION/LICENSURE

Animal Ethics Training Course 2005

Certified by HSLAS, University of Alberta

Radiation Safety Course 2008

Certified by Radiation Control Committee, University of Alberta Care and Use of the Rat in Research (UAPWC) Animal User Training Course 2010 Certified by Health Sciences Laboratory Animal Services Care and Use of the Mouse in Research (UAPWC) Animal User Training Course 2010 Certified by Health Sciences Laboratory Animal Services Heart and Stroke CPR 2015

Intravenous Certification 2015

Certified by University of Alberta Faculty of Nursing GCP Certification 2015

Collaborative Institutional Training Initiative

DR. CHRISTIAN R.J. CARTER

#3105, 7347 South Terwillegar Drive

Edmonton, Alberta T6R 0M3

780-***-****

acufr2@r.postjobfree.com

MEETINGS ATTENDED

Society for Neuroscience 34th, 35th and 37th Annual Meetings 2004, 2005 and 2007 Western Pharmacological Society Meeting, 2007

National Emergency Nurses Association (NENA) Alberta 2015 REFERENCES

Available upon request

Contact this candidate