Management Development

Deputy Manager (R&D, QA),

Indian Immunologicals limited,

Gachibowli, Hyderabad. 500032.

India.

092******** (Mobile)

acu3n5@r.postjobfree.com (E-Mail)

Complete Home Address

DD1-306, Aarambh township,

Rajeev Swagruha,

Papi reddy colony, Chandanagar,

Hyderabad. 50019.

PROFESSIONAL QUALIFICATIONS

Ph.D. (Biotechnology ) : 2005- 2010

Jawaharlal Technological University, Hyderabad

Development of a recombinant tick vaccine”

M.Sc (Biochemistry) : 1999-2001

University of Madras

B.Sc (Biochemistry) : 1995-1998

University of Madras.

WORK EXPERIENCE: 12 years in Indian immunologicals ltd. (R&D, QA)

Deputy Manager : Currently with Indian Immunologicals limited

Senior research fellow : Feb 2002 Sep 2004 (Indian Institute of Science)

RESEARCH SKILLS:

1.Over 12 years of experience in the field of Yeast Molecular biology (Pichia pastoris and saccharomyces cerevisiae), cloning, expression and purification of different recombinant heterlogous proteins from Yeast Pichia pastoris, Saccharomyces and E.coli

2.Protein purification, characterization and downstream processing.

3.Extremely talented in conventional protein purification through different chromatographic methods.

4.Experienced in recombinant protein purification from E.coli and Yeast.

5.Extensive hands-on experience in performing various molecular biology techniques such as DNA and RNA isolation, molecular cloning, reverse transcription and polymerase chain reaction (RT-PCR), Real time RT-PCR, genome sequencing and sequence analysis

6.Proficient in immunological and techniques such as enzyme linked immunosorbent assay, western blotting and confocal microscopy.

7.Experienced in preparation of primary cell cultures and propagation of cell lines both monolayer and suspension cultures

MANAGEMENT SKILLS:

1.Strong organizational skills.

2.Proven ability to handle multiple projects simultaneously.

3.Solid ability of Conceptual thinking, and proficiency in group management.

4.Strong knowledge and practice of project management.

5.Prepare and present results in reports update Management or Project Team members.

6.Maintain awareness of relevant areas of research and competitive activity through reading the literature and occasional attendance of appropriate scientific meetings.

7.Interaction between other departments like purchase and stores related to our lab activities.

EXPERIENCE IN RESEARCH & DEVELOPMENT.

DEVELOPMENT OF ANIMAL BIOLOGICALS (PROJECTS HANDELED):

1.Development of Recombinant Tick vaccine in Yeast. (Ph.D. Project).

2.Development of recombinant vaccine in Yeast and diagnostic tools for bovine Tuberculosis in cattle.

3.Construction of chimeric full length cDNA of a specific virus. (Novel vaccine stratergy).

4.Development of Yeast expressed recombinant vaccine against porcine cysticercosis in porcine and human.

5.Development of VLP (Viral coat protein) based canine vaccines and designing of diagnostic kit.

6.Development of recombinant viral vectors.

7.Analysis of Cis and Trans acting elements of AOX promoter in pichia pastoris.

DEVELOPMENT OF HUMAN BIOLOGICALS (BIOSIMILARS):

1.Development of neutralizing antibody fragments against Japanese Encephalitis virus and Tetanus toxin through phage display technology.

2.Development of identification of neutralizing antibody fragments against CVS strain of Rabies virus through phage display technology.

PRODUCTS CONTRIBUTED:

1.Development of Recombinant vaccine against porcine cysticercosis.

The world s first vaccine for porcine cysticercosis has been developed (Indigenously) and registered under the brand name of CYSVAX. It s a recombinant vaccine developed using Pichia pastoris as an expression platform. The vaccine will be commercialized soon across the world.

WORK EXPERIENCE AS QA R&D Quality Assurance (Technology transfer)

QA professional in technology transfer at R&D centre, Indian Immunologicals limited.

QA EXPERIENCE in R&D:

1.Involved in the technology transfer of the self developed recombinant cysticercosis vaccine from R&D to production.

2.Involved in the technology transfer of single chain variable fragment based assay for Hepatitis A antigen quantifiation in ELISA.

3.Extremely knowledged in preparing the technology transfer documents.

4.Well knowledged in developing the Product developement report (PDR) documents in related to bio pharma molecules.

5.Involved in preparation of several termination documents of projects handled in the R&D centre.

6.Knowledged in developing a report including preparation, review, evaluate and decision making in the product development and assay development.

QA EXPERIENCE (RISK ASSESSMENT, IN PROCESS AND DOCUMENTATION):

RISK ASSESSMENT:

1.Extremely knowledged and experieneced in performing risk assessment activities in various process, system and facility.

2.Knowledged in using the risk assessemnt tools like SWIFT (structured what if techniques), FMEA.

3.Established a system for conducting risk assessment using SWIFT as a tool in the current organization.

4.Trained many employees from various departments for conducting risk assessment in their respective work areas.

CHANGE CONTROL AND DEVIATION:

1.Well experienced in handling the change control issues from the production.

2.Knowledged in raising change over, reviewing, evaluating the impact of change over and closing.

3.Experienced in addressing the issues of deviation from production and QC departments.

4.Extremely experienced in the developing the plan for corrective actions and preventive actions.

RISK MANAGEMENT CO-ORDINATOR (QUALITY MANAGEMENT SYSTEM):

1.Establishing the bio risk management system called GAPIII (Global action plan III) in current organization.

2.This is the first bio risk management system is being established in India in bio pharma industrai lsector.

3.Global Action Plan III is the WHO upgraded system for bio risk management in bio pharma sector.

4.ONE OF THE WHO CERTIFIED INDIVIDUAL IN UNDERSTANDING AND ESTABLISHING GAP III IN INDIA.

5.Bio risk managment system is a part of quality mangement programme in the QA department in current organization.

6.Framed a risk management committe through cross functional team members including production, QC, QA, engineering departments to establish the bio risk management system.

7.The implementation of the system through committee members across the plant is in progress.

8.The ultimate aim is to implement the system till the lowest level employee of the organization.

OVERALL STRENGTHS:

1.Extremely experienced in writing SOPs for various activities across different departments.

2.Interacting with all senior management for framing policies.

3.Co-ordinating with members from every department to establish a system across the organization.

4.Knowledged in reviewing the SOPs during change over and document the changed SOPs.

5.Well expereicned in framing chek lists for internal auditing and conduct auditing betweeen different departments.

6.Good knowledged in framing the system for auditing.

7.Experienced in facing internal and external auditing.

8.Having good knowledge about HVAC (Heat ventillation and air conditioning ) systems and air handling systems in production areas with the co-ordination of engineering department during risk assessment activities.

9.Interacting with cross functional department members.

10.Well experienced in writing policies, procedures plans in related to management system.

11.Having good communication skills.

INTERNATIONAL PUBLICATIONS:

1.Use of ESAT6-CFP10 fusion protein in the bovine interferom gamma ELISPOT assay for diagnosis of Mycobacterium bovis infection in cattle.

Parthasarathy Sugumar, Veerasami M, Appana G, Chandran D, Das D, Srinivasan VA. Journal of Microbiological Methods. June 9, 2012.

2.Recombinant mid gut antigen (Bm95) as a vaccine against Indian Rhiphicephalus haemaphysaloides in Bos indicus cattle

Parthasarathy Sugumar, Dev Chandran, Gudavalli Sudha Rani, Pallichera Vijayan Shahana,Dasarath Keshavrao Maske, Pundi Narasimhan Rangarajan, Lakshmi Narasu Mangamoori,Villuppanoor Alwar Srinivasan, Research in Veterinary Science. 2011. 90 262-268.

3.Assessment of immunoprophylactic efficacy of recombinant midgut antigen (Bm95) of Rhiphicephalus microplus in Bos indicus.

Parthasarathy Sugumar, Jadhav Vishwanath Tukaram, Mukhulesh Gatne, DevChandran, Lakshmi Narasu Mangamoori, Pundi Narasimhan Rangarajan and Villuppanoor Alwar Srinivasan. Current Trends in Biotechnology and Pharmacy 2010. 4(4) 855-861.

4.Assessment of critical parameters in blood processing for bovine interferon-gamma ELISpot assay on detection of Mycobacterium bovis infected cattle.

Maroudam Veerasami, Loganathan Moorthy, Dipankar Das, Sugumar Parthasarathy, Dev Chandran, Rajendra Lingala and Villuppanoor Alwar Srinivasan. Veterinaria Italiana 2011. 47(1) 25-34.

5.MVA recombinants expressing the fusion and hemagglutinin genes of PPRV protects goats against virulent challenge.

Dev Chandran Kolli Bhaktavatsala Reddy Shahana Pallichera Vijayan, Parthasarthy Sugumar Gudavalli Sudha Rani, Ponsekaran Santha Kumar, Lingala Rajendra, Villuppanoor Alwar Srinivasan. Indian Journal of Microbiology. 2010, 50 : 266-274.

6.Development of a Recombinant Epsilon Toxoid Vaccine against Enterotoxemia and Its Use as a Combination Vaccine with Live Attenuated Sheep Pox Virus against Enterotoxemia and Sheep Pox

Dev Chandran, Sureddi Satyam Naidu, Parthasarathy Sugumar, Gudavalli Sudha Rani, Shahana Pallichera Vijayan, Deepika Mathur, Lalit C. Garg, and Villuppanoor Alwar Srinivasan. CLINICAL AND VACCINE IMMUNOLOGY, 2010, 17, 1013 1016

7.Immune responses against recombinant tick antigen, Bm95, for the control of Rhipicephalus (Boophilus) microplus ticks in cattle.

Kumar A, Garg R, Yadav CL, Vatsya S, Kumar RR, Sugumar P, Chandran D, Mangamoori LN, Bedarkar SN. Veterinary Parasitology. 2009. 28;165(1-2):119-24.

8.Display of neutralizing epitopes of Canine parvovirus and a

T-cell epitope of the fusion protein of Canine distemper virus on chimeric tymovirus-like particles and its use as a vaccine candidate both against Canine parvo and Canine distemper.

Chandran D, Shahana PV, Rani GS, Sugumar P, Shankar CR, Srinivasan VA. Vaccine. 2009. Dec 10; 28(1):132-9.

9.Identification of Japanese encephalitis virusinducible genes in mouse brain and characterization of GARG39/IFIT2 as a microtubule-associated protein.

Sougata Saha, Parthsarathy Sugumar, Prakash Bhandari and Pundi N. Rangarajan. Journal of General Virology(2006) 87, 3285-3289.

10. Multi antigen print immuno assay for seroepidemiological surveillance of bovine tuberculosis on Indian cattle farms.

V.Maroudam, D. Sunil, P.Sugumar, S.Sathyam naidu, Vijay B, E.K.Mahesh kumar, F.Mukherjee, S.K.Rana, Dev Chandran, Dipankar das, VA Srinivasan. Veterinaria Italiana, Sep 2012, 48 (3), 253-268. Impact factor: 0.66

11.Detection of IFN-γ responses in cattle using Recombinant TB antigens, ESAT-6 and CFP-10.

Jaya Bhavani, Dev Chandran, Maroudam Veerasami, Parthasarathy sugumar, Pallichera Shahana, Dipankar Das, Mangamoori lakshmi Narasu & Villuppanoor Alwar Srinivasan. Biotechnology, Bioinformatics and Bioengineering 2011, 1 (2):255-264.

12.Recombinant human antibody fragment against Tetanus Toxoid produced by Phage display.

.B.Neelakantam, N.V.Sridevi,, A.Shukra, P.Sugumar, S.Samuel, R.Lingala, Eur J Microbiol Immunol (Bp). 2014 Mar;4(1):45-55.

13. Epitope mapping of Tetanus Toxoid through Fab fragment using Phage display library

B.Neelakantam, N.V.Sridevi,, A.Shukra, P.Sugumar, S.Samuel, R.Lingala, (Manuscript submitted).

PATENT AUTHORSHIPS:

1Vaccine composition for novel FMDV vaccine.

Dev Chandran, Parthasarathy Sugumar, Singanallur Balasubramanian Nagendrakumar and Villuppanoor Alwar Srinivasan. (IPA 216/CHE/2010; Application date 10.02.2010; Filing date 10.02.2010).

2Anti Tetanus Toxoid antibody and uses thereof.

N.V.Sridevi, B.Neelakantam, A.Shukra, P.Sugumar, S.Samuel, R.Lingala, K.Anandkumar (2843/CHE/2013 Published in 2015)

3 Anti Japanes Encephalitis Virus antibody and uses thereof.

N.V.Sridevi, S.Samuel,, A.Shukra, B.Neelakantam, P.Sugumar,, R.Lingala, K.Anandkumar (2842/CHE/2013- Published in 2015)

4. Monovalent antibody fragment against rabies CVS and uses thereof

N.V.Sridevi,, A.Shukra, S.Samuel P.Sugumar, B.Neelakantam, R.Lingala, K.Anandkumar (4265/CHE/2013- Published in 2015)

AWARDS AND HONOURS

1Received best poster presentation award in XXIV Annual Convention of Indian Association of Veterinary Microbiologists and Immunologists. An international conference on protecting animal health, held at Raipur, Chattisgarh, India on January 27-29, 2010.

CONFERENCES AND SEMINARS:

1Participated in oral presentation at XXIV Annual Convention of Indian Association of Veterinary Microbiologists and Immunologists. An international conference on protecting animal health, held at Raipur, Chattisgarh, India on January 27-29, 2010.

2Participated in the Indo American international conference on Avian Influenzae held at University of Hyderabad on September 2008,

LIST OF REFERENCES:

Dr. Sridevi,

Head, Analytical R&D,

Indian immunological limited,

Hyderabad

Ph 096********

Email : acu3n5@r.postjobfree.com

Dr. S. Rajagopal,

Associate professor,

School of life sciences,

Department of plant sciences,

Hyderabad Central university.

Hyderabad.

Ph. 986-***-****.

E-mail. acu3n5@r.postjobfree.com

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