Nora C. Goscinski

661-***-**** actx6u@r.postjobfree.com 1622 High School Drive, Brentwood, MO

Laboratory Skills and Instrumentation (Operation and Interpretation)

Chromatography:

o HPLC (4 years FTE)

o GC

o Ion Exchange

o Affinity

o TLC, RadioTLC

Wet Chemistry

Colorimetric assays (Since

June 2012)

Familiar with cGMP/cGLP

(Since Jan 2014)

o Lindmo assays

o Batch release

Radiolabeling:

o Cu-64, Cu-67

o Zr-89, Y-86

Trace metals analysis

(including sample

preparation)

HG-AAS

ICP-MS

UV-Visible

Spectrophotometry

Fluorometry

Gamma Spectroscopy

FT-Infrared Spectroscopy

Refractometry

Aseptic technique

Microbial Culture

Bacterial Transformation

PCR

Protein purification,

conjugation, manipulation

Western Blotting

Restriction Digests

Gel Electrophoresis: SDS-

PAGE, agarose

Isotachophoresis

Gene Annotation

Bomb Calorimetry

Mass Spectrometry

Software:

o Chromleon

o ChemStation

o Prism

o Excel

o MS Office Suite

Research Experience

Washington University in St. Louis St. Louis, MO

Department of Chemistry

May 2013 Dec 2015 PI: Suzanne Lapi Graduate Student o Examined the uptake of 89Zr-siderophore complexes by bacteria; evaluated complexes as potential radiotracers. o Evaluated a quality control assay for determining cyclotron produced 64Cu specific activity for robustness and reliability; identified sources of interfering contaminants and determined extent of interferences. o Mentored undergraduate students in radiochemical and analytical chemical research. Brookhaven National Laboratory, Upton, NY

Radioisotope Research and Production Group, Collider-Accelerator Dept

Jun-Aug 2012 PI: Suzanne Smith SULI Intern

o Evaluated the suitability of a range of bifunctional ligands for use in Yttrium-86/88 radiolabeling of protein-ligand conjugates under bio-compatible conditions: performed synthesis, radiolabeling and in vitro stability studies o Evaluated complexation kinetics of Y3+ with various ligands under bio-compatible conditions. Lawrence Livermore National Laboratory, Livermore CA Center for Meso, Micro and Nano-Technology

Sept-Dec 2011 PI: Maxim Shusteff SULI Intern

o Characterized performance of microfluidic chip utilizing isotachophoresis for rapid, high-throughput isolation of DNA from complex aqueous samples

California Polytechnic State University, San Luis Obispo, CA Department of Chemistry and Biochemistry

June 2009 June 2011, PI: Corinne Lehr Laboratory Research Assistant Jan Mar, Sept Dec 2012

o Optimized analytical methods for separation and detection of Arsenic in biological samples via HPLC and HG-AAS. o Developed a novel kinetic method for Sb(III) detection in aqueous samples via UV-visible spectroscopy. o Assayed purity of cyanuric acid samples via HPLC for industrial client.

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Education

Washington University in St. Louis St. Louis, MO

A.M. in Chemistry: December 2015

Thesis: “Investigation of 89Zr-Siderophores as Molecular Imaging Agents for Positron Emission Tomography Imaging of Bacterial Infections”, Chair: Dr. Suzanne Lapi. California Polytechnic State University (Cal Poly) San Luis Obispo, CA Bachelor of Science: December 2012

Thesis: “Design and Experimental Validation of Continuous DNA Separation Using ITP-Based Microfluidic Device”.

Major: Biochemistry GPA: 3.63

Conversational French Dean’s List: 8 out of 13 quarters Publications and Presentations s

“ 89Zr-Siderophores as molecular imaging agents for infection identification”. Goscinski, NC, Wencewicz, TA, Lapi, SA. Poster presentation: Mallinckrodt Institute of Radiology Research Symposium, 24 March 2015.

“Drosophila Muller F Elements Maintain a Distinct Set of Genomic Properties Over 40 Million Years of Evolution”. Leung, W., et al. Genes Genetics Genomes (in press)

“Differential uptake of 89Zr-DFO by Staphylococcus aureus and Pseudomonas aeruginosa”. Goscinski, NC, Wencewicz, TA., Lapi, SE. Oral Presentation: Invited Radiochemistry Symposium, ACS Midwestern Regional Meeting, 13 November 2014.

Kinetic analysis of Sb(III): An experiment for the quantitative analysis laboratory. Lehr, RC, Goscinski, NC, Lewis, KC, et al. J. Chem. Ed, 90(11):1501-1503

“Radiochemistry of yttrium-86 (Y-86) produced at the Brookhaven Linac Isotope Producer (BLIP)”. Goscinski, NC, Stubleski, J, Medvedev, D, et al. Abstracts of papers of the American Chemical Society, 245 (April 2013). Abstract.

“Comparing protein radiolabelling of the new NCS-SARAR with NCS-NOTA and NCS-DOTA using copper-67 produced at the Brookhaven Linac Isotope Producer (BLIP)”. Stubleski, J, Goscinski, NC, Mume, E, et al. Abstracts of papers of the American Chemical Society, 245 (April 2013). Abstract.

“Radiochemistry of Yttrium-86: designing Yttrium-86 positron emission tomography agents for personalized medicine.” Goscinski, NC, Smith, SV. Oral Presentation and Poster: Summer Symposium, Brookhaven National Laboratory, 9 August 2012.

“Development of a digestion method for the determination of arsenic in alkali flies by hydride generation-atomic absorption spectrophotometry”. Fylstra, N, Goscinski, N, Bindi, V, et al. Poster Presentation: ACS National Meeting, 22 March 2010. Grants and Fellowships

Imaging Sciences Pathway Fellowship NIH T32EB014855-03 Sept. 2014 Aug 2016

ISRS 2015 DOE Travel Bursary Award Jan 2015

Management and Teaching Experience

Hazelwood West High School

Instructor, Chemistry

July 2015 Present

Taught five sections of 10th grade chemistry as the instructor of record in a high-need, urban school district.

Juggled multiple projects while managing expectations of students, parents and administration.

Managed classrooms of 15 to 30 students.

Collaborated with other chemistry instructors as well as teachers across departments to ensure high-quality, data-driven, consistent presentation of scientific concepts across disciplines

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Washington University in St. Louis

Department of Chemistry:

Graduate Teaching Assistant

August 2013 May 2014, January May 2015 General Chemistry I/II

Led recitation sections of general introductory chemistry course; reviewed key concepts and presented novel problems to students; assisted students in independently discovering problem solving strategies.

Graded quizzes and exams. Types of questions included computational, short answer, and multiple choice. August December 2015 Nuclear and Radiochemistry Lab

Led advanced laboratory course in radiochemistry, focusing on safe handling of radioactive material, key radiochemical techniques, and the principles behind and hands-on use of nuclear chemistry instrumentation; assisted students in independently discovering problem solving strategies

Graded lab reports, focusing on evidence of comprehension, quality of data interpretation and coherence of explanation.

California Polytechnic State University

Department of Chemistry and Biochemistry:

March-May 2012 Grader

o Graded lab reports and quizzes for general chemistry course. Types of questions included multiple choice, short answer, computational, graphs.

Student Support Services:

Jan-Jun 2010 Tutor

o Assisted students in general chemistry courses with reviewing concepts from lecture and lab, problem solving strategies, and test preparation.

Other Work Experience

Imerys, Lompoc, CA

Research and Development:

January May 2013 Laboratory Technician (temporary)

Examined the effect of various polymer coatings on the surface properties of a wide range of minerals, mainly diatomaceous earth and various micas.

Properties examined included particle size distribution, water and oil absorption, viscosity in oil, and color. California Polytechnic State University

Department of Chemistry and Biochemistry:

September 2010 June 2011, Jan Jun 2012, Chemistry Stockroom Assistant Sept Dec 2012

o Aided stockroom manager in running chemical stockroom for a large number of labs o Performed Chemical Inventory, Sanitation; provided Lab Support; Reagent and Unknown Preparation, Customer Service.

o Worked closing shift March-June 2011

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