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Medical Engineering

Atlanta, GA
February 28, 2016

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***** ******* **. ************, ** 32246



o Motivated and accomplished Ph.D. with 5 years of experience in biomedical engineering o Expertise in orthobiologics and biomechanics with a focus in translational and preclinical research o Experience with Class II and III medical devices in manufacturing, validation, research, and development o Knowledge of ISO 13485 standards using good manufacturing practices o Experience in pre-clinical consulting and strategic planning for biotechnology companies o Proficient in in vitro and in vivo models, mechanical testing, and image analysis o Practical knowledge in technical product sales, consulting, and collaborations across various departments o Strong communication skills, along with demonstrated ability to design, execute, and analyze experiments EDUCATION

o Rutgers Biomedical and Health Sciences and New Jersey Institute of Technology, Newark, NJ Ph.D. in Biomedical Engineering; Advisor: Dr. J. Patrick O’Connor GPA: 3.9/4.0 Defended: Dec 2015 o University of Florida, Gainesville, FL

B.S. in Biological Engineering; Biomechanics Minor Graduated: Dec 2009 INDUSTRIAL EXPERIENCE


Developed and maintained validations for orthopaedic implants and surgical instruments July 2015 – present

o Lead of validation operations for new cleaning and passivation machine in manufacturing plant o Drafted and executed IQ/OQ/PQ protocols for total joint implants and reverse osmosis/de-ionized water system o Refined knowledge in ISO 13485:2003, current Good Manufacturing Practices, and Design of Experiments o Collaborated with Quality, Design, and Manufacturing Engineers for completion of multiple projects with competing deadlines

CONSULTANT, INVESTIGATOR, ANIMAL SURGEON, AUTHOR – CREOSSO, LLC. Dec 2013 – Dec 2015 Investigated therapeutic compounds to enhance spinal fusions; created novel mechanics analysis procedure o Conducted rabbit spinal fusion and rat femur fracture surgeries in pre-clinical trials for novel therapeutics o Worked with orthopedic surgeons to provide expertise and strategic guidance of research plan and results o Assessed healing by microCT and torque-to-failure mechanical testing analysis o Developed novel methods to correlate microCT analysis to mechanical properties of bone using MatLab o Authored peer-reviewed journal paper investigating the effects of biological therapeutics for spinal fusions CONSULTANT, INVESTIGATOR, ANIMAL SURGEON, AUTHOR – TISSUEGENE, INC. Dec 2011 – May 2013 Examined the effect of a proprietary cell line on bone regeneration using a segmental defect model o Drafted official statement of work outlining experimental plan and negotiated budget o Developed surgical procedure for cell/vehicle implantation o Produced new histological staining method for detecting cartilage o Prepared technical report summarizing findings including detailed results, and explanations for conclusions MEDICAL INNOVATION INTERN – TOKYO WOMEN’S MEDICAL UNIVERSITY May 2008 – Jul 2008 Isolated hematopoietic stem cells for use in autologous reimplantation studies o Identified hematopoietic stem cell niches in mice using fluorescent cell markers, magnetic activated cell sorting

(MACS), flow cytometry, and fluorescent activated cell sorting (FACS) o Prepared technical presentations on FACS, stem cell markers, and N-Cadherin SALES REPRESENTATIVE, PRODUCT CONSULTANT – EPSON AMERICA, INC. June 2007 – Dec 2010 Demonstrated Epson products, presented solutions to equipment problems, and trained retail store employees o Competitively sold Epson electronics to become top-selling representative in the district o Performed market research on competitor pricing, product lines, merchandising techniques, and sales strategies o Traveled to all retail stores in the district to maintain merchandising endcaps, confirm accurate pricing, train current employees, and build professional relationships with managers SANGEETA ABRAHAM, PH.D.

12779 Caribou Ct. Jacksonville, FL 32246




Aug 2011 – Dec 2015

Expert in pre-clinical research investigating orthobiologic adjuncts, biomaterials, and pharmaceuticals o Developed new, safer methods for bone morphogenetic protein-2 delivery to regenerate bone leading to two peer-reviewed publications

o Investigated the effects of cyclooxygenase inhibitors upon bone healing and authored a journal review article o Studied the use of non-steroidal anti-inflammatory drugs on the composition and degradation of bone o Refined skills in analytical biology, small and large animal surgical techniques, and image analysis o Evaluated drug-infused scaffolds and polyaspirin sealant as a guided bone regeneration device in rabbits o Conducted dose response study of BMP-2 in segmental defects in rats o Devised novel method of using electrospun polyaspirin to enhance functionality of BMP-2 o Investigated the effects of novel method in limiting ectopic bone formation PH.D. STUDENT – NEW JERSEY INSTITUTE OF TECHNOLOGY Oct 2011 – Dec 2015 Researched the effects of varying bone biology on mechanical integrity of bones o Researched the benefits of insulin and insulin-mimetics on bone regeneration resulting in a U.S. patent o Studied the effects of diabetes mellitus on bone biology o Developed skills in mechanical testing of animal and cadaveric camples o Created a predictive model for assessing the mechanical integrity of injured bone o Analyzed microCT images using MatLab for a better understanding of fracture and bone defect healing o Performed ex vivo study to determine activity and efficacy of biomaterials o Conducted pilot in vivo study to determine ideal femur scaffold composition o Studied novel electrospun scaffolds in adjunct with autologous bone marrow in enhancing bone regeneration o Authored a peer-reviewed journal article investigating the effects of autologous bone marrow on defect healing UNDERGRADUATE RESEARCH – ORTHOPEDIC BIOMECHANICS LABORATORY, UF Oct 2009 – April 2010 Utilized JointTrack (University of Florida-developed analysis software) to model 3-D behavior of joint implants o Used JointTrack to match three-dimensional autoCAD models of prosthetic implants to two-dimensional x-rays o Analyzed implant behavior in patients using JointTrack-rendered images o Organized a technical manual for JointTrack software MENTORING EXPERIENCE


o Trained high school, undergraduate, master’s, and medical students in surgical techniques, experimental analysis, laboratory safety, technical writing, and presentation skills o Demonstrated ability to assess students’ strengths and delegate tasks accordingly SKILLS/TRAINING

In Vivo Models Pharmacokinetics Medical Device Engineering Class II/III Medical Devices Ex Vivo/In Vitro Models IACUC/IRB Materials Testing Fluid Mechanics Mechanics of Materials Mechanical Testing Diffusion Assays Pre-Clinical Testing AutoCAD ProE Design 3-D Modeling FEA Analysis

o Software: AutoCAD, CTAn, EndNote, ImageJ, Matlab, Minitab, Microsoft Office Suite, ProE, SigmaPlot, Simulink, Vizio

o Language: Fluent in Tamil


12779 Caribou Ct. Jacksonville, FL 32246



o Abraham, S., Schussler, S., Bakhtina, A., Lin, SS., Arinzeh, TL. A NanoComposite Scaffold for Bone Tissue Engineering. Biomaterials. (2016). Submitted.

o Abraham, S., Vives, MJ., Cottrell, JA., Mitchell, AM., Lin, HL., Iqbal, E., Jingar, N., Kim, BD., Shah, N., Munoz, W., Chaudhary, SB., Lin, SS., Benevenia, J., O’Connor, JP. Local Insulin Application has a Dose- Dependent Effect on Lumbar Fusion in a Rabbit Model. The Spine Journal. (2016). Submitted. o Koerner, J., Vives, M., O’Connor, J.P., Chirichella, P., Breitbart, E., Chaudhary, S., Uko, L., Subramanian, S., Benevenia, J., Lin, S. Zinc has Insulin-Mimetic Properties which Enhance Spinal Fusion in a Rat Model. The Spine Journal. February 2nd, 2016.

o Mitchell, A.M., Kim, B.D., Engler, S.S., Subramanian, S., Uhrich, K.E., O’Connor, J.P. Use of Salicylic Acid Polymers and BMP-2 to Promote Bone Regeneration in Rabbit Parietal Bone Defects. Journal of Bioactive and Compatible Polymers. September 21st, 2015.

o Subramanian, S., Mitchell, A.M., Yu, W., Engler, S.S., Uhrich, K.E., O’Connor, J.P. Salicylic Acid-based Polymers for Guided Bone Regeneration using BMP-2.Tissue Engineering Part A. July 8th, 2015. o O’Connor, J. P., Manigrasso, M. B., Kim, B. D., & Subramanian, S. Fracture healing and lipid mediators. BoneKEy Reports. 3. April 2nd, 2014.

o Subramanian, S., Mitchell, A.M., Engler, S.S., Uhrich, K.E, O’Connor, J.P. The Use of BMP-2 and Novel Polymers for Guided Bone Regeneration. Poster session presented at: 60th Annual Orthopaedic Research Society Meeting. March 15th-18th, 2014. New Orleans, LA. & 2nd Annual Musculoskeletal Repair and Regeneration Symposium October 10th, 2013. Bronx, NY.

o Lin, S.S., Paglia, D.N., O’Connor, J.P., Benevenia, J., Wey, A., Subramanian, S., Chirachella, P., Vives, M.J. Insulin-Mimetics as Therapeutic Adjuncts for Bone Regeneration. Patent WO 201-***-**** A1. June 6th, 2013.

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