Engineering Research

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Objective: Seeking for Scientist Position

Shanta Raj Bhattarai

Home Address: **** ********* **, *** # **-1F, Houston, TX 77054 Tel: (Cell) 510-***-****

Office Address: Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Anderson Central (B3.4579f), 1515 Holcombe Blvd, Unit 0066, Houston, TX 77030

Tel: (Office) 713-***-****

E-mails: actp76@r.postjobfree.com and actp76@r.postjobfree.com Work Experiences: ~12 years Science and Engineering Research Fields US Working Permission: US Permanent Residency

QUALIFICATION SUMMARY

Ph.D./Master’s degree in Bio-Chemical Engineering, focus on Chemistry, Material Science with 8 years post Ph.D. and 12 years post Master research experience in the field of material characterization

Extensive experience in applying a variety of analytical instruments in research with demonstrated proficiency in data interpretation for more than one of the following characterization techniques including physical property analysis, thermal property analysis(TGA, DSC), elemental analysis (XRF, ICP), vibrational spectroscopy (FTIR, Raman), electron microscopy (TEM, SEM), structural determination (XRD), and surface analysis (XPS, AES)

Knowledge and experience in sample preparation and analysis of a wide variety of materials, particularly in structure and property analysis

Ability to provide day-to-day supervision of chemists and research chemists in the analytical lab

Knowledge in petrochemicals and catalysis and strong communication (written and spoken) and interpersonal skills to interface with project teams to understand the needs and provide total characterization solutions

Ability to work independently and effectively within a team

Ability to multitask and contribute to multiple projects simultaneously and deliver results on time

Excellent laboratory skills including record keeping, safe handling of chemicals and equipment

Strong Chemist in technical expert for synthesis, design and characterization of nanomaterials

Well experienced in multidisciplinary projects involving biology, medicine, polymer chemistry, materials science, bioengineering, and nanotechnology

Experienced on writing experimental reports, protocols, journal articles and grant drafts

Demonstrated teamwork, leadership and organizational skills EMPLOYMENT AND WORK EXPERIENCES

20012~now Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX

Title: Research Instructor

Responsibilities:

2

Lead scientist/chemist in designing and developing of anti-cancer nanoparticles (nano conjugates of gold Nano-rod, Thermosensative Liposome and Nano-sphere) for drug and gene/siRNA/miRNA delivery

Apply the expertise in material characterization by using a variety of analytical instruments and conducting analysis on a wide range of materials including composites, and polymers

Work with research teams to develop analytical methods, deliver high quality analytical results and provide in-depth data interpretation to understand the relationships between structures, compositions and properties of the materials associated with the synthesis or manufacturing process

Acquire, use and maintain lab equipment, set up the best practice and train teammates

Stay current on state-of-the-art characterization techniques and methods, propose and implement new capabilities

Provide consultation and hands-on assistance to researches and teammates on non-routine analysis (e.g. in-situ process monitoring)

Handle multiple projects and stay on schedule for project deliverables

Communicate research results to stakeholders through reports and presentations

Follow safety procedures and practices, build and maintain a safe working environment 2009~2011 Department of Physical Biosciences, Lawrence Berkeley National Lab/Department of Bioengineering, UC Berkeley, CA/Center for Immunology and Vaccine Development, Children’s Hospital Oakland Research Institute (CHORI), Oakland, CA Title: Postdoctoral Research Scientist

Lead scientist/chemist in designing and developing of engineered biological nanoparticles for anti-chlamydial disease

2007~2009 Department of Pharmaceutical Sciences, School of Pharmacy, Wayne State University, Detroit, MI

Title: Postdoctoral Research Scientist

Lead scientist/chemist in developing of engineered mesoporous silica and iron oxide nanoparticles

Technical leader for the nanoparticles coating using thermo and pH responsive polymer

Nano-therapeutic evaluation using cell based assay and Fluorescence Microscopy 2004~2007 Cancer Biology and Nanomaterial Fabrication Lab, School of Medicine, Chonbuk National University (CBNU), Jeonju, Korea

Title: Research Assistant Scientist and Team Leader

Designing and developing of engineered polymeric micellar, gold and iron oxide nanoparticles, and screening of new anti-cancer therapeutics using cancer model 2000~2003 Nanomaterials Fabrication & Tissue Engineering Lab, CBNU, Jeonju, Korea Title: Research Assistant Scientist

Fabrication and characterization of engineered nanomaterials for drug/gene delivery and developing of electrospoon nanofibrous for tissue regenerative matrix

Technical leader for materials characterization sampling of Electron Microscopy, Spectroscopy, Thermo-mechanical, Chromatography, Particle size and charge analyzer SPECIALIZED TECHNICAL SKILLS

Nano Fabrication Chemistry: Hands on fabrication of; Liposome, Polymeric micellar nanoparticles, microgel, and colloidal metallic nanoparticles (gold, magnetic and silica nanoparticles) 3

Surface Modification and Biomaterials Development: Surface grafting or coating of Biomaterials for Tissue Engineering and Drug/Gene delivery. Biocompatibility tests; Cell-Polymer matrix interactions, Cyto-toxicity, Biodegradation, Fluorescnce-labelling

Polymer Synthesis and Processing: Familiarity; Bio-conjugation, Radical & ROP Polymerization, Electro-spinning, and Nanocomposite Fabrication

Gene/Drug Delivery: Hands on; IV Injection (tail vein), intra tracheal/nasal/intestinal/muscular injection and oral route. Familiarity; nebulizer

Analysis and Characterization Techniques: Morphology: Hands on; Fluorescence/Optical and Confocal Microscopy. Familiarity; Electron Microscopy (SEM, TEM, and AFM), Spectroscopy (UV- Vis, FTIR, XRD, NMR), Thermo-mechanical (TGA, DSC, Tensile), Chromatography (HPLC, GPC, HPTLC), Particle size and charge analyzer (DLS and ELS). Computer skills: Microsoft Office, Origin, Chem-Draw, Photoshop

REPRESENTAIVE PUBLICAITONS

Peer Reviewed Articles: 33, Book Chapter: 2, Invited Talks: 5, Conference Abstracts and presentation: 20 and Articles under submission: 4

SELECTED PUBLICATIONS

1. Bhattarai SR, Yoo SY, Lee SW, Dean D. Engineered phage-based therapeutic materials inhibit Chlamydia trachomatis intracellular infection. Biomaterials 2012; 33;5166-5174. 2. Bhattarai SR, Muthuswamy E, Wani A, Brichacek M, Castaneda AL, Brock S, Oupicky D. Enhanced gene and siRNA delivery by polycation-modified mesoporous silica nanoparticles loaded with chloroquine. Pharmaceutical Research 2010;27;2556-2568. 3. Regmi R, Bhattarai SR, Sudakar C, Wani AS, Cunningham R, Washnava PP, Naik R, Oupicky D, & Lawes G. Hyperthermia Controlled Rapid Drug Release from Thermosensitive Magnetic Microgels. Journal of Materials Chemistry 2010;20;6158-6163.

4. Bhattara SR, Kim SY, Yi HK, Bhattarai N, Kiam HK, Hwang PH. Amphiphilic Triblock Copolymer Poly (p-Dioxanone-co-L-Lactide)-block- Poly (ethylene glycol), Enhancement of Gene Expression and Inhibition of Lung Metastasis by Aerosol Delivery. Gene Therapy 2007;14;476-483. 5. Bhattara SR, Kim SY, Jung KY, Lee KC, Yi HK, Lee DY, Kim HY, Hwang PH. N-hexanoyl Chitosan Stabilized Magnetic Nanoparticles: Enhancement of Adenoviral-Mediated Gene Expression both In vitro and In vivo. Nanomedicine: Nanotechnology, Biology and Medicine 2008;4;1462-154. 6. Bhattarai SR, Kc RB, Aryal S, Bhattarai N, Kim SY, Yi HK, Hwang PH, Kim HY. Hydrophobically modified chitosan/gold nanoparticles for DNA delivery. Journal of Nanoparticle Research 2008;10;151-162.

7. Bhattarai SR, Khalil ARK, Montasser D, Hwang PH, Yi HK, Kim HY. Novel Production Method and Invitro Cell Compatibility of Ti-6V-4Al Alloy for Tissue Engineering. Journal of Biomedical Materials Research A 2008;86 (A);289-299.

8. Bhattarai SR, Kc RB, Kim SY, Sharma M, Khil MS, Hwang PH, Chang GH, Kim HY. Modified Chitosan Stabilized Magnetic Nanoparticles: Implication for Cellular Labeling and Magnetic Resonance Imaging (MRI). Journal of Nanobiotechnology 2008;6;1-29. 9. Bhattarai SR, Kim SY, Jhang KY, Lee CK, Yi HK, Lee DY, Kim HY, Hwang PH. Laboratory Formulated Magnetic Nanoparticles for Enhancement of Viral Gene Expression in Suspension Cell Line (K562 cells). Journal of Virological Methods 2007;147;213-218. PROFESSIONAL EXPERIENCES

2013-now Editorial Board; Journal of Cancer Research and Therapeutic Oncology 2011-now Editorial Board; ISRN Materials Science

4

2007-now Ad Hoc Reviewer; Journal of Biomedical Materials Research, Journal of Polymer Science Part B; Polymer Physics, Journal of Applied Polymer Science, Journal of Colloids B: Biointerfaces, Acta Biomaterialia

EDUCATION & TRAINING

2009-2011 Postdoc training; Department Bioengineering, UC Berkeley & CHORI, Oakland CA 2009-2010 Postdoc training; Lawrence Berkeley National Lab, Berkeley, CA 2007-2009 Postdoc training; Pharmaceutical Sciences, Wayne State University, Detroit, MI 2005-2007 Ph.D; Biochemical Engineering, CBNU, Jeonju, South Korea 2001-2003 M.Sc; Biochemical Engineering, CBNU, Jeonju, South Korea AWARDS & MEMBERSHIPS

2005-2007 Ph.D. Research Assistantship; by Korean Government of Healthcare Technology 2007 Invited Speaker; Clinical Research Center, School of Medicine, CBNU, Jeonju, South Korea 2006 Young Scientist Award; “International Symposium on HTD” CBNU, Jeonju, South Korea 2006 Best Poster Award; Young Scientist Competition Symposium, CBNU, Jeonju, South Korea 2007 Best Research Award; Clinical Research Center, CBNU, Jeonju, South Korea. 2007-now Member; International Nanoscience Community REFERENCE:

1. Dr. Mani Chaulagain, Ph.D.

Scientist, SABIC Innovative Plastics

Email: actp76@r.postjobfree.com

Phone: 812-***-****

2. Prof. Santosh Aryal, Ph. D.

Department of Chemistry, Nanotechnology Innovation Center of Kansas State-NICKS P218, Mosier Hall, Manhattan, KS 66506

Tel: 785-***-****

Email: actp76@r.postjobfree.com

3. Prof. Narayan Bhattarai, Ph.D

Department of Bioengineering, McNair 326, North Carolina A&T State University 1601 East Market Street, Greensboro, NC 27407

Phone: 336-***-**** x107, Fax: 336-***-****

Email: actp76@r.postjobfree.com

4. Prof. Parmeswaran Diagaradjane, Ph.D

Experimental Radiation Oncology-Research, The University of Texas, MD Anderson Cancer Center 1515 Holcombe Blvd, Unit-99, Houston, TX 77030

Phone: 713-***-**** Fax: 713-***-****

Email: actp76@r.postjobfree.com

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