Biographical Sketch Format Page

Kim, Eun Joo

CURRICULUM VITAE

NAME

Eun Joo Kim

Birth date

Feb. 06, 1971

Phone

978-***-****

Email

acstgv@r.postjobfree.com

INSTITUTION AND LOCATION

DEGREE

(if applicable)

YEAR(s) FIELD OF STUDY

Seoul Women's University (Seoul, Korea)

B.S 1989-1993 Biology

Seoul Women's University (Seoul, Korea)

M.S 1993-1995 Molecular Biology

Ajou University School of Medicine (Suwon, Korea) 1995-1997 Physiology Ajou University, School of Medicine (Suwon, Korea) Ph. D. 1997-2000 Neurophysiology Ajou University, School of Medicine (Suwon, Korea) 2000-2001 Neurophysiology Yonsei University, School of Medicine (Seoul, Korea) 2002-2003 Electrophysiology Ohio State University (Ohio, USA) 2003-2004 Molecular Biochemistry University of Miami, School of Medicine (FL, USA) 2004-2008 Neurology A. Positions and Honors

Positions and Employment

1995-1997 Teaching assistant, Department of physiology, Ajou University School of Medicine (Suwon, Korea) 2000-2001 Postdoctoral Researcher, Department of Physiology, Ajou University School of Medicine (Suwon, Korea). 2002-2003 Postdoctoral Fellow, Medical Research Center, Yonsei University, School of Medicine (Seoul, Korea) 2003-2004 Postdoctoral Fellow, Department of Molecular and Cellular Biochemistry, Ohio State University

(Columbus,OH.)

2004- 2008. Jan. Postdoctoral Associate, Department of Neurology, University of Miami, School of Medicine (Miami, FL.) Awards

2005. April. Bursary Brain’05& Brain PET’05

2005. June American Heart Association Postdoctoral fellowship award Research Support

2005. July- 2007.June : American Heart Association Postdoctoral fellowship Other experience and memberships

1997- 2007 Member, Society for Neuroscience

2002-2003 Member, IBRO

2005- 2007 Member, ISCBFM

B. Peer-reviewed publications

1. Raval AP, Lin HW, Dave KR, Defazio RA, Morte DD, Kim EJ, Perez-Pinzon MA (2008) Resveratrol and ischemic preconditioning in the brain. Curr Med Chem.15(15):1545-51. 2. Kim EJ, Perez-Pinzon MA (2008) Preconditioning mediated by sublethal oxygen glucose deprivation induced cyclooxygenase-2 expression via the signal transducers and activators of transcription 3 phosphorylation. J Cereb Blood Flow Metab. Jul;28(7):1329-40.

3. Kim EJ, Raval AP, Defazio RA, Perez-Pinzon, MA (2007) Ischemic preconditioning via epsilon protein kinase C activation requires cyclooxygenase-2 activation in vitro. Neuroscience 145 : 931-941 Kim, Eun Joo

4. Kim EJ, Park YG, Baik EJ, Jung SJ, Won R, Nahm TS, Lee BH (2005) Dehydroascorbic acid prevents oxidative cell death through glutathione pathway in primary astrocytes. J. Neurosci. Res. 79(5):670-679 5. Park JY, Kim EJ, Kwon KJ, Jung YS, Moon CH, Lee SH, Baik EJ.( 2004) Neuroprotection by fructose-1,6-bisphosphate involves ROS alterations via p38 MAPK/ERK Brain Res. 1026(2):295-301. 6. Kim EJ, Kwon KJ, Park JY, Lee SH, Moon CH, Baik EJ.(2002) Neuroprotective effects of prostaglandin E2 or cAMP against microglial and neuronal free radical mediated toxicity associated with inflammation. J. Neurosci. Res. 70:97-107.

7. Lee BH, Ran W, Kim EJ, Nahm HY, Kim EJ, Park YG.(2002) Nitric oxide synthase inhibitor facilitates functional recovery after sciatic nerve injury. Korean Journal of Biological and Physiological Psychology.14(1): 29-37 8. Kim EJ, Kwon KJ, Park JY, Lee SH, Moon CH, Baik EJ (2002) Effect s of peroxisome proliferator-activate agonists on LPS-induced neuronal death in mixed cortical neurons: assoiciated with iNOS and COX-2 Brain Res.941:1-10 9. Kim EJ, Lee JE, Kwon KJ, Lee SH, Moon CH, Baik EJ (2001) Differential roles of cyclooxygenase isoforms after kainic acid- induced prostaglandin E2 production and neurodegeneation in cortical and hippocampal cell cultures. Brain Res. 908:1-9

10. Baik EJ, Kim EJ, Lee SH, Moon CH, Park SH(2000). Tunel-positive cell death in the dorsal root ganglia of streptozotocin –induced diabetic rats. Experimental Neurobiology. 9: 113-117 11. Baik EJ, Kim EJ, Lee SH, Moon C (1999). Cyclooxygense-2 selective inhibitors aggravate kainic acid-induced seizure and neuronal cell death in the hippocampus. Brain Res. 843: 118-129. 12. Kim EJ, Lee SH, Moon CH, Baik EJ(1999). Upregulated cyclooxygenase-2 expression by cyclooxygenase-2 selective inhibitor is highly correlated with kainic-acid –induced delayed hippocampal neuronal death..Experimental Neurobiology 8: 61-71.

13. Baik EJ, Kim EJ, Lee SH, Moon CH, Park SH, Park KA. (1998)Low dose of NGF improved sensory functions in streptozotocin induced diabetic rat. Experimental Neurobiology 7(2):59-67. 14. Moon CH, Park RM, Kim EJ, Lee BH, Baik EJ (1996). Effect of nerve growth factor on peripheral injury model. Ajou Medical J. 1:37-44.

C. Abstracts Presented:

1. EJ Kim, Jesus Purroy Anna M. Planas, Migule A. Perez-Pinzon Ischemic preconditioning via epsilon PKC induces ERK1/2 and STAT3 pathways in mixed cortical neurons/astrocytes. Brain’07 & Brain PET’ 07. 2007. 2. Jesus Purroy, Roser Gornia, EJ Kim, Anna M Planas, Miguel A, Perez-Pinzon PKC MEDIATES THE SERINE-727 PHOSPHORYLATION OF STAT1 AND STAT3 IN ASTROCYTES FOLLOWING OXIDATIVE INJURY. Brain’07 & Brain PET’ 07. 2007.

3. EJ Kim, Ami P Raval, Migule A. Perez-Pinzon. Cyclooxygenase-2 activation promotes ischemic preconditioning neuroprotection in vitro via the epsilon PKC and ERK1/2 pathways. 36th Soc. Neurosci 2006. 4. EJ Kim, Ami P Raval, Miguel A. Perez-pinzon. Ischemic preconditioning promotes neuroprotection via cyclooxygenase-2 induction in vitro. Brain’05 & Brain PET’ 05. 2005. 5. EJ Kim, AW Harrington, K Giehl, SO Yoon. JNK3 is required for p75- dependent death of neuron and oligodendrocytes after CNS trauma. 34th Soc. Neurosci. 2004. 6. BH Lee,EJ Kim, HJ Cho, KH Lee .Functional recovery after transplantation of human embryonic stem cells in contusion spinal cord injury model of rats. 33th Soc. Neurosci. 2003. 7. EJ Kim, BH Lee, SJ Jung, KH Lee, JH Kim, YG Park. Antioxidant defense mechanism of dehydroascorbic acid different from ascorbic acid against oxidative stress in primary astrocytes. 33th Soc. Neurosci. 2003. 8. KH Lee, EJ Kim, HJ Cho, BH Lee. Effects of glial transplantation on functional recovery following acute spinal cord injury. 6th IBRO world congress. 2003.

9. EJ Kim, SJ Jung, KH Lee, YG Park, BH Lee. Dehydroascorbic acid but not ascorbic acid prevents cell death induced by oxidative stress through increase of glutathione and ATP levels depleted by H2O2 in primary astrocytes. 6th IBRO world congress .2003.

10. EJ Kim, MF Chun, YH Cho, BH Lee SS Chung, JW Chang Change of Neuronal Activity in Basal Ganglia Nuclei and Behavior by Subthalamic Lesion with Kainic Acid in Rat Parkinsonian Models with 6-hydroxydopamine 31th Soc. Neurosci. 2001.

11. KJ Kwon, EJ Kim, JY Park, SH Lee, CH Moon, EJ Baik. Lipoxygenase and cytochrome P450 pathway are associated with arachidonic acid-induced neuronal death in mixed cortical neurons..31th Soc. Neurosci. 2001 12. EJ Kim, KJ Kwon, SH Lee, CH Moon, EJ Baik. Effects of peroxisome proliferator-activated receptor isoforms agonists on neuronal death associated with iNOS and COX-2 in cortical neurons. 30th Soc. Neurosci. 2000. 13. EJ Kim, JE Lee, SH Lee, CH Moon, EJ Baik. The kainate-induced prostaglandin E2 release in the primary neuronal culture through COX-1 but COX-2. 29th Soc. Neurosci. 1999. 14. SH Park, YY Lee, EJ Kim, SH Lee, CH Moon,EJ Baik,, Expression of cyclooxygenase-a and cyclooxygenase-2 in the dorsal root ganglia of the rat. 29th Soc Neurosci.1999. Kim, Eun Joo

15. SH Park, EJ Baik, YY Lee, EJ Kim, SH Lee, CH Moon, KA Park. The effect of exogenous nerve growth factor(NGF) on the cyclooxygenase(COX) expression in dorsal root ganglion of streptozotocin induced diabetic rats. IASP.1999. 16. EJ Baik, EJ Kim, YY Lee, SH Lee, CH Moon. Potentiating effect of cyclooxygenase inhibitor on kainic acid induced seizure. 28th Soc Neurosci.1998.

17. YS Jung, HG Woo, EJ Kim, SH Lee, EJ Baik, CH Moon. Possible role of nitric oxide in the decrease of Na+K+ ATPase activity by high glucose in vascular smooth muscle cells. FASEB. 1998 18. EJ Baik, EJ Kim, YY Lee, SH Lee, CH Moon. Role of cyclooxygenase in sensory neurons with Freund’s complete adjuvant (FCA) inflammatory pain. J Neurochemistry 1998. 19. EJ Kim, SH Park, BH Lee, CH Moon, EJ Baik. Programmed cell death of dorsal root ganglion neurons in diabetes. 27th Soc. Neurosci. 1997

D. Technical Expertise

In vitro experiment

-Cell culture – primary cortical/ hippocampal /cerebellar granule neuronal culture: pure and mixed cultures of neurons, astrocytes, and microglia cell line culture.

- Northern blot,RT-PCR,

-DNA purification and transfection to mammalian cells

-Transformation, transfection with siRNA, oligonucleotide.

- Making virus

-Western blot, Immunoprecipitation

-Immunocytochemistry – double staining and TUNEL staining

-Confocal microscopy-ROS and Ca++ imaging

- Electrophoresis mobility shift assay and super shift assay –NF-kB assay

-ELISA (Enzyme –linked immuosorbent assay), RIA( Radio-immunoassay)-Prostaglandin assay

-Enzyme activity- Caspase-3 activity assay

In vivo experiment

-Model – Traumatic spinal cord injury rat model

Hemisection spinal cord injury mouse model

Mouse seizure model

Rat diabetic neuropathic pain model

Rat peripheral neuropathic pain

-Behavior anlaysis - seizure behavior test,

Pain behavior test

locomotor behavior anlaysis (BBB)

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