Research Management

ABHIJIT ROYCHOWDHURY, PhD

(US Citizen)

**** ***** **** ***, **********, AL 35209

Home 205-***-****, Cell: 205-***-****; Email: *********@*****.***

Summary

Results-oriented Research Scientist adept at developing new applications and products, generating intellectual properties and providing technical solutions with quality performance

Productive research experience: industrial, contract research organization and academic organizations

Detail-oriented with expertise in the synthesis, design, formulation and characterization of material properties, as well as coordinating testing and development

Design, synthesis, purification and characterization of various organic entities, nucleosides, nucleotides, peptides, bio-conjugate, ceramides, fatty acids, lipids polymers and Gold Nanoparticles (AuNPs)

Extensive design and synthesis in various Sphingolipids, Phospholipids, Sterols, Fluorescent Lipids, Polymers and Polymerizable Lipids, Coenzyme A and various Deutrated lipids used for pre-formulations and formulation applications

Highlights

Advanced chemical research; Multi-step synthesis; Nanomaterials, Polymers

Proficient in UV, IR, NMR and Mass Spectrometry and purification systems; Practiced in automation

Management of research personnel

SOPs, BPR, Direct Reports in cGMP guidelines

Accomplishments

Successful result oriented completion of industrial projects

Led the development of anti-viral, which received excellent customer evaluations.

Recipient of the “Award for Outstanding Accomplishment" for four consecutive years

Developed a new process method, which increased production by 70%

Isophosphoramide mustard entities for solid tumors in pre-clinical stage

Experience

Research Scientist

July 2015

Texas A & M, College Station, TX

Lead optimization and process development on Industrial Assignment

Lab management

Scientist

June 2015

ARC, Inc. Saint Louis, MO

Synthesis and production of radio-labeled APIs

Consultant

January 2015 – May 2015

Management and technical support to small scientific and non-scientific organizations

R & D Scientist

February 2012 – December 2014

Avanti Polar Lipids, Alabaster, Al

Coordinated all phases of product development, including formulation, experimentation and documentation.

Executed experimental design techniques and evaluation reports.

Regulatory and GLP and GMP requirements for Pharmaceutical developments; SOP and BPR (Batch Production Record) regulations and execution

Process and production, from gram to kilogram scale reaction, 40L reactors

Researcher

July 2011 to January 2012

Targeted Metabolomics and Proteomics Laboratory, UAB, Birmingham, Al

Basics in Quantitative Small Molecule Assays and Method Development

Mass Spectroscopic studies

Research Consultant

July 2010 to June 2011

ITT Labs, Birmingham, Al

Design optimization strategies of scaffolds derived from known chemotherapeutic agents

Conferred with scientists and engineers on conducting analysis of research projects.

Associate Research Chemist & Adjunct Faculty

February 2005 to July 2010

Southern Research Institute & School of Medicine, UAB, Birmingham, Al

Very successful in major project; Anti HCV, productive patents and publications

Co-Principal Investigator of anticancer and antiviral project

Trained advanced technology using the 'High Performance Flash Chromatography' systems, 'microwave reactor' and LCMS.

Research Associate

February 2004 to January 2005

University of Alabama at Birmingham - Birmingham, AL

Successful Bio-conjugate chemistry with antibody for targeted drug delivery for cancer

Post-Doctoral Fellow

August 1999 to January 2004

University of Florida - Gainesville, FL

Improved methods and processes to increase efficiency for functionalized and non-standard nucleosides

Developed a short and efficient route to the synthesis of functionalized nucleotides with one-pot insertion of thio functionality (Sulfur) in the nucleosides

Shorter and efficient synthesis of ‘zwitterionic’ and ‘C’nucleosides

Synthesis of phosphoramides and triphosphates

Supervised undergraduate, graduate students, post-doc fellows and had lab management responsibilities including technical instruments

Research Officer

February 1999 to June 1999

Alembic Limited - Vadodara, India

Executed the synthesis of MDR pharmacophores

Research Scientist

June 1998 to March 1999

Indian Institute of Technology - Bombay, India

Designed and synthesized molecular receptor for binding studies; host-guest chemistry.

Conferred with scientists and engineers on conducting analysis of research projects.

Research Fellow

July 1992 to June 1998

Central Drug Research Institute CSIR - Lucknow, India

Chemo-enzymatic reactions; synthesis of heterocycle annealed amino acids; novel methodologies.

Supervised junior research fellows and oversaw lab management tasks including technical instruments.

EDUCATION

1998 Ph.D., Chemistry, Central Drug Research Institute (CSIR), Lucknow, India

1991 Diploma in Marketing and Sales Management, Kanpur, India

1990 M.S., Chemistry, Kanpur University, Kanpur, India

ADDITIONAL TRAINING

Continuing Education: Community and Corporate Education; Myers Briggs/ Jefferson State Community College Birmingham, Al, 2005

●OSHA, MSDS and Accident Prevention and Response, Southern Research Institute, Birmingham, Al: 2005

●Florida Heterocyclic Couse and Conference Gainesville, FL 2000

●Florida Heterocyclic Couse and Conference Gainesville, FL 2001

●Radiochemical Handling and Disposal, University of Florida, Gainesville, FL 2001

●Florida Heterocyclic Couse and Conference Gainesville, FL 2002

●Florida Heterocyclic Couse and Conference Gainesville, FL 2003

●Workshop on Sophisticated Instruments in Biomedical R & D Activities Luck now, India, 1997

●VIIth National Users Workshop on Application of High Resolution NMR, Mass Spectroscopy and Electron Microscopy, Lucknow, India, 1995

TECHNICAL SKILLS

●Spectroscopy: UV, IR, NMR (2D & 3D), LCMS and TEM

●Purification Systems: TLC, HPLC, Normal Phase Chromatography, Reverse Phase, Ion-Exchange and Flash purification systems (viz. Biotage, Teledyne & Yamazen)

●Microwave reactor with automation

●Automated Parallel Synthesis System

●Computer: MS Office, CS Chem Draw (1D & 3D), Beilstein Commandar, Web of Science, Scifinder Scholar, PC and Mac compatible, Molecular modeling on Sybil

●Data Mining and Route Scouting

PATENTS

●Ethynyl-substituted pyridine and pyrimidine derivatives and their use in treating viral infections, C. D. Kwong, F. G. Njoroge, S. Ananthan, A. Arasappan, F. Bennett, J. Clark, A. T. Fowler, F. Geng, H. Kezar III, J. M. Maddry, J. J. Piwinski, R. C. Reynolds, Abhijit Roychowdhury, J. Secrist III, N-Y, Shih. US Patent, US8541434 B2

●Ethenyl-substituted pyridine and pyrimidine derivatives and their use in treating viral infections, C. D. Kwong, F. G. Njoroge, S. Ananthan, J. Clark, F. Geng, H. Kezar III, J. M. Maddry, J. J. Piwinski, R. C.. Reynolds, Abhijit Roychowdhury, J. Secrist III, N-Y, Shih. US Patent, US8715638 B2

●Substituted pyridine and pyrimidine derivatives and their use in treating viral infections, A. Arasappan, F. G. Njoroge, C. D. Kwong, S. Ananthan, F. Bennett, J. Clark, F. Geng, V. M. Girijavallabhan, Y. Huang, R. Huelgas, H. Kezar III, J. M. Maddry, J. J. Piwinski, R. C.. Reynolds, Abhijit Roychowdhury, J. Secrist III, N-Y, Shih. US Patent, US 8697694 B2

●Azo-substituted pyridine and pyrimidine derivatives and their use in treating viral infections, C. D. Kwong, F. G. Njoroge, S. Ananthan, J. Clark, F. Geng, H. Kezar III, J. M. Maddry, J. J. Piwinski, R. C.. Reynolds, Abhijit Roychowdhury, J. Secrist III, N-Y, Shih. US Patent, US8470834 B2

PUBLICATIONS

●Novel substituted pyrimidines as HCV replication (replicase) inhibitors Ashok Arasappanan, Cecil D. Kwong, Jeremy L. Clark, Anita Fowler, Feng Geng, Hollis S. Kezar III, Abhijit Roychowdhury, Robert C. Reynolds, Joseph A. Maddry, Subramaniam Ananthan, John A. Secrist III, Neng-Yang Shih, John J. Piwinski, Cheng Li, Hsueh-Cheng Huang, Xiao Tong, and F. George Njoroge. Bioorganic and Medicinal Chemistry Letters 2012, 22, 1160-64

●5-Benzothiazole substituted pyrimidine derivatives as HCV replication (replicase) inhibitors Ashok Arasappan, Frank Bennett,Vinay Girijavallabhan, Yuhua Huang, Regina Huelgas, Carmen Alvarez, Lei Chen, Stephen Gavalas, Seong-Heon Kim, Aneta Kosinski, Patrick Pinto, Razia Rizvi, Randall Rossman, Bandarpalle Shankar, Ling Tong, Francisco Velazquez, Srikanth Venkatraman, Vishal A. Verma, Joseph Kozlowski, Neng-Yang Shih, John J. Piwinski, Malcolm MacCoss, Cecil D. Kwong, Jeremy L.Clark, Anita T. Fowler, Feng Geng, Hollis S. Kezar III, Abhijit Roychowdhury, Robert C. Reynolds, Joseph A. Maddry, Subramaniam Ananthan, John A. Secrist III, Cheng Li, Robert Chase, Stephanie Curry, Hsueh-Cheng Huang, Xiao Tong, F. George Njoroge. Bioorganic and Medicinal Chemistry Letters, 2012, 22, 3229-3234

●Pyridofuran substituted pyrimidine derivatives as HCV replication (replicase) inhibitors

Frank Bennett, Hollis S. Kezar III, Vinay Girijavallabhan, Yuhua Huang, Regina Huelgas, Randall Rossman, Neng-Yang Shih, John J. Piwinski, Malcolm MacCoss, Cecil D. Kwong, Jeremy L. Clark, Anita T. Fowler, Feng Geng, Abhijit Roychowdhury, Robert C. Reynolds, Joseph A. Maddry, Subramaniam Ananthan, John A. Secrist III, Cheng Li, Robert Chase, Stephanie Curry, Hsueh-Cheng Huang, Xiao Tong, F. George Njoroge, Ashok Arasappan Bioorganic and Medicinal Chemistry Letters, 2012, 22, 5144-5149

●Diarylimidoylcyanides, an attractive class of intermediate. Novel synthesis of -nitroenamines, N, N/ - di-subtituted amidines and substituted phenyl glyoxylate. Abhijit Roychowdhury, Versha V. Kumar and A.P.Bhaduri, Synth. Commun. 2006, 36, 715-727

●Incorporation of a 5-position Modified 2'-Deoxycytidine by Vent Polymerase. Abhijit Roychowdhury, Heshan Illagkoon, Cynthia L. Hendrickson and Steven A. Benner Org. Lett. 2004, 6(4), 489-492

●C-5 Modified nucleosides: Direct insertion of alkynyl-thio functionality in pyrimidines. Heike Held, Abhijit Roychowdhury and Steven A. Benner Nucleosides Nucleotides and Nucleic Acids. 2003, 22, 391-404

●A novel chemoselective hydrolysis of fatty acid ester by lipase from a soil isolate Pseudomonas mendocina. Umesh K. Jinwal, Manish K. Tripathi, Uma Roy, Abhijit Roychowdhury, A.P. Bhaduri and P.K. Roy. Bioorganic and Medicinal Chemistry, 2003, 11(6), 1041

●Chemoselective hydrolysis of esters by fungal lipases. Abhijit RoyChowdhury, Manish K. Tripathi, Umesh K. Jinwal, U. Roy, Versha V. Kumar, A. P. Bhaduri and P. K. Roy, J. Chem.Res., 1999 (S), 266-267

●Chemoselective reduction of carbamates by LiAlH4 Abhijit RoyChowdhury and A. P. Bhaduri, Ind. J. Chem., 1998, 37B, 82-83

●Novel TBTH/AIBN induced intermolecular ring closure reaction: A convenient synthesis of substituted azetidine-3-ones. Abhijit RoyChowdhury, Versha V. Kumar, Raja Roy and A. P. Bhaduri. J. Chem. Res., 1997, (S), 254-255

●One pot synthesis of hexahydro-1, 2, 4-triazolo [4, 3-a] pyrimidine-3, 7-diones Abhijit RoyChowdhury, S. Sharma and A. P. Bhaduri. Ind. J. Chem., 1996, 35B, 567-571

SELECTED PRESENTATIONS

●Synthesis of analogs (BM-IPM and CM-IPM) of isophosphoramide mustard (IPM, ZIO-201) and comparison of their experimental antitumor activity against human tumor xenografts. W.R. Waud, A. Roychowdhury, J.A. Maddry, B. Wallner, J. Lewis, R.P.Gale and R.F. Struck. Southern Research Institute, Birmingham, AL 35205 and Ziopharm Oncology, Inc., N 10036-8401. AACR April 1-5, 2006, Washington, DC, USA

●Fluorescent Nucleotides for Applications in Artificial Genetic Systems & A Promising Fluorescent Cytidine Analog. Heshan Illagkoon, Abhijit Roychowdhury and Steven A. Benner. Gordon Conference on Nucleic Acids, June 1-6, 2003, Newport, RI, USA

●Unnatural C-Nucleosides: Design and synthesis of pyridine and pyrazine nucleosides. Abhijit Roychowdhury and Steven A. Benner 224th A.C.S. National Meeting, August 18-22, 2002, Boston, MA, U.S.A

●Design and Synthesis of a Possible 'Non-Epimerizable' Pyrazine C-Nucleoside Abhijit Roychowdhury, A. Michael Sismour and Steven A. Benner 3rd Annual Florida Heterocyclic IUPAC-Sponsored Conference, 2002, Gainesville, Fl, USA

●Modified Nucleosides: Metal catalyst mediated insertion of thio functionality in pyrimidines Abhijit RoyChowdhury, Heike Held and Steven A. Benner. 221st A.C.S. National Meeting, April1-5, 2001, San Diego, CA, USA

●A Novel Chemoselective Hydrolysis of Fatty Acid Ester by soil isolate Pseudomonas mendocina and its Lipolytic characteristics. Umesh K. Jinwal, Abhijit Roy Chowdhury, Manish K. Tripathi, Uma Roy, Angney Lal, A.P.Bhaduri and P.K.Roy. International Conference on New Horizons in Biotechnology, Regional Research Laboratory.April 18-21, 2001, Trivandrum, India

●Redesigning nucleic acids, synthesis of uridine and cytidine derivatives that carry expanded functionality, K. G. Devine, S. A. Benner and A. RoyChowdhury, Florida Annual A.C.S. Meeting, May 12-13, 2000, Orlando, FL, USA

●Chemoselective hydrolysis of esters by fungal lipase. Abhijit RoyChowdhury, Manish K. Tripathi, Umesh K. Jinwal, Ram Pratap, U. Roy, A.P. Bhaduri and P.K. Roy, First University -Industry meets on Lipase Research, Needs and Components, May 20-21, 1999, New Delhi, India

●Synthesis of polynitrogenous substituted aminoalkanes as a new class of spermicidal agents. Abhijit RoyChowdhury, Versha V. Kumar, J. D. Dhar, G. Gupta and J. P. Maikuri, International Symposium on Perspectives in Biomolecular Research, January. 12-13, 1998, Luck now, India

●Design, synthesis and biological evaluation of 1,3-diaminopropanes: A new class of leishmanicidal agents. Versha V. Kumar, Abhijit RoyChowdhury, (late) S. Sharma, A. P. Bhaduri, Suman Gupta and J.C. Katiyar. Global Meet on Parasitic Diseases, March 18-22, 1996, New Delhi, India

●Chemistry of 5-amino-2, 4-dihydro-3H-1, 2, 4-triazol-3-ones. Abhijit Roy Chowdhury, Versha V. Kumar, and A. P. Bhaduri. 14th Annual Conference of Indian Council of Chemists, December 28-30, 1995, Bombay, India

●In search of lead materials for leishmanicidal agents: Generation of diverse molecular structures from 1, 2-diaminomethane. Abhijit RoyChowdhury, Versha V. Kumar, S. Sharma. Global Challenges in Drug Development, December 16-18, 1994, Lucknow, India

AWARDS, SCHOLARSHIPS and RECOGNITION

●2010 US Census Bureau selects to comment on NSF

●2008 Letter of Recognition from Southern Research Institute for extraordinary success in the industrial project

●2006 Nominated in Marquis’s ‘Who’s who in America’

●2002 New ‘C-Nucleosides’ which were presented at the IUPAC sponsored Heterocyclic Meeting and at the ACS National Meeting, Boston was highly recognized by the Albany Molecular, Inc., NY

●2000 Metal catalyst mediated insertion of thio functionality in pyrimidines. Presented at the ACS National Meeting, San Diego. This work was selected for SCIMIX and later acknowledged by a local (San Diego) scientific organization

●1996 - 1998 Senior Research Fellowships Award, (C.S.I.R.), New Delhi, India

●1992 - 1996 Research Assistantships from Dept. of Biotechnology, New Delhi, India and CONRAD, VA, USA

●1984 - 1986 State Government Merit Scholarship, Uttar Pradesh., Allahabad, India

AFFILIATION & REVIEWER

American Chemical Society, Washington, DC, USA

Indian Council of Chemists (Life Member), Agra, India

U.P. Association for the Advancement of Science and Technology, Lucknow, India

Reviewer for Nucleosides Nucleotides and Nucleic Acids

Reviewer for Drug Discovery & Development and Current Pharmaceutical Design

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