Project Assistant

WEI HUANG

601-***-**** ******.********@*****.***

1

QUALIFICATION

* *****’ experience with complex organic syntheses, process development, scale up and condition optimization through micro-reactor technology

Hands-on experience in purifying compounds by: HPLC, GC, LC-MS, LH-20, C-18, P-2, and flourous tag assisted separation

Strong analytical skill in identifying chemical structure by: FT IR, MALDI, 1D and 2D NMR

Knowledge of immunology and glycobiology

Extensive experience using Sci-Finder, Web of science and Beilstein database

Ability to successfully work independently and in a dynamic team environment

Excellent and effective communication and documentation skills

Fluency in Chinese

EDUCATION

The University of Georgia Athens, GA

Ph.D. Organic chemistry Expected 2015

Tongji University Shanghai, China

B.E. Material Science and Engineering July 2008

RESEARCH EXPERIENCE

Complex Carbohydrate Research Center, The University of Georgia Athens, GA Ph.D. Researcher June 2010-present

Developed α stereoselective glycosylation methodology using bicyclic beta-sulfonium, applied the methodology to 2 complex substrate syntheses, completely solved the difficulty in chemical formation of α galactose linkage and first demonstrated rapid complex oligosaccharide assembly by flourous tag separation technology.

Led a 3-person research team on bicyclic beta-sulfonium glycosylation mechanism study.

Synthesized a glycoconjugate vaccine candidate for C. difficile treatment, collectively evaluated 3 existing synthetic routes and designed a coupling method between complex oligosaccharides for the first time.

Tongji University Shanghai, China

Undergraduate Researcher Aug 2006-June 2008

Synthesized and characterized a multi-functional micro polymer bead for mercury adsorption in wastewater treatment.

WORKING EXPERIENCE

State Key Lab of Bio-Organic & Natural Products Chemistry, SIOC, CAS Shanghai, China Visiting student, Biao Yu’s Group Sept 2009-June 2010

Explored curcumenol modification for an industrial client, comprehensively evaluated existing experimental techniques to investigate modification methods.

Synthesized glycosyl flavonoids with anti-stroke property. WEI HUANG

601-***-**** ******.********@*****.***

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Shanghai Institute of Pharmaceutical Industry Shanghai, China Lab Assistant Jan 2009-June 2009

Synthesizing flavonoid compounds with anti-stroke activity in an environmentally friendly way, improved the final yield by 14% and significangly improved the stereo-selectivity.

Outsourced project: synthesized chiral phosphoramide-Zn(II) ligands in commercial scale for an industrial client.

Reaction Technology, Bayer Technology Service Shanghai, China Intern Sept 2008-Dec 2008

Process development, scale up and optimization of 3-amino propanenitrile and 2,4-fluorophenyl boronic acid by micro-reactor.

Demonstrated micro-reactor technology for Zhejiang Hisun Pharmaceutical Co. Ltd.

Maintenance of micro-reactor.

PUBLICATIONS

Wei Huang, Tao Fang, Qi Gao, Geert Jan Boons. “Rapid Assembly of Complex Oligosaccharides by Employing Fluorous Supported Synthesis and Anomeric Sulfonium Ions as Glycosyl Donors.” Chemistry a European Journal, (Accepted, selected as frontispiece). Tao Fang, Wei Huang, Yi Gu, Geert Jan Boons. "The Investigation of Mechanism of Glycosylation through Chiral Auxiliary.” Journal of The American Chemical Society, (Project accomplished, submitting).

Jianli Chen, Wei Huang, Gaoyan Lian, Feng Lin. “The Efficient Total Synthesis of Bis-glycosyl Apigenin from Naringenin: A Greener Way.” Carbohydrate Research, 344:16 (2009). QW Xu, WH Shang, ZY Li, Wei Huang. “The Influence of Carboxylic Acid Dental Adhesive Monomer on Adhesive Strength of Visible-light Curing Orthodontic Adhesive.” Chinese Materials Science Technology and Equipment, 2 (2008).

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