IR, NMR, Mass spectroscopy and x-ray crystsllographic studies

Curriculum Vitae of Ms Deepika Gautam

Address for correspondence: Deepika Gautam

Department of Chemistry

Sant Longowal Institute of Engg. & Technology

Longowal-148106, Punjab, INDIA

e-mail: acq39w@r.postjobfree.com

Mob. 094***-*****

Date of Birth: 28-10-1983

Educational Qualifications: Ph.D. (Organic Chemistry), 2015 (Degree Awarded)

Sant Longowal Institute of Engineering and Technology, Longowal

M.Sc (Chemistry), 2006 Agra University, Agra

B.Sc. (Chemistry, Botony, Zoology), 2003, H.P. University, Shimla

B. Ed. 2004, H. P. University, Shimla

Title of Ph.D Thesis: “Synthesis and antimicrobial studies of 4-thiazolidinone derivatives”

Employment History: (i) Lecturer in Chemistry (June 2008 to May 2010) at Guru Nanak Institute of Engg. & Technology, Hoshiarpur, Punjab

(ii) Technician (Sep. 2010 to June 2011) at Sant Longowal Institute of Engineering and Technology, Longowal(Sangrur)-148106, Punjab

Brief resume of research work:

My research work during PhD was mainly the synthesis of hydrazono-thiazolidin-4-ones and 2,4-disubstituted thiazoles containing naphthalene, carbazole, benzofuran, benzothiophene etc. moieties. The synthesis of new Indazoly-thiazolidin-4-ones, hydrazo-thiazinan-4-ones and thiazolo[2,3-b]benzo[f]quinazoline derivatives have also been accomplished. The structure and regiochemistry of the cyclised products under study was established by spectroscopic methods such as IR, NMR (1H, 13C & 2D-COSY) and Mass spectroscopy. X-ray crystallographic studies of some of the cyclised products was undertaken to establish their structure in the solid state.

Computational studies (DFT method) of cyclised products and their regioisomers were done on Gaussian 09W software package. Proton and Carbon NMR chemical shifts of the isomers were calculated and compared with experimental results for structure validation. The antimicrobial activities (antibacterial and antifungal) of all the newly synthesized thiazolidin-4-one and thiazole derivatives have been examined and compared with standard drugs.

Skills: (i) Organic synthesis and characterization

(ii) Modern analytical methods such as LC-MS, HPLC, TLC, UV-Visible, IR, NMR, Mass etc. spectroscopic methods.

(iii) X-ray diffraction

(iv) Fluorescence,

(v) Computational studies (DFT method)

(vi) Gaussian 09W software package (Molecular modeling and DFT studies)

(vii) ChemBioDraw 13

(viii) Knowledge of Common computer software and

Programming.

Awards: Awarded research fellowship for pursuing PhD by Sant Longowal Institute of Engg. & Technology, Longowal

References:

1.Dr. R. P. Chaudhary 2. Dr. S. Bhattacharya

Associate Professor, Professor of Chemistry

Deptt. of Chemistry Deptt. of Chemistry

SLIET, Longowal, Punjab Banaras Hindu University, Varanasi (U.P.)

Signature

LIST PUBLICATIONS IN NATIONAL/INTERNATIONAL JOURNALS

1.Gautam, D., Gautam, P. and Chaudhary, R.P. 2011. Efficient synthesis of 2, 4-disubstituted thiazoles and 2-substituted-4-thiazolidinones under solvent free conditions. Heterocyclic Communication. 17(3-4): 147-150.

2.Gautam, D., Gautam, P. and Chaudhary, R.P. 2012. Expedient and green synthesis of some novel 4-thiazolidinones and new 2,4-disubstituted thiazoles with tetrahydro carbazole pendant. Letters in Organic Chemistry. 9: 660-663.

3.Gautam, D., Gautam, P. and Chaudhary, R.P. 2012. N-methylpyridinium tosylate catalysed green and efficient synthesis of some novel 2,4-disubstituted thiazoles and 4-thiazolidinones. Chinese Chemical Letters. 23: 1221-24.

4.Gautam, D., Gautam, P. and Chaudhary, R.P. 2013. Efficient synthesis, X-ray diffraction study and antimicrobial activity of some novel thiazolidin-4- ones and perhydro-1,3-thiazin-4-ones. Heterocyclic Communication. 19: 43-47.

5.Gautam, D., Gautam, P. and Chaudhary, R.P. 2014. Carbodiimide mediated synthesis of some novel 4-thiazolidinones and 2,4-disubstituted thiazoles bearing N-methyl tetrahydrocarbazole moiety. Indian J. Chem. 53B: 1606-1610.

6.Gautam, D. and Chaudhary, R.P. 2015. Synthesis, structure and antimicrobial evaluation of new 3,3a,4,5-tetrahydro-2H-benzo[g]indazol-2-yl-thiazol-4(5H)-ones. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy. 135: 219–226

7.Gautam, D. and Chaudhary, R.P. 2015. Synthesis, crystal structure, computational and photophysical studies of new hydrazono-thiazole derivatives decorated with N-methyl tetrahydrocarbazole pendant. Journal of Molecular Structure. 1080: 137–144.

8.Gautam, D. and Chaudhary, R.P. Synthesis, X-ray, DFT and photophysical properties of some new ferrocenyl hydrazono thiazolidin-4-ones and their derivatives. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy. (accepted for publication).

9.Gautam, P., Gautam, D. and Chaudhary, R.P. 2014. One pot regioselective synthesis and antimicrobial studies of some novel Indazolyl-thiazole derivatives. Journal of Heterocyclic Chemistry. In press. DOI 10.1002/jhet

10.Gautam, P., Gautam, D. and Chaudhary, R.P. 2013. Synthesis, crystal structure and DFT studies of N-(4-acetyl-5,5-dimethyl-4,5-dihydro-1,3,4-thiadiazol-2-yl)acetamide. Crystallography Reports. 58: 1079-1083.

11.Gautam, P., Gautam, D. and Chaudhary, R.P. 2014. Regioselective synthesis of new 2,5,6 trisubstituted 5,6-dihydro-2H-pyrazolo[3,4-d]thiazoles from 5-dimethylaminoethylene-thaozolidin-4-thiones. Journal of Sulfur Chemistry. 35(6): 628-640.

12.Gautam, D. and Chaudhary, R.P. Studies on orientation of cyclization in benzo[f]thiazolo[2,3-b]quinazolin-10(9H)-one system by spectral and DFT methods. Synthesis (submitted).

List of papers presented in conferences (National/International)

1.Ionic liquid-mediated, one-pot synthesis for 2,3-Disubstituted 4-Thiazolidinones. Deepika Gautam, Poonam Gautam, Richa Gupta and Ram Pal Chaudhary at 14th Punjab Science Congress held at Sant Longowal Institute of Engg and Technology, Longowal from Feb 7- 9, 2011.

2.Solvent free one-pot synthesis for 2-3 disubstituted 4-Thiazolidinones. Deepika Gautam, Poonam Gautam, Richa Gupta and Ram Pal Chaudhary at National Conference on Recent Advances in Chemical and Environmental Science (RACES-2011) held at Multani Mal Modi College, Patiala from Feb 28- March 1, 2011.

3.Green and efficient synthesis of novel 2-imino-4-thiazolidinones and 2,4-disubstituted thiazoles containing carbazole moiety. Deepika Gautam and Ram Pal Chaudhary at International Conference on Chemical Constellation Cheminar held at NIT Jalandhar from September 10-12, 2012.

4.Dicyclohexylcarbodiimide mediated synthesis of 2,3-disubstituted 4-thiazolidinones by one-pot three-component condensation. Deepika Gautam and Ram Pal Chaudhary at National conference on global challenges: new frontiers in chemical sciences (GC: NFCS-2012) held at Kurukshetra University from September 22-23, 2012.

5.An efficient synthesis of novel 2-imino-4-thiazolidinones and 2,4-disubstituted thiazoles containing indazole moiety. Deepika Gautam and Ram Pal Chaudhary at International conference on “Recent advances in chemical sciences” organized by Arya P.G. College Panipat, Haryana from February 24-26, 2013.

6.Synthesis, X-ray and DFT studies of some Indazole derivatives and their conversion to novel indazol-thiazolidin-4-one and indazol-thiazinan-4-one system. Deepika Gautam and R. P. Chaudhary 101st Indian Science Congress held at Jammu University, Jammu from 03-07 Feb, 2014.

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