Safety Management

Adip Roy, Ph.D.

**** ***** ********, ************, ********* - 560067

Mobile: 990*******

Email: *******@*******.***

Profile:

. Over 12 years of experience in regulatory toxicology

. Key role in networking with regulators and key opinion formers in the

areas of animal alternatives, risk based approaches for assuring

safety of personal care products and

food ingredients

. Expertise in risk assessment of food ingredients, cosmetics, personal

care and home care products

Work Experience:

. Research Scientist 2008 -

present

Safety and Environmental Assurance Centre (SEAC)

Unilever R&D, Bangalore, India.

Key responsibilities:

- Leading Unilever's 'animal alternatives' strategy in India

- Building networks with regulators and key opinion formers in areas

of animal alternatives and risk based approaches for safety

assessments

- Partner with Unilever Regulatory Affairs and engage externally with

leading Regulatory bodies e.g. BIS and scientific organizations to

provide science-based leadership on toxicological risk assessments

- Lead toxicologist for product safety risk assessments for clinical

trials and market launches of food ingredients and

cosmetics/personal care and home care formulations

- Organize symposium/workshops on risk assessment strategies for

foods and personal care products

- Developing Science &Technology for newer risk assessment approaches

- Leading / mentoring role in risk assessment and S&T activities

. Research Scientist 2003 -

2008

Safety and Environmental Assurance Centre (SEAC)

Unilever R&D, Mumbai/Bangalore, India.

Key responsibilities:

- Toxicological risk assessments of food ingredients,

cosmetics/personal care and home care formulations

- Risk assessment of Naturals (Ayurveda &TCM)

- Conduct clinical trials for safety assessment of personal care and

homecare products (e.g. skin irritation tests, HRIPT, patch tests,

diagnostic patch tests, hand immersion tests etc.}

. Post-Doctoral Research Associate 1999 -

2002

Department of Psychiatry,

University of Illinois at Chicago, USA

Area of research:

- Neurobiology of Addiction

- Role of cAMP dependent signaling pathways in the brain during

nicotine and alcohol addiction (tolerance, dependence and

preference).

Education:

. Ph.D, Toxicology 1994 -

1999

Indian Institute of Toxicology Research (formerly ITRC), Lucknow and

Jamia Hamdard, New Delhi, India

Area of research:

- Behavioural and neurochemical restoration by fetal neural

transplants in chemical induced neurotoxicity.

- Peripheral markers for neurotoxicity

(Thesis: Restorative potential of fetal neural transplants in

chemical induced neurotoxicity)

. M.Sc, Biochemistry 1991 -

1993

Lucknow University, Lucknow, India

. B.Sc, Chemistry, Physics 1988 -

1991

Lucknow University, Lucknow, India

Publications:

Dasgupta MN, Roy A. Technical workshop on risk based approaches for

food safety management. Toxicology International. 21(1): 115-17,

2014.

1. Roy A, Akbarsha MA. Novel Strategies for Toxicological Risk

Assessments. ALTEX. 31 (1): 44-46, 2014.

2. Draaisma RB, Wijffels RH, Ellen Slegers P, Brentner LB, Roy A, Barbosa

MJ. Food commodities from microalgae. Current Opinion in

Biotechnology. 24 (2): 169-177, 2013.

3. Proceedings of the One Day Symposium on "Safety and Risk Assessment

Approaches for Materials of Herbal Origin" Organized by Unilever

Research India, along with Ayurvedic Drug Manufacturers Association,

and Indian Drug Manufacturers Association, at Bangalore, on 3

September, 2010. Toxicology International. Aug; 18 (Suppl 1):S3-S19,

2011.

4. Peters L, Marriott M, Mukerji B, Indra P, Iyer JV, Roy A, Rowson M,

Ahmed S, Cooper K, Basketter D. The effect of population diversity on

skin irritation. Contact Dermatitis. 55 (6): 357 - 363, 2006.

Pandey SC, Zhang H, Roy A, Misra K. Central and medial amygdaloid

brain-derived neurotrophic factor signaling plays a critical role in

alcohol-drinking and anxiety-like behaviors. Journal of Neuroscience

26 (32): 8320 - 8331, 2006.

Pandey SC, Zhang H, Roy A, Xu T. Deficits in amygdaloid cAMP-

responsive element-binding protein signaling play a role in genetic

predisposition to anxiety and alcoholism. Journal of Clinical

Investigation. 115 (10): 2762-73, 2005.

5. Pandey SC, Zhang HB, Roy A, Xu T. Effect of voluntary ethanol intake

on anxiety-like behaviors and CREB phosphorylation and expression of

NPY in amygdaloid sturctures of alcohol-preferring and non-preferring

rats Alcoholism: Clinical and Experimental Research 28: 98A-98A Suppl.

2004

6. Pandey SC, Roy A, Zhang H. CREB haplodeficient mice: Role in anxiety

and alcohol drinking behaviors Alcoholism: Clinical and Experimental

Research 28: 194A-194A Suppl. 2004.

7. Pandey SC, Roy A, Zhang HB, Xu T. Partial deletion of the cAMP

response element-binding protein gene promotes alcohol-drinking

behaviors. Journal of Neuroscience 24 (21): 502*-****-****

8. Pandey SC, Roy A, Zhang HB. The decreased phosphorylation of cyclic

adenosine monophosphate (cAMP) response element binding (CREB) protein

in the central amygdala acts as a molecular substrate for anxiety

related to ethanol withdrawal in rats. Alcoholism: Clinical and

Experimental Research 27: 396-***-****.

9. Roy A, Pandey SC. The decreased cellular expression of neuropeptide Y

protein in rat brain structures during ethanol withdrawal after

chronic ethanol exposure. Alcoholism: Clinical and Experimental

Research 26: 796-803, 2002

10. Roy A, Mittal N, Zhang HB, Pandey SC. Modulation of cellular

expression of glucocorticoid receptor and glucocorticoid response

element-DNA binding in rat brain during alcohol drinking and

withdrawal. Journal of Pharmacology and Experimental Therapeutics 301:

774-784, 2002.

11. Misra K, Roy A, Pandey SC. Effects of voluntary ethanol intake on the

expression of Ca2+/calmodulin-dependent protein kinase IV and on CREB

expression and phosphorylation in the rat nucleus accumbens.

Neuroreport 12: 4133-4137, 2001.

12. Pandey SC, Roy A, Xu T, Mittal N. Effects of protracted nicotine

exposure and withdrawal on the expression and phosphorylation of the

CREB gene transcription factor in rat brain. Journal of Neurochemistry

77: 943-952, 2001.

13. Pandey SC, Roy A, Mittal N. Effects of chronic ethanol intake and its

withdrawal on the expression and phosphorylation of the CREB gene

transcription factor in rat cortex. Journal of Pharmacology and

Experimental Therapeutics 296: 857-868, 2001.

14. Pandey SC, Roy A, Xu T, Mittal N. CREB gene transcription factor acts

as a neurobiological substrate for nicotine dependence. Journal of

Addictive Diseases 19 (2): 17A 2000.

15. Husain M, Khanna VK, Roy A, Tandon R, Pradeep S, Seth PK. Platelet

dopamine receptors and oxidative stress parameters as markers of

manganese toxicity. Human and Experimental Toxicology 20: 631-636,

2001.

16. Roy A, Agrawal AK, Husain R, Dubey MP, Seth PK. Cholinergic and

serotonergic alterations in the rat hippocampus following trimethyltin

exposure and fetal neural transplantation. Neuroscience Letters 259:

173-176, 1999.

17. Roy A, Agrawal AK, Husain R, Seth PK. Restoration of trimethyltin

induced hippocampal degeneration by single and multiple

transplantation. Restorative Neurology and Neuroscience 11: 195-201,

1997.

Presentations - Invited Talks:

Have done oral and poster presentations in several national and

international conferences (presentations done in last three years):

1. Progressing Non-Animal Approaches to Safety in India. Adip Roy, Gaurav

Jain, Paul Carmichael, Andrew White and Fiona Reynolds. 34th Annual

Conference of Society of Toxicology (STOX), India', December 10 - 12,

2014, Chennai, India.

2. Invited talk on 'Risk based approaches for assuring safety of

chemicals in food' at "International Conference on Emerging Food

safety Risk: Challenges for Developing Countries" organized by

National Institute of Food Technology Entrepreneurship and Management

(NIFTEM), January 9-11, 2014, Sonepat, India.

3. Invited talk on "Non-animal approaches to safety: successes and future

challanges" at '33rd Annual Conference of Society of Toxicology

(STOX), India', October 23 - 25, 2013, Mathura, India.

4. Invited talk on "Risk based approaches for food safety" at 'Technical

Workshop on Risk Based Approaches for Food Safety Management'

organized by AFSTI, September 18, 2013, Bangalore, India.

5. Invited lecture on "Pathway based risk assessment - novel strategies

for toxicological safety assurance" at the '32nd Annual Conference of

Society of Toxicology (STOX), India', December 5 - 7, 2012, Lucknow,

India.

6. Invited to present Case Studies on "Food contact/packaging materials"

and on "Naturals" at the 'Technical Workshop on Risk Based Approaches

for Food Safety Management' organized by International Life Sciences

Institute (ILSI), India, September 26 - 27, 2012, New Delhi, India.

7. Invited talk on "Risk assessment: Whether a criteria for product

approval" at the 'Workshop on Food Safety & Standard Regulations:

Building Awareness' organized by Confederation of Indian Food Trade &

Industry (Food Wing of FICCI), August 17, 2012, 2012, Bangalore,

India.

8. Invited talk on "Safety assessment / generation of history of safe use

data for herbal products" at the 'Herbal products: Regulatory aspects'

organized by the Department of Clinical Pharmacology, T.N. Medical

college and B.Y.L. Nair Ch. Hospital, Mumbai. June 29 - 30, 2012,

Mumbai, India.

9. Invited talk on "Safety evaluation of cosmetics" at the '31st Annual

Conference of Society of Toxicology (STOX), India', December 22 - 24,

2011, Jaipur, India.

10. Invited talk on "Non animal approaches for consumer safety risk

assessment: Unilever's risk assessment approach" at the '30th Annual

Conference of Society of Toxicology (STOX), India', December 9 - 11,

2012, New Delhi, India.

Honours:

. Awarded the 'Surajben jethalal Thaker Prakruti Mandir Award' by

Society of Toxicology, India and Academy of Science for Animal

Welfare, for promoting 'alternatives to animal testing' at the

'33rd Annual Conference of Society of Toxicology (STOX), India',

October 23 - 25, 2013, Mathura, India.

. Elected 'Member of Executive Committee' Society of Toxicology

(STOX), India, since 2012.

. Invited to Chair the session on "Drug and Chemical Toxicology" at

the '32nd Annual Conference of Society of Toxicology (STOX),

India', December 5 - 7, 2012, Lucknow, India.

. Invited to Co-chair the session on "Alternative models on toxicity

assessment" at the '30th Annual Conference of Society of Toxicology

(STOX), India', December 9 - 11, 2010, New Delhi, India.

Other Professional Activities:

. Memberships: Society of Toxicology (STOX), India; British

Toxicology Society (BTS).

. Symposiums / workshops conducted:

- 'Technical Workshop on Risk Based Approaches for Food Safety

Management', September, 2013, Unilever R&D, Bangalore, India.

- Symposium on 'Novel Strategies for Toxicological Risk Assessments',

September, 2013, Unilever R&D, Bangalore, India.

- 'Food Toxicology Module' at the 'Technical Workshop on Risk Based

Approaches for Food Safety Management' organized by International

Life Sciences Institute (ILSI), India, September 26 - 27, 2012, New

Delhi, India.

- Special session on "Alternative models on toxicity assessment" at

the '30th Annual Conference of Society of Toxicology (STOX),

India', December 9 - 11, 2012, New Delhi, India.

- One Day Symposium on 'Safety and Risk Assessment Approaches for

Materials of Herbal Origin' at Bangalore in 2010.

Office Details:

SEAC - Safety & Environmental Assurance Centre,

Unilever R&D,

64 Main Road, Whitefield

Bangalore - 560066

****.***@********.***

Personal Details:

Date of birth 26th April, 1970

Nationality Indian

Marital status Married

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