Lead Clinical Data Manager / SAS Programmer
Resume:
G regory S. Tullo
***A Spitz Lane
Basye, VA ****0
****.*****@*****.***
QUALIFICATIONS
As the lead clinical data manager and director of our data management team, it has been my responsibility
to lead the data management team of the Laboratory of Malaria and Vector Research in all data collection,
processing, and data management needs from study start-up through data lock. This includes, but is not
limited to the design of custom data collection plans using the Clinical DataFax hybrid EDC system,
management and quality assurance of collected data, and post processing of data using custom SAS
programs for the generation of general descriptive statistics, analysis datasets, and reports. In addition, I
have created custom data management solutions for researchers and analysis based on their needs. Much
of my work includes project management of several concurrent clinical and non-clinical studies,
responding to ad-hoc data summary requests, the generation of data management solutions and plans, and
the supervision of several data managers and data entry personnel. The vast majority of this work is
performed from a home-based office with minimal oversight.
EXPERIENCE
Laboratory of Malaria and Vector Research, January 2011 – Present
Kelly Scientific Resources
National Institutes of Health – Bethesda, MD
Lead Clinical Data Manager
Generate custom SAS programs and macros for users which generate data subsets of interest,
descriptive statistics, and reports.
Lead data standardization efforts including proper MedDRA coding and migration to CDISC
standards.
Create all digital and paper CRFs.
Program all edit checks in EDC system using a C-family programming language.
Organize data collection operations and manage data management staff in all remote field sites
(Mali, Cambodia) including remote training sessions.
Act as liaison between field site investigators and monitoring groups/cyber infrastructure teams.
Oversight of data query generation, reporting, and resolution including regular ‘batch’ quality
control queries.
Manage the Clinical DataFax system, which uses Intelligent Character Recognition (ICR) for
collection of data from scans of paper CRFs; a system which greatly reduces the time from data
collection to data availability to research teams.
Provide regular reports on data validation efficiency and accuracy, query resolution time, and
other requested metrics through database lock.
Accomplishments include:
- Expanded use of DataFax to include eight clinical studies and three novel data collection uses
of the system. The effort has resulted in the ability to run more studies concurrently while
collecting vastly more data and yet allowing the generation of custom reports, datasets, and
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simple statics with ease. The creation of such datasets prior to the system was a process
which took weeks and was highly error prone. It now takes a matter of minutes to create high
quality, valid results with an error rate of less than one percent.
- Created a barcoded labeling system which interfaces with DataFax. This system
increased the sample collection count fivefold, reduced the sample logging time from
an estimated two or more weeks to three or four days, and vastly increased accuracy.
Laboratory of Malaria and Vector Research, January 2008 – December 2010
Kelly Scientific Resources
National Institutes of Health – Bethesda, MD
Research Scientist II
Worked as ‘defacto’ data manager until official position was created in 2011.
Lead the effort in the implementation of the Clinical DataFax hybrid EDC system for all clinical
studies.
Managed all pre-DataFax data from a large cohort clinical study (see Lopera-Mesa et al 2015) and
migrated this data into the DataFax system.
Member of ‘Growth Inhibition Reference Center’ and responsible for testing of malaria vaccine
candidates from outside clients.
Maintained positive working relationships with clients who were often competing for same
discovery.
Accomplishments include:
- Proposed the creation of lead clinical data manager / director of data management position
and was appointed to that position.
- Implemented Clinical DataFax system resulting in a reduction in time from field data
collection to delivery in the lab from over one month to one week, increased the number of
data samples collected by an order of magnitude, and reduced historical data collection error
rate from over 10% to less than 1%.
- Created custom database for a group working on a four year longitudinal cohort study which
allowed all members of the team to independently query a dataset of close to one million data
points in a matter of seconds rather than the hours needed before the system was created.
University of Kentucky, Markey Cancer Center – Lexington, KY 2006 – 2007
Undergraduate Independent Research under John D’Orazio, M.D., Ph.D.
Created an Excel workbook which enabled researchers to quickly determine correct exposure time
for various UVA and UVB doses as well as the correct amount of DNA suspension to load for
southwestern blots.
Investigated the role of the Melanocortin-1 Receptor in nucleotide excision repair and oxidative
damage repair in melanocytes exposed to UVA irradiation in a transgenic murine model
Conducted procedures such as southern blots, western blots, primer design, cell culture, animal
handling, DNA isolation, DNA purification, DNA manipulation, PCR, and interpretation of
sequencing data.
Introduced and developed technical aspects of southwestern blotting to quantify DNA damage in
skin biopsies caused by UVA and UVB irradiation.
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RELEVANT SKILLS
Base SAS programming language including automated macros
Familiarity with GCP, GCDMP, MedDRA, and CDISC
CRF design
Regular entry, validation, export, and manipulation of data collected in EDC systems
Edit check programming
General knowledge of C programming language
Expert user of Microsoft Office Suite including Excel and Access
Project management skills
Comfortable public presenter
Experienced leader of focused teams
EDUCATION
Bachelor of Science, Biology. University of Kentucky, Lexington, KY May 2007
Relevant courses include: Reemerging Infectious Diseases, statistics, recombinant DNA
techniques, genetics, cell and molecular biology, organic chemistry, physics, animal physiology.
Independent research of Melanocortin-1 Receptor under John D’Orazio, M.D., Ph.D.
PUBLICATIONS
Amaratunga, C., S. Sreng, S. Mao, G. S. Tullo, J. M. Anderson, C. M. Chuor, S. Suon and R. M. Fairhurst
(2014). "Chloroquine remains effective for treating Plasmodium vivax malaria in Pursat province,
Western Cambodia." Antimicrob Agents Chemother 58(10): 6270-6272.
Bei, A. K., A. Diouf, K. Miura, D. B. Larremore, U. Ribacke, G. Tullo, E. L. Moss, D. E. Neafsey, R. F.
Daniels, A. E. Zeituni, I. Nosamiefan, S. K. Volkman, A. D. Ahouidi, D. Ndiaye, T. Dieye, S.
Mboup, C. O. Buckee, C. A. Long and D. F. Wirth (2015). "Immune characterization of Plasmodium
falciparum parasites with a shared genetic signature in a region of decreasing transmission." Infect
Immun 83(1): 276-285.
Christian, P. V., J.; Scott, T.; Tullo, G.; D’Orazio, J.A. (2011). "Epidermal Pigmentation, Nucleotide
Excision Repair and Risk of Skin Cancer." Carcinogenesis & Mutagenesis.
Guo, J., J. A. McQuillan, B. Yau, G. S. Tullo, C. A. Long, P. Bertolino, B. Roediger, W. Weninger, G. A.
Taylor, N. H. Hunt, H. J. Ball and A. J. Mitchell (2015). "IRGM3 Contributes to Immunopathology
and Is Required for Differentiation of Antigen-Specific Effector CD8+ T Cells in Experimental
Cerebral Malaria." Infect Immun 83(4): 1406-1417.
Lopera-Mesa, T. M., S. Doumbia, D. Konaté, J. M. Anderson, M. Doumbouya, A. S. Keita, S. A. S.
Diakité, K. Traoré, M. A. Krause, A. Diouf, S. E. Moretz, G. S. Tullo, K. Miura, W. Gu, M. P. Fay,
S. M. Taylor, C. A. Long, M. Diakité and R. M.
Fairhurst (2015). "Effect of red blood cell variants on childhood malaria in Mali: a prospective cohort
study." The Lancet Haematology 2(4): e140-e149.
Miura, K., B. Deng, G. Tullo, A. Diouf, S. E. Moretz, E. Locke, M. Morin, M. P. Fay and C. A. Long
(2013). "Qualification of standard membrane-feeding assay with Plasmodium falciparum malaria and
potential improvements for future assays." PLoS One 8(3): e57909.
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Miura, K., M. Diakite, A. Diouf, S. Doumbia, D. Konate, A. S. Keita, S. E. Moretz, G. Tullo, H. Zhou, T.
M. Lopera-Mesa, J. M. Anderson, R. M. Fairhurst and C. A. Long (2013). "Relationship between
malaria incidence and IgG levels to Plasmodium falciparum merozoite antigens in Malian children:
impact of hemoglobins S and C." PLoS One 8(3): e60182.
Miura, K., E. Takashima, B. Deng, G. Tullo, A. Diouf, S. E. Moretz, D. Nikolaeva, M. Diakite, R. M.
Fairhurst, M. P. Fay, C. A. Long and T. Tsuboi (2013). "Functional comparison of Plasmodium
falciparum transmission-blocking vaccine candidates by the standard membrane-feeding assay."
Infect Immun 81(12): 4377-4382.
Miura, K., H. Zhou, A. Diouf, G. Tullo, S. E. Moretz, J. A. Aebig, M. P. Fay, L. H. Miller, O. K.
Doumbo, I. Sagara, A. Dicko, C. A. Long and R. D. Ellis (2011). "Immunological responses against
Plasmodium falciparum Apical Membrane Antigen1 vaccines vary depending on the population
immunized." Vaccine 29(12): 2255-2261.
Zeituni, A. E., K. Miura, M. Diakite, S. Doumbia, S. E. Moretz, A. Diouf, G. Tullo, T. M. Lopera-Mesa,
C. D. Bess, N. K. Mita-Mendoza, J. M. Anderson, R. M. Fairhurst and C. A. Long (2013). "Effects of
age, hemoglobin type and parasite strain on IgG recognition of Plasmodium falciparum-infected
erythrocytes in Malian children." PLoS One 8(10):e76734.
Zhang, Y., K. Miura, J. Li, G. Tullo, F. Zhu, L. Hong, T. Lin, X. Z. Su and C. Long (2012). "Macrophage
migration inhibitory factor homolog from Plasmodium yoelii modulates monocyte recruitment and
activation in spleen during infection." Parasitol Res 110(5): 1755-1763.
REFERENCES
References available upon request
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