Project Plant

Jiangyong Shao

**********@*****.*** 832-***-**** 1885 EL Paseo St. Houston TX

77054

Summary

Basic biology lab technology, and

* *****' experience in: Chemical process R&D for API and intermediates; QC

work for the process; Process scale up (from lab to pilot plant); Process

EHS analysis; non-GMP/GMP API manufacture; Support pre-clinical & clinical

trials; Technology transfer and support the CMO.

Experience

? Research Technician

Baylor College of Medicine Houston, Texas Area September 2013 ~ Present

Research on one kind of progression and metastasis of prostate cancer,

doing the basic biology lab work like making clones, protein purification

and analysis, protein-protein interaction analysis, mouse management, etc.

? Project Intern

Baylor College of Medicine Houston, Texas Area August 2013 ~ August

2013

Preliminary work on synthesizing the small molecules which were used to

develop nanocarriers for targeted drug delivery and studying the reaction

kinetics

? Scientist (project leader)

Hutchison MediPharma Limited Shanghai, China September 2007 ~ February

2013

1. Discovered, amended the multi-step synthetic route, developed the

chemical processes for the new compounds which could be novel drug

candidates on oncology

2. Joined to the analysis team to set up the analytic methods like GC, LC-

MS, HPLC, and set up the standard specification for each intermediate

3. Scale up the synthesis from mg-scale to Kg-scale, in charge of the

technology transfer from the laboratory to the plant, usually stayed in

the plant-site while leading a team

4. Impurities and Metabolizes studies (Isolation, Identification,

Preparation)

Isolation, usually using the preparative TLC, silica gel column, and

preparative LC;

Identification, usually using NMR (H, C, cosy, noesy), LC-MS-MS;

Preparation, usually developing new synthetic routes if could not get

enough sample from isolation

5. Following the guideline of cGMPs (Current Good Manufacturing Practices),

kept the original records and collected the data, wrote the IND

(Investigational New Drug) application documents on CMC (Chemistry,

Manufacturing and Controls) part.

Achievements: Five and half years dedicated to the chemical process R&D,

grown up with the company, my occupation was from Associate Scientist I to

Scientist II, and as a project leader for more than three years, I was

lucky to join to several single chemical entities' development including

the current five anti-cancer drug candidates in various stages of clinical

trials: HMPL-012 Sulfatinib, HMPL-013 Fruquintinib, HMPL-813 Epitinib, HMPL-

309 Theliatinib, HMPL-504 Volitinib. Please refer to the company website

link: http://www.hmplglobal.com/en/

? Process Engineer (team leader)

Shanghai Pharmaceutical (Group) Company Limited Shanghai, China March

2006 ~ August 2007

1. Chemical process development & improvement for generic drugs

2. Process verification with local starting materials for a transferred-in

project (cooperated with Pfizer)

3. Quality studies for the starting materials, intermediates and final

products

4. Support the APIs manufacture

Achievements: Trouble-shooting on the problems of starting materials for

the Pfizer's project, developed the chemical process timely in lab-scale

and supported the plant manufacture (followed the front 9 batches in

plant).

Education

Master, Organic Chemistry, 2003 ~ 2006 East China University of Science

and Technology (ECUST)

Bachelor, Pharmaceutical Engineering, 1999 ~ 2003 ECUST

Minor, Law, 2000 ~ 2003 ECUST

Patent and Paper

Compound, Certain Novel Forms Thereof, Pharmaceutical Compositions

Thereof and Methods for Preparation and Use US20120270889A1/ CN

201080052921.2

A kind of compound and its crystal form CN 200910199259.2

Improved Synthesis of Quetiapine [J]. Chinese Journal of New Drugs, 2007,

(11).

The Synthesis of Aripiprazole [J]. Chinese Journal of New Drugs, 2006,

(15).

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