Project Development

Tina Wu

**** * ***** ** **** WA ***** 206-***-**** *********@*******.***

OBJECTIVE

To obtain a challenging position as a chemist that utilizes my skill sets and allows

further professional growth.

SUMMARY & TECHNICAL SKILLS

• Skilled scientist with an analytical background.

• Adept at liquid formulations development for protein and peptide therapeutics.

• Driven to succeed. Consistently exceeded expectations in both academic and industry positions.

• Knowledge of good laboratory practices (GLPs) and good manufacturing practices

(GMPs).

• Excellent hands-on experimental and communication skills.

• Familiar with Optical Microscopy, Spectramax microplate reader, Titratior, ultrafiltration

process, HPLC, GC/MS, TLC, PCR, SDS-PAGE, Malvern Nano ZS instrument, osmometer,

liquid handling robots, lyophilization, viscosity meter, ESI-IMS-TOF, UV-Vis

spectroscopy, and peptide synthesizer.

PROFESSIONAL EXPERIENCE

Associate Scientist (Contract position) Amgen Seattle, WA April 2013-Dec2014

• Planed and conducted experiments, records and organizes data,

o Characterized molecular using analytical instruments.

Water HPLC, UPLC, Beckman coulter CE System, Agilent UV-Vis, Agilent LC.

o Software: Empower, 32 Karats and chem station

• Supported QC team, validation and method transfer for the analytical method and drug release.

Scientist II Alcon/CIBA Vision Duluth, GA Mar 2011 – Oct 2012

• Executed product release and verification activates under cGMP.

• Method Validation support base on product

• Experience executing wet chemistry techniques, HPLC and GC (Empower 2)

• Analyzing the raw materials and the polymer samples (contact lenses formulation and saline

solution).

o Instruments

HPLC(Water): Use C18 column, reverse phase, GC(Agilent): capillary column,

FTNIR, KF(coulometric), UV-Vis(Varian Cary WinUV application), Viscometer,

Refractive Index, Osmometer, Particle sizing(Horbia Instrument), and

FTIR(SpectraMax)

• Experienced in GMP environment.

• Peer review the laboratory data and troubleshooting instruments.

Research Associate Scientist Alcon/CIBA Vision (contract)

• Focus on the process and future development of contact lenses.

o Prepare contact lens formulation.

o Making lenses to study the interaction of lenses, coating solution and saline.

• Optimization of contact lens properties of detection through Design of Experiment.

o Stability testing

o Gauge repeatability and reproducibility

• Perform polymer synthesis to measure quantity of coated contact lenses.

Tina Wu

9709 S 237th Pl Kent WA 98031 206-***-**** *********@*******.***

o Purification/Ultrafiltration, and Lyophilization

• Conducted an investigation to understand the imperfections associated with the front surface of the

contact lenses.

o Developed new method to test the charge interaction on the surface of contact lenses.

o Design the testing device to detect the front surface imperfections

• Enhancement and characterization of coating. .

• Supervised the co-op students with current project.

LCMS Tech(Contract position) Seattle BioMed Seattle, WA Sept 2010 –Nov 2010

• Performed solution and gel enzymatic digestions.

• Analyzed samples from various sources and provided information regarding the protein sequence

• Duties included troubleshooting the LCMS instrument

QA Associate (Contract position) Seattle Genetics Bothell, WA June 2010 – Sept 2010

• Verified technical reports against raw data and edited the reports for content and readability, in order

to clear the backlog of tech reports that needed to be finalized prior to BLA submission for

brentuximab vedotin(ADC).

Research Associate Nastech Pharmaceutical Company Bothell, WA 2007- 2008

• Developed and analyzed liquid product formulations for several peptide candidates with an emphasis

on utilizing lipid and surfactant excipients for enhanced nasal permeation.

• Assisted in the project planning of preclinical trial studies. Assisted in writing batch records.

Manufactured newly developed formulations and analyzed their chemical and physical

characteristics under GLP.

• Validated formulations to assist in the development of the future pipeline.

Instruments: Malvern Nano ZS, Osmometer, Spectramax plate reader.

• Performed pre-formulation studies:

o Formulations development, and performed analytical data analysis.

o Stability studies time and temperature controlled studies.

o Developed and tested formulations with different excipients: lipids, surfactants, buffers,

and sugars.

Research Chemist HaloSource Bothell, WA 2005-2007

• Performed organic synthesis for the development of antimicrobial formulations.

• Implemented analytical methods to validate newly developed formulations.

• Developed formulations for pool and spa products.

• Wrote and updated Standard Operating Procedures (SOPs).

• Assisted senior scientists and engineers conduct experiments, interpret test results, and develop new

testing methods.

EDUCATION

Master of Science in Chemistry Washington State University Pullman, WA May 2005

Bachelor of Science in Biochemistry Eastern Washington University Cheney, WA Jun 2003

Bachelor of Art in Chemistry University of Washington Seattle, WA Aug 2002

PUBLICATION

• Dwivedi, P., Wu, P., Klopsch, S. J., Puzon, G. J., Xun, L., and Hill Jr., H . H.,

“Metabolic Profiling by Ion Mobility Mass Spectrometer (IMMS)” Metabolomics, 2008, 4, 63-80.

Contact this candidate