Laboratory Manager

Lucinda Davies, B.Sc., Ph.D.

** ******* **** *****, ***** Brook, NY 11790

**********@*****.*** ! "631-***-****

Education

2000: Ph.D., School of Biomedical Sciences, University of Leeds, UK

1994: Bachelor of Science in Pharmacology and Physiology (Joint Honours), Kings College London, UK

Clinical and Pre-Clinical Research Training and Experience

2012-present: Collaborator with CRO, Laboratory for Computational Neurodiagnostics, NY

Collaborative project on oxytocin in the regulation of trust performing fMRI on human subjects following intranasal

administration of oxytocin

Collaborative Institutional Training Initiative (CITI), SUNY Stony Brook

Good clinical practice course (US FDA focus)

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Good clinical practice course for clinical trials involving drugs (International ICH focus)

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Good clinical practice course for clinical trials involving devices (International focus)

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2010: Clinical Research Assistant, Clinical Trial Unit, University of Bern Medical School, Switzerland

Objective: To facilitate clinical trial research of the highest caliber and quality

Responsibilities: Ensuring quality assurance of clinical trial NCT00962416 comparing bare versus polymer

coated cardiac stents. Creation and revision of standard operating procedures (SOPs), preparation of a standard

risk assessment document for all trials and other paperwork to ensure CTU Bern compliance with Good

Clinical Practice (GCP) guidelines and Swiss Clinical Trial Organization (SCTO) requirements.

2007-2008: Introduction to the principles and practices of Clinical Research

A seminar course at the National Institutes of Health (NIH), Bethesda USA (grade 90%)

1995-1996: Study Supervisor, Huntingdon Life Sciences, UK

Objective: To perform pre-clinical safety evaluation studies at a contract research facility

Responsibilities: Outlining experimental protocols and execution to technical staff according to GLP standards.

Coordinating meetings between clients and contract research staff during site visits

General Skills in Clinical Research:

Trial monitoring on site, assuring quality and adherence with ICH-GCP guidelines

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Preparation of SOPs and trial master files

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Database development (Oracle)

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Computational skills including data analysis and reporting (MS Office suite), database management (Oracle)

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and acquisition programs (Neuralynx/Axon)

Preparation of synopses and reports for clients within a specific time frame

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Preparation, presentation and editing of study reports, posters and oral presentation

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Management of scheduling, performance and reporting of safety evaluation studies

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Team leading experience as a study supervisor within a pre-clinical center: ensuring all studies complied with

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Good Laboratory Practice (GLP) guidelines

Management experience with technical staff and liaising with clients and higher level staff; setting out clear

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objectives and delegating jobs between team members as appropriate

Research Training and Experience

2011-present: Lab manager and Senior Research Associate, Neurobiology and Behavior, SUNY Stony Brook

Objective: Computational modeling of oxytocin in the regulation of trust

A multidisciplinary project involving i) fMRI in humans following intranasal administration of oxytocin, ii)

multi-electrode recording of single units activity in rat brain regions underlying trust under oxytocin and iii)

creation of a biologically plausible computational model of trust behavior with oxytocin.

Responsibilities: Lab manager, preparation of protocols through IRBnet, performance of research studies,

budgeting lab grant money, data collection, analysis and presentation at scientific meetings

Teaching: Guidance and mentoring of graduate students

CITI Training: Working with IACUC, Working with rats in research settings, Post-procedure care of mice and

Lucinda Davies, CV: Page 1 of 2

rats in research

2003-2007: Postdoctoral Research Associate, UVA Medical School, Department of Pharmacology, Charlottesville,

Virginia, USA

Objective: To determine aldosterone levels in vivo in mice lacking TASK channels

Genetically modified mice were assessed for their Na+ handling ability defined by their plasma aldosterone

level. Astonishing levels of aldosterone were noted in the absence of TASK-1 and 3 channels, describing an

exciting, unique model for idiopathic primary hyperaldosteronism (IHA). Current studies define the individual

contribution of TASK-1 or 3 channels in the IHA phenotype.

Responsibilities: Design and creation of experimental protocols, budgeting my own grant money, delegation of

duties between technical staff and students and data collection, analysis and presentation.

Teaching: Guidance and mentoring of undergraduate students

1999-2002: Postdoctoral Research Assistant, University of Bern, Department of Physiology, Bern, Switzerland

Objective: To characterize innexin gap junctions in invertebrate Sf9 cells

Using the dual patch system, I patched either two adjacent cells or two separate cells and pushed them together

to form a communicating pair. I described complete electrical closure due to membrane depolarization: a

quality not shared by their mammalian counterparts.

Responsibilities: Data collection, analysis and presentation and registration of participants for local scientific

meetings

Teaching: Medical school physiology practicals on ECG and vision

Technical Skills in Basic Research:

Data analysis and scientific data presentation

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Electrophysiology:

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- Extracellular neuronal recording via implanted electrodes, whole cell and dual cell patch recording

Animal handling:

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- Surgery: Chronic and acute survival surgery

- Metabolic studies

- Training for behavioral studies

Electrode bundle design and construction

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Biochemistry: metabolite analyses, ELISA drug assay, in situ hybridization, immunohistochemistry, protein,

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DNA measurements

Tissue collection and histology

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Presentations

Effect of oxytocin on rat neural activity and behavior in a reward-based task, Washington DC, SfN 2014

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(poster)

The effect of oxytocin on orbitofrontal and amygdalar neurons of awake rats, San Diego, SfN 2013 (poster)

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“TASK channel deletion in mice causes primary hyperaldosteronism”, Ca2+ channel conference, Moorea,

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Tahiti, 2007 (invited talk)

University of Sussex, UK, 2003 (invited talk)

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King’s College London, UK 2002 (invited talk)

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Physiological Society UK and Czech Physiological Society joint meeting, Prague 1998

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Physiological Society, Bristol, UK 1997, Liverpool, UK 1998

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Anaesthetic Research Society, Leicester, UK 1997, London, UK 1997

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Honors and Awards

American Heart Association postdoctoral fellowship (2005-2007)

Language skills

Italian, Competent conversational level

German, Intermediate conversational level

Lucinda Davies, CV: Page 2 of 2

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