Molecular, Drug Development, Toxicology
Resume:
Marshall S. Scicchitano, MS
Douglassville, PA 19518
Professional Experience Highlights
Drug Discovery and Development (Laboratory Activities)
* Proficient in an extensive array of molecular biology and cellular techniques *
Maintained expert knowledge of state of the art technologies for biomarker discovery and
application on DNA, RNA and protein levels
* 3 years experience in Molecular Diagnostics *
3 years in Discovery Research * 15
years in Safety Assessment/Toxicology – mechanism of toxicology studies, biomarkers and drug
development (including cancer epigenetic drug targets)
* Proficient in an extensive array of molecular biology and cellular techniques
* Experience in molecular diagnostics and clinical evaluation of diagnostic kits *
Published 21 peer reviewed manuscripts and 34 abstracts *
Inventor on 2 issued patents *
Masters and PhD committee member/advisor for direct reports
Drug Development/Regulatory
* Served as Co-chair of the FDA’s Critical Path Institute/Predictive Safety Testing Consortium
(PSTC), Vascular Injury Working Group and member of the Testicular Toxicity Working group with
the goal to identify biomarkers of pre-clinical drug induced vascular and testicular injury with the
vision of clinical translation * Served
as a Safety Assessment Project Representative on GSK Project Teams
* Interpreted, and reported non-clinical toxicity studies (GLP and non-GLP) and disseminated
information to project teams *
Provided toxicology study designs (in vitro and in vivo) to support individual drug development
plans *
Involved with study monitoring, planning, and regulatory support including interpretation and
presentation of the toxicology data
* Experience in interactions with regulatory authorities (FDA, EMEA) related to Pre-IND, End of
Phase I and end of Phase 2a meetings (TC and F2F). *
Advanced compounds into Phase 1 and 2 clinical trials
* Experience in Due Diligence involved with in-licensing activities *
Experience in preparing Investigative Brochures, IND’s and Development Safety Update Reports
(DSURs) * Strong
knowledge of pre-clinical drug development and FDA and ICH guidance *
Experience in chemical hazard/risk assessments *
Discovery Safety leader for early drug discovery teams and provided a very early toxicology
perspective on the targets and lead molecules *
Technical knowledge in conducting toxicity studies with laboratory animals with understanding of
regulatory guidelines, GLP regulations, mechanistic animal models, and relevant SOPs *
Consistently met project team timelines during drug development by providing high quality
scientific support and insight
Managerial
* Over 8 years experience *
Managed group of up to 5 people *
Effectively lead, motivate, support and mentored direct reports to help them solve problems,
prioritize tasks and appropriately utilize resources *
Ensured group was aligned with department and company the business plan and vision
* Developed and approved budgets and ensured projects, workload and timelines were met to
support department/company goals
Work Experience
GlaxoSmithKline Pharmaceuticals
2007- 2014 Manager- Investigative Mechanistic Toxicology
Responsibilities:
1. Successfully lead a group investigating molecular mechanisms of toxicity of
selected compounds and work closely with cross-functional project teams to
discover and implement novel pharmacodynamic and predictive safety
biomarkers.
2. Served as the Safety Assessment project representative for early programs
and projects in the clinic
3. Served as the Safety Assessment Discovery Safety Leader for early discovery
programs
2003 – 2007 Investigator – Safety Assessment
Responsibilities:
1. Developed molecular/cellular assays using emerging technologies to evaluate
toxicity and support a variety of discovery projects.
2. Served as the Safety Assessment project representative for early programs
and projects in the clinic
1999- 2003 Principal Scientist- Safety Assessment
Responsibilities:
1. Identified and applied expert knowledge of state of the art technologies using
RNA and protein for biomarker discovery and mechanism of toxicity
investigations
2. Developed molecular/cellular assays of expression profiling datasets with a
focus on the analysis of gene/protein expression data related to the
characterization of drug safety/efficacy or diseases at the molecular level
Wyeth Research
1995-1998 Senior Biologist- Women’s Health Research
Responsibilities:
1. Responsible for setting up in vitro assays for screening compounds from the
estrogen mimetic drug discovery program
2. Implemented many molecular biology assays/methods to study the molecular
signaling of the estrogen receptor
Oncor Inc./ Oncor Med Inc.
1993-1995 Clinical Evaluations/Methods Development Scientist
Responsibilities:
1. Responsible for developing, testing and implementing new molecular assay
technologies to support
2. Validated cancer diagnostic assays and trained junior scientists.
3. Participated in collaboration with Dr. David Sidransky at the John’s Hopkins
University investigating microsatellite instability markers in bladder cancer.
4. Transferred the learnings and assay implementation internally
Children’s National Medical Center
1992-1993 Research Assistant II- Department of Genetics
Responsibilities:
1. Responsible for using a transgenic mouse that produces human insulin to
study Type II diabetes using genomic and proteomic techniques
Education
Master of Science Degree in Biology, Shippensburg University, Shippensburg, Pennsylvania
Bachelor of Science Degree in Biology, Mansfield University, Mansfield, Pennsylvania
Professional Organizations
Member Society of Toxicology
Member of Mid-Atlantic Society of Toxicology
Member Society of Toxicologic Pathology
Member North American Vascular Biology Organization
Served as Co-chair of the FDA’s Critical Path Institute/Predictive Safety Testing Consortium
(PSTC), Vascular Injury Working Group- with the goal to identify biomarkers of pre-clinical drug
induced vascular injury with the vision of clinical translation.
Toxicology Courses
Basic Training Course on Drug Development, Sponsored by Pharmaceutical Education &
Research Institute, Inc. (PERI).
Pharmaceutical Toxicology: Toxicology in the Nonclinical Development of Drugs and Biologics.
Sponsored by (PERI).
Toxicology: Principles and Applications/Chemical Mechanisms in Toxicology. Sponsored by The
American Chemical Society.
Technical (Molecular) Skills
RNA, DNA and Protein isolation and characterization (including FFPE tissue), Cell/Tissue Culture,
Taq-Man Analysis (mRNA, miRNA), Microarray (RNA and Protein) E.L.I.S.A., Immuno-PCR,
Western Blot, Northern and Southern Blot (non-isotopic), Immunoprecipation, Electrophoretic
Mobility Shift Assay, Ribonuclease Protection Assay, Flow Cytometry, DNA cloning, cDNA Library
Screening, Antibody Purification, Laser Capture Microdissection(LCM), Differential Display
Analysis, RNA amplification(aRNA and cDNA), Transfection, Oligonucleotide Antisense
Experiments (RNAi and Molpholino), In-gel Kinase Assays, Bacterial transformation, Plasmid
preparation, Immunoprecipitation, Nuclear run-on analysis, DNA sequencing, Denaturing Gradient
Gel Electrophoresis, Heteroduplex analysis, In Vitro transcription and translation, Single-Stranded
Conformational Polymorphism Analysis, Non-isotopic colony hybridization, Agarose gel
electrophoresis,Tissue and peripheral blood Fluorescent in situ hybridization, Tissue ISH (mRNA
and miRNA). Capillary electrophoresis (DNA, RNA and protein), Isolation, enrichment and
manipulation of cells and cell lines (human and animal), Small animal handling and surgery and
Cytogenetic analysis of mouse chromosomes
Computer Skills
Microsoft Office, Cricket Graph, Sigma Plot, Graph Pad Prism, JMP Statistical Programs,
Spotfire.
Proficient in searching and using nucleic acid and protein databases and interaction network
construction and pathway analysis (Ingenuity and GeneGo),
Affymetrix and Data Assist software and statistical analysis
Abstracts
Mao, L., Lee, D., Scicchitano, M. and Sidransky, D. Microsatellite Alterations as Markers for the
Detection of Cancer Cells in Urine. Proceedings of The American Association for Cancer
Research. 1995. 36:229.
D.C. Harnish, M. Evans, M. Scicchitano, R.Bhat and S.K. Karathanasis. Estrogen Receptor and
RIP 140 Can Regulate the Apolipoprotein A1 Gene Promoter in HePG2 Cells. Mid Atlantic Lipid
Research Symposium. 1998.
Scicchitano, M.S., D.C. McFarland, L.A. Tierney, P.K. Narayanan and Lester W. Schwartz. In vitro
Expansion of Human Cord Blood CD36+ Erythroid Progenitors: Temporal Changes in Gene and
Protein Expression. FASEB Journal. 2001. Late Breaking Abstracts, LB418, pg. 76.
L. Tierney, J. Alston, D. Dalmas, M. Scicchitano, R. Boyce, L. Schwartz. Comparison of Regional
Hepatic CXCR2 Gene Expression in Dog and Rabbit Using Laser Capture Microdissection and in
situ hybridization. Veterinary Pathology. 2001. 38(5): 599.
D. Zimmerman, J. Alston, L. DeBoer, M. Scicchitano, L. Tierney, R. Boyce, and L. Schwartz.
Optimization of an Automated Non-isotopic in situ Hubridization Protocol. Veterinary Pathology.
2001. 38(5): 598.
Scicchitano, M.S., Kokan, S., Byers, S., McFarland, D.C., Tierney, L.A. and L.W. Schwartz. Effect
of p38 Inhibitors on Cytokine Production in Human Bone Marrow Stromal Cells: A Comparison
With Inhibitors of the NFkB, Protein Kinase C and MEK1 Pathways. 2002. Accepted as an Oral
Presentation for the International Society of Experimental Hematology. Experimental
Hematology. 2002. 30(6):77.
Dalmas, D., M. Scicchitano, C. Zhang, D. McFarland, L. Tierney, P. Naraynan and L. Schwartz.
Effects of p38 MAP Kinase Inhibitors on the Maturation and Differentation of Murine Erythroid
Progenitor Cells. Experimental Hematology. 2002. 30(6):63.
N. Aiyar, J. Disa, Z. Ao, L. Patel, M. Scicchitano, D. Zimmerman, R. Boyce, C. Macphee, Stephen
A Douglas. Neuromedin U and its receptor GPR66, as potential mediators of vascular inflamation
and atherosclerosis. FASEB Journal. 2003. 17(5) A1051.
M. Scicchitano, R. Thomas, D. McFarland, P. Narayanan, H. Thomas, L. Tierney, and L. Schwartz.
Transcriptional phenotyping of circulating endothelial cells from sorted rat whole blood. Accepted
as an oral presentation for the American College of Veternary Pathology Meeting. Veterinary
Pathology. 2003. 40(5) 626.
D.Dalmas, MS Scicchitano, D Zimmerman, LA Tierney, RW Boyce, LW Schwartz. Validation of
potential therapeutic targets using laser capture microdissection and real-time RT-PCR analysis.
Veterinary Pathology. 2003. 40(5) 623.
D. Dalmas, MS Scicchitano, Y Chen, KB Tan, RW Hantuk, LA Tierney, RW Boyce, LW Schwartz.
Expression profiling of drug-induced vascular injury: methods development. Veterinary
Pathology. 2003. 40(5) 624.
R. Thomas, M. Scicchitano, W. Bao, D. Zimmerman, R. Mirabile, M. Tirmenstein, S. Rehm, L.
Tierney, R. Boyce, T.L. Yue, Lester Schwartz. Oxidative Stress Indicators in a Murine Cardiac
Ischemia/Reperfusion Model. Veterinary Pathology. 2003. 40(5) 606.
D. C. McFarland, M. S. Scicchitano, R. A. Thomas, P. K. Narayanan, L.W. Schwartz and H. C.
Thomas. 6-color Flow-Sorting of Rat Circulating Endothelial Cells and Subsequent Taqman™
Real-time PCR Analysis. Cytometry. 2004. 59A, p65.
MS, Scicchitano, DC, McFarland, LA, Tierney, DA Dalmas, M. Cassium, K. Alexander and LW,
Schwartz. Effect of p38 MAP Kinase inhibition on transcription factor activity in LPS stimulated
human bone marrow stromal cells. FASEB Journal. 2004. 18(4) A1199. 792.11.
DA Dalmas, MS Scicchitano, Y Chen, KB, Tan, RW Hnatuk, LA Tierney, RW Boyce and LW
Schwartz. Utility of laser capture microdissection (LCM), RNA linear amplification (LA) and
GeneChip expression analysis to investigate drug-induced vascular injury. FASEB Journal.
2004. 18(4) A566. 385.2.
DA Dalmas, MS Scicchitano, Y Chen, HC Thomas, LA Tierney, RW Boyce, S Clark, LW Schwartz.
Transcriptome Analysis of Microdissected Mesenteric Vascular Elements from Rats Given SKF-
82526 (Fenoldopam). Cardiovascular Pathology. 2004. 13(3) Suppl. 1.
R Mirable, D Zimmerman R Thomas MS Scicchitano R Boyce and LW Schwartz. Cathepsin S
expression in adult murine tissues. J Histochemistry & Cytochemistry. 2004. 52:S53.
D. Zimmerman, D. Dalmas, M. Scicchitano, J. Kane, R. Boyce, D. Ennulat and L. Schwartz.
Functional Diversity of U-II/GPR14 Suggested by Expression Profiles of GPR14 in Rat and Non-
Human Primate Tissues. J. Histochem Cytochem. 2004. 52:S57.
KS Frazier, JB Nold, MS Scicchitano, R Thomas, E Grygielko, N Laping, F Gellibert, A DeGouville,
S Huet. Physeal Hypertrophy is a Pharmacologic Biomarker for Transforming Growth Factor-
Beta Receptor Inhibitory Activity in Rats. Veterinary Pathology. 2004. 41(5), p. 588.
DA Dalmas, MS Scicchitano, Y Chen, HC Thomas, P Narayanan, LA Tierney, RW Boyce, S Clark,
LW Schwartz Analysis of Microdissected Mesenteric Vascular Elements from Rats Given SKF-
82526 (Fenoldopam): Temporal Gene Expression Using Affymetrix GeneChip®. Accepted as an
Oral Presentation for the American College of Veterinary Pathology Meeting. Veterinary
Pathology. 2004. 41(5): 587
DA Dalmas, MS Scicchitano, Y Chen, H Olsen, LA Tierney, PK Naraynan, HC Thomas, RW
Boyce, S. Clark and L Schwartz. Differential gene expression in microdissected mesenteric
vascular elements of rats1-hour following fenoldopam (SKF-82526) administration.
Toxicological Sciences. 2005. 84(S-1): 373.
AR Chadderton, R Kartikeyan, C Zhang, P Bushdid, M Schiccitano, RL Clark, TE White.
Hematopoiesis and Erythopoiesis in the Rat Embryo and Visceral Yolk Sac. Birth Defects
Research Part A 2005. 73, 297.
DC McFarland, DC Pietrzak, LM Stork, KS Tatsuoka, M Cool-Bainter, M Magid-Slav, RA Thomas,
G. Paulazzo, R Ray, MS Scicchitano and HC Thomas. Methodological considerations for
identification, enumeration and isolation of circulating endothelial and endothelial progenitor cells
using magnetic sepatation and flow cytometry for subsequent gene array analysis. Gordon
Research Conference: Endothelial Cell Phenotypes in Health and Disease. 2006.
L Dubois, D Dalmas, M Scicchitano, D. Schlatzer, M. Moyer, J Liu, A Moseley, N Cariello, M
Darfler, K Blackburn. Biomarker Proteomics from Formalin-Fixed Paraffin-Embedded Liver and
Breast Tissue Sections. 55th ASMS Conference on Mass Spectrometry and Allied Topics,
Indianapolis, IN, 2007.
Marshall S. Scicchitano, Deidre A. Dalmas, Rogely W. Boyce, Ken Frazier, Heath C. Thomas.
Obtaining mass spectrometry proteomic information from Formalin-Fixed Paraffin-Embedded
(FFPE) tissue: Comparison to frozen OCT-embedded tissue. American College of Veterinary
Pathology Meeting. Veterinary Pathology. 2007. 44(5): 784.
Marshall S. Scicchitano, Deidre A. Dalmas, Kendall S. Frazier, Rogely W. Boyce, Heath C.
Thomas. Proteomic (LC/MS/MS) Analysis of FFPE Rat Liver to Identify Atorvastatin Regulated
Proteins: Comparison to Frozen OCT Embedded Liver Tissue. Toxicological Sciences. 102(1)
Abstract #1596.
Roberta A. Thomas, Dana C. Pietrzak, Marshall S. Scicchitano, David C. McFarland, Kendall S.
Frazier, Heath C. Thomas. Assessing circulating endothelial cell progenitors as a source for
potential biomarkers of drug-induced cardiovascular toxicity in the rat. Oral Platform Presentation.
Toxicological Sciences. 108(1) Abstract #723.
Marshall S. Scicchitano, Roberta A. Thomas, William K. Weiner, Kendall S. Frazier, Heath C.
Thomas. Use of microRNA expression adds a regulatory component to microarray data: a case
study. Toxicological Sciences. 108(1) Abstract #1016.
D Dalmas, L Drobatz, S Hughes, E Moore, K Frazier, H Thomas, M Scicchitano. Novel Methods to
Assess Gene Expression in Nasal Epithelium Collected from Conscious Cynomolgus Monkeys.
2011 Society of Toxicology Meeting.
Roberta A. Thomas, Kendall S. Frazier, Heath C. Thomas, and Marshall S. Scicchitano.
microRNA Changes in Rat Mesentery and Plasma Associated with Drug-Induced Vascular Injury.
2011 Society of Toxicology Meeting.
Deidre Dalmas, Scicchitano MS, DW Morel. In vitro Evaluation of Murine-specific Vascular
Toxicity Induced by an Integrin Antagonist. 2012 Mid-Atlantic Pharmacology Society Meeting.
Roberta Thomas and M. Scicchitano. microRNAChanges in Rat Mesentery and Serum
Associated with Drug-Induced Vascular Injury. Oral presentation at 2012 Society of Toxicology
Meeting.
Deidre Dalmas, Heath Thomas, Marshall Scicchitano. Circulating mRNA Changes in Rat Serum
Associated with Drug-Induced Vascular Injury. 2013 Society of Toxicology Meeting.
Deidre Dalmas, Kimberly Roland, Kendall Frazier, Heath Thomas, Marshall Scicchitano.
Involvement of Shear Stress in Fenoldopam and Dopamine Induced Mesenteric Medial Arterial
Necrosis. 2013 Society of Toxicology Meeting.
Publications
Mao, L., Schoenberg, P., Scicchitano, M., Merlo, A., Schwab, D. and David Sidransky. Molecular
detection of primary bladder cancer by microsatellite analysis. Science. 271:659-662, 1996.
Harnish, D., Scicchitano, M. and Sotirios K. Karathanasis. Estrogen Regulation of the
Apolipoprotein AI Gene Promoter Through Transcription Cofactor Sharing. Journal of
Biochemistry. 273:9270-9278, 1998.
Breithofer, A., Graumann, K., Scicchitano, M., Karathanasis, S., Butt, T. and Alois Jungabuer.
Regulation of human estrogen receptor by phytoestrogens in yeast and human cells. Journal of
Steroid Biochemistry and Molecular Biology. 67(5-6):421-429, 1998.
Kilbourne, E. and Marshall Scicchitano. The Activation of Plasminogen Activator Inhibitor-1
Expression by IL-1B is Attenuated by Estrogen In Hepatoblastoma HePG2 Cells Expressing
Estrogen Receptor Alpha.Thrombosis and Heameostasis. 81:423-427, 1999.
Harnish C.D., Scicchitano, M.S., Adelman, S.J., Lyttle, R.C. and Sotirios K. Karathanasis. The
Role of CBP in Estrogen Receptor Cross-Talk with Nuclear Factor-kB in HepG2 Cells.
Endocrinology. 141:3403-3411, 2000.
Scicchitano, M.S., D.C. McFarland, L.A. Tierney, P.K. Narayanan and Lester W. Schwartz. In vitro
Expansion of Human Cord Blood CD36+ Erythroid Progenitors: Temporal Changes in Gene and
Protein Expression. Experimental Hematology. 31(9):760-769, 2003.
Zimmerman, D., Scicchitano, MS, Dalmas, D., Thomas, R., Tierney, LA., De Boer, L, Boyce, R.,
and Lester Schwartz. Automation of Non-Isotopic In Situ Hybridization. Journal of
Histochemistry. 26(3): 181-184. 2003
Tirmenstein, MA, C.X. Hu, M.S. Scicchitano, P.K. Narayanan, D.C. McFarland, H.C. Thomas and
Lester W. Schwartz. Effects of 6-Hydroxydopamine on Mitochondrial Function and Glutathione
Status in SH-SY5Y Human Neuroblastoma Cells. Toxicology in Vitro. 19:471-479, 2005.
Dalmas, D.A., Scicchitano, M.S., Zimmerman, D., Tierney, L.A., Boyce, R.W. and Lester W.
Schwartz. Target gene localization using laser capture microdissection and Real-Time RT-PCR
analysis. Journal of Histotechnology. 28(3):177-180, 2005.
Scicchitano, M.S., D.A. Dalmas, M.A. Bertiaux, S.M. Anderson, L.R. Turner, R.A. Thomas and
Rogely W. Boyce. Preliminary comparison of quantity, quality, and microarray performance of
RNA extracted from formalin-fixed paraffin- embedded and unfixed frozen tissue samples.
Journal of Histochemistry & Cytochemistry. 54-11-122*-****, 2006.
Frazier KS, Thomas RA, Zimmerman DA, Scicchitano MS, Mirabile RC, Grygielko E, Nold J,
Boyce RW, DeGouville A-CM, Huet SR, Laping NJ, and Gellibert FJ. Inhibition of ALK5 Signaling
Induces Physeal Hypertrophy in Rats. Toxicologic Pathology. 35(2) 284-292, 2007.
D.A Dalmas, M.S. Scicchitano, Y. Chen, L.A. Tierney, S. Clark, H. Thomas, R.W. Boyce and
Lester W. Schwartz. Transcriptional profiling of laser capture microsdissected rat arterial
elements: Fenoldopam-induced vascular toxicity as a model system. Toxicologic Pathology.
36(3) 496-519. 2008.
Scicchitano, M.S., McFarland DC, Tierney LA, Frazier K, Thomas H. Role of p38 in Regulation of
Hematopoiesis: Effect of p38 Inhibition on Cytokine Production and Transcription Factor Activity in
Human Bone Marrow Stromal Cells. Blood, Cells, Molecules and Disease. 40(3) 370-380.
2008.
Dalmas, D.A., Zhang, C., McFarland, D.C., Tierney, L.A., Narayanan, P.K., Thomas, H., and
Lester W. M.S. Scicchitano. Effects of p38 MAP Kinase Inhibitors of Differentiation and
Maturation of Erythroid Progenitor Cells. Accepted: Toxicologic Pathology. 36(7) 958-971.
2008.
Thomas, RA, Pietrzak, DC, Scicchitano, MS, Thomas, HC, McFarland, DC,, Kendall S. Frazier.
Detection and phenotypic and genotypic characterization of a circulating endothelial progenitor
population in normal rat blood. Journal of Pharmacological & Toxicological Methods. 60(3)
263-274. 2009.
Scicchitano MS, Dalmas, DA, Thomas RA, Boyce RW, Frazier KA, Thomas HC. Formalin-fixed
paraffin-embedded tissue yields robust proteomic profiles by mass sprectometry. Journal of
Histochemistry & Cytochemistry. 57(9) 849-860. 2009.
Dalmas DA, Scicchitano MS, Mullins D, Tatsuoka K, Magid-Slav M, Hughes-Earle A, Frazier KS,
Heath C. Thomas. Potential Candidate Genomic Biomarkers of Drugs Induced Vascular Injury in
the Rat. Toxicology and Applied Pharmacology. 257(2) 284-300. 2011.
Thomas RA, Scicchitano MS, Chau N, Frazier KS, Heath C. Thomas. microRNA Changes in Rat
Mesentery and Plasma Associated with Drug-Induced Vascular Injury. Toxicology and Applied
Pharmacology. 262(3) 310-320. 2012.
Mikaelian I, Scicchitano MS, Mendes O, Thomas RA, Bruce E. Leroy. Frontiers in Preclinical
Safety Biomarkers: MicroRNAs and Messenger RNAs Manuscript Toxicologic Pathology.
41:18-31. 2013.
Dalmas DA, Scicchitano MS, DW Morel. In vitro Evaluation of Murine-specific Vascular Toxicity
Induced by an Integrin Receptor Antagonist (SB-273005). Toxicology In Vitro. 27:272-281. 2013.
Fraizer K, Sorby C, Castillo V, Scicchitano M, et al.. Glomerular Lesions Associated with Chronic
Administration of an Antisense 2’-OMe Oligonucleotide Therapy Have an Immune-Mediated
Pathogeneisis in Mice and Monkeys. Toxicologic Pathology. 42, epub ahead of print, 2014).
DOI 1Q1177/0192623313505781
Mikaelian I, Scicchitano MS, Dalmas DA. et al. Nonclinical Safety Biomarkers of Drug-Induced
Vascular Injury: Current Status and Blueprint for the Future. Toxicologic Pathology 42:635-657.
2014.
Kendall S. Frazier, Jeff Engelhardt, Pierluigi Fant, Silvia Guionaud, Scott P. Henry, Michael Leach,
Calvert Louden, Marshall S. Scicchitano, James L. Weaver,Tanja S. Zabka. Drug-Induced
Vascular Injury associated with non-traditional therapeutics in preclinical development. Part I.
Biotherapeutics. Society of Toxicologic Pathology Vascular Injury Working Group. Submitting to
Toxicologic Pathology.
Jeff Engelhardt, Pierluigi Fant, Silvia Guionaud, Scott P. Henry, Michael Leach, Calvert Louden,
Marshall S. Scicchitano, James L. Weaver, Tanja S. Zabka, Kendall S. Frazier. Drug-Induced
Vascular Injury associated with non traditional therapeutics in preclinical development. Part 2.
Antisense oligonucleotide associated vasculitis. Society of Toxicologic Pathology Vascular Injury
Working Group. Submitting to Toxicologic Pathology.
Dalmas DA, Lynch K, Chau N, and MS Scicchitano. A Comparative Study of Gene Expression
Changes in Frozen vs Archived, Formalin-Fixed Paraffin Embedded Liver Samples from Rats
treated with a LDL-Receptor Antagonist. Manuscript in Preparation.
Thomas RA, Gales T, Casey W, Frazier K, Scicchitano MS Genotypic and Ultrastructural
Differences in the RPE and Outer Segments of the Mid-Peripheral and Central Retina in the Rat.
Manuscript in Preparation.
Dalmas DA, Kendall S. Frazier KS, Heath C. Thomas, MS Scicchitano. Circulating Genomic
(mRNA) Biomarkers Drug-Induced Vascular Injury in the Rat. Manuscript in Preparation.
Oral Presentations
Invited speaker: International Society of Experimental Hematology Meeting. 2002. Effect of
p38 Inhibitors on Cytokine Production in Human Bone Marrow Stromal Cells: A Comparison with
Inhibitors of the NFkB, Protein Kinase C and MEK1 Pathways.
Invited speaker: American College of Veternary Pathology Meeting. 2003. Transcriptional
phenotyping of circulating endothelial cells from sorted rat whole blood.
Invited speaker: Cambridge Healthtech Institute Meeting. 2009. Advances in Gene Expression
Profiling.
Invited speaker: 2012. Society of Toxiclogy Meeting. Symposia entitled - Circulating
microRNAs, a new class of biomarkers for tissue-specific toxicity.
Invited speaker: 2012. American College of Veterinary Pathology Meeting. Obtaining Quality
Genomic/Proteomic Information from Frozen and FFPE Tissue Blocks: Pitfalls and Caveats.
Chaired a Plenary Session at the 2013 American College of Veterinary Pathology Meeting
entitled: Epigenetics: Biologic Targets, Biomarkers and Role in Disease.
Invited Speaker: 2014 . Applied Pharmaceutical Toxicology Meeting. Current State of
Toxicogenomics.
Patents
U.S Patent Number 7,094,559. Assay To Identify Estrogen Receptor Dependent Ligands That
Regulate Hepatic Lipase Promoter. Harnish, D.C., Scicchitano, M.S., Hsiao, C.L. and S.
Karathanasis. American Home Products Corporation
U.S. Patent Number 7,208,300. Cloning of a Novel Member of the lysyl oxidase gene family.
Evans; Mark J, Scicchitano; Marshall S., Bapat; Ashok R., Bhat; Ramesh A., Mastroeni; Robert,
Karathanasis; Sotirios K. American Home Products Corporation
Other Information
Previous reviewer for the following journals:
Experimental Hematology, Experimental and Molecular Pathology, Veterinary Pathology,
Cell Proliferation, European Cytokine Network, Toxicologic Pathology
I am a very hard working self motivated individual with excellent communication and interpersonal
skills. I have the ability to work well under pressure and always strive for endpoints that are far
beyond my job requirements.
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Contact this candidate