Z ach (Zhida) Zheng

Address: *** ******* ****, ************ ** 08094

Cell: 812-***-****; Email:acg8yl@r.postjobfree.com

PROFESSIONAL

O VERV IEW

S tatistician with 4 year PhD t raining, a Master’s degree and experience in Pharmaceutical

i ndustry

Proficient SAS Programmer, R Programmer

Available from Feb 15, 2015

OBJECT IVES

Full t ime positions as:

Data Scientist Biostatistician Statistical Business

SAS/R Programmer Statistical Consultant A nalyst

Applied Statistician

EDUCAT ION

Bloomington, I N

A.B.D/M.S. (Dec,2014) in Statistics I ndiana University

Bloomington, I N

M.S. (Aug,2011) i n Applied I ndiana University

S tatistics

Bloomington, I N

M.S. (Aug,2011) i n Biochemistry I ndiana University

Changchun,

B.S. (July,2001) in Chemistry Jilin University

C HINA

STATIST ICAL SOFTWARE

Proficient user of SAS for 6 years: SAS Base, SAS Graph, SAS Stats, SAS Advance,

SAS/Macro.

U se SAS EM (Enterprise Mine) to do predictive modeling

U se SAS/JMP to create graphs and charts, discover patterns, explore and summarize large

dataset

2010 Certified Based Programmer for SAS

2010 Certified Advanced Programmer for SAS

Proficient with R for 6 years

Proficient with Matlab for 3 years

RESEARCH EXPER IENCES

PhD dissertation: Comparative Network Analysis: With Applications to Brain Networks. Sep,

2013-Aug, 2014

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Zach (Zhida) Zheng: Resume

F unctional Magnetic Resonance Imaging (fMRI) and D iffusion Tensor Imaging (DTI) data

were collected from schizophrenia and healthy participants by t he Imaging Research Facility

a t Indiana University .

• Applied Network analysis to the functional and structural networks which were

constructed from fMRI and DTI data.

• Proposed new methods to detect the community structure of brain and then

conducted network analysis at local, global, and community level of the human

b rain network.

• Obtained in teresting results and statistically proved that some regions of the

b rain were related to schizophrenia disease.

Gene Expression Data Analysis for Beetle project. Sep 2012-Aug, 2013

Gene expression data were collected from 16 unbalanced different classes of 96 beetles by the

researchers in the Center for Genomic Biology at Indiana University.

• Applied least square regression to the gene expression data

• Employed Turkey’s biweight function to identify outliers in groups of small

sample size and verified the methods by simulation study.

• Proposed a robust linear regression method by modifying the least square

regression with Turkey’s biweight function.

• Successfully identified significantly differential expression of genes by our

robust linear regression combined with FDR.

Factors Affecting Employment Among Informal Caregivers Assisting People with

M ul tiple Sclerosis. Sep, 2011-Aug, 2012

Data were collected during telephone interviews with 530 MS caregivers, including 215

employed caregivers.

• Analyzed the survey data using logistic regression to identify characteristics of

i nformal caregivers, caregiving, and the people with multiple sclerosis (MS)

receiving assistances that were associated with reduced caregiver employment.

WORK ING EXPER IENCES

Consultant (Contractor), Oct 2013-Dec, 2014

GPRD Neuroscience Development, Abbvie, North Chicago, I L

• Provided individual consultancy expertise and conducted data analysis for

P hase I I/I I I clinical t r ial:

E valuated the Efficacy and safety of ABT-126 in subjects with Mild to moderate

A lzheimer’s Disease;

Supported the analysis of blinded data for ongoing ABT-126 CIAS (Cognitive

I mpairment Associated with

Schizophrenia) Studies

• Analyzed ADNI (Alzheimer’s Disease Neuroimaging Ini tiative) data, ADCS

(Alzheimer’s Disease

Cooperative Study) data, and CAMD (Coalition Against Major Diseases) data

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• Simulated clinical t rials in Alzheimer’s disease

Statistician In tern, M ay 2013-Aug 2013

GPRD Neuroscience Development, Abbvie, North Chicago, I L

• Conducted primary and secondary endpoint analysis for Alzheimer’s disease

• Survival analysis for the Alzheimer’s disease study

• Applied I tem Response Theory to evaluate the i tem performance of ADAS-Cog,

M MSE, NPI and ADCS-ADL.

• Used the generalizability theory to evaluate the rater’s impact on the variabili ty

of AD rating scale total scores.

• Conducted analysis of ADNI (Alzheimer’s Disease Neuroimaging initiative) and

CAMD (Coalition Against Major Diseases) data

Consulting Associate, Jun 2012-Aug 2012

Indiana Statistical Consulting Center, Bloomington, I N

• Performed structural equation modeling and factor analysis

• Fit generalized linear/additive mixed-effect models

• Fit survival modes to panel longitudinal data

• Used JAGS to do MCMC in R and perform post simulation inference and

g raphing in R

• Fit zero-inf lated and other mixture modes in R

• Performed r idge regression and LASSO in R

• Developed I UPS (Incorporating Uncertainties in Propensity Scores) R-package

Associate Instructor, A ug 2011-May 2014

Department of Statistics, Indiana University, Bloomington, I N

• Assisted the instructor with grading assignments and exams, proctoring exams,

and holding office hours and review sessions

Research Associate, M ar 2005-Aug 2011

Department of Biochemistry, Indiana University, Bloomington, I N

• Structural studies of protein-ligand interactions

• Developed methods for protein expression, purification, characterization, and

s tructure determination

• Primer design, gene cloning, and mutagenesis study

Research Scientist, Oct 2003-Feb 2005

The HongKong Polytechnic University, Hongkong, China

• Organic synthesis of drug intermediate

Research Scientist, J ul 2001-Sep 2003

Beijing Institute of Pharmacology and Toxicology, Beijing, China

• Organic synthesis of the anti-HBV drug: Entecavir

ME MBERSH IP

• American Statistical Association (ASA) since 2013

• Casualty Actuarial Society (CAS) since 2012

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Zach (Zhida) Zheng: Resume

P UBL ICAT IONS

• An, W., Xu, H., Z heng, Z . I ncorporating Uncertainties in Propensity Scores

(http://cran.r-project.org/web/packages/IUPS/index.html ) (2013)

• Buchanan, R., Huang, C., Z heng, Z . Factors Affecting Employment Among

I nformal Caregivers Assisting People with Mul tiple Sclerosis. I nternational

J ournal of Multiple Sclerosis Care (2013)

• Zheng, Z ., B iochemical and Mutational Studies of Quorum Sensing

A ntiactivation TraM-TraR Complex in Rhizobium sp. NGR-234

System(http://www.amazon.com/Biochemical-Mutational-Antiactivation-TraM-

TraR-Rhizobium/dp/124*******/ref=sr_1_1?s=books&ie=UTF8&qid=

137*******&sr=1-1)(2012)

• Zheng, Z ., Fuqua, C., and Chen, L. T he binding site of DNA on quorum-sensing

t ranscript factor TraR does not overlap with that of the Anti-Activator .

B iochemical and Biophysical Research Communications (2012).

• Zheng, Z., Ma, D., Yahr, T.L., and Chen, L. The t ransiently ordered regions in

i nt r insically disordered ExsE are correlated with structural elements involved

i n chaperone binding. B iochemical and Biophysical Research Communications,

i n press (2011).

• I l l ingworth, M., Ramsey, A., Z heng, Z., and Chen, L. Stimulating the substrate

folding activity of a single-r ing variant GroEL by modulating the cochaperonin

G roES. Journal of Biological Chemistry 286 (35): 30401–30408 (2011).

• Pan, Y., Fiscus, V., Meng, W., Z heng, Z ., Zhang, L-H., Fuqua, C., & Chen, L.

T he Agrobacterium tumefaciens t ranscription factor BlcR is regulated via

oligomerization. Journal of Biological Chemistry 286 (23): 20431–20440 (2011)

• L i Y., Z heng Z., Ramsey A., & Chen L . Analysis of peptides and proteins in

t heir binding to GroEL. J Pept Sci.16:693-700 (2010).

• Zheng, Z ., Chen, G., Joshi, S., Brutinel, E. D., Yahr, T. L. & Chen, L.

B iochemical characterization of a regulatory cascade controlling t ranscription of

t he Pseudomonas aeruginosa t ype I I I secretion system .J. Biol. Chem. 282: 6136-

6142 (2007).

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