Mechanical Engineering Engineer

Tim Chang

*******@*****.***

**** **** ********** **** *, Apt# D213 • Renton, WA 98056 • 206-***-****

OBJECTIVE

Seeking a full-time engineer position where I can apply my expertise in fluid physics, prototyping, biological

assay, and computational analysis experience to solve problems in the development of microfluidic

technology

EDUCATION

University of Washington, Seattle, WA

• Ph.D. in Bioengineering, August 2014

Chung Yuan Christian University, Chung Li, Taiwan

• M.S. in Mechanical Engineering, July 2007

• B.S. in Mechanical Engineering, July 2005

SUMMARY OF QUALIFICATIONS

• Over 6 years of experience in MEMS, microfabrication, microfluidics, device prototyping, cell- and

tissue-based assays, immunoassay, fluorescence and confocal microscopy

• Software literate in AutoCAD, Inventor, COMSOL, MATLAB, Image J

• Other experience: Surface modification, 3D printing, Thermal bonding, Western blot

• Fluent in English and Mandarin

RESEARCH EXPERIENCE

University of Washington, 2008-2014

Dissertation: Towards personalized cancer therapy: microfluidic approaches for drug screening

• Developed a microfluidic device that integrates live slice cultures with an intuitive multiwell

platform that allows for exposing the slices to multiple compounds at once or in sequence

• Designed biological assays and experiments to demonstrate the proof of concept in cancer

diagnostics on intact tissues and to characterize the fluid transport in porous structures

• Created quantitative methods to measure drug response in tissue slices using automated microscopy,

image processing, and cell recognition software

• The accomplished research work has been awarded by National Cancer Institute with a top 7

percentile and a high impact score

Collaborations: Formed collaborations in multiple projects with different expertise.

• Dr. Robert C. Rostomily, Institute for Stem Cell and Regenerative Medicine, School of

Medicine/Neurosurgery, University of Washington

Developed a microfluidic diagnostic device with a user-friendly interface for drug testing on

o

tumor slice culture models

• Dr. Raymond J. Monnat Jr., Pathology/Genome sciences, University of Washington

Investigated the lack of WRN protein in response to the proliferation of primary human

o

fibroblasts for the study of cellular senescence

Chung Yuan Christian University, Research Assistant, 2005~2007

Dissertation: High-throughput QCM biosensor for measuring protein concentration

INTERN EXPERIENCE

Inotera Memories (DRAM manufacturing company), Taiwan, 2005-2007

Programmer in the Advanced Engineering Services Division

Responsibilities include:

• Developed computer programs using MATLAB to establish a real-time feedback model for the

control of the manufacturing machines, and ultimately increase the production yield

• Presented the work progress in the team group meetings biweekly

TEACHING EXPERIENCE

University of Washington

• Supervised > 5 undergraduate students for their capstone projects

• Instructed > 50 students in microfabrication techniques

PATENT

“Microfluidic Assay Apparatus and Methods” US 61/716,214, October 19, 2013.

• This invention describes a microfluidic method which allows for the multiplexed delivery of soluble

compounds to an intact tissue slice or biopsy. The novelties include an integration of microfluidic

devices with multi-well plates, modular tissue culture platform, and diffusion-based selective mass

transport.

PUBLICATIONS

Boardman, T. Chang, A. Folch, and N.J. Dovichi. Indium-Tin Oxide Coated Microfabricated Device for the

Injection of a Single Cell into a Fused Silica Capillary for Chemical Cytometry, Analytical Chemistry USA

2010; 82(23):9959-9961

T. C. Chang, A.M. Mikheev, R.J. Monnat, Jr., R.C. Rostomily, and A. Folch. Parallel Microfluidic

Chemosensitivity Testing on Individual Slice Cultures, under review

T. C. Chang, W. Tang, W.J.H. Koh, A.J.E. Rettie, M.J. Emond, R.J. Monnat, Jr., and A. Folch. Microwell

Arrays Reveal Cellular Heterogeneity during the Clonal Expansion of Transformed Human Cells, under

review

J. Cheng1, T. C. Chang1, N. Bhattacharjee, A. Folch. An Open-Chamber Flow-Focusing Device for Focal

Stimulation of Micropatterned Cells, in preparation

A. K. Au, N. Bhattacharjee, T. C. Chang, and A. Folch, 3D-Printed Fluidic Automation, in preparation

Y. Chang, Y. Kang, C. Hsu, C. Chang, and T. Chan. Virtual Metrology Technique for Semiconductor

Manufacturing. IEEE, Neural Networks, 2006 IJCNN 06: 5289-5293

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