Research Scientist

Martin Rogers

P.O. Box ***

Lansdale, PA *****

Cell 610-***-****

**********@*****.***

SUMMARY

Research Scientist with expertise in Metabolism and Pharmacokinetics in the

pharmaceutical industry. Honorably discharged U.S. military veteran with

excellent leadership and interpersonal skills. Primary strengths include a

hands-on, creative self- starter with excellent time management,

organizational, writing and oral communication skills, along with report

and document review experience. Able to work independently or in a team

environment. High degree of personal and professional dedication to

integrity and quality. Computer literate with proficiency in several

software applications, including Microsoft Office Professional,

ChemStation, Laura, SMS, WinNonLin, Xcalibur, SigmaPlot, and various

literature search applications.

Technical Skills:

. Biotransformation: Study Director; In Vitro/In Vivo/In-life; HPLC

Method Development/Profiling (HPLC 1100/1200, LTQ MS); Report

Writing/Reviewing; P450 inhibition

. Pharmacokinetics: Study Director; In Vitro (Protein Binding, Red Blood

Cell Partitioning); In Vivo/In- life (rodents, lagomorphs, dogs,

nonhuman primates); Report Writing/Reviewing

. Toxicokinetics: Principle Investigator/Responsible Scientist: In-life;

Data Analysis; Toxicology Report Contributions; Report

Reviewing/Quality Control; PBPK (modeling)

. Safety: Radiation Safety Committee Member; Principal Radiation User;

Safety Coordinator

. Additional Knowledge: Project Representative (in training); LC/MS

(LTQ, HRMS, MS Interpretation, & NMR; Western Blotting, PCR and Gel

Electrophoresis; Knowledge in RNA Isolation, cDNA Synthesis and

TaqMan; Histological Skills.

PROFESSIONAL EXPERIENCE

INDEPENDENT STUDY / TRAINING / SELF EMPLOYMENT

2011 - Present

. Independent Study/Training - Attended webinars and viewed various

training slides/presentations; researched industry leaders and tracked

industry trends; and participated in networking discussions.

. Owner, Farm & Land Management - Managed and restored year 1850

farmhouse and outbuildings; preserved 3 acres of farmland, along with

orchards, forests, apiary, greenhouse and gardens.

GlaxoSmithKline Pharmaceuticals, King of Prussia, PA

2001 - 2011

Senior Scientist

Designed, coordinated, conducted and reported preclinical radiolabeled and

non-radiolabeled absorption, distribution, metabolism and excretion (ADME)

studies. Supported toxicology studies with provision of toxicokinetic data

as Principal Investigator/Responsible Scientist. Received several

promotions from Associate Scientist to Scientist and Senior Scientist.

Research & Development:

Technical

. Developed HPLC methods and assisted other profilers with the HPLC

Method Development of candidate selected compounds through LC/MS.

. Developed sample preparation/extraction methods for plasma, liver,

bile, urine, and feces for metabolite identification and

quantification.

. Assisted on the isolation of metabolites via prep-LC for NMR analysis.

. Conducted monthly calibrations on the LTQ MS; Performed preventive

maintenance and repairs on various equipment, and maintained equipment

logs, as HPLC Pod Leader/Repair Team member.

In Vivo/In Vitro

. Independently set-up and conducted metabolism assays (P450 inhibition,

metabolic stability, microsome/hepatocyte incubation) and PK studies

(including dose prep, dosing, and sample collection, protein binding,

blood cell partitioning) for DMPK, to evaluate the performance of drug

candidates from drug discovery programs and development programs.

. Coordinated, conducted and reported non-radiolabeled human metabolism

studies.

. Prepared cold [12C] and radiolabeled [14C] stock solutions and dose

formulations for in vitro/in vivo studies.

. Supported toxicology studies with provision of toxicokinetic data as

Principal Investigator/Responsible Scientist.

. Collaborated with various departments to help develop a model of

testosterone homeostasis in the rat (PBPK).

Safety

. Represented the DMPK department as a member of the Radiation Safety

Committee; and trained Radiation Users in the safe use of sources of

radiation within the department, as the PRU.

. Represented the DMPK department as a Safety Coordinator, ensuring the

safety of the first floor employees during an emergency situation.

. Received 5 GSK R&D Recognition Awards for performance and the

development of compounds.

Kelly Scientific (SB Pharmaceuticals), King of Prussia, PA

2000 - 2001

Research Assistant

Conducted and/or assisted with over 150 in vivo and in vitro PK studies to

evaluate the performance of drug candidates from drug discovery programs

and development programs.

. Ran all phases of a study for more than 40 PPK studies, including

protocol, study conduct, data analysis, and report generation and

communication of study results.

. Interpreted metabolism and pharmacokinetic results, in vivo/in vitro

extrapolation, and PK/PD relationships, which were presented to the

team in a timely fashion (less than 2 days).

. Supported Lead Scientist and Supervisor in the preparation of dose

formulations.

DAKE Maintenance Services, Newark, DE

1999 - 2000

Maintenance Technician

. Conducted various building repairs and/or renovations in commercial

and residential areas.

John Evans & Sons', Inc., Lansdale, PA

1991 - 1999

Springmaker

. Short-order springmaker: Setup, operated, and PM various machinery and

tooling; used degreasers, passivators, tumblers, vacuum oilers, and

ovens; operated Micro-vu comparator and CATS system (computer-aided

testing system) to inspect product; supervised second shift work crew

when needed.

United States Navy, USS Tuscaloosa LST-1187, San Diego, CA

1986 - 1991

GMG2(SW) Gunner's Mate Second Class (Surface Warfare Specialist)

Equivalent Civilian Occupations: First-Line Supervisor/Managers of Weapons

Specialists.

Weapons Systems/Defense Systems, Small arms, Magazine Sprinkler TL, Damage

Control PO, Work Center Supervisor, LPO, Training PO, Supply PO, Master-at

Arms and Security Alert Team Leader, SSET/SSEW.

EDUCATION

Bachelor of Arts, Biology, Arcadia University, Glenside, PA

Associate in Biological Sciences, Montgomery County Community College, Blue

Bell, PA

College of Lake County, Great Lakes, IL

. Electro-Hydraulic Control Systems, MST-115 (GM School)

Department of the Navy-Chief of Naval Technical Training, Great Lakes, IL

. Basic Electricity & Electronics Certificate (Modules 1-21)

Special training: CPR; First Aid; O2 Provider; Fire Fighting

COMPUTER SKILLS

?Microsoft Word/ Excel/PowerPoint ? ChemStation ? Laura ? SMS 2000

?WinNonLin ?Xcalibur

? Lotus Notes ? Prism ? Graphit ? ISIS Desktop ? Discovery Explorer

?Medline ? Merck ?Index? PDR

? CrossFire ? SciFinder ? Organic Syntheses ? eEROS ? RTECS ?IRIS ? Index

Nominum ?DRUGDEX

AFFILIATIONS

American Association of Pharmaceutical Scientists ? International Society

for the Study of Xenobiotics

Professional Association of Diving Instructors ? United States Parachute

Association

ADDENDUM

Publications/Posters:

Publications:

Deng, Y, Rogers, M, Sychterz, C, Talley, K, Qian, Y, Bershas, D, Ho, M,

Shi, W, Chen, E, Serabjit-Singh, C and Gorycki, P. Investigations of the

Mechanism of Hydrazine Cleavage of Eltrombopag in Humans. Drug Metabolism

Disposition, 39: 1734-1746, 2011.

Posters:

Martin Rogers, Yan Ji, Thomas Neiss. 19F NMR Detection of Fluoroacetic Acid

in Biological Matrices after Dosing with GSK1387891. TKB Department, Drug

Metabolism and Pharmacokinetics Division, GlaxoSmithKline Pharmaceuticals,

2008.

Caroline Sychterz, Martin Rogers, Yanli Deng, Kitaw Negash, and May Ho; In

Vitro and In Vivo Methodology for Investigating the Impact of Intestinal

Microbiota on Drug Metabolism in Humans and Preclinical Species. Drug

Metabolism and Pharmacokinetics, GlaxoSmithKline, 2009.

Kimberley Talley, Caroline Sychterz, Yanli Deng, Martin Rogers; Effect of

Antibiotic Treatment on Eltrombopag Excretion and Systemic Exposure in

Mice. PCD DMEXEC Poster Meeting, GlaxoSmithKline, 2009.

Emile Chen1, Dinesh Stanislaus2, Marty Rogers1, April Apostoli2 and Matt

Szapacs1 Toxicodynamic Modelling of the Hypothalamus-Pituitary-Gonad and

Bone Homeostasis: From Rat to Human. 1: PTS DMPK, 2: PTS Safety

Assessment, GlaxoSmithKline, 2010.

Training/Courses:

? Research & Development

? Drug Metabolism, Drug design & Lead Cmpd. Improvement/Robert P.

Hanzlik, PhD/14, 15-Jan-2002

? PHARMGAME: The Pharmaceutical Business: Drug Discovery-Prod.

Launch/Jan Hammer/04-Feb- 2003

? Introduction to Pharmacokinetics & Pharmacodynamics/ University of

Wisconsin/ 17-19 Oct-2005

? ADME, PK/TK, & Drug Metabolism in Drug Discovery & Development/ CfPIE/

29-30 Mar-2006

? Good Laboratory Practice Training-various/ GSK/ June 2000 (annual)

? Care and Ethical Use of Animals in Research/ GSK/ 01-May-2007

? Laboratory Animal Euthanasia/ GSK/ 19-Jun-2007

? Performing with Integrity/ GSK/ 24-Sep-2004

? Standards for Obtaining Human Tissue for Use in Research/ GSK/ 28-May-

2007

? Principles of PK (DPET 855)/ UNC/ Aug 2009-Dec 2009

? Technical

? Intro to HPLC Training/ Chromatography Forum of DE Valley/ 09-May-2001

? Advanced HPLC Training/ Chromatography Forum of DE Valley/ 05-Jun-2001

? Basics of LC/MS and LC/MS/MS 101/ Cecilia Basic via Waters/ 04, 05-Nov-

2002

? Mass Spectral Interpretation/ Henry Nowicki, PhD/ 20-22 Oct-2004

? Agilent LC Chemstation/ Agilent Technologies/ 24-Sep-2001

? Practical NMR Spectroscopy/ University of Delaware/ 05-Dec-2001

? Advances in Radio-LC & LC-ARC System 2.1 User/ Dian Y. Lee, PhD/ 29-

Jul-2003

? Laura v3.3/GSK/ 07-Oct-2005

? Intro to LC/MS-Industry Applications and Strategies for MS/Mike Lee,

PhD/ 25-26 Jun-2009

? Essential Guide: Understanding Stationary Phase Chemistry Reversed

Phase HPLC/ 07-Jun-2010

? Corporate Policy and Ethics

? Building a Respectful Workplace/ GSK/ 24-Mar-2004

? Management of Clinical Safety Information for GSK Products/ GSK/ 03-

Mar-2005

? Using the GSK Global Records Retention Schedule/ GSK/ 08-Mar-2005

? Dangerous Goods Transport - General Awareness/ GSK/ 17-Jul-2007

? Personal Effectiveness

? Assertiveness from the Inside Out/ GSK/ 09-Jun-2007

? Building Effective Intercultural Relationships/ GSK/ 03-Jun-2007

? Building Relationships to Get Results/ GSK/ 09-Nov-2007

? Leadership

? Recruitment the GSK Way of Interviewing: What You Need to Know Before

You Start /13-Apr-2005

? Recruitment the GSK Way of Interviewing: Preparing For the Interview

/13-Apr-2005

? Recruitment the GSK Way of Interviewing: Conducting an Interview /13-

Apr-2005

? Leadership Framework Overview/ GSK/ 28-May-2007

? Ethical Leadership-Enhance our Reputation/ GSK/ 30-May-2007

? Ethical Leadership-Developing an Ethical Mindset/ GSK/ 30-May-2007

? Ethical Leadership-Being an Ethical Leader/ GSK/ 01-Jun-2007

? Environment Health and Safety

? Bloodborne Pathogen Training/ GSK/ 07-Jun-2000 (annual)

? Cyanide Safety/ GSK/ 10-Jun-2007

? Filtering Face Piece Training/ 11-Apr-2006 (annual)

? Fire Extinguisher Safety/ GSK/ 08-Oct-2004 (annual)

? Radiation User Training/ GSK/ 25-Apr-2001 (annual)

? Principal Radiation User Training/ GSK/ 28-Nov-2001

? GSK Radiation Management System (RAMS) for Radionuclide Inventory/

GSK/ 01-Jun-2006

? Hearing Conservation Program/ GSK/ 22-Nov-2005 (annual)

? Risk Assessment Training/ GSK/ 14-Feb-2002 (annual)

? Laboratory Animal Allergy Training/ GSK/ 16-Oct-2006

? Laboratory Inspection Training/ GSK/ 14-Jun-2007

? Laboratory Safety & Chemical Hygiene/ GSK/ 09-Jun-2005

? Managing Safety/ GSK/ 28-Nov-2005

? Manual Handling/ GSK/ 22-Nov-2005

? Non-Human Primate Training/ GSK/ April 2000 (triennial)

? Respiratory Protection/ GSK/ 11-Apr-2006 (annual)

? Workstation Safety/ GSK/ 22-Nov-2005

? SHARPS Safety in Laboratories/ GSK/ 04-Jun-2007

? Working Safely with OHC4/5 Compounds/ GSK/ 09-Nov-2007

? Project Management

? Elements of Project Time Management/ GSK/ 25-Nov-2006

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