C University

Location:

Omaha, NE

Posted:

September 26, 2014

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Biographical sketch

Applicants Name/PI Name: SUNEET MEHROTRA MBA, PhD.

Position Title: Research Fellow, Department of Pharmacology, Creighton University,

Omaha, NE

Visa Status: Permanent Resident United States of America

EDUCATION/TRAINING

INSTITUTION AND LOCATION DEGREE YEAR(s) FIELD OF STUDY

University of Lucknow, India BS 1991-1994 Chemistry, Zoology

University of Lucknow, India MS 1994-1996 Biochemistry

University of Allahabad, India MBA 1996-1998 Marketing

Erasmus University, The Netherlands PhD. 2002-2006 Pharmacology

A. Positions and Honors.

Positions

1998-2000 Amersham Pharmacia Biotech, India

2000-2002 Lecturer, University of Seychelles, American Institute of Medicine, Mahe,

Seychelles

2007-2008 Postdoctoral Fellow, University of Illinois at Chicago, IL

2008-2011 Research Associate, Department of Molecular Pharmacology, Loyola

University, IL

2011- Present Research Fellow, Department of Pharmacology, Creighton University,

Other Experience and Professional Memberships

Reviewer

2009- European Journal of Pharmacology, Elsevier Publication.

2010- Basic and Clinical Pharmacology and Therapeutics; published by Danish

Pharmacological Society.

2012- Life Sciences Journal, Elsevier Publications.

Honors

1) Judge, Midwest Student Biomedical Research Forum, Feb 2013 and 2014:

The Midwest Student Biomedical Research Forum (MSBRF) provides medical and

graduate students as well as other health professional students the opportunity to

present their original biomedical research in either an oral or poster format.

2) Maarten E.A. Reith, Solav Ali, Audrey Hashim, Imran S. Sheikh, Naresh Theddu,

Narendra V. Gaddiraju, Suneet Mehrotra, Kyle C. Schmitt, Thomas F. Murray, Henry

Sershen, Ellen M.Unterwald, Franklin A. Davis. Novel C-1 Substituted Cocaine

Analogues unlike Cocaine or Benztropine. (Cover Page of journal J. Pharmacol. and

Exp. Ther. Nov; 343(2).

3) Best Poster Award in American Society of Pharmacology and Experimental

Therapeutics, Great Lakes Chapter, 24th Annual Scientific Meeting 2011.

4) Research Grant (2011) for Secreted Frizzled-Related Protein-1 Expression in

Keratoconus. Co-investigator.

5) Judged the undergraduate poster competition in the Great Lake Chapter of

American Society for Pharmacology and Experimental Therapeutics, held in

University of Chicago 2010.

Selected for Oral Presentation for the 1st Post doctoral Symposium in

American Society of Pharmacology and Experimental Therapeutics (ASPET), Great

lakes Chapter, June 18, 2010, Chicago, USA.

7) 2010 ADDF YOUNG INVESTIGATOR SCHOLARSHIP, in 4th Drug Discovery

Neurodegeneration Conference, Houston, Texas, USA, Feb 1 -2, 2010 Link:

http://www.worldeventsforum.com/addf/2010/html/awards.html

8) Platform presentation in Society of Neurosciences, Chicago, Oct 2009-

“Mixed lineage kinase-3 ablation averts neurodegeneration in mouse model of MPTP”

http://www.abstractsonline.com/plan/ViewSession.aspx?sKey=d832349b -f820-4103-

b602-e267d1ffa40d&mKey=%7b081F7976-E4CD-4F3D-A0AF-E8387992A658%7d

9) Best Poster Award in VII European Headache Federation 2004 in Rotterdam,

The Netherlands. Title poster: Molecular cloning, tissue distribution and signaling

characterization of the porcine 2B-adrenoceptor.

10) Dutch Pharmacological Society, for presenting paper in Anglo -Dutch Migraine

Association, Chester, United Kingdom 2005.

11) Trust Fonds, Erasmus University, for presenting paper in International Headache

Society, Kyoto, Japan 2005.

12) Danish Pharmacological Society, for presenting paper in Dutch-Danish Pharma

Days, Copenhagen, Denmark 2006.

13) Dutch Pharmacological Society, for presenting paper in Anglo -Dutch Migraine

Association, Exeter, United Kingdom 2006.

B. Selected peer-reviewed publications (in chronological order).

1) Mehrotra Suneet, Duggan Brendan, Tello-Aburto Rodolfo, Newar Tara, Gerwick

William, Murray Thomas, Maio William. A Detailed Analysis of -Palmyrolide A and

Some Synthetic Derivatives as Voltage-Gated Sodium Channel Antagonists (Journal of

Natural Product: Submitted) Impact factor: 3.95

2) Zhengyu Cao, Yanjun Cui, Eric Busse, Suneet Mehrotra, Jon D. Rainier, and

Thomas F. Murray. Gambierol inhibition of voltage-gated potassium channels augments

spontaneous Ca2+ oscillations in cerebrocortical neurons (J. Pharmacol. and Exp.

Ther. 2014 Sep;350 (3):615-23.) Impact factor: 4.31

3) Maarten E.A. Reith, Solav Ali, Audrey Hashim, Imran S. Sheikh, Naresh Theddu,

Narendra V. Gaddiraju, Suneet Mehrotra, Kyle C. Schmitt, Thomas F. Murray, Henry

Sershen, Ellen M.Unterwald, Franklin A. Davis. Novel C-1 Substituted Cocaine

Analogues unlike Cocaine or Benztropine, (J. Pharmacol. and Exp. Ther. 2012 Nov;

343(2):413-25.) Impact factor: 4.31 Journal Cover page

4) Thylur RP, Senthivinayagam S, Campbell EM, Rangasamy V, Thorenoor N,

Sondarva G, Mehrotra S, Mishra P, Zook E, Le PT, Rana A, Rana B. Mixed Lineage

Kinase 3 modulates {beta}-catenin signaling in cancer cells. (J. Biol. Chem. 2011 Aug

31.) Impact factor: 6.9

5) Anumantha Kanthasamy, Huajun Jin, Suneet Mehrotra, Rajakishore Mishra,

Arthi Kanthasamy, and Ajay Rana. Novel Cell Death Signaling Pathways in

Neurotoxicity Models of Dopaminergic Degeneration: Relevance to Oxidative Stress

and Neuroinflammation in Parkinson’s disease (Neurotoxicology 2010 Sep;31(5):555-

61) Impact factor: 3.054

6) Gautam Sandorva, Chankya Kundu, Suneet Mehrotra, Rajakishore Mishra,

Velusamy Rangasamy, Rajarshi S. Ray and Ajay Rana. TRAF-2-MLK3 interaction is

essential for TNF- induced MLK3 activation. (Cell Research 2010: Jan;20(1):89-98)

Impact factor: 8.1

7) Velusamy Rangasamy, Rajakishore Mishra, Suneet Mehrotra, Gautam

Sandorva, Rajarshi S. Ray, Arundhati Rao, Basabi Rana and Ajay Rana. Estrogen

suppresses MLK3-Mediated apoptosis sensitivity in ER+ breast cancer cells. (Cancer

Research 2010: Feb; 15 70(4): 1731-40) Impact factor: 8.2

8) Suneet Mehrotra, Saurabh Gupta, David Centurión, Carlos M. Villalón,

Pramod R. Saxena and Antoinette MaassenVanDen Brink. Current and prospective

pharmacological targets in relation to antimigraine action. (Invited Review Naunyn

Schmiedeberg’s Archives of Pharmacology 2008: Oct; 378(4):371-94.) Impact

factor: 2.64

9) Suneet Mehrotra, Kaate R.J. Vanmolkot, Rune R. Frants, Arn M.J.M. van den

Maagdenberg, Michel D. Ferrari and Antoinette MaassenVanDen Brink.. The

Phe-124-Cys and A-161T variants of the human 5-HT1B receptor are not major

determinants of the clinical response to sumatriptan (Headache 2007 May; 47(5):711-

6) Impact factor: 3.189

10) Suneet Mehrotra, Saurabh Gupta, Carlos M. Villalón, Pramod R. Saxena,

Ad J.J.C. Bogers and Antoinette MaassenVanDenBrink. Effects of current and

prospective antimigraine drugs on the porcine isolated meningeal artery. (Naunyn

Schimedberg’s Archives of Pharmacology: 2006 Dec; 374(3):163-75) Impact

factor: 2.64

11) Suneet Mehrotra, Saurabh Gupta, David Centurión, Carlos M. Villalón,

Pramod R. Saxena and Antoinette MaassenVanDen Brink. A61603-induced

contractions of the porcine meningeal artery are mediated by 1- and 2-adrenoceptors.

(Basic clinical pharmacology and toxicology: 2007 Apr; 100(4):279-85.) Impact

factor: 2.294

12) Suneet Mehrotra*, Saurabh Gupta*, C.M. Villalón, Pramod R. Saxena, and

Antoinette MaassenVanDen Brink. Rat carotid artery responses to -adrenergic

receptor agonists and 5-HT after ovariectomy and hormone replacement. (Headache

2007 Feb; 47(2):236-46). Impact factor: 3.189

13) *Saurabh Gupta, *Suneet Mehrotra, C.M. Villalón, René De Vries, Ingrid

Garrelds, Pramod R. Saxena, and Antoinette MaassenVanDen Brink. Effect of female

sex hormones to CGRP, acetylcholine, and 5-HT in rat isolated arteries. (Headache:

2007; 47:564-575). * both first author Impact factor: 3.189

14) David Centurión, Suneet Mehrotra, Araceli Sánchez-López, Saurabh Gupta,

Antoinette MaassenVanDenBrink and Carlos M. Villalón. Potential vascular 1-

adrenoceptor blocking properties of an array of 5 -HT receptor ligands in the rat

(European Journal. Pharmacology: 2006 Mar 27; 535(1-3): 234-42). Impact factor:

2.754

15) Chai W, Suneet Mehrotra, Jan Danser AH, Schoemaker RG. The role of

calcitonin gene-related peptide (CGRP) in ischemic preconditioning in isolated rat

hearts. (European Journal Pharmacology 2006 Feb 15; 531(1-3): 246-53). Impact

factor: 2.754

16) Saurabh Gupta, Suneet Mehrotra, Perusquia Mercedes, Pramod R. Saxena,

Carlos M. Villalón and Antoinette MaassenVanDenBrink. Potential role of female sex

hormones in pathophysiology of migraine (Pharmacology & Therapeutics 2007 Feb;

113(2):321-40). Impact factor: 9.3

17) Saurabh Gupta, Suneet Mehrotra, C.M. Villalón, Pramod R. Saxena, and

Antoinette MaassenVanDenBrink. Characterization of CGRP receptors in the human

isolated middle meningeal artery (Life Sciences 2006 Jun 13; 79(3): 265-71). Impact

factor: 2.7

18) Saurabh Gupta, C.M. Villalón, Suneet Mehrotra, R. de Vries, I.M. Garrelds, and

Pramod R. Saxena, Antoinette MaassenVanDen Brink Female sex hormones and rat

dural vasodilatation to CGRP, periarterial electrical stimulation and capsaicin

(Headache 2007 Feb;47(2):225-35). Impact factor: 3.189

19) Saurabh Gupta, Suneet Mehrotra, Carlos M. Villalón, Ingrid M. Garrelds,

René de Vries, Jorge P. van Kats, Hari S. Sharma, Pramod R. Saxena and

Antoinette MaassenVanDenBrink. Characterisation of CGRP receptors in human and

porcine isolated coronary arteries: evidence for CGRP re ceptor heterogeneity

(European Journal Pharmacology 2006 Jan 13; 530(1-2): 107-16). Impact factor:

2.754

20) Jimenez-Mena LR, Gupta S, Munoz-Islas E, Lozano-Cuenca J, Sanchez-Lopez

A, Centurion D, Suneet Mehrotra, Antoinette MaassenVanDen Brink and Carlos M.

Villalón. Clonidine inhibits the canine external carotid vasodilatation to capsaicin by

2A/2C-adrenoceptors. (European Journal Pharmacology 2006 Aug 14; 543(1-3): 68-

76). Impact factor: 2.754

21) Enriqueta Muñoz-Islas, Saurabh Gupta, Luisa R. Jiménez-Mena, Jair Lozano-

Cuenca, Araceli Sánchez-López, David Centurión, Suneet Mehrotra, Antoinette

MaassenVanDenBrink and Carlos M.Villalón, Donitriptan, but not sumatriptan, inhibits

capsaicin-induced canine external carotid vasodilatation via 5 -HT1B rather than 5-HT1D

receptors (British Journal of Pharmacology: 2006 149,82-91). Impact factor: 4.99

C. Book and Book Chapters.

1. Suneet Mehrotra, Antoinette MaassenVanDenBrink, Pramod R. Saxena and

Hari. S. Sharma, Molecular cloning and tissue distribution of porcine 2B-adrenoceptor,

In Couturier E.G.M, ed., Anglo-Dutch Migraine Association Proceedings, (Volume 9),

edited by Sorbi MJ, Couturier EGM, Merelle SYM, p. 67-82 (ISBN 90-808770-2-6).

2. Suneet Mehrotra, Saurabh Gupta, Pramod R. Saxena and Antoinette

MaassenVanDen Brink, Current and potential pharmacological targets for migraine

therapy, In Couturier E.G.M, ed Anglo-Dutch Migraine Association Proceedings, Exeter:

United Kingdom 2006.

3. Saurabh Gupta, Suneet Mehrotra, C.M. Villalón,, René de Vries, I.M. Garrelds,

and Pramod R. Saxena, Antoinette MaassenVanDen Brink. Potential role of sex

steroids in migraine pathophysiology In: Couturier E.G.M, ed. Anglo-Dutch Migraine

Association Proceedings, Exeter: United Kingdom 2006.

4. Suneet Mehrotra, Characterization of vascular 5-hydroxytryptamine, adrenergic

and CGRP receptors in relation to migraine. Thesis, Erasmus University, Rotterdam

2006. ISBN-10: 90-8559-252-6

D. Gene cloned and sequence submitted to National Center for Biotechnology

Information (NCBI).

1. Mehrotra S., Teunissen, A.W.R.H., Saxena, P.R. and Sharma, H.S. GenBank:

DQ182110.1, Sus scrofa alpha 2b adrenergic receptor mRNA, complete cds.

2. Mehrotra S., Gupta, S., MaassenVanDenBrink A., Saxena, P.R. and Sharma,

H.S, GenBank: DQ225117.1, Sus scrofa alpha 2C adrenergic receptor mRNA, partial

cds.

E. Course completed.

Cardio Vascular Pharmacology Oct 2003, Erasmus University, The Netherlands.

Cardio Vascular Medicine, Oct 2003, Erasmus University, The Netherlands.

Biomedical Research Techniques, Nov 2003, Erasmus University, The

Netherlands..

Atherosclerosis Research, March 2004, Erasmus University, The Netherlands.

Cardio Vascular Imaging and diagnostics, April 2004, Erasmus University, The

Netherlands.

Cardio Vascular Clinical Epidemiology, April 2004, Erasmus University, The

Netherlands.

Peripheral Vascular Disease, March 2005, Erasmus University, The Netherlands.

Molecular Biology in Cardio Vascular Research, April 2005, Erasmus University,

The Netherlands.

Arrhythmia Research, April 2005, Erasmus University, The Netherlands.

Molecular Medicine, July 2005, Erasmus University, The Netherlands.

Radiation Safety Training, May 2007, University of Illinois, Chicago, USA

Quantitative Fluorescence Microscopy, Mount Desert Biological Laboratory in

Salisbury Cove, Maine, USA 2012.

F. Published Abstracts and Presentations.

1. S. Mehrotra, S. Gupta, C.M. Villalón, P.R. Saxena, A. MaassenVanDenBrink.

A61603-induced vasoconstrictions of the porcine isolated meningeal artery are

mediated: possible involvement of novel receptor. Naunyn Schmiedeberg’s Archives

of Pharmacology, 2006; 373:95.

2. S. Mehrotra, S. Gupta, C.M. Villalón, P.R. Saxena, A. MaassenVanDenBrink.

Contraction to the rat carotid artery to α-adrenoceptor agonists and 5-HT after

ovariectomy and replacement of female sex hormone. The Journal of Headache and

Pain, 2006; 7:S25.

3. S. Mehrotra, S. Gupta, C.M. Villalón, P.R. Saxena, A. MaassenVanDenBrink.

Effects of current and prospective antimigraine drugs in the porcine isolated meningeal

artery. Cephalalgia, 2005; 25:886.

4. S. Mehrotra, S. Gupta, C.M. Villalón, P.R. Saxena, A. MaassenVanDenBrink.

A61603-induced vasoconstriction in the porcine isolated meningeal artery: possible

involvement of a novel receptor Cephalalgia, 2005; 25:886.

5. S. Mehrotra, A.W.R.H. Teunissen, A. MaassenVanDenBrink P.R. Saxena, H.S.

Sharma. Molecular cloning of the porcine α2B-adrenoceptor: A potential target for novel

antimigraine drugs, Presented in European Headache Society Rotterdam. 2004: Pg

177 (Best Poster award).

6. S. Gupta, S. Mehrotra, C.M. Villalón, P.R. Saxena, A. MaassenVanDenBrink. 17β-

Estradiol potentiates CGRP-mediated in vivo relaxations in caudal and mesenteric

arteries in ovariectomized rats. The Journal of Headache and Pain, 2006; 7:S54.

7. S. Gupta, S. Mehrotra, I.M. Garrelds, H.S. Sharma, P.R. Saxena, A.

MaassenVanDenBrink. Evidence for a heterogeneous CGRP receptor population in the

human coronary artery. Neuropeptides, 2004; 38, 122-123.

8. S. Gupta, S. Mehrotra, I.M. Garrelds, H.S. Sharma, P.R. Saxena, A.

MaassenVanDenBrink. Evidence for CGRP receptor heterogeneity in the human

coronary artery. Presented in European Headache Society Rotterdam. 2004; p71.

9. S. Gupta, A. MaassenVanDenBrink, S. Mehrotra, C.M. Villalón, P.R. Saxena.

Effect of female sex steroids on CGRP mediated vasodilatation in rat s. Naunyn

Schmiedeberg’s Archives of Pharmacology, 2006; 373:93.

10. A. MaassenVanDenBrink, C.M. Villalón, S. Mehrotra, R. de Vries, I. M. Garrelds,

P. R. Saxena, S. Gupta. Effect of female sex steroids on dural vasodilatation induced by

CGRP, capsaicin and electrical stimulation. Headache, 2006; 46:41.

11. A. MaassenVanDenBrink, C.M. Villalón, S. Mehrotra, R. de Vries, I. M. Garrelds,

P. R. Saxena, S. Gupta. Effect of female sex steroids on CGRP - and acetylcholine-

mediated relaxant responses in rat mesenteric and basilar artery. Headache, 2006;

46:842-843. Research Papers 209

12. A. MaasenVanDenBrink, S. Gupta, S. Mehrotra, J.P.C. Heiligers, C.M. Villalón,

P.R. Saxena. Effect of female sex steroids on CGRP-mediated vasodilatation in rat.

Cephalalgia, 2005; 25:856.

13. V.K.T. Alagappan, S. Mehrotra, J.P.C. Heiligers. A.R. Kranenburg, H.S. Sharma

Interleukin-1β induced vascular endothelial growth factor synthesis by airway smooth

muscle cells. American Journal of respiratory critical care medicine, 2004; 169(7):

A163.

14. C.M. Villalón, E. Muñoz-Islas, L.R. Jiménez-Mena, J. Lozano-Cuenca, S.

Mehrotra, S. Gupta, A. MaassenVanDenBrink, D. Centurión. Effects of

dihydroergotamine on capsaicin- and CGRP-induced canine external carotid

vasodilatation Cephalalgia, 2005; 25:884-885.

15. Ajay Rana, Suneet Mehrotra, Anamitra Ghosh, Rajarshi S. Ray, Velusamy

Rangasamy, Gautam Sondarva, Anumantha Kanthasamy. Mixed Lineage Kinase 3

signaling: Relevance to neuroinflammatory processes in neurotoxic cell death. 12th

Biennial Meeting of the International Neurotoxicology Association, 2009; Page 28 .

16. Suneet Mehrotra, Anamitra Ghosh, Rajarshi S. Ray, Velusamy Rangasamy,

Gautam Sondarva, Anumantha Kanthasamy and Ajay Rana. Mixed lineage kinase -3

ablation avert neurodegeneration in a sub-acute MPTP mouse model of Parkinson’s

disease; Society of Neurosciences, Chicago, Oct 2009, Oral Presentation in

session 401. Parkinson's Disease: Models II, Monday, Oct 19, 2009, 1:00 PM - 2:45

17. Gautam Sondarva, Suneet Mehrotra, Rajakishore Mishra, Velusamy Rangasamy,

Jawed Fareed, Basabi Rana, Ajay Rana. Role of MLK3 in breast cancer cell migration

and metastasis; Abstract number:5200; AACR; Wednesday, Apr 21, 2010, 8:00 AM -

11:00 AM

18. Suneet Mehrotra, Anamitra Ghosh, Velusamy Rangasamy, Gautam Sondarva,

Anumantha Kanthasamy and Ajay Rana. Mixed Lineage Kinase -3 (MLK3) ablation

attenuates neurodegeneration in a sub-acute 1-methyl-4-phenyl-1, 2, 3, 6-

tetrahydropyridine (MPTP) mouse model of Parkinson’s disease (PD); Veterans Affairs

Meeting April 19-2010, Chicago

19. Suneet Mehrotra, Anamitra Ghosh, Velusamy Rangasamy, Gautam Sondarva,

Anumantha Kanthasamy and Ajay Rana. Mixed Lineage Kinase -3 (MLK3) ablation

attenuates neurodegeneration in a sub-acute 1-methyl-4-phenyl-1, 2, 3, 6-

tetrahydropyridine (MPTP) mouse model of Parkinson’s disease (PD); Selected as Oral

Presentation in Post doctoral Symposium in American Society of Pharmacology

and Experimental Therapeutics, Chicago Chapter, June 18, 2010

20. Suneet Mehrotra, Lauren Petty, Gautam Sondarva, Anumantha G. Kanthasamy,

Fletcher A. White and Ajay Rana. Mixed Lineage Kinase-3 Promotes Axonal Self

Destruction Following Nerve Injury. Society of Neurosciences, San Diego, Nov. 2010.

21. White FA*, Bauer WR, Mehrotra S, Rana A, Jellish WS. Proteomic analysis of

differential protein expression in the cerebrospinal fluid of chronic lower back pain

patients. Neurosciences, Washington, Nov. 2011.

22. Arnav Rana, Velusamy Rangasamy, Gautam Sondarva, Joanna Bakowska and

Suneet Mehrotra (Corresponding Author). Cigarette smoke induces a pulmonary

inflammatory response which leads to an increase activity of Mixed Lineage Kinase -3

and possibly cell death. American Society of Pharmacology and Experimental

Therapeutics, Chicago Chapter, June 2011.

23. Suneet Mehrotra, Gautam Sondarva, Velusamy Rangasamy, Rajakishore Mishra,

David Freeman, Edward Campbell and Ajay Rana. Mixed Lineage Kinase-3

phosphorylates α-Synuclein, leads to its aggregation: Possible Mechanism of α -

Synuclein toxicity in Parkinson’s disease. American Society of Pharmacology and

Experimental Therapeutics, Chicago Chapter, June 2011 (BEST POSTER

AWARD).

24. Maarten E.A. Reith, Solav Ali, Audrey Hashim, Imran S. Sheikh, Naresh Theddu,

Narendra V. Gaddiraju, Suneet Mehrotra, Kyle C. Schmitt, Thomas F. Murray, Henry

Sershen, Ellen M.Unterwald, Franklin A. Davis. Novel C-1 Substituted Cocaine

Analogues unlike Cocaine or Benztropine. Society of Neurosciences, New

Orleans Nov. 2012.

25. S. Mehrotra, S.M. Dravid and T. F. Murray. The enhancement of cerebrocortical

neuron neurite outgrowth by a voltage-gated sodium channel activator requires both the

N-methyl-D-aspartate receptor 2B and p21 protein (Cdc42/Rac)-activated kinase 1

(PAK1). Nebraska EPSCoR, Omaha, Neuroscience symposium, (Page 10) Oct.

2013.

26. S. Mehrotra, S.M. Dravid and T. F. Murray. Voltage-gated sodium channel

activator enhancement of immature cerebrocortical neuron development requires both

the N-methyl-D-aspartate receptor 2B (GluN2B) and p21 protein (Cdc42/Rac) -activated

kinase 1 (PAK1). Society of Neurosciences, Program/Poster: 321.04/E24, Monday,

Nov 11, 2013, San Diego.

27. S. Mehrotra, W . H. Gerwick and T. F. Murray. Sodium channel activator-stimulated

neurite outgrowth involves the brain-derived neurotrophic factor (BDNF) - Tropomyosin

related kinase B (TrkB) signaling pathway. Society of Neurosciences,

Program/Poster: 298, Monday, Nov 17, 2014, Washington DC.

28. Thomas F. Murray and Suneet Mehrotra. Sodium channel activator-induced

enhancement of cerebrocortical neuron neurite outgrowth requires both GluN2B NMDA

receptors and p21 protein (Cdc42/Rac)-activated kinase 1 (PAK1). Cell Biology of the

Neuron. Mechanistic Insight into Neuronal Development, Plasticity, Disease and

Regeneration. Gordon Research Conference, June 22-27, 2014, Waterville Valley

Resort, Waterville Valley, NH.

29. Matthew Q Schmidt, Suneet Mehrotra and Thomas F Murray. Kappa-opioid

receptor activation leads to decreased neurite outgrowth in immature murine

cerebrocortical neurons. Nebraska EPSCoR, Omaha, Neuroscience symposium,

Oct. 2014.

30. Suneet Mehrotra, W. H. Gerwick and Thomas F Murray. Antillatoxin (ATX), a

voltage-gated sodium channel (VGSC) activator, stimulates neurite outgrowth through

the brain-derived neurotrophic factor (BDNF) - tropomyosin related kinase B (TrkB)

signaling pathway. Nebraska EPSCoR, Omaha, Neuroscience symposium, Oct.

2014. Poster number 1340.

G. Manuscript in Preparation.

1. S. MEHROTRA, W . H. Gerwick and T. F. MURRAY. Sodium channel activator-

stimulated neurite outgrowth involves the brain-derived neurotrophic factor (BDNF) -

Tropomyosin related kinase B (TrkB) signaling pathway. (Journal: Science Signaling;

Impact factor: 7.648).

2. S. MEHROTRA, S.M. Dravid and T. F. MURRAY. Voltage-gated sodium channel

activator enhancement of immature cerebrocortical neuron development requires both

the N-methyl-D-aspartate receptor 2B (GluN2B) and p21 protein (Cdc42/Rac)-activated

kinase 1 (PAK1). (Journal: Journal of Neurosciences; Impact factor: 7.115).

3. Paul D. Boudreau, Emily Monroe, Suneet Mehrotra, Shane Desfor, Thomas F.

Murray, Lena Gerwick, Pieter C. Dorrestein, and William H. Gerwick. The Metabolome

of a Well-Studied Cyanobacterial Strain Expands Three -fold When Examined by Novel

Techniques. (Journal: Chem Med Chem; Impact factor: 3.075).

4. S. Mehrotra, Anamitra Ghosh, Velusamy Rangasamy, Rajakishore Mishra,

Gautam Sondarva, Fletcher A. White, Anumantha Kanthasamy and Ajay Rana. Mixed

lineage kinase-3 ablation averts neurodegeneration in a sub-acute MPTP mouse model

of Parkinson’s disease (Journal: Proceedings of the National Academy of Sciences;

Impact factor: 9.737).

H. Laboratory Techniques Expertised.

1. In-vitro drug screening and analyzing high throughput Pharmacological

data

FLIPR, FLEX STATION II, based fluorescence assay using SBFI (Na+), Fluo3

(Ca ), Fluo8 (no wash Ca2+), FluxOR (K+) and membrane potential assay

measurement.

Screening compounds for Ion channels and GPCRs both potential chemical and

natural compounds or plant based extracts.

Analyzing large Pharmacological data set and generating logistic fit -3 or 4

parameter, using Graph Pad prism software.

Evidence to support:

Mehrotra Suneet, Duggan Brendan, Tello-Aburto Rodolfo, Newar Tara, Gerwick

William, Murray Thomas, Maio William. A Detailed Analysis of -Palmyrolide A and

Some Synthetic Derivatives as Voltage-Gated Sodium Channel Antagonists (Journal of

Natural Product: Submitted)

Zhengyu Cao, Yanjun Cui, Eric Busse, Suneet Mehrotra, Jon D. Rainier, and

Thomas F. Murray. Gambierol inhibition of voltage-gated potassium channels augments

spontaneous Ca2+ oscillations in cerebrocortical neurons J. Pharmacol. and Exp. Ther.

2014 Sep; 350 (3):615-23.)

Maarten E.A. Reith, Solav Ali, Audrey Hashim, Imran S. Sheikh, Naresh Theddu,

Narendra V. Gaddiraju, Suneet Mehrotra, Kyle C. Schmitt, Thomas F. Murray, Henry

Sershen, Ellen M.Unterwald, Franklin A. Davis. Novel C-1 Substituted Cocaine

Analogues unlike Cocaine or Benztropine, (J. Pharmacol. and Exp. Ther. 2012 Nov;

343(2):413-25.) Journal Cover page

2. In-vitro screening using Organ bath study and analyzing high throughput

Pharmacological data

Experience in isolating micro coronary artery, middle meningeal artery, basilar

artery from human and porcine heart and brain

Running Mulvane myographs and large artery organ baths

Handling animal tissue and organs, IRB approved

Evidence to support:

Suneet Mehrotra, Saurabh Gupta, Carlos M. Villalón, Pramod R. Saxena,

Ad J.J.C. Bogers and Antoinette MaassenVanDenBrink. Effects of current and

prospective antimigraine drugs on the porcine isolated meningeal artery. (Naunyn

Schimedberg’s Archives of Pharmacology: 2006 Dec; 374(3):163-75)

Suneet Mehrotra, Saurabh Gupta, David Centurión, Carlos M. Villalón,

Pramod R. Saxena and Antoinette MaassenVanDen Brink. A61603-induced

contractions of the porcine meningeal artery are mediated by 1- and 2-adrenoceptors.

(Basic clinical pharmacology and toxicology: 2007 Apr; 100(4):279-85.)

Suneet Mehrotra*, Saurabh Gupta*, C.M. Villalón, Pramod R. Saxena, and

Antoinette MaassenVanDen Brink. Rat carotid artery responses to -adrenergic

receptor agonists and 5-HT after ovariectomy and hormone replacement. (Headache

2007 Feb; 47(2):236-46).

*Saurabh Gupta, *Suneet Mehrotra, C.M. Villalón, René De Vries, Ingrid

Garrelds, Pramod R. Saxena, and Antoinette MaassenVanDen Brink. Effect of female

sex hormones to CGRP, acetylcholine, and 5-HT in rat isolated arteries. (Headache:

2007; 47:564-575). * both first author

3. Animal Model

Parkinson disease model for inducing Parkinson symptoms in mice and isolating

substantia Niagara and striatum from mouse brain

Nerve transection model in mice

Bleomycin model in mice to induce fibrosis in lungs

Peritoneal lavage collection from mice

Evidence to support:

Suneet Mehrotra, Anamitra Ghosh, Rajarshi S. Ray, Velusamy Rangasamy,

Gautam Sondarva, Anumantha Kanthasamy and Ajay Rana. Mixed lineage kinase -3

ablation avert neurodegeneration in a sub-acute MPTP mouse model of Parkinson’s

disease; Society of Neurosciences, Chicago, Oct 2009, Oral Presentation in

session 401. Parkinson's Disease: Models II, Monday, Oct 19, 2009, 1:00 PM - 2:45

Suneet Mehrotra, Anamitra Ghosh, Velusamy Rangasamy, Gautam Sondarva,

Anumantha Kanthasamy and Ajay Rana. Mixed Lineage Kinase -3 (MLK3) ablation

attenuates neurodegeneration in a sub-acute 1-methyl-4-phenyl-1, 2, 3, 6-

tetrahydropyridine (MPTP) mouse model of Parkinson’s disease (PD); Veterans Affairs

Meeting April 19-2010, Chicago

Suneet Mehrotra, Anamitra Ghosh, Velusamy Rangasamy, Gautam Sondarva,

Anumantha Kanthasamy and Ajay Rana. Mixed Lineage Kinase -3 (MLK3) ablation

attenuates neurodegeneration in a sub-acute 1-methyl-4-phenyl-1, 2, 3, 6-

tetrahydropyridine (MPTP) mouse model of Parkinson’s disease (PD); Selected as Oral

Presentation in Post-doctoral Symposium in American Society of Pharmacology

and Experimental Therapeutics, Chicago Chapter, June 18, 2010

Suneet Mehrotra, Lauren Petty, Gautam Sondarva, Anumantha G. Kanthasamy,

Fletcher A. White and Ajay Rana. Mixed Lineage Kinase-3 Promotes Axonal Self

Destruction Following Nerve Injury. Society of Neurosciences, San Diego, Nov. 2010.

4. IACUC

Expertise in writing IACUC protocols

5. Animal Behavior Model

Rota rod

Open field

Y-maze