MOHAMED R. AKL Ph.D. (Pharmacology)

**** ******** **, *** *, Monroe, LA 71203 ● 318-***-**** ● acexew@r.postjobfree.com

SUMMARY

• Highly self-motivated Assistantship Award from School of Pharmacy, University of Louisiana at Monroe

Teaching scientist with knowledge of cancer drug discovery including emerging concepts in

cancer therapeutics.

• Strong scientific track record of publications in peer-reviewed journals.

• Research and teaching experience in pharmacology and cancer biology.

• Authorized to work in the USA (Green Card).

Postdoctoral Research Scientist.

School of Pharmacy, University of Louisiana at Monroe, USA.

EDUCATION

2013-Present

2013

2008

2004

PROFESSIONAL

2013-Present

2009-2013 Teaching and Research Assistant

School of Pharmacy, University of Louisiana at Monroe, USA.

2004-2008 Assistant Lecturer

Faculty of Pharmacy, Mansoura University, Egypt

CORE KNOWLEDGE &

• In vitro Cell Culture and Molecular Biology

o Experience with sterile cell culture

o Western blot

o Flow cytometry

o Immunofluorescence and immunohistochemistry

o siRNA knock-down experiments

o Cell proliferation assays and cell cycle analysis

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o Apoptosis and autophagy assays

o Migration, invasion, colony-formation and angiogenesis assays

o Antioxidant assays (ABTS, AAPH, erythrocyte hemolysis assays)

o Knowledge of cancer signal transduction pathways

o Basic knowledge of microscopy (confocal, electron and fluorescence)

• In vivo Pharmacology

o Experience using xenographic mouse models of cancer to evaluate

molecule drugs targeting cancer

o Experience and strong working knowledge including preparation of test compounds, handling and

dosing of mice, anesthesia and collection of blood and tissues for PK and PD biomarker analysis

o Ehrlich ascites carcinoma model

o Cytotoxicity using brine shrimp (

• Phytochemistry and Biological Analysis

o HPLC analysis of biological samples.

o Isolation techniques using classical column chromatography, HPLC, TLC

o Various sample extraction and separation techniques

o Spectroscopy (UV, IR, NMR and MS)

o Microbial biotransformation

o Phytochemical screening of plant extracts

o Microscopic examination of plant tissues and powders

• Laboratory Research General Operations:

o Prepare solutions, reagents, media or stains necessary for experimental procedures

o Maintain inventory of laboratory supplies and equipment and prepare requisitions for approval

• Statistical and Data Analysis:

o SPSS, GraphPad Prism, SigmaPlot

• Teaching:

o Provided assistance to faculty in teaching professional pharmacy students by strengthening concepts

presented in lectures, recitations and laboratories in specified courses

o Graded homework and tests

o Observed students' performance, and recorded relevant data to assess progress

• Other Skills:

o Excellent presentation skills

o Multitasking abilities to deliver outstanding results even under long work hours, and stressful situations

o Excellent interpersonal and communication skills that forge productive teamwork and relationships with

faculty and research peers, senior management and students

o Language Proficiency in English

o Licensed pharmacist in Egypt with good experience in retail pharmacy work

o Computer and Internet Proficiency, MS Office productivity apps and Adobe Photoshop

PUBLICATIONS

1. Akl MR, Ebrahim HY, Foudah AI, Mohyeldin MM, El Sayed KA. Araguspongine C induces autophagy through

suppression of c-Met/ Akt/mTOR axis in breast cancer cells. (Submitted June 2014).

2. Akl MR, Elsayed HE, Haggag EG, Kamal AM, El Sayed KA. 3-O-[N-(p-Fluorobenzenesulfonyl)-carbamoyl]-

oleanolic acid, a semisynthetic analog of oleanolic acid, induces apoptosis in breast cancer cells.

in Eur J Pharmacol.

3. Akl MR, Ayoub NM, Mohyeldin MM, Busnena BA, Foudah AI, Liu Y, El Sayed KA. Olive phenolics as c-Met

inhibitors: -Oleocanthal attenuates cell proliferation, invasiveness, and tumor growth in breast cancer

models. PLoS One

4. Akl MR, Foudah AI,

dichlorobenzoate inhibits breast cancer growth and motility

and FAK signaling.

5. Akl MR, Ayoub NM. Tumor cell transformation using

2014;1139:259-68. doi: 10.1007/978-1-4939-0345-0_22.

6. Akl MR, Ayoub NM, Abuasal BS, Kaddoumi A,

anticancer effects of

3

7. Akl MR, Ayoub NM,

tocotrienol and sesamin treatment.

8. Akl MR, Sylvester

Medicinal Plants, Volume 38, “Essential Oil III and Phytopharmacology, ed, J.N. Govil, pp 43-58. Stadium

Press (USA), Houston, TX, 2013.

9. Akl MR, Badria FA, Hassan MA. A study on some natural products with potential anticancer activity.

Academic Publishing

10. Sallam AA, Mohyeldin M, Foudah AI,

synthesis of novel phenylmethylene hydantoin derivatives with potent

activities Org. Biomol. Chem

11. Elsayed HE,

optimization and pharmacophore modeling of oleanolic acid and analogs as breast cancer cell

migration and invasion inhibitors via targeting Brk/Paxillin/Rac1 axis.

doi: 10.1111/cbdd.12380.

12. Foudah AI, Sallam AA,

Studies of Sipholanes as Breast Cancer Migration and Proliferation Inhibitors.

Chem 2013, 12;73C:310-324.

13. Ayoub NM, Akl MR

cancer cell proliferation, epithelial-to-mesenchymal transition, and migration

14. Sylvester PW,

breast cancer.

15. Behery FA, Akl MR

products as breast cancer proliferation and migration inhibitory leads.

16. Sylvester PW, Ayoub NM,

In: Lipids: Categories, Biological Functions and Metabolism, Nutrition and Health, ed, Frank Columbo, Nova

Science Publishers, Inc., Hauppauge, NY. ed, Paige L. Gilmore, 2010; 371-388.

17. Sylvester PW,

Side Effects and Supplements, ed, Alice E. Lindberg, Nova Science Publishers, Hauppauge, NY. 2011; 1-43.

18. Sylvester PW, Wali VB, Bachawal SV, Shirode AB, Ayoub NM,

results in synergistic anticancer response.

19. Behery FA, Elnagar AY,

tocotrienol esters as breast cancer proliferation and migration inhibitors.

2010;18(22):8066-75.

20. Badria FA, Ameen M,

Egypt. Z. Naturforsch

CONFERENCES

1. Akl MR et al.,

Oleocanthal in Breast Cancer Cells. AACR-NCI-EORTC International Conference on Molecular Targets and

Cancer Therapeutics

2. Akl MR et al.,

AACR 103rd Annual Meeting 2012-- Mar 31-Apr 4, 2012; Chicago, IL.

3. Akl MR et al.,

AAPS Annual Meeting and Exposition 2010. November 14–18, 2010; New Orleans, LA.

HONORS & AWARDS

2009-2013

2013 Member of American Association for Cancer Research (AACR)

2012 Best Oral Presentation Award, ULM Annual Research Symposium

2011 Best Poster Presentation Award, ULM Annual Research Symposium

AFFILIATIONS

2013

Member of ULM Alumni Association

2011

Member of American Association for Cancer Research (AACR)

2011

Member of The Honor Society of Phi Kappa Phi

2010

5

Member of American Association of Pharmaceutical Scientists (AAPS)

TRAINING

2011

Using Animal Models in Preclinical Trials, University of Louisiana at Monroe (2 days)

2008

Using Technology in Teaching, Mansoura University, Egypt (4 days)

2008

Nanotechnology Workshop, Mansoura University, Egypt (1 day)

2005

Basics of HPLC and GC, Misr University for Science and technology, Egypt (5 days)

2003

Training in the Production Department at Novartis Pharmaceutical Company, Egypt (5 days)

REFERENCES

Dr. Khalid El Sayed, PhD

Professor of Medicinal Chemistry and Natural Products

School of Pharmacy, University of Louisiana at Monroe, ph: 318-***-****, email: acexew@r.postjobfree.com

Dr. Paul W. Sylvester, PhD

Director of Research and Graduate Studies, Professor of Pharmacology

School of Pharmacy, University of Louisiana at Monroe, ph: 318-***-****, email: acexew@r.postjobfree.com

Dr. Yong-Yu Liu, PhD

Associate Professor of Pharmacology

School of Pharmacy, University of Louisiana at Monroe, ph: 318-***-****, email: acexew@r.postjobfree.com

Dr. Sharon A. Meyer, PhD

Associate Professor of Toxicology

School of Pharmacy, University of Louisiana at Monroe, ph: 318-***-****, email: acexew@r.postjobfree.com

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