Recombinant Antigens Product Manager

Christopher F. Hoehamer, Ph.D.

**** ******* ****** *****

Lakeland, Tennessee 38002

aceboe@r.postjobfree.com

RESEARCH AND PROFESSIONAL EXPERIENCE:

****-**** *********** ******** ******* Manager

Meridian Life Science, Inc.

Memphis, Tennessee, 38104

2009-2011 Protein Chemist

Meridian Life Science, Inc.

Memphis, Tennessee, 38104

2005-2009 Postdoctoral Research Fellow

Department of Clinical Pharmacy

University of Tennessee Health Science Center (UTHSC)

Memphis, Tennessee 38103

2001-2004 National Research Council Postdoctoral Fellow

National Exposure Research Laboratory

United States Environmental Protection Agency (USEPA)

Athens, Georgia 30605

EDUCATION:

1994-2000 Ph. D. Department of Biochemistry and Molecular Biology

University of Georgia, Athens, Georgia 30602

1989-1993 B.S. Department of Biochemistry

University of Georgia, Athens, Georgia 30602

AWARDS AND FELLOWSHIPS (SINCE 2000):

2014, Excellence Award of Outstanding Leadership, UTHSC, Memphis, TN.

2008, Postdoctoral Award, UTHSC, Memphis, TN.

2007, Accredo Pediatric Scientist Award, LeBonheur Children’s Medical Center, Memphis, TN.

2002, Scientific Technology Achievement Award, USEPA

2000, National Research Council Fellowship, USEPA

PROFESSIONAL SUMMARY AND SELECTED TECHNICAL SKILLS:

Laboratory management and protein production under cGMP guidelines in manufacturing

Fermentation of microorganisms (yeast and E.coli) and downstream purification of recombinant viral antigens and enzymes using column chromatography (HIC, IEC, IMAC, and SEC)

Large-scale antibody purification from goat, sheep, and mouse

Protein characterization methods (SDS-PAGE, 2-D, Western blotting, IEF, and ELISA)

Downstream process development, method optimization, analysis, scale-up, process

troubleshooting, validation, and technology transfer to manufacturing under cGMP guidelines

Analysis of product cost reduction, planning, and reducing lead times in manufacturing

Molecular biology techniques such as gene disruption, PCR, cloning, and Southern blotting

Instrumentation-Microfluidizers, AKTA FPLCs, HPLCs, BioFlow reactors, MALDI-TOF, and CE

Analytical software programs- PDQuest, Unicorn, ChemStation, 32Karat, and BioCommand

Following regulatory standards compliant with ISO 9001:2008 and 21 CFR 210, 211

Writing batch records, protocols, MasterControl document system, lean six sigma, and 5S

CONFERENCES AND PRESENTATIONS: (SINCE 2001)

2008, Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC),

Washington, D.C.

2008, American Society for Microbiology (ASM): Candida and Candidiasis, Newark, NJ.

2007, ICAAC, Chicago, IL.

2006, ICAAC, San Francisco, CA.

2006, ASM General Conference, Denver, CO.

2002, International Symposium for Environmental Biotechnology, Veracruz, MX.

2001, Society of Environmental Toxicology and Chemistry, Baltimore, MD.

PUBLICATIONS:

1. Christopher F. Hoehamer, Edwin D. Cummings, George M. Hilliard, and P. David

Rogers. (2010) Antifungal-Induced Proteome Changes in Response to Azole, Polyene,

and Echinocandin Agents in Candida albicans. Antimicrobial Agents and Chemotherapy

54; 1655-1664.

2. Christopher F. Hoehamer, Edwin D. Cummings, George M. Hilliard, Joachim

Morschhäuser, and P. David Rogers. (2009) Proteomic Analysis of Mrr1p- and Tac1p-

Associated Differential Protein Expression in Azole-Resistant Clinical Isolates of

Candida albicans. Proteomics 3(8) 968-978.

3. Christopher F. Hoehamer, Edwin D. Cummings, George M. Hilliard, Joachim

Morschhäuser, and P. David Rogers. (2009) Upc2p-Mediated Differential Protein

Expression in an Azole-Resistant Clinical Isolate of Candida albicans. Proteomics 20

4726-4730.

4. Christopher F. Hoehamer, N. Lee Wolfe, and Karl Erik L. Eriksson. (2006)

Biotransformation of 2,4,6-Trinitrotoluene (TNT) in Wild and Axenic Isolates of

Myriophyllum aquaticum. International Journal of Phytoremediation. 8 (2); 107- 115.

5. Christopher F. Hoehamer, N. Lee Wolfe, and Karl Erik L. Eriksson. (2006)

Biotransformation of 2,4,6-Trinitrotoluene (TNT) by the Plant-Associated Fungus

Fusarium oxysporum. International Journal of Phytoremediation. 8 (2); 95-105.

6. Christopher F. Hoehamer, Chris S. Mazur, and N. L. Wolfe. (2003) Purification and

Characterization of an Acid Phosphatase from Spirodela oligorrhiza and its affinity for

selected organophosphates. J. Agricul. Food Chem. 53 (1); 90-97.

7. Gao, J., Wayne. A. Garrison, Christopher Hoehamer, Chris Mazur, and N. L. Wolfe.

(2000) Biotransformation of Organophosphate Compounds with Aquatic plants and

Aquatic Plant Extracts. J. Agricul. Food Chem. 48; 6113-6120.

8. Gao, J., Wayne. A. Garrison, Christopher Hoehamer, Chris Mazur, and N. L. Wolfe.

(2000) Biotransformation of o-DDT and r-DDT by Axenic Tissue Cultures and Aquatic

Extracts. J. Agricul. Food Chem. 48; 6121-6127.

9. N. Lee. Wolfe and Christopher F. Hoehamer. (2003) Enzymes in Plants and

Microorganisms that Detoxify Organic Compounds. In Phytoremediation. (Eds) Steven

McCutcheon and Jerald Schnoor. 159-187. Wiley and Sons. New York, NY.

REFERENCES: Available upon request

Contact this candidate