Fermentation, Bioprocess Optimization, scale up, microbiology

CURRICULUM VITAE

Mr. Jitukrushna Swain

***********.******@*****.***

Mobile: +91-974*******

An experienced problem solver with a range of theoretical,

technical and practical experience gained within academic and

industrial environments. Detail focused, flexible and resourceful

with the ability to effectively manage projects within required

performance requirements.

OBJECTIVE

Seeking a quality environment, that ensures exposure to new

technologies and innovation, where my skills and knowledge gets

utilized to its full potential and my career is enriched in all

spheres.

EDUCATIONAL DETAILS

. M.Sc. Biotechnology (2007-2009) with first class

from School of Life sciences (affiliated to DBT)

Sambalpur University, Orissa

. B.Sc. Life Sciences (2004-2007) with distinction

from Neelasaila Mahavidyalaya, Rourkela, under

Sambalpur University, Orissa

TECHNICAL SKILLS

. More than 4.5 years of hands on experience over fermentation

processes and fermenters of various capacities and make

. Expertise on Multi step fermentation

. Expertise in Microbial culture handling and preservation

. Microbial mutation for strain development

. Hands on experience over Downstream processing of targeted

product after fermentation

. Scientific data analysis and compilation

PROFESSIONAL EXPERIENCE

More than 4.5 years in R&D

Working currently, as Senior Scientist in the Microbial Up streaming

Lab (MUL) at Biocon Research Limited, Bangalore from September 2012

till date

Biocon Research Limited is the R&D devision of Biocon Industries ltd:

Biocon is an emerging global biopharmaceutical enterprise focused on

delivering affordable innovation. It is committed to reduce therapy

costs of chronic diseases like diabetes, cancer and autoimmune

diseases by leveraging India's cost advantage to deliver affordable

healthcare solutions to patients, partners and healthcare systems

across the globe.

Responsibilities:

. Process optimization for production improvement of Tacrolimus,

Lipstatin, Pravastatin, RifamycinB, Fedaxomycine, Epothilone,

Micafungin & EchinocandinB

. Advance strain development for new molecules and existing small

molecules

. Member of Core committee R&D for process cost reduction of small

molecules

. Preparation of POC's for new pharmaceutically important molecules

. Trouble shooting of fermentation related issues at 10kl and 30kl plant

. Coordination with pilot fermenter group for scale up of technology

. Coordination with DSP, SYNTHETIC CHEMISTRY for product

characterization and stability studies.

. Facing Internal and International AUDIT.

. Preparing & updating SOPs.

. Preparing -Technical Reports, Technology transfer data, Development

Reports.

. Delivering Technical presentations.

. Giving technical Trainings to fresher's

Achievements at BIOCON RESEARCH LIMITED, Bangalore:

. Optimized the multi step fermentation of Micafungin till 10kl and

submitted the POC for Tech transfer to production

. Optimised the High throughput mutant screening technique by plug assay

. Optimized the mutation process for the production species of

Lipstatin, Sirolimus, Tacrolimus and Fedexomycine

. Tacrolimus mutant with 25% higher productivity from the existing

strain

. Protoplasting process optimization for the fungal cultures for strain

development

. Ruled out the problem of inconsistent productivity in Pravastatin

production at shake flask and bench scale level

. POC submitted for EchinocandinB multi step fermentation

. Developed new chemical and biochemical assay's for small molecules

PREVIOUS PROFESSIONAL EXPERIENCE

> Worked as Executive Research Technologist through Adecco India

Pvt Ltd at Praj Matrix- The Innovation Center Pune from June

2011 to October 2012

Praj matrix -The innovation center a division of Praj industries ltd:

Praj is a global Indian company that offers innovation solutions to

significantly add value to Bioethanol, Biodiesel and Brewery plants.

Responsibilities:

. Process optimization for Xylose Fermentation at lab, bench and

Pilot scale

. Pretreatment process optimization study

. Basic Microbial culture preservation, Master Culture bank

preparation work

. Process Validation of ethanol fermentation at bench scale and

pilot scale

. Mutation (chemical and UV) for Advance Strain Development

. Preparation of scientific reports, batch sheets, operating

procedures and qualification documentation for process and

equipment

> Worked as Executive Fermentation- Microbiology Officer at

Aumgene Biosciences, Gujarat from September 2010 to May 2011

Aumgene Biosciences Pvt. Ltd.: a contract research and production

company that offers innovative solutions to significantly add value

in recombinant yeast, fermentation of biopesticides, microbial enzyme

production and biofertilizers. This is a knowledge based company with

specialization in Fermentation and Microbiology.

Responsibilities handled:

. Microbial Culture banking and master culture revival and

preservation

. Recombinant Yeast Fermentation (TMOF) at production scale

. Lipase fermentation by Recombinant Yeast

. Fermentation of enzymes and biopesticides at bench scale

for bioprocess optimization.

. Scale up of fermentation processes up to 5KL fermenters for

production and Downstreaming of the targeted product.

. Enzyme Formulation for Textile grade and Animal feeds

. Preparation of SOP's and process validation documents.

. Clean Room Facility and Pilot Plant infrastructure

development at Aumgene.

> Worked as a DBT trainee at Praj Matrix-The Innovation Center,

Pune (December 2009 to Aug 2010)

The training was funded by Department of Biotechnology Govt. Of India

for a hands on exposure to Industrial Biotechnology where I was work

on the project entitled "Bioprocess optimization of Xylose

fermentation"

Responsibilities:

. Conducted shake Flask and Bench scale trials of Xylose

fermentation.

. Screening of UV mutants for Strain Improvement

. Master culture cell banking

. Xylose fermentation trials conducted at Pilot Scale

. Pretreatment process scale up at bench(10Lit) and Pilot

scale(1KL)

. Developmental trials of different pretreatment processes for

Xylose hydrolysates

INTERNSHIP

Worked as a trainee at Jaypee University of Information Technology

(JUIT) Solan, Himachalpradesh, India for a month (December 2008) that

helped me to get exposed to

Downstream processing of different targeted products and fermentation

at bench scale

THESIS WORK

Master's Thesis: "Fermentation and downstream processing of the

metabolites produced by soil microorganisms"

Veer Narmad South Gujarat University, Surat, Gujarat

Supervisor: Dr. Gaurav Shah

Duration: January 2009 - March 2009

ACHIEVEMENTS

. Received Fellowship from Department of Biotechnology, Government

of India for Industrial Training under BIPT 2009-10

. Selected for M.Sc. Biotechnology at national level entrance test

conducted by UGC

. Selected and attained blood sample collection camp from tribal

population of eastern India organized by CCMB, Hyderabad for

"Population migration studies"

. Attained study tour cum work shop at Jaypee University

Information Technology, Simla on Bioinformatics tools.

SOFTWARE PROFICIENCY

. Programming language : C

. Software Package : MS - Office 2010

. Operating System : Windows 2000/XP &

VISTA

LANGUAGE KNOWN

ENGLISH, HINDI, GUJRATI (read, write, speak), ORIYA (Mother tongue)

PERSIONAL INFORMATION

Date of Birth : 28th January 1986

Gender : Male

Nationality : Indian

Material Status : Single

Permanent Address : Mr. Jitukrushna Swain

C/106, Pardesi Park

Near Jalaram Petrol Pump, Sayan Road, Amroli

Pin Code. - 394107, Surat, Gujarat

DECLARATION

I hereby declare that the information furnished above is true to the

best of my knowledge and belief.

Place:

Date :

Jitukrushna Swain

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