Quality Assurance Engineering

WEI MENG

*** ***** ********

Email: ********@*****.***

New Brunswick, NJ 08901

Cellular Phone: 732-***-****

PROFILE

Master Degree in Chemical Engineering seeking a position on formulation

development or oral solid dosage forms manufacturing; seasoned in

pharmaceutical manufacturing of solid drugs and quality assurance;

excellent problem solving and strong communication skills, highly

dedicated and self-motivated, team-oriented and highly adaptable to

diverse working environment.

PROFESSIONAL EXPERIENCE

Research Assistant, PI: Dr. Fernando J. Muzzio, Oct. 2012-present,

Engineering Research Center on Structured Organic

Particulate Systems (ERC-SOPS), Piscataway, NJ

> Continuous Manufacturing based on Direct Compression

. Developed statistical models to characterize and optimize the

mixing behavior and blend homogeneity in commercial blenders

(Glatt, Gericke and Lodige); Investigated effects of process and

design parameters and material flow properties on powder

residence time distribution, hold up and energy input; Delivered

design space based blends variance reduction ratio and relative

standard deviation; Successfully implemented Quality by Design

for pharmaceutical manufacturing process

. Investigated continuous mixing performance for formulations

exhibiting a large tendency to segregate; Enhanced the blend

uniformity by 40% compared with batch mixing

> Continuous Manufacturing based on Wet Granulation

. Developed statistical models to characterize and optimize the

granulation behavior in commercial granulators (Glatt and

Lodige); Implemented more efficient regime maps based models to

continuous wet granulation process and accomplished desirable

particle size distribution

. Characterized the effects of hold up and air flow rate and

temperature in commercial fluidized bed dryers (Glatt) and

controlled the drying dynamics to achieve desired moisture

content

. Integrated, tested and optimized a complete continuous wet

granulation line for manufacturing tablet drugs; Decreased

capital investment by 50% and waste by 60% compared with batch

process; Required smaller footprint of 50% less area; Facilitated

and simplified process scaling up; Reduced raw materials supply

by 90%

. Investigated the PAT in manufacturing line; Used NIR for inline

measurement of blend uniformity and Eyecon camera for real-time

granule size monitoring; Expedited process control and

comprehensive process understanding

> Prediction of flow properties of blends by a statistical fractional

factorial design

. Built DoE model to correlate the flow properties of blends to

formulation and process parameters; Succeeded in predicting flow

factor, cohesion and bulk density of blends with the given

formulation

> Comparison of mixing performance of Resodyn Acoustic Mixer with V-

blender

. Correlated energy input in Acoustic Mixer to V-blender and

compared mixing performance with different mixing principles

> Characterization of Tapped Feeders

. Used Schenck Accurate Accpro II as a "catch scale" to test powder

flow rate of different types of tapped feeders under both

horizontal and vertical vibration modes; Developed and validated

Discrete Element Method (DEM) models

> Analysis of Shear Behavior of Binary Mixtures in a Rotational Shear

Cell

. Explored the dependence of major principle stress of mixtures on

particle size, composition and consolidation levels; Accomplished

the development of a mixing rule for mixture shear behavior

SKILLS

1. Formulation and Solids Process Engineering: Feeders and Feed Frames;

Powder Mixing; Roller Compaction; Milling; Drying; Wet Granulation;

Compression and Coating

2. Material characterization: FT4 Powder Rheometer; Laser Diffraction

Analysis; Eyecon Camera

3. Computer: MATLAB, EDEM, SolidWorks, SAS, OriginLab, Umetrics SIMCA,

Unscrambler, JMP, Minitab; Flow sheet modeling: Aspen Plus, gPROMs;

Statistics: DoE; ANOVA/PCA/PLS

4. Analysis: HPLC; GC-MS; SEM; TGA

EDUCATION

Rutgers University, School of Engineering, Piscataway, NJ Sept.

2012-present

Master of Science, Chemical Engineering, Oct. 2014 (expected) GPA:

3.7/4.0

Dissertation: "Parametric Analysis of High Shear Continuous Wet

Granulation"

Tianjin University, School of Chemical Engineering and Technology,

Tianjin, China Sept. 2006- Jul. 2010

Bachelor of Engineering, Chemical Engineering (major);

Bachelor of Science, Chemistry (minor)

PUBLICATIONS AND PRESENTATION

Gao, Y. J.; Boukouvala, F.; Engisch, W.; Meng, W.; Muzzio, F. J.;

Ierapetritou, M. G., Improving Continuous Powder Blending Performance

Using Projection to Latent Structures Regression. Journal of

Pharmaceutical Innovation 2013, 8 (2), 99-110;

Four more papers are in preparation; One presentation: 2014 AIChE Annual

Meeting, City of Atlanta GA, Nov 2014.

1 / 1

Contact this candidate