CURRICULUM VITAE

Hira Choudhury

acdymi@r.postjobfree.com

Cell: +91-801*******

Objective:

To acquire a leading and challenging position in the teaching profession

where I can utilize my education and experience to its full potential while

effectively serving and contributing to the society, simultaneously

nourishing my skills and knowledge.

Synopsis:

. PhD thesis submitted (Pharmacy) from the Department of Pharmaceutical

Technology, Jadavpur University, Kolkata.

. Received DST-Women Scientist (WOS-A) award (Ministry of Science and

Technology, Govt. of India) in Department of Pharmaceutical Technology

at Jadavpur University, Kolkata during PhD tenure.

. Industrial experience (5years) as Associate Scientist (DMPK) at

Discovery Research (DR), Dr. Reddy's Laboratories Ltd., Hyderabad,

India.

Expertise

. Performed bio-analytical method development and validations in HPLC

and LC-MS/MS.

. Analytical method development and validation in HPLC.

. 'In vivo' pharmacokinetic studies in different preclinical species.

. Dissolution study for generics drugs for BA/BE studies.

. Bioequivalence studies assignments (industry) for DCGI approval

. Industrial pre-clinical and clinical development activities for

regulatory requirement.

. Computer knowledge acquainted with softwares such as Analyst,

Millennium, Chromeleon, Class VP, EZChrom Elite, Spinchrom, WinNonlin

etc.

Research Experience:

2009 - till date

Institute: Jadavpur University

Position: Women Scientist WOS-A (DST) (Ministry of Science and Technology,

Govt. of India)

I have completed my research work on "An approach to intravenous to oral

switch in cancer chemotherapy based on nanoemulsion formulation". The work

includes

. Development and optimization of paclitaxel nanoemulsion

. Characterization and stability study of nanoemulsion

. Pharmacokinetic study of paclitaxel nanoemulsion and solution by

developed and validated LC-MS/MS method

. Pharmacokinetic study of paclitaxel nanoemulsion in presence of P-

glycoprotein inhibitors by developed and validated LC-MS/MS method

. In vitro and in vivo evaluation of anticancer activity

. Toxicity study of paclitaxel nanoemulsion

. Bioanalysis of bioequivalence study samples by HPLC and LC-MS/MS

method.

2004- 2009

Organization: Dr. Reddy's Laboratories Ltd., Hyderabad (later taken over by

Aurigene Discovery Technologies Limited)

Position: Associate Scientist

Department: Drug Metabolism and Pharmacokinetics, Discovery Research

. Pre-clinical pharmacokinetics, metabolism and clinical drug

development of metabolic disorder New Chemical Entities (NCE), anti-

cancer and anti-infective and CB1 antagonist NCEs under GLP norms.

. Also involved in dose proportionality, quantitative tissue

distribution and oral bioavailability studies in different lab animals

(mouse, rat, dog and rabbit).

. Identification and characterization of metabolites in plasma, urine,

feces and bile using LC-MS/MS and HPLC method. Correlating the

metabolites from in-vivo and in-vitro studies.

. Gender variation in pharmacokinetics studies and effect of food on

pharmacokinetics in rodents.

. Bio-analytical method validation of different NCEs using HPLC-FL, UV

detector and LC-MS/MS in different biological matrices.

. In-vitro metabolic stability of NCEs of various therapeutic areas in

mouse, rat, dog and human liver microsomes.

. In-vitro protein binding study.

. Knowledge about in-vitro CYP Phenotyping and CYP Liability study of

different NCEs.

Technical Skills:

. Acquainted with the operation of HPLC (Shimadzu, Agilient, Waters,

Dionex, Knauer), LC-MS/MS (API-2000, API-3000, API-4000, and API-4000-

QTrap.

. Bioanalytical method development and validation for new NCEs/NMEs and

generic drugs using HPLC and LC-MS/MS.

. In vitro screening of NCEs for microsomal stability.

. In vivo experimentations for necessary profiling of molecules such as

dosing, sampling, pharmacokinetic, toxicokinetic and tissue

distribution studies.

. Development and optimization of nanoemulsion (oil in water type).

. Development of tumorous model in animal for evaluating antitumor

activity of drugs/ developed formulations

. Column chromatography, TLC.

Educational Qualifications

2009-2013

PhD in Pharmacy (thesis submitted) with DST Women Scientist (WOS-A)

award (Ministry of Science and Technology, Govt. of India), under the

guidance of Prof. (Dr.) T. K. Pal, in the Dept. of Pharm. Tech.,

Jadavpur University, Kolkata, India.

Title of PhD work: "An approach to intravenous to oral switch in

cancer chemotherapy based on nanoemulsion formulation"

2002 - 2004

M. Pharm. (Pharmaceutical Chemistry) Jadavpur University, Kolkata,

India (First Class with 79.77 %).

Title of M. Pharm. work: "Synthesis of ruthenium complexes and

evaluation of their pharmacological activities with special reference

to antineoplastic activity"

1998 - 2002

B.Pharm, Jadavpur University, Kolkata, India (First class with

Honours; 76.25 %).

Professional Diploma in Clinical Research

2013

(Catalyst Clinical Services Pvt. Ltd., Delhi)

Scholastic Achievements:

. Achieved Women Scientist award (WOS-A) by Department of Science and

Technology (Ministry of Science and Technology, Govt. of India, New

Delhi), for the project entitled "Enhancement of oral bioavailability

of paclitaxel, an anticancer drug using curcumin along with

nanoemulsion formulation" as Principal Investigator. Fund released for

the project: 20 Lakh.

. Qualified Graduate Aptitude Test in Engineering (GATE) conducted by

Indian Institute of Science (IIS), Bangalore, 2002.

Percentile Score: 91.94

. Junior Research Fellowship, University Grants Commission (UGC), 2002-

2004.

. Honored with Second Prize in the poster presented in the International

Seminar on Clinical Research & Regulatory Affairs - Present Scenario"

entitled "Development and validation of LC-MS/MS-ESI method for the

determination of paclitaxel in mice plasma: Its application to

pharmacokinetic study with special emphasis on bioavailability"

Publications (16):

. Top of Form

. Hira Choudhury, Bapi Gorain, Sanmoy Karmakar, Easha Biswas, Goutam Dey,

Rajib Barik, Mahitosh Mandal, Tapan Kumar Pal. Improvement of cellular

uptake, in vitro antitumor activity and sustained release profile with

increased bioavailability from a nanoemulsion platform. International

Journal of Pharmaceutics. 2014; 460: 131-143.

. Hira Choudhury, Bapi Gorain, Sanmoy Karmakar and Tapan Kumar Pal.

Development and validation of RP-HPLC method: Scope of application in

the determination of oil solubility of paclitaxel. Journal of

Chromatographic Science. 2013. doi:10.1093/chromsci/bms206

. Hira Choudhury, Bapi Gorain, Ayan Das, Balaram Ghosh and Tapan K. Pal.

Development and validation of a sensitive HPLC-MS/MS-ESI method for

determination of febuxostat: Application to pharmacokinetic study.

Current Analytical Chemistry. In Press. DOI:

10.2174/1573411010999131129102723

. Bapi Gorain, Hira Choudhury, Amit Kundu, Lipi Sarkar, Sanmoy Karmakar,

P. Jaisankar, Tapan Kumar Pal. Nanoemulsion strategy for olmesartan

medoxomil improves oral absorption and extended antihypertensive

activity in hypertensive rats. Colloids and Surfaces B: Biointerfaces.

2014; 115: 286-294.

. Bapi Gorain, Hira Choudhury, Easha Biswas, Anwesha Barik, P. Jaisankar

and Tapan Kumar Pal. A novel approach for nanoemulsion components

screening and nanoemulsion assay of olmesartan medoxomil through a

developed and validated HPLC method. RSC Advances. 2013; 3: 10887-

10893.

. Bikash Roy, Hira Choudhury, Ayan Das, Anjan Kumar Das, Tapan Kumar Pal.

Development and validation of a liquid chromatography-tandem mass

spectrometry method to determine ulifloxacin, the active metabolite of

prulifloxacin in rat and rabbit plasma: application to toxicokinetic

study. Biomed. Chromatogr. 2011; 25: 890-901

. Bapi Gorain, Hira Choudhury, Dhiman Halder, Amlan K. Sarkar, Pradipta

Sarkar, Easha Biswas, Balaram Ghosh, Tapan K. Pal. A comparative

pharmacokinetic study of a fixed dose combination for essential

hypertensive patients: A randomized crossover study in healthy human

volunteers. Drug Res (Stuttg). 2013; 63(04): 177-184.

. Utpal Nandi, Ayan Das, Bikash Roy, Hira Choudhury, Bapi Gorain, Tapan

Kumar Pal. Development and validation of an HPLC-UV method for

simultaneous determination of zidovudine, lamivudine, and nevirapine in

human plasma and its application to pharmacokinetic study in human

volunteers. Drug Testing Analysis. 2013; 5(6): 485-491.

. Bapi Gorain, Hira Choudhury, Utpal Nandi, Ayan Das, Shubhasis Dan,

Tapan K. Pal. Development and validation of an HPLC method for

simultaneous detection and quantification of paracetamol and etodolac

in human plasma and its application to a pharmacokinetic study. Journal

of AOAC International. 2013; 96(3): 573-579.

. Utpal Nandi, Bapi Gorain, Hira Choudhury, Bikash Roy, Tapan K Pal.

Development and validation of a high-performance liquid chromatographic

method with ultraviolet detection for quantitation of lornoxicam in

human plasma: Application to bioequivalence study. Journal of Pharmacy

Research. 2011; 4(9): 3203-3205.

. P. Venkatesh, T. Harisudhan, Hira Choudhury, Ramesh Mullangi,

Nuggehally R. Srinivas. Simultaneous estimation of six anti-diabetics-

glibenclamide, gliclazide, glizipide, pioglitazone, repaglinide and

rosiglitazone: development of a novel HPLC method for use in

pharmaceutical formulations analysis and human plasma assay. Biomed

Chromatogr. 2006; 20(10): 1043-1048.

. P. Venkatesh, T. Harisudhan, Hira Choudhury, Ramesh Mullangi,

Nuggehally R. Srinivas. Pharmacokinetics of Etoposide in rats with

Acute Renal Failure (ARF) induced by Uranyl Nitrate - Optimization of

duration of Uranyl nitrate treatment for inducing acute renal failure

with PK perspective. Eur J Drug Metab Pharmacokinet. 2007; 32(4): 189-

96.

. Pradip K. Sasmal, Rashmi Talwar, J. Swetha, D. Balasubrahmanyam, B.

Venkatesham, Khaji Abdul Rawoof, B. Neelima Devi, Vikram P. Jadhav,

Sanjoy K. Khan, Priya Mohan, D. Srinivasa Reddy, Vijay Kumar

Nyavanandi, Srinivas Nanduri, K. Shiva Kumar, M. Kannan, P. Srinivas,

Prabhakar Nadipalli, Hira Chaudhury, V. J. Sebastian. Structure-

activity relationship studies of novel pyrazole and imidazole

carboxamides as cannabinoid-1 (CB1) antagonists. Bioorg Med Chem Lett.

2011; 21: 4913-4918.

. Pradip K. Sasmal, D. Srinivasa Reddy, Rashmi Talwar, B. Venkatesham, D.

Balasubrahmanyam, M. Kannan, P. Srinivas, K. Shiva Kumar, B. Neelima

Devi, Vikram P. Jadhav, Sanjoy K. Khan, Priya Mohan, Hira Chaudhury,

Debnath Bhuniya, Javed Iqbal, Ranjan Chakrabarti. Novel pyrazole-3-

carboxamide derivatives as cannabinoid-1 (CB1) antagonists: Journey

from non-polar to polar amides. Bioorg Med Chem Lett. 2011; 21: 562-

568.

. Jayanti Mukherjee, Ayan Das, Uday Sankar Chakrabarty, Bijay Kumar

Sahoo, Goutam Dey, Hira Choudhury and Tapan Kumar Pal. Development and

validation of RP HPLC method to determine nandrolone phenylpropionate

in different pharmaceutical formulations. Acta Poloniae Pharmaceutica -

Drug Research 2011; 68 (2): 155-160.

. Jayanti Mukherjee, Hira Choudhury, Sanmoy Karmakar, Tapan K Pal.

Comparative pharmacokinetic and relative bioavailability study of

ursodeoxycholic acid tablets in healthy Indian volunteers. Int J Pharm

Sci Rev Res. 2013; 22(2): 69-72.

Workshops and symposia:

. Participation in National workshop on "Registration of bio-ethics

committee for clinical research - Its practice & prospect" organized by

Bioequivalence Study Centre, Jadavpur University, Kolkata, 2013.

. Delivered lecture in the four weeks long Quality Improvement Programme

on "Innovation and excellence in Pharmaceutical sciences" on 13th July,

2013.

. Delivered lecture in refresher course on UGC sponsored "Process control

and analytical techniques in food processing and quality evaluation" on

18th June, 2012.

. Participated as organizing committee and presented poster in the

International Seminar on Clinical Research & Regulatory Affairs -

Present Scenario" organized by Bioequivalence Study Centre, Jadavpur

University, Kolkata, 2012.

. Participation in training program on "Good Clinical Practice Training

for Investigator" at Bioequivalence Study Centre, Jadavpur University,

Kolkata, 2012.

. Delivered lecture in the two week long short-term course on "Pharmacy:

A fulcrum of knowledge of drug and drug research" of Quality

Improvement Programme on 12th February, 2011.

. Participated as organizing committee and delivered lecture in the DST

Sponsored 5 day National Workshop on Application of Chromatography &

Mass Spectrometry in Clinical Research at Bioequivalence Study Centre,

Jadavpur University, Kolkata, 2010.

. Training on OECD Principles on Good Laboratory Practice Dr. Reddy's

Laboratories Ltd, Hyderabad, 2008.

. Participated at the Young Scientists' Symposium-2006 held at Discovery

Research Foundation of Dr. Reddy's Laboratory Ltd., Hyderabad, 2006.

. Training on HPLC / GC Instrumentation and Method Development organised

by R & D Automation & Analytical Instrumentation Forum at Discovery

Research Foundation of Dr. Reddy's Laboratory Ltd., Hyderabad, 2004.

. Training on HPLC at Discovery Research Foundation of Dr. Reddy's

Laboratory Ltd., Hyderabad, 2004

. Participated in the 54th and 55th Indian Pharmaceutical Congress.

. Attended a workshop cum seminar on Bioequivalence Study organized by

Bioequivalence Study Center, Department of Pharmaceutical Technology,

Jadavpur University, Kolkata, 2003

. One Month Vocational training at Dey's Medical Stores (Manufacturing)

Limited, Kolkata, 2001.

PERSONAL DETAILS:

. Father's Name : Tarapada Choudhury

. Date of Birth : 23rd August, 1978

. Marital Status : Married

. Nationality : Indian

. Languages known : English, Hindi, and Bengali.

. Address : Flat -20l (A wings)

Selene Park, Kalepadal,

Hadapsar, Pune.

DECLARATION:

All the information provided above are true, complete and correct to the

best of my knowledge and belief. In the event of any information being

found false or incorrect at any stage, my candidature will stand

automatically cancelled.

Place: Pune

Date: 18th April, 2014 Hira

Choudhury

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