Assistant Years Experience

ELENA ZELIN

**** ****** ****, *** #*, Champaign, IL 61820

217-***-**** [Mobile]; E-mail: acdx7n@r.postjobfree.com

STATUS IN USA Permanent Resident (National Interest Waiver Green Card)

SUMMARY OF QUALIFICATIONS

• Scientist with more then ten years experience working in area of Molecular Immunology, Nucleic Acid

Biochemistry, Cellular, Molecular, and Receptor Biology

• Highly motivated professional that works well independently and as part of a team

• Strong analytical, problem-solving and communication skills

• Highly organized goal-driven professional with supervisory experience

• Experienced in working in industrial and academic settings

INDUSTRIAL EXPERIENCE

Quark Pharmaceutical Inc., Israel

Research Assistant in the in vivo unit 2000-2001

• Cloned and characterized novel genes that were identified by BiFAR microarray platform

• Studied the regulation and biological effects associated with the overexpression of hypoxia-inducible genes

RTP801 and Hi95

• Presented work during internal meetings and collaborated with internal and external partners

• Co-authored two publications in scientific journals; RTP801 (PF-655) is being evaluated in Phase II studies

by Pfizer

RESEARCH AND PROFESSIONAL EXPERIENCE

University of Illinois at Urbana-Champaign

Postdoctoral Fellow 2008-current

• Identified a novel regulatory network for monitoring the dynamics of protein DNA interactions

• Developed a strong expertise in a variety of biochemical, molecular and cellular biology assays, including

cloning, PCR, qRTPCR, ChIP, virus production and delivery into mammalian cell lines, luciferase assay,

cDNA and siRNA transfections, Southern, Northern and Western blot analysis, chromatin biology, receptor

biology, EMSA, protein purification, cell culture, stem cells, fluorescent microscopy

• Mentored undergraduate, rotation, and master students

• Managed radioactivity in the laboratory

• Presented research at the “ Midwest Stress Response and Molecular Chaperone Meeting”

University of Illinois at Urbana-Champaign

Research Assistant 2004-2008

• Utilized in vitro section to identify and characterize DNAzymes that synthesize branched RNA-DNA

conjugates

• Applied the double-stranded DNA strategy to control RNA folding and catalysis

• Designed in vitro selections and isolated deoxyribozymes that create 3’-5’ branched RNA in collaboration

with Dr. Picirilli JA, University of Chicago

• Developed expertise in nucleic acid biochemistry

• Independently guided the work of rotation students

• Presented research at the “Annual Meeting of RNA Society”

Ben-Gurion University of the Negev, Israel

Research Assistant 1996-1998

• Studied molecular biology and pathogenic mechanisms of HTLV-1

• Determined the effects of various PKC isoforms on activating the expression of HTLV-1

• Characterized the role of PKC in inducing cell cycle arrest and apoptosis by TPA in human T cells

• Designed and implemented retroviral vector over-expressing the negative trans-dominant tax mutant in

collaboration with Dr. Flugel RM, DFKZ-ATV, Heidelberg, Germany

• Developed technical expertise in mammalian cell culture, protein and antibody characterization (Western blot

analysis, immunopresipitation, ELISA)

• Published research in Experimental Cell Research and in Virology

Teaching EXPERIENCE

University of Illinois at Urbana-Champaign

Teaching assistant for Biochemistry 2005-2006

Ben-Gurion University of the Negev, Israel

Teaching assistant for Microbiology and Molecular Biology 1996-1998

EDUCATION

University of Illinois at Urbana-Champaign

Ph.D. in Biochemistry 2004-2008

Thesis: “Deoxyribozyme-mediated synthesis of branched nucleic acids and application to modulation of

ribozyme catalysis”. Advisor: Dr. Scott K. Silverman

Ben-Gurion University of the Negev, Israel

M.S. Honors in Microbiology and Immunology 1998-2000

Ben-Gurion University of the Negev, Israel

B.A. in Teacher Training (Teacher of Biology) 1996-1998

Ben-Gurion University of the Negev, Israel

B.S. in Life Sciences 1994-1998

CERTIFICATE

University of Illinois at Urbana Champaign, College of Business

Certificate in Business Administration 2007

fellowships

American Heart Association Postdoctoral Fellowship 2012-2013

NIH Postdoctoral Research Fellowship 2010-2012

SELECTED PUBLICATIONS

1. Zelin, E., Freeman, BC. “Differential role of cellular deacetylases on HSF1 activities” manuscript in

preparation.

2. Geng, Y., Zhao, Y., Xu, Y., Feng, B., Lu, H., Zelin, E., Lynn, D., Austin, K., Stoklosa, J., Marrion, J.,

Hergenrother, PJ., Cheng, J, Freeman, BC., Liao, J., Wang F. “High-throughput chemical screening reveals

novel regulatory mechanism of human pluripotent stem cells pluripotency and near-homogeneity mesoderm

and endoderm differentiation conditions” submitted to Cell.

3. Zelin, E., Zhang, Y., Toogun, OA., Zhong, S., Freeman, BC. “The p23 molecular chaperone and GCN5

acetylase jointly modulate protein-DNA dynamics and open chromatin status”. Mol. Cell, 2012, 48, 1-12.

4. Zelin, E*., Echtenkamp, FJ*., Oxelmark, E., Woo, JI., Andrews, BJ., Garabedian, M., Freeman, BC. “Global

functional map of the p23 molecular chaperone reveals an extensive cellular network”. Mol. Cell, 2011, 43, 1-

14. * authors contributed equally. Featured Article.

5. Zelin, E., Silverman, SK. “Efficient control of group I intron catalysis by DNA constraints”. Chem. Commun.,

2009, 767-769. “Hot Article” Feature Story.

6. Zelin, E., Silverman, SK. “Allosteric control of ribozyme catalysis”. ChemBiochem., 2007, 8, 1907-1911.

7. Zelin, E., Wang, Y., Silverman, SK. “Adenosine is inherently favored as the branch-site RNA nucleotide in a

structural context that resembles natural RNA splicing”. Biochemistry, 2006, 45, 2767-2771.

COmmunity service and volunteer work

Carle Foundation Hospital, Pediatrics summer, 2012

ACES and Bio-Sciences Career Fair, UIUC 2011

Christine Rich Dance Studio 2008-2013

Illini Biotechnology Organization, UIUC 2007

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