Supply Chain Quality Assurance

BIOGRAPHICAL SKETCH

Last name: Afeli

First name: Serge

Middle name: Amani Yao

Address: ** ***** ****** ******, ****, SC, 29063

Email: *******@*******.***

Phone: 803-***-****

A- EDUCATION

NASBITE Certification Global Business Professional June 2013

University of South Carolina PhD degree Pharmaceutical sciences-pharmacology May 2013

Kansas State University B.S degree Physical Sciences December 2007

Kansas State University _ Pre-pharmacy curriculum May 2008

B. PERSONAL STATEMENT

During my PhD training at the University of South Carolina College of Pharmacy, I investigated several

potassium ion (K+) channels as well as beta3 adrenergic receptors in human bladder and demonstrated that

these proteins could be promising drug targets for overactive bladder treatment. My work has led to several

publications (see list of publications below) and has contributed to make our research team, the first research

group in the U.S. to identify and characterize K+ channels in the human bladder. I was first author of a paper

that applied for the first time, qPCR techniques to identify K+ channels expression in enzymatically isolated

detrusor smooth muscle cells, therefore providing direct molecular evidence for K+ channels in the human

bladder (Afeli et al., 2012). I presented numerous seminars and posters in my department as well as at national

conferences and was awarded several prizes (see list of awards below).

As a PhD candidate, I also received business training from the South Carolina Small Business Development

Center (SCSBDC) and the National Association of Small Business International Trade Educators (NASBITE)

and became certified as a Global Business Professional. This certification confirms my knowledge in

international trade and my abilities to practice global business at the professional level required in today’s

competitive environment. This certification also outlines my proficiency in global business management, global

marketing, supply chain management, and trade finance.

After completion of my PhD degree, I was recruited by Nephron Pharmaceuticals Corporation for a

postgraduate internship. During my tenure at Nephron Pharmaceuticals Corporation, I lead the design of

marketing strategies for the African market. I conducted risk assessment analysis, market share analysis, and

drafted a budget for the company operation in Nigeria. I helped improve standard operating procedures (SOP)

for blow-fill-seal (BFS) technology. I worked as quality control (QC) associate (chemistry and microbiology). I

also worked as a quality assurance (QA) associate and became familiar with compliance and regulatory

procedures for CGMP and FDA-requirements. I also acquired knowledge about drug formulation in ISO class 5

clean room.

From 2012-2013, I served as treasurer-elect of the National Black Graduate Student Association (NBGSA), an

organization dedicated to help increase the number of black graduate and professional students in higher

education by providing resources that will enhance the likelihood of their academic and career success.

In July 2013, I founded AFELI PHARMACEUTICALS LLC, a startup pharmaceutical Supply Chain Company

aiming to address the unmet needs for consistent delivery of healthcare products throughout the African

continent. We help U.S. manufacturers increase their yearly product sale through product launch, advertising,

and marketing campaign in Africa.

My strong background in pharmaceutical research, my business management skills, my leadership aptitudes,

and my proficiency in both French and English make me a valuable candidate to fill the current position.

C. POSITIONS AND HONORS

Previous Positions and Employment

August 2013 – Present: Adjunct Faculty in Chemistry and Pharmacology at Newberry College and

Presbyterian College.

July 2013 – Present: Founder and CEO of AFELI PHARMACEUTICALS LLC.

May 2013 – June 2013: Postgraduate Intern at Nephron Pharmaceuticals Corporation, Orlando FL.

January 2013 – May 2013: Graduate Teaching Assistant, Department of Biology at the University of South

Carolina, College of Pharmacy, Columbia, SC

January 2009 – May 2013: Graduate Research Assistant, Department of Drug Discovery and Biomedical

Sciences at the University of South Carolina, College of Pharmacy, Columbia, SC

August 2008 – December 2008: Pharmacy Technician at Wamego Drug store, Wamego, Kansas

May 2007 – August 2008: Mentor and Academic tutor of General Chemistry, Organic Chemistry, Calculus,

Biology, and Physics, at the Student Services for Intercollegiate Athletics, Kansas state university, Manhattan,

Kansas

Professional Memberships

2010 – present: American Physiological Society

2010 – 2012: Founder and first president of the College of Pharmacy Graduate Student Association (CPGSA)

2010 – present: Member of the National Black Graduate Student Association (NBGSA)

2012 – 2013: Treasurer-elect of the National Black Graduate Student Association (NBGSA)

Honors

1- Graduate Student of the year Award from the department of Drug Discovery and Biomedical Sciences at

the South Carolina College of Pharmacy (May 2013)

2- Scholar Award from the Black graduate student association of the University of South Carolina (2012)

3- First place award for best poster competition at the 24th National Black graduate student conference

(2012)

4- Second place award for best doctoral level oral presentation at the 23rd National black graduate student

conference (2011)

5- Winner of the Bob and Lila Snell award of the Kansas state athletics in 2007

6- All-Academic Men's basketball First Team of the BIG XII conference in 2007

7- BIG XII conference Commissioner’s Honor Roll in Spring 2006

8- BIG XII conference Commissioner’s Honor Roll in Fall 2006

D. SELECTED PEER-REVIEWED PUBLICATIONS

1. Afeli, S., Malysz, J., and Petkov, G.: Molecular expression and pharmacological evidence for Kv7

channel subtypes regulating detrusor smooth muscle function in vitro. PLoS One. 2013 Sep

20;8(9):e75875. doi: 10.1371/journal.pone.0075875. eCollection 2013

2. Malysz, J., Afeli, S., Petkov, G.: Ethanol-mediated relaxation of guinea pig urinary smooth muscle:

Involvement of BK and L-type Ca2+ channels. Am J Physiol Cell Physiol. 2014 Jan 1;306(1):C45-58.

doi: 10.1152/ajpcell.00047.2013. Epub 2013 Oct 23

3. Afeli, S. A., Rovner, E., Petkov, G.: Activation of beta3 adrenergic receptors decreases nerve-evoked

contractions in human detrusor smooth muscle isolated strips: Role of BK channels. Urology. 2013 Jul

25. PMID: 23890664

4. Hristov, K. L., Afeli, S. A., Parajuli, S. P., Cheng, Q., Rovner, E., Petkov, G. V.: Neurogenic detrusor

overactivity is associated with decreased expression and function of the large conductance voltage- and

ca(2+)-activated k channels. PLoS One 2013 Jul 5;8(7):e68052. PMID: 23861849

5. Afeli, S. A., Petkov, G. V.: Functional BK channels facilitate the β3-adrenoceptor agonist-mediated

relaxation of nerve-evoked contractions in rat urinary bladder smooth muscle isolated strips. Eur J

Physiology PMID: 23643998 - April 2013

6. Afeli, S. A., Rovner, E. S., Petkov, G. V.: SK but not IK channels regulate human detrusor smooth

muscle spontaneous and nerve-evoked contractions. Am. J. Physiol.- Renal Physiol., 303: F559, 2012

7. Afeli, S. A., Hristov, K. L., Petkov, G. V.: Do beta3-adrenergic receptors play a role in guinea pig

detrusor smooth muscle excitability and contractility? Am. J. Physiol.- Renal Physiol., 302: F251, 2012

8. Hristov, K. L., Chen, M., Afeli, S. A. et al.: Expression and function of K(V)2-containing channels in

human urinary bladder smooth muscle. Am. J. Physiol.- Cell Physiol., 302: C1599, 2012

9. Smith, A., Parajuli, S., Hristov, K., Cheng, Q., Soder, Q., Afeli, S., Earley, S., Malysz, J., Petkov, G.:

TRPM4 channel: A new player in urinary bladder smooth muscle function in rats. Am. J. Physiol.- Renal

Physiol. PMID:23283997)

10. Hristov, K., Afeli, S., Kellett, W. F., Rovner, E. & Petkov, G. V. Neurogenic detrusor overactivity is

associated with decreased BK channel activity: electrophysiological and functional studies on human

detrusor smooth muscle. J. Urol. 183, e73–e74 (2010).

11. Afeli, S., Petkov, G.: Activation of beta3 adrenoreceptors decreases the amplitude of the electrical field

stimulation induced contractions in rat detrusor smooth muscle isolated strips. FASEB. 2011

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